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GRIP1 (glutamate receptor interacting protein 1)

Identity

Other aliasGRIP
HGNC (Hugo) GRIP1
LocusID (NCBI) 23426
Atlas_Id 40754
Location 12q14.3  [Link to chromosome band 12q14]
Location_base_pair Starts at 66741211 and ends at 67072925 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATF1 (12q13.12) / GRIP1 (12q14.3)FRS2 (12q15) / GRIP1 (12q14.3)GRIP1 (12q14.3) / CASK (Xp11.4)
GRIP1 (12q14.3) / TBL1XR1 (3q26.32)GRIP1 (12q14.3) / TNIP1 (5q33.1)KDM2A (11q13.2) / GRIP1 (12q14.3)
SLC22A23 (6p25.2) / GRIP1 (12q14.3)SOX4 (6p22.3) / GRIP1 (12q14.3)SPTA1 (1q23.1) / GRIP1 (12q14.3)
THAP2 (12q21.1) / GRIP1 (12q14.3)ATF1 12q13.12 / GRIP1 12q14.3FRS2 12q15 / GRIP1 12q14.3
KDM2A 11q13.2 / GRIP1 12q14.3SLC22A23 6p25.2 / GRIP1 12q14.3SPTA1 1q23.1 / GRIP1 12q14.3
THAP2 12q21.1 / GRIP1 12q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)GRIP1   18708
Cards
Entrez_Gene (NCBI)GRIP1  23426  glutamate receptor interacting protein 1
AliasesGRIP
GeneCards (Weizmann)GRIP1
Ensembl hg19 (Hinxton)ENSG00000155974 [Gene_View]  chr12:66741211-67072925 [Contig_View]  GRIP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000155974 [Gene_View]  chr12:66741211-67072925 [Contig_View]  GRIP1 [Vega]
ICGC DataPortalENSG00000155974
TCGA cBioPortalGRIP1
AceView (NCBI)GRIP1
Genatlas (Paris)GRIP1
WikiGenes23426
SOURCE (Princeton)GRIP1
Genetics Home Reference (NIH)GRIP1
Genomic and cartography
GoldenPath hg19 (UCSC)GRIP1  -     chr12:66741211-67072925 -  12q14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GRIP1  -     12q14.3   [Description]    (hg38-Dec_2013)
EnsemblGRIP1 - 12q14.3 [CytoView hg19]  GRIP1 - 12q14.3 [CytoView hg38]
Mapping of homologs : NCBIGRIP1 [Mapview hg19]  GRIP1 [Mapview hg38]
OMIM219000   604597   
Gene and transcription
Genbank (Entrez)AI190011 AJ133439 AK095519 AK295565 AK307576
RefSeq transcript (Entrez)NM_001178074 NM_021150
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_021400 NT_029419 NW_004929384
Consensus coding sequences : CCDS (NCBI)GRIP1
Cluster EST : UnigeneHs.505946 [ NCBI ]
CGAP (NCI)Hs.505946
Alternative Splicing GalleryENSG00000155974
Gene ExpressionGRIP1 [ NCBI-GEO ]   GRIP1 [ EBI - ARRAY_EXPRESS ]   GRIP1 [ SEEK ]   GRIP1 [ MEM ]
Gene Expression Viewer (FireBrowse)GRIP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23426
GTEX Portal (Tissue expression)GRIP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y3R0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y3R0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y3R0
Splice isoforms : SwissVarQ9Y3R0
PhosPhoSitePlusQ9Y3R0
Domaine pattern : Prosite (Expaxy)PDZ (PS50106)   
Domains : Interpro (EBI)GRIP1    PDZ   
Domain families : Pfam (Sanger)PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam00595   
Domain families : Smart (EMBL)PDZ (SM00228)  
Conserved Domain (NCBI)GRIP1
DMDM Disease mutations23426
Blocks (Seattle)GRIP1
PDB (SRS)2JIL   
PDB (PDBSum)2JIL   
PDB (IMB)2JIL   
PDB (RSDB)2JIL   
Structural Biology KnowledgeBase2JIL   
SCOP (Structural Classification of Proteins)2JIL   
CATH (Classification of proteins structures)2JIL   
SuperfamilyQ9Y3R0
Human Protein AtlasENSG00000155974
Peptide AtlasQ9Y3R0
IPIIPI00409578   IPI00409579   IPI00871857   IPI00982217   IPI01014115   IPI00789067   IPI01012236   IPI01011814   IPI01010369   IPI01011773   IPI01009485   IPI01010818   IPI01009850   IPI01009429   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y3R0
IntAct (EBI)Q9Y3R0
FunCoupENSG00000155974
BioGRIDGRIP1
STRING (EMBL)GRIP1
ZODIACGRIP1
Ontologies - Pathways
QuickGOQ9Y3R0
