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GRIN2B (glutamate receptor, ionotropic, N-methyl D-aspartate 2B)

Identity

Other namesEIEE27
GluN2B
MRD6
NMDAR2B
NR2B
hNR3
HGNC (Hugo) GRIN2B
LocusID (NCBI) 2904
Atlas_Id 47216
Location 12p13.1
Location_base_pair Starts at 13714410 and ends at 14133022 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GRIN2B   4586
Cards
Entrez_Gene (NCBI)GRIN2B  2904  glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GeneCards (Weizmann)GRIN2B
Ensembl hg19 (Hinxton)ENSG00000273079 [Gene_View]  chr12:13714410-14133022 [Contig_View]  GRIN2B [Vega]
Ensembl hg38 (Hinxton)ENSG00000273079 [Gene_View]  chr12:13714410-14133022 [Contig_View]  GRIN2B [Vega]
ICGC DataPortalENSG00000273079
TCGA cBioPortalGRIN2B
AceView (NCBI)GRIN2B
Genatlas (Paris)GRIN2B
WikiGenes2904
SOURCE (Princeton)GRIN2B
Genomic and cartography
GoldenPath hg19 (UCSC)GRIN2B  -     chr12:13714410-14133022 -  12p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GRIN2B  -     12p13.1   [Description]    (hg38-Dec_2013)
EnsemblGRIN2B - 12p13.1 [CytoView hg19]  GRIN2B - 12p13.1 [CytoView hg38]
Mapping of homologs : NCBIGRIN2B [Mapview hg19]  GRIN2B [Mapview hg38]
OMIM138252   613970   616139   
Gene and transcription
Genbank (Entrez)AB208850 AK091524 BC113618 BC113620 BX648060
RefSeq transcript (Entrez)NM_000834
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_031854 NT_009714 NW_004929383
Consensus coding sequences : CCDS (NCBI)GRIN2B
Cluster EST : UnigeneHs.654430 [ NCBI ]
CGAP (NCI)Hs.654430
Alternative Splicing : Fast-db (Paris)GSHG0007291
Alternative Splicing GalleryENSG00000273079
Gene ExpressionGRIN2B [ NCBI-GEO ]     GRIN2B [ SEEK ]   GRIN2B [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13224 (Uniprot)
NextProtQ13224  [Medical]
With graphics : InterProQ13224
Splice isoforms : SwissVarQ13224 (Swissvar)
Domains : Interpro (EBI)ANF_lig-bd_rcpt    Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    NMDAR2_C    Peripla_BP_I   
Related proteins : CluSTrQ13224
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    NMDAR2_C (PF10565)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10565   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
DMDM Disease mutations2904
Blocks (Seattle)Q13224
PDB (SRS)1S11    1S2S    2IPV   
PDB (PDBSum)1S11    1S2S    2IPV   
PDB (IMB)1S11    1S2S    2IPV   
PDB (RSDB)1S11    1S2S    2IPV   
Human Protein AtlasENSG00000273079
Peptide AtlasQ13224
HPRD00697
IPIIPI00297933   IPI00984364   
Protein Interaction databases
DIP (DOE-UCLA)Q13224
IntAct (EBI)Q13224
FunCoupENSG00000273079
BioGRIDGRIN2B
IntegromeDBGRIN2B
STRING (EMBL)GRIN2B
Ontologies - Pathways
QuickGOQ13224
Ontology : AmiGObehavioral fear response  in utero embryonic development  startle response  suckling behavior  N-methyl-D-aspartate selective glutamate receptor activity  extracellular-glutamate-gated ion channel activity  calcium channel activity  protein binding  plasma membrane  integral component of plasma membrane  transport  glutamate receptor signaling pathway  synaptic transmission  axon guidance  sensory organ development  learning or memory  learning  memory  synaptic vesicle  zinc ion binding  cell surface  regulation of protein kinase A signaling  glycine binding  N-methyl-D-aspartate selective glutamate receptor complex  cell junction  dendrite  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  synaptic transmission, glutamatergic  neuron projection  postsynaptic membrane  response to ethanol  ephrin receptor signaling pathway  regulation of synaptic plasticity  behavioral response to pain  detection of mechanical stimulus involved in sensory perception of pain  regulation of excitatory postsynaptic membrane potential  calcium ion transmembrane transport  neuronal postsynaptic density  
Ontology : EGO-EBIbehavioral fear response  in utero embryonic development  startle response  suckling behavior  N-methyl-D-aspartate selective glutamate receptor activity  extracellular-glutamate-gated ion channel activity  calcium channel activity  protein binding  plasma membrane  integral component of plasma membrane  transport  glutamate receptor signaling pathway  synaptic transmission  axon guidance  sensory organ development  learning or memory  learning  memory  synaptic vesicle  zinc ion binding  cell surface  regulation of protein kinase A signaling  glycine binding  N-methyl-D-aspartate selective glutamate receptor complex  cell junction  dendrite  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  synaptic transmission, glutamatergic  neuron projection  postsynaptic membrane  response to ethanol  ephrin receptor signaling pathway  regulation of synaptic plasticity  behavioral response to pain  detection of mechanical stimulus involved in sensory perception of pain  regulation of excitatory postsynaptic membrane potential  calcium ion transmembrane transport  neuronal postsynaptic density  
Pathways : BIOCARTANitric Oxide Signaling Pathway [Genes]   
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    Neuroactive ligand-receptor interaction    Circadian entrainment    Long-term potentiation    Glutamatergic synapse    Dopaminergic synapse    Alzheimer's disease    Amyotrophic lateral sclerosis (ALS)    Huntington's disease    Cocaine addiction    Amphetamine addiction    Nicotine addiction    Alcoholism    Systemic lupus erythematosus   
Protein Interaction DatabaseGRIN2B
DoCM (Curated mutations)GRIN2B
Wikipedia pathwaysGRIN2B
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerGRIN2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRIN2B
dbVarGRIN2B
ClinVarGRIN2B
1000_GenomesGRIN2B 
Exome Variant ServerGRIN2B
SNP (GeneSNP Utah)GRIN2B
SNP : HGBaseGRIN2B
Genetic variants : HAPMAPGRIN2B
Genomic Variants (DGV)GRIN2B [DGVbeta]
Mutations
ICGC Data PortalGRIN2B 
TCGA Data PortalGRIN2B 
Tumor PortalGRIN2B
Somatic Mutations in Cancer : COSMICGRIN2B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:13714410-14133022
CONAN: Copy Number AnalysisGRIN2B 
Mutations and Diseases : HGMDGRIN2B
OMIM138252    613970    616139   
MedgenGRIN2B
NextProtQ13224 [Medical]
GENETestsGRIN2B
Disease Genetic AssociationGRIN2B
Huge Navigator GRIN2B [HugePedia]  GRIN2B [HugeCancerGEM]
snp3D : Map Gene to Disease2904
DGIdb (Drug Gene Interaction db)GRIN2B
General knowledge
Homologs : HomoloGeneGRIN2B
Homology/Alignments : Family Browser (UCSC)GRIN2B
Phylogenetic Trees/Animal Genes : TreeFamGRIN2B
Chemical/Protein Interactions : CTD2904
Chemical/Pharm GKB GenePA28980
Clinical trialGRIN2B
Cancer Resource (Charite)ENSG00000273079
Other databases
Probes
Litterature
PubMed246 Pubmed reference(s) in Entrez
CoreMineGRIN2B
GoPubMedGRIN2B
iHOPGRIN2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:30:49 CEST 2015

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