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GRIN2B (glutamate receptor, ionotropic, N-methyl D-aspartate 2B)

Identity

Other namesGluN2B
MRD6
NMDAR2B
NR2B
hNR3
HGNC (Hugo) GRIN2B
LocusID (NCBI) 2904
Location 12p13.1
Location_base_pair Starts at 13714410 and ends at 14133022 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GRIN2B   4586
Cards
Entrez_Gene (NCBI)GRIN2B  2904  glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GeneCards (Weizmann)GRIN2B
Ensembl (Hinxton) [Gene_View]  chr12:13714410-14133022 [Contig_View]  GRIN2B [Vega]
cBioPortalGRIN2B
AceView (NCBI)GRIN2B
Genatlas (Paris)GRIN2B
WikiGenes2904
SOURCE (Princeton)NM_000834
Genomic and cartography
GoldenPath (UCSC)GRIN2B  -  12p13.1   chr12:13714410-14133022 -  12p13.1   [Description]    (hg19-Feb_2009)
EnsemblGRIN2B - 12p13.1 [CytoView]
Mapping of homologs : NCBIGRIN2B [Mapview]
OMIM138252   613970   
Gene and transcription
Genbank (Entrez)AB208850 BC113618 BC113620 U11287 U28758
RefSeq transcript (Entrez)NM_000834
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_031854 NT_009714 NW_001838052 NW_004929383
Consensus coding sequences : CCDS (NCBI)GRIN2B
Cluster EST : UnigeneHs.654430 [ NCBI ]
CGAP (NCI)Hs.654430
Alternative Splicing : Fast-db (Paris)GSHG0007291
Gene ExpressionGRIN2B [ NCBI-GEO ]     GRIN2B [ SEEK ]   GRIN2B [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13224 (Uniprot)
NextProtQ13224  [Medical]
With graphics : InterProQ13224
Splice isoforms : SwissVarQ13224 (Swissvar)
Domains : Interpro (EBI)ANF_lig-bd_rcpt [organisation]   Glu_rcpt_Glu/Gly-bd [organisation]   Iontro_glu_rcpt [organisation]   NMDA_rcpt [organisation]   NMDAR2_C [organisation]   Peripla_BP_I [organisation]   SBP_bac_3 [organisation]  
Related proteins : CluSTrQ13224
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    NMDAR2_C (PF10565)    SBP_bac_3 (PF00497)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10565    pfam00497   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
DMDM Disease mutations2904
Blocks (Seattle)Q13224
PDB (SRS)1S11    1S2S    2IPV   
PDB (PDBSum)1S11    1S2S    2IPV   
PDB (IMB)1S11    1S2S    2IPV   
PDB (RSDB)1S11    1S2S    2IPV   
Peptide AtlasQ13224
HPRD00697
IPIIPI00297933   IPI00984364   
Protein Interaction databases
DIP (DOE-UCLA)Q13224
IntAct (EBI)Q13224
BioGRIDGRIN2B
InParanoidQ13224
Interologous Interaction database Q13224
IntegromeDBGRIN2B
STRING (EMBL)GRIN2B
Ontologies - Pathways
Ontology : AmiGObehavioral fear response  in utero embryonic development  startle response  suckling behavior  N-methyl-D-aspartate selective glutamate receptor activity  extracellular-glutamate-gated ion channel activity  calcium channel activity  protein binding  plasma membrane  integral component of plasma membrane  transport  glutamate receptor signaling pathway  synaptic transmission  sensory organ development  learning or memory  learning  memory  synaptic vesicle  zinc ion binding  cell surface  postsynaptic density  glycine binding  N-methyl-D-aspartate selective glutamate receptor complex  cell junction  dendrite  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  synaptic transmission, glutamatergic  neuron projection  postsynaptic membrane  response to ethanol  regulation of synaptic plasticity  behavioral response to pain  detection of mechanical stimulus involved in sensory perception of pain  regulation of excitatory postsynaptic membrane potential  calcium ion transmembrane transport  
Ontology : EGO-EBIbehavioral fear response  in utero embryonic development  startle response  suckling behavior  N-methyl-D-aspartate selective glutamate receptor activity  extracellular-glutamate-gated ion channel activity  calcium channel activity  protein binding  plasma membrane  integral component of plasma membrane  transport  glutamate receptor signaling pathway  synaptic transmission  sensory organ development  learning or memory  learning  memory  synaptic vesicle  zinc ion binding  cell surface  postsynaptic density  glycine binding  N-methyl-D-aspartate selective glutamate receptor complex  cell junction  dendrite  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  synaptic transmission, glutamatergic  neuron projection  postsynaptic membrane  response to ethanol  regulation of synaptic plasticity  behavioral response to pain  detection of mechanical stimulus involved in sensory perception of pain  regulation of excitatory postsynaptic membrane potential  calcium ion transmembrane transport  
Pathways : BIOCARTANitric Oxide Signaling Pathway [Genes]   
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    Neuroactive ligand-receptor interaction    Circadian entrainment    Long-term potentiation    Glutamatergic synapse    Dopaminergic synapse    Alzheimer's disease    Amyotrophic lateral sclerosis (ALS)    Huntington's disease    Cocaine addiction    Amphetamine addiction    Nicotine addiction    Alcoholism    Systemic lupus erythematosus   
Protein Interaction DatabaseGRIN2B
Wikipedia pathwaysGRIN2B
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)GRIN2B
snp3D : Map Gene to Disease2904
SNP (GeneSNP Utah)GRIN2B
SNP : HGBaseGRIN2B
Genetic variants : HAPMAPGRIN2B
Exome VariantGRIN2B
1000_GenomesGRIN2B 
Somatic Mutations in Cancer : COSMICGRIN2B 
CONAN: Copy Number AnalysisGRIN2B 
Mutations and Diseases : HGMDGRIN2B
Mutations and Diseases : intOGenGRIN2B
Genomic VariantsGRIN2B  GRIN2B [DGVbeta]
dbVarGRIN2B
ClinVarGRIN2B
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM138252    613970   
MedgenGRIN2B
GENETestsGRIN2B
Disease Genetic AssociationGRIN2B
Huge Navigator GRIN2B [HugePedia]  GRIN2B [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneGRIN2B
Homology/Alignments : Family Browser (UCSC)GRIN2B
Phylogenetic Trees/Animal Genes : TreeFamGRIN2B
Chemical/Protein Interactions : CTD2904
Chemical/Pharm GKB GenePA28980
Clinical trialGRIN2B
Other databases
Probes
Litterature
PubMed235 Pubmed reference(s) in Entrez
CoreMineGRIN2B
iHOPGRIN2B
OncoSearchGRIN2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 26 16:48:43 CEST 2014

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