Ontology : AmiGOtranscription coactivator activity  protein binding  endoplasmic reticulum  cytosol  plasma membrane  plasma membrane  beta-catenin binding  protein C-terminus binding  protein localization  cytoplasmic, membrane-bounded vesicle  dendrite development  cell junction  receptor signaling complex scaffold activity  dendrite  androgen receptor signaling pathway  glucocorticoid receptor binding  intracellular signal transduction  neuron projection  membrane raft  postsynaptic membrane  positive regulation of transcription, DNA-templated  androgen receptor binding  recycling endosome  
Ontology : EGO-EBItranscription coactivator activity  protein binding  endoplasmic reticulum  cytosol  plasma membrane  plasma membrane  beta-catenin binding  protein C-terminus binding  protein localization  cytoplasmic, membrane-bounded vesicle  dendrite development  cell junction  receptor signaling complex scaffold activity  dendrite  androgen receptor signaling pathway  glucocorticoid receptor binding  intracellular signal transduction  neuron projection  membrane raft  postsynaptic membrane  positive regulation of transcription, DNA-templated  androgen receptor binding  recycling endosome  
Pathways : BIOCARTARole of ERBB2 in Signal Transduction and Oncology [Genes]    CARM1 and Regulation of the Estrogen Receptor [Genes]   
NDEx NetworkGRIP1
Atlas of Cancer Signalling NetworkGRIP1
Wikipedia pathwaysGRIP1
Orthology - Evolution
OrthoDB23426
GeneTree (enSembl)ENSG00000155974
Phylogenetic Trees/Animal Genes : TreeFamGRIP1
HOVERGENQ9Y3R0
HOGENOMQ9Y3R0
Homologs : HomoloGeneGRIP1
Homology/Alignments : Family Browser (UCSC)GRIP1
Gene fusions - Rearrangements
Fusion : MitelmanATF1/GRIP1 [12q13.12/12q14.3]  [t(12;12)(q13;q14)]  
Fusion : MitelmanFRS2/GRIP1 [12q15/12q14.3]  [t(12;12)(q14;q15)]  
Fusion : MitelmanGRIP1/TNIP1 [12q14.3/5q33.1]  [t(5;12)(q33;q14)]  
Fusion : MitelmanKDM2A/GRIP1 [11q13.2/12q14.3]  [t(11;12)(q13;q14)]  
Fusion : MitelmanSLC22A23/GRIP1 [6p25.2/12q14.3]  [t(6;12)(p25;q14)]  
Fusion : MitelmanSPTA1/GRIP1 [1q23.1/12q14.3]  [t(1;12)(q23;q14)]  
Fusion : MitelmanTHAP2/GRIP1 [12q21.1/12q14.3]  [t(12;12)(q14;q21)]  
Fusion: TCGAATF1 12q13.12 GRIP1 12q14.3 LUAD
Fusion: TCGAFRS2 12q15 GRIP1 12q14.3 LGG
Fusion: TCGAKDM2A 11q13.2 GRIP1 12q14.3 BRCA
Fusion: TCGASLC22A23 6p25.2 GRIP1 12q14.3 BRCA
Fusion: TCGASPTA1 1q23.1 GRIP1 12q14.3 BRCA
Fusion: TCGATHAP2 12q21.1 GRIP1 12q14.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRIP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRIP1
dbVarGRIP1
ClinVarGRIP1
1000_GenomesGRIP1 
Exome Variant ServerGRIP1
ExAC (Exome Aggregation Consortium)GRIP1 (select the gene name)
Genetic variants : HAPMAP23426
Genomic Variants (DGV)GRIP1 [DGVbeta]
DECIPHER (Syndromes)12:66741211-67072925  ENSG00000155974
CONAN: Copy Number AnalysisGRIP1 
Mutations
ICGC Data PortalGRIP1 
TCGA Data PortalGRIP1 
Broad Tumor PortalGRIP1
OASIS PortalGRIP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRIP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRIP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRIP1
DgiDB (Drug Gene Interaction Database)GRIP1
DoCM (Curated mutations)GRIP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRIP1 (select a term)
intoGenGRIP1
Cancer3DGRIP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM219000    604597   
Orphanet1046   
MedgenGRIP1
Genetic Testing Registry GRIP1
NextProtQ9Y3R0 [Medical]
TSGene23426
GENETestsGRIP1
Huge Navigator GRIP1 [HugePedia]
snp3D : Map Gene to Disease23426
BioCentury BCIQGRIP1
ClinGenGRIP1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23426
Chemical/Pharm GKB GenePA38652
Clinical trialGRIP1
Miscellaneous
canSAR (ICR)GRIP1 (select the gene name)
Probes
Litterature
PubMed67 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRIP1
EVEXGRIP1
GoPubMedGRIP1
iHOPGRIP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Mar 14 13:08:13 CET 2017

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