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GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A)

Identity

Alias (NCBI)EPND
FESD
GluN2A
LKS
NMDAR2A
NR2A
HGNC (Hugo) GRIN2A
HGNC Alias symbGluN2A
HGNC Previous nameNMDAR2A
HGNC Previous nameglutamate receptor, ionotropic, N-methyl D-aspartate 2A
LocusID (NCBI) 2903
Atlas_Id 47251
Location 16p13.2  [Link to chromosome band 16p13]
Location_base_pair Starts at 9753405 and ends at 10182067 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CABIN1 (22q11.23) / GRIN2A (16p13.2)GRIN2A (16p13.2) / GRIN2A (16p13.2)MOB1A (2p13.1) / GRIN2A (16p13.2)
SHB (9p13.2) / GRIN2A (16p13.2)CABIN1 22q11.23 / GRIN2A 16p13.2MOBKL1B GRIN2A 16p13.2
SHB 9p13.2 / GRIN2A 16p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GRIN2A   4585
Cards
Entrez_Gene (NCBI)GRIN2A    glutamate ionotropic receptor NMDA type subunit 2A
AliasesEPND; FESD; GluN2A; LKS; 
NMDAR2A; NR2A
GeneCards (Weizmann)GRIN2A
Ensembl hg19 (Hinxton)ENSG00000183454 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183454 [Gene_View]  ENSG00000183454 [Sequence]  chr16:9753405-10182067 [Contig_View]  GRIN2A [Vega]
ICGC DataPortalENSG00000183454
TCGA cBioPortalGRIN2A
AceView (NCBI)GRIN2A
Genatlas (Paris)GRIN2A
SOURCE (Princeton)GRIN2A
Genetics Home Reference (NIH)GRIN2A
Genomic and cartography
GoldenPath hg38 (UCSC)GRIN2A  -     chr16:9753405-10182067 -  16p13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRIN2A  -     16p13.2   [Description]    (hg19-Feb_2009)
GoldenPathGRIN2A - 16p13.2 [CytoView hg19]  GRIN2A - 16p13.2 [CytoView hg38]
ImmunoBaseENSG00000183454
genome Data Viewer NCBIGRIN2A [Mapview hg19]  
OMIM138253   245570   
Gene and transcription
Genbank (Entrez)AB209695 AK124698 AK295620 AK308862 BC117131
RefSeq transcript (Entrez)NM_000833 NM_001134407 NM_001134408
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRIN2A
Alternative Splicing GalleryENSG00000183454
Gene ExpressionGRIN2A [ NCBI-GEO ]   GRIN2A [ EBI - ARRAY_EXPRESS ]   GRIN2A [ SEEK ]   GRIN2A [ MEM ]
Gene Expression Viewer (FireBrowse)GRIN2A [ Firebrowse - Broad ]
GenevisibleExpression of GRIN2A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2903
GTEX Portal (Tissue expression)GRIN2A
Human Protein AtlasENSG00000183454-GRIN2A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12879   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12879  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12879
Splice isoforms : SwissVarQ12879
PhosPhoSitePlusQ12879
Domains : Interpro (EBI)ANF_lig-bd_rcpt    Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    NMDAR2_C    Peripla_BP_I   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    Lig_chan-Glu_bd (PF10613)    NMDAR2_C (PF10565)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10613    pfam10565   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
Conserved Domain (NCBI)GRIN2A
Blocks (Seattle)GRIN2A
PDB (RSDB)3NFL    5H8F    5H8H    5H8N    5H8Q    5I2K    5I2N    5KCJ    5KDT    5TP9    5TPA    6IRA    6IRF    6IRG    6IRH   
PDB Europe3NFL    5H8F    5H8H    5H8N    5H8Q    5I2K    5I2N    5KCJ    5KDT    5TP9    5TPA    6IRA    6IRF    6IRG    6IRH   
PDB (PDBSum)3NFL    5H8F    5H8H    5H8N    5H8Q    5I2K    5I2N    5KCJ    5KDT    5TP9    5TPA    6IRA    6IRF    6IRG    6IRH   
PDB (IMB)3NFL    5H8F    5H8H    5H8N    5H8Q    5I2K    5I2N    5KCJ    5KDT    5TP9    5TPA    6IRA    6IRF    6IRG    6IRH   
