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GRIN2A (glutamate ionotropic receptor NMDA type subunit 2A)

Identity

Other namesEPND
FESD
GluN2A
LKS
NMDAR2A
NR2A
HGNC (Hugo) GRIN2A
LocusID (NCBI) 2903
Atlas_Id 47251
Location 16p13.2  [Link to chromosome band 16p13]
Location_base_pair Starts at 9847262 and ends at 10276611 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CABIN1 (22q11.23) / GRIN2A (16p13.2)GRIN2A (16p13.2) / GRIN2A (16p13.2)MOB1A (2p13.1) / GRIN2A (16p13.2)
SHB (9p13.2) / GRIN2A (16p13.2)CABIN1 22q11.23 / GRIN2A 16p13.2MOBKL1B GRIN2A 16p13.2
SHB 9p13.2 / GRIN2A 16p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRIN2A   4585
Cards
Entrez_Gene (NCBI)GRIN2A  2903  glutamate ionotropic receptor NMDA type subunit 2A
AliasesEPND; FESD; GluN2A; LKS; 
NMDAR2A; NR2A
GeneCards (Weizmann)GRIN2A
Ensembl hg19 (Hinxton)ENSG00000183454 [Gene_View]  chr16:9847262-10276611 [Contig_View]  GRIN2A [Vega]
Ensembl hg38 (Hinxton)ENSG00000183454 [Gene_View]  chr16:9847262-10276611 [Contig_View]  GRIN2A [Vega]
ICGC DataPortalENSG00000183454
TCGA cBioPortalGRIN2A
AceView (NCBI)GRIN2A
Genatlas (Paris)GRIN2A
WikiGenes2903
SOURCE (Princeton)GRIN2A
Genomic and cartography
GoldenPath hg19 (UCSC)GRIN2A  -     chr16:9847262-10276611 -  16p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GRIN2A  -     16p13.2   [Description]    (hg38-Dec_2013)
EnsemblGRIN2A - 16p13.2 [CytoView hg19]  GRIN2A - 16p13.2 [CytoView hg38]
Mapping of homologs : NCBIGRIN2A [Mapview hg19]  GRIN2A [Mapview hg38]
OMIM138253   
Gene and transcription
Genbank (Entrez)AB209695 AK124698 AK295620 AK308862 BC117131
RefSeq transcript (Entrez)NM_000833 NM_001134407 NM_001134408
RefSeq genomic (Entrez)NC_000016 NC_018927 NG_011812 NT_010393 NW_004929400
Consensus coding sequences : CCDS (NCBI)GRIN2A
Cluster EST : UnigeneHs.411472 [ NCBI ]
CGAP (NCI)Hs.411472
Alternative Splicing GalleryENSG00000183454
Gene ExpressionGRIN2A [ NCBI-GEO ]   GRIN2A [ EBI - ARRAY_EXPRESS ]   GRIN2A [ SEEK ]   GRIN2A [ MEM ]
Gene Expression Viewer (FireBrowse)GRIN2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2903
GTEX Portal (Tissue expression)GRIN2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12879 (Uniprot)
NextProtQ12879  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12879
Splice isoforms : SwissVarQ12879 (Swissvar)
PhosPhoSitePlusQ12879
Domains : Interpro (EBI)ANF_lig-bd_rcpt    Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    NMDAR2_C    Peripla_BP_I   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    Lig_chan-Glu_bd (PF10613)    NMDAR2_C (PF10565)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10613    pfam10565   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
DMDM Disease mutations2903
Blocks (Seattle)GRIN2A
PDB (SRS)3NFL   
PDB (PDBSum)3NFL   
PDB (IMB)3NFL   
PDB (RSDB)3NFL   
Structural Biology KnowledgeBase3NFL   
SCOP (Structural Classification of Proteins)3NFL   
CATH (Classification of proteins structures)3NFL   
SuperfamilyQ12879
Human Protein AtlasENSG00000183454
Peptide AtlasQ12879
HPRD00698
IPIIPI00029768   IPI01012161   IPI00902706   
Protein Interaction databases
DIP (DOE-UCLA)Q12879
IntAct (EBI)Q12879
FunCoupENSG00000183454
BioGRIDGRIN2A
STRING (EMBL)GRIN2A
ZODIACGRIN2A
Ontologies - Pathways
QuickGOQ12879
Ontology : AmiGOMAPK cascade  startle response  response to amphetamine  NMDA glutamate receptor activity  Ras guanyl-nucleotide exchange factor activity  extracellular-glutamate-gated ion channel activity  calcium channel activity  protein binding  endoplasmic reticulum  plasma membrane  integral component of plasma membrane  transport  glutamate receptor signaling pathway  synaptic transmission  learning or memory  memory  synaptic vesicle  protein localization  zinc ion binding  visual learning  response to wounding  cell surface  NMDA selective glutamate receptor complex  sensory perception of pain  neurogenesis  cell junction  sleep  directional locomotion  ionotropic glutamate receptor signaling pathway  negative regulation of protein catabolic process  dopamine metabolic process  serotonin metabolic process  response to drug  presynaptic membrane  neuron projection  positive regulation of apoptotic process  positive regulation of GTPase activity  postsynaptic membrane  response to ethanol  regulation of sensory perception of pain  excitatory postsynaptic potential  long-term synaptic potentiation  calcium ion transmembrane transport  neuronal postsynaptic density  positive regulation of long-term synaptic potentiation  
