GRK5 (G protein-coupled receptor kinase 5)

2014-11-01  

Identity

HGNC
LOCATION
10q26.11
LOCUSID
ALIAS
FP2025,GPRK5
FUSION GENES

Other Information

Locus ID:

NCBI: 2869
MIM: 600870
HGNC: 4544
Ensembl: ENSG00000198873

Variants:

dbSNP: 2869
ClinVar: 2869
TCGA: ENSG00000198873
COSMIC: GRK5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198873ENST00000392870P34947

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Chemokine signaling pathwayKEGGko04062
Chemokine signaling pathwayKEGGhsa04062
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10074escitalopramChemicalClinicalAnnotationassociatedPD
PA164712445AntihypertensivesChemicalClinicalAnnotationassociatedPD18425130, 21127457
PA164712535Beta Blocking AgentsChemicalClinicalAnnotationassociatedPD18425130, 21127457
PA444368Heart DiseasesDiseaseClinicalAnnotationassociatedPD18425130, 21127457
PA444370Heart FailureDiseaseClinicalAnnotationassociatedPD
PA447207Depressive DisorderDiseaseClinicalAnnotationassociatedPD
PA449015citalopramChemicalClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
184251302008A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure.118
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
229610802013A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.60
190083572008The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha.55
155428282004G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence.48
168496372006Impaired neutrophil chemotaxis in sepsis associates with GRK expression and inhibition of actin assembly and tyrosine phosphorylation.48
196281192009Clinical and genetic modifiers of long-term survival in heart failure.46
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
149762072004A predicted amphipathic helix mediates plasma membrane localization of GRK5.41

Citation

Dessen P

GRK5 (G protein-coupled receptor kinase 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/54940/grk5