Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GRIN2C (glutamate ionotropic receptor NMDA type subunit 2C)

Identity

Alias_namesNMDAR2C
glutamate receptor, ionotropic, N-methyl D-aspartate 2C
Alias_symbol (synonym)GluN2C
Other aliasNR2C
HGNC (Hugo) GRIN2C
LocusID (NCBI) 2905
Atlas_Id 64046
Location 17q25.1  [Link to chromosome band 17q25]
Location_base_pair Starts at 74842023 and ends at 74859884 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRIN2C   4587
Cards
Entrez_Gene (NCBI)GRIN2C  2905  glutamate ionotropic receptor NMDA type subunit 2C
AliasesGluN2C; NMDAR2C; NR2C
GeneCards (Weizmann)GRIN2C
Ensembl hg19 (Hinxton)ENSG00000161509 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000161509 [Gene_View]  chr17:74842023-74859884 [Contig_View]  GRIN2C [Vega]
ICGC DataPortalENSG00000161509
TCGA cBioPortalGRIN2C
AceView (NCBI)GRIN2C
Genatlas (Paris)GRIN2C
WikiGenes2905
SOURCE (Princeton)GRIN2C
Genetics Home Reference (NIH)GRIN2C
Genomic and cartography
GoldenPath hg38 (UCSC)GRIN2C  -     chr17:74842023-74859884 -  17q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRIN2C  -     17q25.1   [Description]    (hg19-Feb_2009)
EnsemblGRIN2C - 17q25.1 [CytoView hg19]  GRIN2C - 17q25.1 [CytoView hg38]
Mapping of homologs : NCBIGRIN2C [Mapview hg19]  GRIN2C [Mapview hg38]
OMIM138254   
Gene and transcription
Genbank (Entrez)AB208799 BC031077 BC041128 BC059384 BC140801
RefSeq transcript (Entrez)NM_000835 NM_001278553
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRIN2C
Cluster EST : UnigeneHs.436980 [ NCBI ]
CGAP (NCI)Hs.436980
Alternative Splicing GalleryENSG00000161509
Gene ExpressionGRIN2C [ NCBI-GEO ]   GRIN2C [ EBI - ARRAY_EXPRESS ]   GRIN2C [ SEEK ]   GRIN2C [ MEM ]
Gene Expression Viewer (FireBrowse)GRIN2C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2905
GTEX Portal (Tissue expression)GRIN2C
Human Protein AtlasENSG00000161509-GRIN2C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14957   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14957  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14957
Splice isoforms : SwissVarQ14957
PhosPhoSitePlusQ14957
Domains : Interpro (EBI)ANF_lig-bd_rcpt    Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    NMDAR2_C    Peripla_BP_I   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    Lig_chan-Glu_bd (PF10613)    NMDAR2_C (PF10565)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10613    pfam10565   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
Conserved Domain (NCBI)GRIN2C
DMDM Disease mutations2905
Blocks (Seattle)GRIN2C
SuperfamilyQ14957
Human Protein Atlas [tissue]ENSG00000161509-GRIN2C [tissue]
Peptide AtlasQ14957
HPRD00699
IPIIPI00215887   IPI00446795   IPI00788944   
Protein Interaction databases
DIP (DOE-UCLA)Q14957
IntAct (EBI)Q14957
FunCoupENSG00000161509
BioGRIDGRIN2C
STRING (EMBL)GRIN2C
ZODIACGRIN2C
Ontologies - Pathways
QuickGOQ14957
Ontology : AmiGOMAPK cascade  NMDA glutamate receptor activity  Ras guanyl-nucleotide exchange factor activity  extracellular-glutamate-gated ion channel activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  transport  glutamate receptor signaling pathway  protein localization  response to wounding  postsynaptic density  NMDA selective glutamate receptor complex  cell junction  directional locomotion  regulation of ion transmembrane transport  ionotropic glutamate receptor signaling pathway  negative regulation of protein catabolic process  positive regulation of GTPase activity  postsynaptic membrane  neuromuscular process controlling balance  excitatory postsynaptic potential  cation transmembrane transport  
Ontology : EGO-EBIMAPK cascade  NMDA glutamate receptor activity  Ras guanyl-nucleotide exchange factor activity  extracellular-glutamate-gated ion channel activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  transport  glutamate receptor signaling pathway  protein localization  response to wounding  postsynaptic density  NMDA selective glutamate receptor complex  cell junction  directional locomotion  regulation of ion transmembrane transport  ionotropic glutamate receptor signaling pathway  negative regulation of protein catabolic process  positive regulation of GTPase activity  postsynaptic membrane  neuromuscular process controlling balance  excitatory postsynaptic potential  cation transmembrane transport  
Pathways : BIOCARTANitric Oxide Signaling Pathway [Genes]   
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Circadian entrainment    Long-term potentiation    Glutamatergic synapse    Alzheimer's disease    Amyotrophic lateral sclerosis (ALS)    Cocaine addiction    Amphetamine addiction    Nicotine addiction    Alcoholism   
NDEx NetworkGRIN2C
Atlas of Cancer Signalling NetworkGRIN2C
Wikipedia pathwaysGRIN2C
Orthology - Evolution
OrthoDB2905
GeneTree (enSembl)ENSG00000161509
Phylogenetic Trees/Animal Genes : TreeFamGRIN2C
HOVERGENQ14957
HOGENOMQ14957
Homologs : HomoloGeneGRIN2C
Homology/Alignments : Family Browser (UCSC)GRIN2C
Gene fusions - Rearrangements
Fusion: Tumor Portal GRIN2C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRIN2C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRIN2C
dbVarGRIN2C
ClinVarGRIN2C
1000_GenomesGRIN2C 
Exome Variant ServerGRIN2C
ExAC (Exome Aggregation Consortium)ENSG00000161509
GNOMAD BrowserENSG00000161509
Genetic variants : HAPMAP2905
Genomic Variants (DGV)GRIN2C [DGVbeta]
DECIPHERGRIN2C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRIN2C 
Mutations
ICGC Data PortalGRIN2C 
TCGA Data PortalGRIN2C 
Broad Tumor PortalGRIN2C
OASIS PortalGRIN2C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRIN2C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRIN2C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRIN2C
DgiDB (Drug Gene Interaction Database)GRIN2C
DoCM (Curated mutations)GRIN2C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRIN2C (select a term)
intoGenGRIN2C
Cancer3DGRIN2C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138254   
Orphanet
MedgenGRIN2C
Genetic Testing Registry GRIN2C
NextProtQ14957 [Medical]
TSGene2905
GENETestsGRIN2C
Target ValidationGRIN2C
Huge Navigator GRIN2C [HugePedia]
snp3D : Map Gene to Disease2905
BioCentury BCIQGRIN2C
ClinGenGRIN2C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2905
Chemical/Pharm GKB GenePA28981
Clinical trialGRIN2C
Miscellaneous
canSAR (ICR)GRIN2C (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRIN2C
EVEXGRIN2C
GoPubMedGRIN2C
iHOPGRIN2C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 11:49:45 CET 2017

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