Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B)

Identity

Other namesEIEE27
GluN2B
MRD6
NMDAR2B
NR2B
hNR3
HGNC (Hugo) GRIN2B
LocusID (NCBI) 2904
Atlas_Id 47216
Location 12p13.1  [Link to chromosome band 12p13]
Location_base_pair Starts at 13714410 and ends at 14133022 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GRIN2B (12p13.1) / CYP4F3 (19p13.12)RNF215 (22q12.2) / GRIN2B (12p13.1)RNF215 22q12.2 / GRIN2B 12p13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRIN2B   4586
Cards
Entrez_Gene (NCBI)GRIN2B  2904  glutamate ionotropic receptor NMDA type subunit 2B
AliasesEIEE27; GluN2B; MRD6; NMDAR2B; 
NR2B; hNR3
GeneCards (Weizmann)GRIN2B
Ensembl hg19 (Hinxton)ENSG00000273079 [Gene_View]  chr12:13714410-14133022 [Contig_View]  GRIN2B [Vega]
Ensembl hg38 (Hinxton)ENSG00000273079 [Gene_View]  chr12:13714410-14133022 [Contig_View]  GRIN2B [Vega]
ICGC DataPortalENSG00000273079
TCGA cBioPortalGRIN2B
AceView (NCBI)GRIN2B
Genatlas (Paris)GRIN2B
WikiGenes2904
SOURCE (Princeton)GRIN2B
Genomic and cartography
GoldenPath hg19 (UCSC)GRIN2B  -     chr12:13714410-14133022 -  12p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GRIN2B  -     12p13.1   [Description]    (hg38-Dec_2013)
EnsemblGRIN2B - 12p13.1 [CytoView hg19]  GRIN2B - 12p13.1 [CytoView hg38]
Mapping of homologs : NCBIGRIN2B [Mapview hg19]  GRIN2B [Mapview hg38]
OMIM138252   613970   616139   
Gene and transcription
Genbank (Entrez)AB208850 AK091524 BC113618 BC113620 BX648060
RefSeq transcript (Entrez)NM_000834
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_031854 NT_009714 NW_004929383
Consensus coding sequences : CCDS (NCBI)GRIN2B
Cluster EST : UnigeneHs.654430 [ NCBI ]
CGAP (NCI)Hs.654430
Alternative Splicing GalleryENSG00000273079
Gene ExpressionGRIN2B [ NCBI-GEO ]   GRIN2B [ EBI - ARRAY_EXPRESS ]   GRIN2B [ SEEK ]   GRIN2B [ MEM ]
Gene Expression Viewer (FireBrowse)GRIN2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2904
GTEX Portal (Tissue expression)GRIN2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13224 (Uniprot)
NextProtQ13224  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13224
Splice isoforms : SwissVarQ13224 (Swissvar)
PhosPhoSitePlusQ13224
Domains : Interpro (EBI)ANF_lig-bd_rcpt    Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    NMDAR2_C    Peripla_BP_I   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    Lig_chan-Glu_bd (PF10613)    NMDAR2_C (PF10565)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10613    pfam10565   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
DMDM Disease mutations2904
Blocks (Seattle)GRIN2B
PDB (SRS)1S11    1S2S    2IPV   
PDB (PDBSum)1S11    1S2S    2IPV   
PDB (IMB)1S11    1S2S    2IPV   
PDB (RSDB)1S11    1S2S    2IPV   
Structural Biology KnowledgeBase1S11    1S2S    2IPV   
SCOP (Structural Classification of Proteins)1S11    1S2S    2IPV   
CATH (Classification of proteins structures)1S11    1S2S    2IPV   
SuperfamilyQ13224
Human Protein AtlasENSG00000273079
Peptide AtlasQ13224
HPRD00697
IPIIPI00297933   IPI00984364   
Protein Interaction databases
DIP (DOE-UCLA)Q13224
IntAct (EBI)Q13224
FunCoupENSG00000273079
BioGRIDGRIN2B
STRING (EMBL)GRIN2B
ZODIACGRIN2B
Ontologies - Pathways
QuickGOQ13224