Ontology : EGO-EBIMAPK cascade  startle response  response to amphetamine  NMDA glutamate receptor activity  Ras guanyl-nucleotide exchange factor activity  extracellular-glutamate-gated ion channel activity  calcium channel activity  protein binding  endoplasmic reticulum  plasma membrane  integral component of plasma membrane  transport  glutamate receptor signaling pathway  synaptic transmission  learning or memory  memory  synaptic vesicle  protein localization  zinc ion binding  visual learning  response to wounding  cell surface  NMDA selective glutamate receptor complex  sensory perception of pain  neurogenesis  cell junction  sleep  directional locomotion  ionotropic glutamate receptor signaling pathway  negative regulation of protein catabolic process  dopamine metabolic process  serotonin metabolic process  response to drug  presynaptic membrane  neuron projection  positive regulation of apoptotic process  positive regulation of GTPase activity  postsynaptic membrane  response to ethanol  regulation of sensory perception of pain  excitatory postsynaptic potential  long-term synaptic potentiation  calcium ion transmembrane transport  neuronal postsynaptic density  positive regulation of long-term synaptic potentiation  
Pathways : BIOCARTANitric Oxide Signaling Pathway [Genes]   
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    Calcium signaling pathway    Neuroactive ligand-receptor interaction    Circadian entrainment    Long-term potentiation    Glutamatergic synapse    Dopaminergic synapse    Alzheimer's disease    Amyotrophic lateral sclerosis (ALS)    Cocaine addiction    Amphetamine addiction    Nicotine addiction    Alcoholism    Systemic lupus erythematosus   
NDEx NetworkGRIN2A
Atlas of Cancer Signalling NetworkGRIN2A
Wikipedia pathwaysGRIN2A
Orthology - Evolution
OrthoDB2903
GeneTree (enSembl)ENSG00000183454
Phylogenetic Trees/Animal Genes : TreeFamGRIN2A
Homologs : HomoloGeneGRIN2A
Homology/Alignments : Family Browser (UCSC)GRIN2A
Gene fusions - Rearrangements
Fusion: TCGACABIN1 22q11.23 GRIN2A 16p13.2 BLCA
Fusion: TCGAMOBKL1B GRIN2A 16p13.2 BRCA
Fusion: TCGASHB 9p13.2 GRIN2A 16p13.2 LGG
Polymorphisms : SNP, variants
NCBI Variation ViewerGRIN2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRIN2A
dbVarGRIN2A
ClinVarGRIN2A
1000_GenomesGRIN2A 
Exome Variant ServerGRIN2A
ExAC (Exome Aggregation Consortium)GRIN2A (select the gene name)
Genetic variants : HAPMAP2903
Genomic Variants (DGV)GRIN2A [DGVbeta]
Mutations
ICGC Data PortalGRIN2A 
TCGA Data PortalGRIN2A 
Broad Tumor PortalGRIN2A
OASIS PortalGRIN2A [ Somatic mutations - Copy number]
Cancer Gene: CensusGRIN2A 
Somatic Mutations in Cancer : COSMICGRIN2A 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRIN2A
DgiDB (Drug Gene Interaction Database)GRIN2A
DoCM (Curated mutations)GRIN2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRIN2A (select a term)
intoGenGRIN2A
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)16:9847262-10276611  ENSG00000183454
CONAN: Copy Number AnalysisGRIN2A 
Mutations and Diseases : HGMDGRIN2A
OMIM138253   
MedgenGRIN2A
Genetic Testing Registry GRIN2A
NextProtQ12879 [Medical]
TSGene2903
GENETestsGRIN2A
Huge Navigator GRIN2A [HugePedia]
snp3D : Map Gene to Disease2903
BioCentury BCIQGRIN2A
ClinGenGRIN2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2903
Chemical/Pharm GKB GenePA28979
Clinical trialGRIN2A
Miscellaneous
canSAR (ICR)GRIN2A (select the gene name)
Probes
Litterature
PubMed189 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRIN2A
EVEXGRIN2A
GoPubMedGRIN2A
iHOPGRIN2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 19 18:51:45 CEST 2016

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