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GRK4 (G protein-coupled receptor kinase 4)

Identity

Alias_namesGPRK2L
G protein-coupled receptor kinase 2-like (Drosophila)
Alias_symbol (synonym)GPRK4
Other aliasGRK4a
IT11
HGNC (Hugo) GRK4
LocusID (NCBI) 2868
Atlas_Id 43301
Location 4p16.3  [Link to chromosome band 4p16]
Location_base_pair Starts at 2965343 and ends at 3042474 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GRK4 (4p16.3) / GRK4 (4p16.3)HTT (4p16.3) / GRK4 (4p16.3)TET3 (2p13.1) / GRK4 (4p16.3)
WHSC1 (4p16.3) / GRK4 (4p16.3)HTT 4p16.3 / GRK4 4p16.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRK4   4543
Cards
Entrez_Gene (NCBI)GRK4  2868  G protein-coupled receptor kinase 4
AliasesGPRK2L; GPRK4; GRK4a; IT11
GeneCards (Weizmann)GRK4
Ensembl hg19 (Hinxton)ENSG00000125388 [Gene_View]  chr4:2965343-3042474 [Contig_View]  GRK4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000125388 [Gene_View]  chr4:2965343-3042474 [Contig_View]  GRK4 [Vega]
ICGC DataPortalENSG00000125388
TCGA cBioPortalGRK4
AceView (NCBI)GRK4
Genatlas (Paris)GRK4
WikiGenes2868
SOURCE (Princeton)GRK4
Genetics Home Reference (NIH)GRK4
Genomic and cartography
GoldenPath hg19 (UCSC)GRK4  -     chr4:2965343-3042474 +  4p16.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GRK4  -     4p16.3   [Description]    (hg38-Dec_2013)
EnsemblGRK4 - 4p16.3 [CytoView hg19]  GRK4 - 4p16.3 [CytoView hg38]
Mapping of homologs : NCBIGRK4 [Mapview hg19]  GRK4 [Mapview hg38]
OMIM137026   
Gene and transcription
Genbank (Entrez)AK223581 AK292390 AK293569 BC027597 BC039732
RefSeq transcript (Entrez)NM_001004056 NM_001004057 NM_005307 NM_182982
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_029102 NT_006051 NW_004929314
Consensus coding sequences : CCDS (NCBI)GRK4
Cluster EST : UnigeneHs.32959 [ NCBI ]
CGAP (NCI)Hs.32959
Alternative Splicing GalleryENSG00000125388
Gene ExpressionGRK4 [ NCBI-GEO ]   GRK4 [ EBI - ARRAY_EXPRESS ]   GRK4 [ SEEK ]   GRK4 [ MEM ]
Gene Expression Viewer (FireBrowse)GRK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2868
GTEX Portal (Tissue expression)GRK4
Protein : pattern, domain, 3D structure
UniProt/SwissProtP32298   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP32298  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP32298
Splice isoforms : SwissVarP32298
Catalytic activity : Enzyme2.7.11.16 [ Enzyme-Expasy ]   2.7.11.162.7.11.16 [ IntEnz-EBI ]   2.7.11.16 [ BRENDA ]   2.7.11.16 [ KEGG ]   
PhosPhoSitePlusP32298
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    RGS (PS50132)   
Domains : Interpro (EBI)AGC-kinase_C    GPCR_kinase    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    RGS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00069    pfam00615   
Domain families : Smart (EMBL)RGS (SM00315)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)GRK4
DMDM Disease mutations2868
Blocks (Seattle)GRK4
PDB (SRS)4YHJ   
PDB (PDBSum)4YHJ   
PDB (IMB)4YHJ   
PDB (RSDB)4YHJ   
Structural Biology KnowledgeBase4YHJ   
SCOP (Structural Classification of Proteins)4YHJ   
CATH (Classification of proteins structures)4YHJ   
SuperfamilyP32298
Human Protein AtlasENSG00000125388
Peptide AtlasP32298
HPRD00656
IPIIPI00337306   IPI00217944   IPI00180426   IPI00182614   IPI00910710   IPI00966880   
Protein Interaction databases
DIP (DOE-UCLA)P32298
IntAct (EBI)P32298
FunCoupENSG00000125388
BioGRIDGRK4
STRING (EMBL)GRK4
ZODIACGRK4
Ontologies - Pathways
QuickGOP32298
Ontology : AmiGOG-protein coupled receptor internalization  G-protein coupled receptor kinase activity  ATP binding  cytosol  cell cortex  protein phosphorylation  signal transduction  regulation of G-protein coupled receptor protein signaling pathway  regulation of rhodopsin mediated signaling pathway  dendrite  receptor internalization  neuronal cell body  rhodopsin kinase activity  photoreceptor disc membrane  
Ontology : EGO-EBIG-protein coupled receptor internalization  G-protein coupled receptor kinase activity  ATP binding  cytosol  cell cortex  protein phosphorylation  signal transduction  regulation of G-protein coupled receptor protein signaling pathway  regulation of rhodopsin mediated signaling pathway  dendrite  receptor internalization  neuronal cell body  rhodopsin kinase activity  photoreceptor disc membrane  
Pathways : BIOCARTAAttenuation of GPCR Signaling [Genes]   
Pathways : KEGGChemokine signaling pathway    Endocytosis    Morphine addiction   
NDEx NetworkGRK4
Atlas of Cancer Signalling NetworkGRK4
Wikipedia pathwaysGRK4
Orthology - Evolution
OrthoDB2868
GeneTree (enSembl)ENSG00000125388
Phylogenetic Trees/Animal Genes : TreeFamGRK4
HOVERGENP32298
HOGENOMP32298
Homologs : HomoloGeneGRK4
Homology/Alignments : Family Browser (UCSC)GRK4
Gene fusions - Rearrangements
Fusion : MitelmanHTT/GRK4 [4p16.3/4p16.3]  [t(4;4)(p16;p16)]  
Fusion: TCGAHTT 4p16.3 GRK4 4p16.3 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRK4
dbVarGRK4
ClinVarGRK4
1000_GenomesGRK4 
Exome Variant ServerGRK4
ExAC (Exome Aggregation Consortium)GRK4 (select the gene name)
Genetic variants : HAPMAP2868
Genomic Variants (DGV)GRK4 [DGVbeta]
DECIPHER (Syndromes)4:2965343-3042474  ENSG00000125388
CONAN: Copy Number AnalysisGRK4 
Mutations
ICGC Data PortalGRK4 
TCGA Data PortalGRK4 
Broad Tumor PortalGRK4
OASIS PortalGRK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRK4
DgiDB (Drug Gene Interaction Database)GRK4
DoCM (Curated mutations)GRK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRK4 (select a term)
intoGenGRK4
Cancer3DGRK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM137026   
Orphanet
MedgenGRK4
Genetic Testing Registry GRK4
NextProtP32298 [Medical]
TSGene2868
GENETestsGRK4
Huge Navigator GRK4 [HugePedia]
snp3D : Map Gene to Disease2868
BioCentury BCIQGRK4
ClinGenGRK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2868
Chemical/Pharm GKB GenePA28941
Clinical trialGRK4
Miscellaneous
canSAR (ICR)GRK4 (select the gene name)
Probes
Litterature
PubMed51 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRK4
EVEXGRK4
GoPubMedGRK4
iHOPGRK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:03:05 CEST 2017

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