Structural Biology KnowledgeBase3NFL    5H8F    5H8H    5H8N    5H8Q    5I2K    5I2N    5KCJ    5KDT    5TP9    5TPA    6IRA    6IRF    6IRG    6IRH   
SCOP (Structural Classification of Proteins)3NFL    5H8F    5H8H    5H8N    5H8Q    5I2K    5I2N    5KCJ    5KDT    5TP9    5TPA    6IRA    6IRF    6IRG    6IRH   
CATH (Classification of proteins structures)3NFL    5H8F    5H8H    5H8N    5H8Q    5I2K    5I2N    5KCJ    5KDT    5TP9    5TPA    6IRA    6IRF    6IRG    6IRH   
SuperfamilyQ12879
Human Protein Atlas [tissue]ENSG00000183454-GRIN2A [tissue]
Peptide AtlasQ12879
HPRD00698
IPIIPI00029768   IPI01012161   IPI00902706   
Protein Interaction databases
DIP (DOE-UCLA)Q12879
IntAct (EBI)Q12879
BioGRIDGRIN2A
STRING (EMBL)GRIN2A
ZODIACGRIN2A
Ontologies - Pathways
QuickGOQ12879
Ontology : AmiGOamyloid-beta binding  startle response  response to amphetamine  NMDA glutamate receptor activity  NMDA glutamate receptor activity  NMDA glutamate receptor activity  protein binding  endoplasmic reticulum  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  glutamate receptor signaling pathway  chemical synaptic transmission  brain development  learning or memory  memory  synaptic vesicle  zinc ion binding  visual learning  response to wounding  cell surface  postsynaptic density  ligand-gated ion channel activity  NMDA selective glutamate receptor complex  NMDA selective glutamate receptor complex  NMDA selective glutamate receptor complex  sensory perception of pain  calcium-mediated signaling  neurogenesis  glutamate-gated calcium ion channel activity  glutamate-gated calcium ion channel activity  sleep  cytoplasmic vesicle membrane  directional locomotion  ionotropic glutamate receptor signaling pathway  signaling receptor activity  negative regulation of protein catabolic process  dopamine metabolic process  serotonin metabolic process  response to drug  presynaptic membrane  positive regulation of apoptotic process  dendritic spine  response to ethanol  regulation of synaptic plasticity  excitatory postsynaptic potential  long-term synaptic potentiation  synaptic membrane  activation of cysteine-type endopeptidase activity  calcium ion transmembrane import into cytosol  calcium ion transmembrane import into cytosol  postsynaptic density membrane  excitatory chemical synaptic transmission  glutamatergic synapse  integral component of postsynaptic density membrane  protein localization to postsynaptic membrane  cellular response to amyloid-beta  regulation of NMDA receptor activity  
Ontology : EGO-EBIamyloid-beta binding  startle response  response to amphetamine  NMDA glutamate receptor activity  NMDA glutamate receptor activity  NMDA glutamate receptor activity  protein binding  endoplasmic reticulum  plasma membrane  plasma membrane  plasma membrane  integral component of plasma membrane  glutamate receptor signaling pathway  chemical synaptic transmission  brain development  learning or memory  memory  synaptic vesicle  zinc ion binding  visual learning  response to wounding  cell surface  postsynaptic density  ligand-gated ion channel activity  NMDA selective glutamate receptor complex  NMDA selective glutamate receptor complex  NMDA selective glutamate receptor complex  sensory perception of pain  calcium-mediated signaling  neurogenesis  glutamate-gated calcium ion channel activity  glutamate-gated calcium ion channel activity  sleep  cytoplasmic vesicle membrane  directional locomotion  ionotropic glutamate receptor signaling pathway  signaling receptor