GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1)

2008-08-01  

Identity

HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
HNRGW,LFG1,NMDARA1,TMBIM3
FUSION GENES

Other Information

Locus ID:

NCBI: 2907
MIM: 138251
HGNC: 4589
Ensembl: ENSG00000178719

Variants:

dbSNP: 2907
ClinVar: 2907
TCGA: ENSG00000178719
COSMIC: GRINA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178719ENST00000313269Q7Z429
ENSG00000178719ENST00000395068Q7Z429
ENSG00000178719ENST00000527194H0YC98
ENSG00000178719ENST00000529301E9PPG3
ENSG00000178719ENST00000530898E9PQF8
ENSG00000178719ENST00000533044H0YCP9
ENSG00000178719ENST00000534791H0YEI4

Expression (GTEx)

0
100
200
300
400
500
600

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
222409012012TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis.27
257649782015The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state.23
208374692010Transmembrane BAX inhibitor motif containing (TMBIM) family proteins perturbs a trans-Golgi network enzyme, Gb3 synthase, and reduces Gb3 biosynthesis.22
184408692008Comparative genomics and function analysis on BI1 family.9
269902862016Extraintestinal manifestations of celiac disease: 33-mer gliadin binding to glutamate receptor GRINA as a new explanation.2
305415912018Transmembrane protein GRINA modulates aerobic glycolysis and promotes tumor progression in gastric cancer.2
307306092019Prioritization of PLEC and GRINA as Osteoarthritis Risk Genes Through the Identification and Characterization of Novel Methylation Quantitative Trait Loci.0
314264462019Deciphering GRINA/Lifeguard1: Nuclear Location, Ca<sup>2+</sup> Homeostasis and Vesicle Transport.0

Citation

Dessen P

GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50312/grina