Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GRK2 (G protein-coupled receptor kinase 2)

Identity

Alias_namesADRBK1
adrenergic
Alias_symbol (synonym)BARK1
Other aliasBETA-ARK1
HGNC (Hugo) GRK2
LocusID (NCBI) 156
Atlas_Id 590
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 67266434 and ends at 67286558 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GRK2 11q13.2 / BAIAP2 17q25.3GRK2 11q13.2 / IQGAP1 15q26.1GRK2 11q13.2 / POLD4 11q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRK2   289
Cards
Entrez_Gene (NCBI)GRK2  156  G protein-coupled receptor kinase 2
AliasesADRBK1; BARK1; BETA-ARK1
GeneCards (Weizmann)GRK2
Ensembl hg19 (Hinxton)ENSG00000173020 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000173020 [Gene_View]  chr11:67266434-67286558 [Contig_View]  GRK2 [Vega]
ICGC DataPortalENSG00000173020
TCGA cBioPortalGRK2
AceView (NCBI)GRK2
Genatlas (Paris)GRK2
WikiGenes156
SOURCE (Princeton)GRK2
Genetics Home Reference (NIH)GRK2
Genomic and cartography
GoldenPath hg38 (UCSC)GRK2  -     chr11:67266434-67286558 +  11q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRK2  -     11q13.2   [Description]    (hg19-Feb_2009)
EnsemblGRK2 - 11q13.2 [CytoView hg19]  GRK2 - 11q13.2 [CytoView hg38]
Mapping of homologs : NCBIGRK2 [Mapview hg19]  GRK2 [Mapview hg38]
OMIM109635   
Gene and transcription
Genbank (Entrez)AB209588 AI888604 AK131506 BC037963 BC090863
RefSeq transcript (Entrez)NM_001619
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRK2
Cluster EST : UnigeneHs.83636 [ NCBI ]
CGAP (NCI)Hs.83636
Alternative Splicing GalleryENSG00000173020
Gene ExpressionGRK2 [ NCBI-GEO ]   GRK2 [ EBI - ARRAY_EXPRESS ]   GRK2 [ SEEK ]   GRK2 [ MEM ]
Gene Expression Viewer (FireBrowse)GRK2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)156
GTEX Portal (Tissue expression)GRK2
Human Protein AtlasENSG00000173020-GRK2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP25098   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP25098  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP25098
Splice isoforms : SwissVarP25098
Catalytic activity : Enzyme2.7.11.15 [ Enzyme-Expasy ]   2.7.11.152.7.11.15 [ IntEnz-EBI ]   2.7.11.15 [ BRENDA ]   2.7.11.15 [ KEGG ]   
PhosPhoSitePlusP25098
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PH_DOMAIN (PS50003)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    RGS (PS50132)   
Domains : Interpro (EBI)AGC-kinase_C    GPCR_kinase    Kinase-like_dom    PH_dom-like    PH_domain    Prot_kinase_dom    Protein_kinase_ATP_BS    RGS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)PH (PF00169)    Pkinase (PF00069)    RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00169    pfam00069    pfam00615   
Domain families : Smart (EMBL)PH (SM00233)  RGS (SM00315)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)GRK2
DMDM Disease mutations156
Blocks (Seattle)GRK2
PDB (SRS)1BAK    3CIK    3KRW    3KRX    3V5W    4MK0    4PNK    5HE1   
PDB (PDBSum)1BAK    3CIK    3KRW    3KRX    3V5W    4MK0    4PNK    5HE1   
PDB (IMB)1BAK    3CIK    3KRW    3KRX    3V5W    4MK0    4PNK    5HE1   
PDB (RSDB)1BAK    3CIK    3KRW    3KRX    3V5W    4MK0    4PNK    5HE1   
Structural Biology KnowledgeBase1BAK    3CIK    3KRW    3KRX    3V5W    4MK0    4PNK    5HE1   
SCOP (Structural Classification of Proteins)1BAK    3CIK    3KRW    3KRX    3V5W    4MK0    4PNK    5HE1   
CATH (Classification of proteins structures)1BAK    3CIK    3KRW    3KRX    3V5W    4MK0    4PNK    5HE1   
SuperfamilyP25098
Human Protein Atlas [tissue]ENSG00000173020-GRK2 [tissue]
Peptide AtlasP25098
HPRD00182
IPIIPI00012497   IPI00555929   IPI00747929   IPI00979267   
Protein Interaction databases
DIP (DOE-UCLA)P25098
IntAct (EBI)P25098
FunCoupENSG00000173020
BioGRIDGRK2
STRING (EMBL)GRK2
ZODIACGRK2
Ontologies - Pathways
QuickGOP25098