Ontology : AmiGOMAPK cascade  NMDA glutamate receptor activity  Ras guanyl-nucleotide exchange factor activity  extracellular-glutamate-gated ion channel activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  transport  glutamate receptor signaling pathway  synaptic transmission  learning or memory  zinc ion binding  cell surface  glycine binding  NMDA selective glutamate receptor complex  cell junction  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  ionotropic glutamate receptor signaling pathway  neuron projection  positive regulation of GTPase activity  postsynaptic membrane  response to ethanol  ephrin receptor signaling pathway  
Ontology : EGO-EBIMAPK cascade  NMDA glutamate receptor activity  Ras guanyl-nucleotide exchange factor activity  extracellular-glutamate-gated ion channel activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  transport  glutamate receptor signaling pathway  synaptic transmission  learning or memory  zinc ion binding  cell surface  glycine binding  NMDA selective glutamate receptor complex  cell junction  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  ionotropic glutamate receptor signaling pathway  neuron projection  positive regulation of GTPase activity  postsynaptic membrane  response to ethanol  ephrin receptor signaling pathway  
Pathways : BIOCARTANitric Oxide Signaling Pathway [Genes]   
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    Neuroactive ligand-receptor interaction    Circadian entrainment    Long-term potentiation    Glutamatergic synapse    Dopaminergic synapse    Alzheimer's disease    Amyotrophic lateral sclerosis (ALS)    Huntington's disease    Cocaine addiction    Amphetamine addiction    Nicotine addiction    Alcoholism    Systemic lupus erythematosus   
NDEx Network
Atlas of Cancer Signalling NetworkGRIN2B
Wikipedia pathwaysGRIN2B
Orthology - Evolution
OrthoDB2904
GeneTree (enSembl)ENSG00000273079
Phylogenetic Trees/Animal Genes : TreeFamGRIN2B
Homologs : HomoloGeneGRIN2B
Homology/Alignments : Family Browser (UCSC)GRIN2B
Gene fusions - Rearrangements
Fusion: TCGARNF215 22q12.2 GRIN2B 12p13.1 LUAD
Polymorphisms : SNP, variants
NCBI Variation ViewerGRIN2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRIN2B
dbVarGRIN2B
ClinVarGRIN2B
1000_GenomesGRIN2B 
Exome Variant ServerGRIN2B
ExAC (Exome Aggregation Consortium)GRIN2B (select the gene name)
Genetic variants : HAPMAP2904
Genomic Variants (DGV)GRIN2B [DGVbeta]
Mutations
ICGC Data PortalGRIN2B 
TCGA Data PortalGRIN2B 
Broad Tumor PortalGRIN2B
OASIS PortalGRIN2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRIN2B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRIN2B
DgiDB (Drug Gene Interaction Database)GRIN2B
DoCM (Curated mutations)GRIN2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRIN2B (select a term)
intoGenGRIN2B
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:13714410-14133022  ENSG00000273079
CONAN: Copy Number AnalysisGRIN2B 
Mutations and Diseases : HGMDGRIN2B
OMIM138252    613970    616139   
MedgenGRIN2B
Genetic Testing Registry GRIN2B
NextProtQ13224 [Medical]
TSGene2904
GENETestsGRIN2B
Huge Navigator GRIN2B [HugePedia]
snp3D : Map Gene to Disease2904
BioCentury BCIQGRIN2B
ClinGenGRIN2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2904
Chemical/Pharm GKB GenePA28980
Clinical trialGRIN2B
Miscellaneous
canSAR (ICR)GRIN2B (select the gene name)
Probes
Litterature
PubMed264 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRIN2B
EVEXGRIN2B
GoPubMedGRIN2B
iHOPGRIN2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:03:26 CEST 2016

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