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GRK3 (G protein-coupled receptor kinase 3)

Identity

Alias_namesADRBK2
adrenergic
Alias_symbol (synonym)BARK2
Other alias
HGNC (Hugo) GRK3
LocusID (NCBI) 157
Atlas_Id 43107
Location 22q12.1  [Link to chromosome band 22q12]
Location_base_pair Starts at 25564894 and ends at 25729291 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GRK3 22q12.1 / SF3A1 22q12.2EHD1 11q13.1 / GRK3 22q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRK3   290
Cards
Entrez_Gene (NCBI)GRK3  157  G protein-coupled receptor kinase 3
AliasesADRBK2; BARK2
GeneCards (Weizmann)GRK3
Ensembl hg19 (Hinxton)ENSG00000100077 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100077 [Gene_View]  chr22:25564894-25729291 [Contig_View]  GRK3 [Vega]
ICGC DataPortalENSG00000100077
TCGA cBioPortalGRK3
AceView (NCBI)GRK3
Genatlas (Paris)GRK3
WikiGenes157
SOURCE (Princeton)GRK3
Genetics Home Reference (NIH)GRK3
Genomic and cartography
GoldenPath hg38 (UCSC)GRK3  -     chr22:25564894-25729291 +  22q12.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRK3  -     22q12.1   [Description]    (hg19-Feb_2009)
EnsemblGRK3 - 22q12.1 [CytoView hg19]  GRK3 - 22q12.1 [CytoView hg38]
Mapping of homologs : NCBIGRK3 [Mapview hg19]  GRK3 [Mapview hg38]
OMIM109636   
Gene and transcription
Genbank (Entrez)AK055687 AK058103 AK096564 AK123767 AK124922
RefSeq transcript (Entrez)NM_005160
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRK3
Cluster EST : UnigeneHs.733960 [ NCBI ]
CGAP (NCI)Hs.733960
Alternative Splicing GalleryENSG00000100077
Gene ExpressionGRK3 [ NCBI-GEO ]   GRK3 [ EBI - ARRAY_EXPRESS ]   GRK3 [ SEEK ]   GRK3 [ MEM ]
Gene Expression Viewer (FireBrowse)GRK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)157
GTEX Portal (Tissue expression)GRK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35626   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35626  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35626
Splice isoforms : SwissVarP35626
Catalytic activity : Enzyme2.7.11.15 [ Enzyme-Expasy ]   2.7.11.152.7.11.15 [ IntEnz-EBI ]   2.7.11.15 [ BRENDA ]   2.7.11.15 [ KEGG ]   
PhosPhoSitePlusP35626
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PH_DOMAIN (PS50003)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    RGS (PS50132)   
Domains : Interpro (EBI)AGC-kinase_C    GPCR_kinase    Kinase-like_dom    PH_dom-like    PH_domain    Prot_kinase_dom    Protein_kinase_ATP_BS    RGS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)PH (PF00169)    Pkinase (PF00069)    RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00169    pfam00069    pfam00615   
Domain families : Smart (EMBL)PH (SM00233)  RGS (SM00315)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)GRK3
DMDM Disease mutations157
Blocks (Seattle)GRK3
SuperfamilyP35626
Human Protein AtlasENSG00000100077
Peptide AtlasP35626
HPRD00183
IPIIPI00019926   IPI01014399   IPI00983785   IPI00879491   
Protein Interaction databases
DIP (DOE-UCLA)P35626
IntAct (EBI)P35626
FunCoupENSG00000100077
BioGRIDGRK3
STRING (EMBL)GRK3
ZODIACGRK3
Ontologies - Pathways
QuickGOP35626
Ontology : AmiGOprotein kinase activity  G-protein coupled receptor kinase activity  ATP binding  cytosol  plasma membrane  protein phosphorylation  signal transduction  receptor internalization  beta-adrenergic receptor kinase activity  
Ontology : EGO-EBIprotein kinase activity  G-protein coupled receptor kinase activity  ATP binding  cytosol  plasma membrane  protein phosphorylation  signal transduction  receptor internalization  beta-adrenergic receptor kinase activity  
NDEx NetworkGRK3
Atlas of Cancer Signalling NetworkGRK3
Wikipedia pathwaysGRK3
Orthology - Evolution
OrthoDB157
GeneTree (enSembl)ENSG00000100077
Phylogenetic Trees/Animal Genes : TreeFamGRK3
HOVERGENP35626
HOGENOMP35626
Homologs : HomoloGeneGRK3
Homology/Alignments : Family Browser (UCSC)GRK3
Gene fusions - Rearrangements
Fusion : MitelmanGRK3/SF3A1 [22q12.1/22q12.2]  
Fusion : MitelmanEHD1/GRK3 [11q13.1/22q12.1]  [t(11;22)(q13;q12)]  
Fusion : MitelmanWWC1/GRK3 [5q34/22q12.1]  [t(5;22)(q34;q12)]  
Fusion: TCGAGRK3 22q12.1 SF3A1 22q12.2 BRCA
Fusion: TCGAEHD1 11q13.1 GRK3 22q12.1 LGG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRK3
dbVarGRK3
ClinVarGRK3
1000_GenomesGRK3 
Exome Variant ServerGRK3
ExAC (Exome Aggregation Consortium)GRK3 (select the gene name)
Genetic variants : HAPMAP157
Genomic Variants (DGV)GRK3 [DGVbeta]
DECIPHERGRK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRK3 
Mutations
ICGC Data PortalGRK3 
TCGA Data PortalGRK3 
Broad Tumor PortalGRK3
OASIS PortalGRK3 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDGRK3
BioMutasearch GRK3
DgiDB (Drug Gene Interaction Database)GRK3
DoCM (Curated mutations)GRK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRK3 (select a term)
intoGenGRK3
Cancer3DGRK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM109636   
Orphanet
MedgenGRK3
Genetic Testing Registry GRK3
NextProtP35626 [Medical]
TSGene157
GENETestsGRK3
Target ValidationGRK3
Huge Navigator GRK3 [HugePedia]
snp3D : Map Gene to Disease157
BioCentury BCIQGRK3
ClinGenGRK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD157
Chemical/Pharm GKB GenePA41
Clinical trialGRK3
Miscellaneous
canSAR (ICR)GRK3 (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRK3
EVEXGRK3
GoPubMedGRK3
iHOPGRK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:36:03 CEST 2017

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