Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GRK1 (G protein-coupled receptor kinase 1)

Identity

Alias_namesRHOK
rhodopsin kinase
Alias_symbol (synonym)GPRK1
RK
Other alias
HGNC (Hugo) GRK1
LocusID (NCBI) 6011
Atlas_Id 40755
Location 13q34  [Link to chromosome band 13q34]
Location_base_pair Starts at 113667282 and ends at 113735664 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TFDP1 (13q34) / GRK1 (13q34)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRK1   10013
Cards
Entrez_Gene (NCBI)GRK1  6011  G protein-coupled receptor kinase 1
AliasesGPRK1; RHOK; RK
GeneCards (Weizmann)GRK1
Ensembl hg19 (Hinxton)ENSG00000185974 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185974 [Gene_View]  chr13:113667282-113735664 [Contig_View]  GRK1 [Vega]
ICGC DataPortalENSG00000185974
TCGA cBioPortalGRK1
AceView (NCBI)GRK1
Genatlas (Paris)GRK1
WikiGenes6011
SOURCE (Princeton)GRK1
Genetics Home Reference (NIH)GRK1
Genomic and cartography
GoldenPath hg38 (UCSC)GRK1  -     chr13:113667282-113735664 +  13q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRK1  -     13q34   [Description]    (hg19-Feb_2009)
EnsemblGRK1 - 13q34 [CytoView hg19]  GRK1 - 13q34 [CytoView hg38]
Mapping of homologs : NCBIGRK1 [Mapview hg19]  GRK1 [Mapview hg38]
OMIM180381   613411   
Gene and transcription
Genbank (Entrez)AK289912 BC140945 BM702747 BX647503 L77503
RefSeq transcript (Entrez)NM_002929
RefSeq genomic (Entrez)NC_000013 NC_018924 NT_187596
Consensus coding sequences : CCDS (NCBI)GRK1
Cluster EST : UnigeneHs.721727 [ NCBI ]
CGAP (NCI)Hs.721727
Alternative Splicing GalleryENSG00000185974
Gene ExpressionGRK1 [ NCBI-GEO ]   GRK1 [ EBI - ARRAY_EXPRESS ]   GRK1 [ SEEK ]   GRK1 [ MEM ]
Gene Expression Viewer (FireBrowse)GRK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)6011
GTEX Portal (Tissue expression)GRK1
Human Protein AtlasENSG00000185974-GRK1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15835   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15835  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15835
Splice isoforms : SwissVarQ15835
PhosPhoSitePlusQ15835
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    RGS (PS50132)   
Domains : Interpro (EBI)AGC-kinase_C    GPCR_kinase    GRK1    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    RGS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00069    pfam00615   
Domain families : Smart (EMBL)RGS (SM00315)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)GRK1
DMDM Disease mutations6011
Blocks (Seattle)GRK1
PDB (SRS)5AFP   
PDB (PDBSum)5AFP   
PDB (IMB)5AFP   
PDB (RSDB)5AFP   
Structural Biology KnowledgeBase5AFP   
SCOP (Structural Classification of Proteins)5AFP   
CATH (Classification of proteins structures)5AFP   
SuperfamilyQ15835
Human Protein Atlas [tissue]ENSG00000185974-GRK1 [tissue]
Peptide AtlasQ15835
HPRD01585
IPIIPI00019980   IPI01012184   IPI00383569   
Protein Interaction databases
DIP (DOE-UCLA)Q15835
IntAct (EBI)Q15835
FunCoupENSG00000185974
BioGRIDGRK1
STRING (EMBL)GRK1
ZODIACGRK1
Ontologies - Pathways
QuickGOQ15835
Ontology : AmiGOprotein kinase activity  G-protein coupled receptor kinase activity  ATP binding  visual perception  regulation of G-protein coupled receptor protein signaling pathway  rhodopsin mediated signaling pathway  regulation of rhodopsin mediated signaling pathway  regulation of rhodopsin mediated signaling pathway  protein autophosphorylation  rhodopsin kinase activity  rhodopsin kinase activity  photoreceptor disc membrane  
Ontology : EGO-EBIprotein kinase activity  G-protein coupled receptor kinase activity  ATP binding  visual perception  regulation of G-protein coupled receptor protein signaling pathway  rhodopsin mediated signaling pathway  regulation of rhodopsin mediated signaling pathway  regulation of rhodopsin mediated signaling pathway  protein autophosphorylation  rhodopsin kinase activity  rhodopsin kinase activity  photoreceptor disc membrane  
Pathways : BIOCARTAVisual Signal Transduction [Genes]   
Pathways : KEGGChemokine signaling pathway    Endocytosis    Phototransduction   
NDEx NetworkGRK1
Atlas of Cancer Signalling NetworkGRK1
Wikipedia pathwaysGRK1
Orthology - Evolution
OrthoDB6011
GeneTree (enSembl)ENSG00000185974
Phylogenetic Trees/Animal Genes : TreeFamGRK1
HOVERGENQ15835
HOGENOMQ15835
Homologs : HomoloGeneGRK1
Homology/Alignments : Family Browser (UCSC)GRK1
Gene fusions - Rearrangements
Tumor Fusion PortalGRK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRK1
dbVarGRK1
ClinVarGRK1
1000_GenomesGRK1 
Exome Variant ServerGRK1
ExAC (Exome Aggregation Consortium)ENSG00000185974
GNOMAD BrowserENSG00000185974
Genetic variants : HAPMAP6011
Genomic Variants (DGV)GRK1 [DGVbeta]
DECIPHERGRK1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRK1 
Mutations
ICGC Data PortalGRK1 
TCGA Data PortalGRK1 
Broad Tumor PortalGRK1
OASIS PortalGRK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRK1
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch GRK1
DgiDB (Drug Gene Interaction Database)GRK1
DoCM (Curated mutations)GRK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRK1 (select a term)
intoGenGRK1
Cancer3DGRK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM180381    613411   
Orphanet923    11079   
DisGeNETGRK1
MedgenGRK1
Genetic Testing Registry GRK1
NextProtQ15835 [Medical]
TSGene6011
GENETestsGRK1
Target ValidationGRK1
Huge Navigator GRK1 [HugePedia]
snp3D : Map Gene to Disease6011
BioCentury BCIQGRK1
ClinGenGRK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD6011
Chemical/Pharm GKB GenePA34391
Clinical trialGRK1
Miscellaneous
canSAR (ICR)GRK1 (select the gene name)
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRK1
EVEXGRK1
GoPubMedGRK1
iHOPGRK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:15:23 CET 2017

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