Ontology : AmiGOdesensitization of G-protein coupled receptor protein signaling pathway  negative regulation of the force of heart contraction by chemical signal  protein kinase activity  G-protein coupled receptor kinase activity  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  cilium  G-protein coupled acetylcholine receptor signaling pathway  tachykinin receptor signaling pathway  heart development  membrane  membrane  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  viral genome replication  receptor internalization  alpha-2A adrenergic receptor binding  Edg-2 lysophosphatidic acid receptor binding  positive regulation of catecholamine secretion  negative regulation of striated muscle contraction  viral entry into host cell  beta-adrenergic receptor kinase activity  cardiac muscle contraction  
Ontology : EGO-EBIdesensitization of G-protein coupled receptor protein signaling pathway  negative regulation of the force of heart contraction by chemical signal  protein kinase activity  G-protein coupled receptor kinase activity  protein binding  ATP binding  cytoplasm  cytosol  plasma membrane  cilium  G-protein coupled acetylcholine receptor signaling pathway  tachykinin receptor signaling pathway  heart development  membrane  membrane  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  viral genome replication  receptor internalization  alpha-2A adrenergic receptor binding  Edg-2 lysophosphatidic acid receptor binding  positive regulation of catecholamine secretion  negative regulation of striated muscle contraction  viral entry into host cell  beta-adrenergic receptor kinase activity  cardiac muscle contraction  
Pathways : BIOCARTARoles of ?-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling [Genes]    Role of ?-arrestins in the activation and targeting of MAP kinases [Genes]    ?-arrestins in GPCR Desensitization [Genes]   
NDEx NetworkGRK2
Atlas of Cancer Signalling NetworkGRK2
Wikipedia pathwaysGRK2
Orthology - Evolution
OrthoDB156
GeneTree (enSembl)ENSG00000173020
Phylogenetic Trees/Animal Genes : TreeFamGRK2
HOVERGENP25098
HOGENOMP25098
Homologs : HomoloGeneGRK2
Homology/Alignments : Family Browser (UCSC)GRK2
Gene fusions - Rearrangements
Fusion : MitelmanGRK2/BAIAP2 [11q13.2/17q25.3]  
Fusion : MitelmanGRK2/IGHMBP2 [11q13.2/11q13.3]  [t(11;11)(q13;q13)]  
Fusion : MitelmanGRK2/IQGAP1 [11q13.2/15q26.1]  [t(11;15)(q13;q26)]  
Fusion : MitelmanGRK2/POLD4 [11q13.2/11q13.2]  [t(11;11)(q13;q13)]  
Fusion: TCGA_MDACCGRK2 11q13.2 BAIAP2 17q25.3 BRCA
Fusion: TCGA_MDACCGRK2 11q13.2 IQGAP1 15q26.1 BRCA
Fusion: TCGA_MDACCGRK2 11q13.2 POLD4 11q13.2 BRCA
Tumor Fusion PortalGRK2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRK2
dbVarGRK2
ClinVarGRK2
1000_GenomesGRK2 
Exome Variant ServerGRK2
ExAC (Exome Aggregation Consortium)ENSG00000173020
GNOMAD BrowserENSG00000173020
Genetic variants : HAPMAP156
Genomic Variants (DGV)GRK2 [DGVbeta]
DECIPHERGRK2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRK2 
Mutations
ICGC Data PortalGRK2 
TCGA Data PortalGRK2 
Broad Tumor PortalGRK2
OASIS PortalGRK2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDGRK2
BioMutasearch GRK2
DgiDB (Drug Gene Interaction Database)GRK2
DoCM (Curated mutations)GRK2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRK2 (select a term)
intoGenGRK2
Cancer3DGRK2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109635   
Orphanet
DisGeNETGRK2
MedgenGRK2
Genetic Testing Registry GRK2
NextProtP25098 [Medical]
TSGene156
GENETestsGRK2
Target ValidationGRK2
Huge Navigator GRK2 [HugePedia]
snp3D : Map Gene to Disease156
BioCentury BCIQGRK2
ClinGenGRK2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD156
Chemical/Pharm GKB GenePA40
Clinical trialGRK2
Miscellaneous
canSAR (ICR)GRK2 (select the gene name)
Probes
Litterature
PubMed197 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRK2
EVEXGRK2
GoPubMedGRK2
iHOPGRK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:15:23 CET 2017

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