activity  negative regulation of protein catabolic process  dopamine metabolic process  serotonin metabolic process  response to drug  presynaptic membrane  positive regulation of apoptotic process  dendritic spine  response to ethanol  regulation of synaptic plasticity  excitatory postsynaptic potential  long-term synaptic potentiation  synaptic membrane  activation of cysteine-type endopeptidase activity  calcium ion transmembrane import into cytosol  calcium ion transmembrane import into cytosol  postsynaptic density membrane  excitatory chemical synaptic transmission  glutamatergic synapse  integral component of postsynaptic density membrane  protein localization to postsynaptic membrane  cellular response to amyloid-beta  regulation of NMDA receptor activity  
Pathways : BIOCARTANitric Oxide Signaling Pathway [Genes]   
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    Calcium signaling pathway    Neuroactive ligand-receptor interaction    Circadian entrainment    Long-term potentiation    Glutamatergic synapse    Dopaminergic synapse    Alzheimer's disease    Amyotrophic lateral sclerosis (ALS)    Cocaine addiction    Amphetamine addiction    Nicotine addiction    Alcoholism    Systemic lupus erythematosus   
NDEx NetworkGRIN2A
Atlas of Cancer Signalling NetworkGRIN2A
Wikipedia pathwaysGRIN2A
Orthology - Evolution
OrthoDB2903
GeneTree (enSembl)ENSG00000183454
Phylogenetic Trees/Animal Genes : TreeFamGRIN2A
HOGENOMQ12879
Homologs : HomoloGeneGRIN2A
Homology/Alignments : Family Browser (UCSC)GRIN2A
Gene fusions - Rearrangements
Fusion : MitelmanCABIN1/GRIN2A [22q11.23/16p13.2]  
Fusion : MitelmanMOB1A/GRIN2A [2p13.1/16p13.2]  
Fusion : MitelmanSHB/GRIN2A [9p13.2/16p13.2]  
Fusion PortalCABIN1 22q11.23 GRIN2A 16p13.2 BLCA
Fusion PortalMOBKL1B GRIN2A 16p13.2 BRCA
Fusion PortalSHB 9p13.2 GRIN2A 16p13.2 LGG
Fusion : QuiverGRIN2A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRIN2A [hg38]
dbVarGRIN2A
ClinVarGRIN2A
MonarchGRIN2A
1000_GenomesGRIN2A 
Exome Variant ServerGRIN2A
GNOMAD BrowserENSG00000183454
Varsome BrowserGRIN2A
Genomic Variants (DGV)GRIN2A [DGVbeta]
DECIPHERGRIN2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRIN2A 
Mutations
ICGC Data PortalGRIN2A 
TCGA Data PortalGRIN2A 
Broad Tumor PortalGRIN2A
OASIS PortalGRIN2A [ Somatic mutations - Copy number]
Cancer Gene: CensusGRIN2A 
Somatic Mutations in Cancer : COSMICGRIN2A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGRIN2A
Mutations and Diseases : HGMDGRIN2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRIN2A
DgiDB (Drug Gene Interaction Database)GRIN2A
DoCM (Curated mutations)GRIN2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRIN2A (select a term)
intoGenGRIN2A
Cancer3DGRIN2A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138253    245570   
Orphanet17532    3321    20705    8736    13835   
DisGeNETGRIN2A
MedgenGRIN2A
Genetic Testing Registry GRIN2A
NextProtQ12879 [Medical]
GENETestsGRIN2A
Target ValidationGRIN2A
Huge Navigator GRIN2A [HugePedia]
ClinGenGRIN2A (curated)
Clinical trials, drugs, therapy
MyCancerGenomeGRIN2A
Protein Interactions : CTD
Pharm GKB GenePA28979
PharosQ12879
Clinical trialGRIN2A
Miscellaneous
canSAR (ICR)GRIN2A (select the gene name)
HarmonizomeGRIN2A
DataMed IndexGRIN2A
Probes
Litterature
PubMed235 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGRIN2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 25 19:23:58 CET 2021
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