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GRK5 (G protein-coupled receptor kinase 5)

Identity

Alias_namesGPRK5
Other alias
HGNC (Hugo) GRK5
LocusID (NCBI) 2869
Atlas_Id 54940
Location 10q26.11  [Link to chromosome band 10q26]
Location_base_pair Starts at 120967197 and ends at 121215131 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CRYAB (11q23.1) / GRK5 (10q26.11)FAM45A (10q26.11) / GRK5 (10q26.11)GRK5 (10q26.11) / GRK5 (10q26.11)
GRK5 (10q26.11) / PDZD8 (10q25.3)GRK5 (10q26.11) / PTPN3 (9q31.3)GRK5 (10q26.11) / PTPRE (10q26.2)
PRRC2B (9q34.13) / GRK5 (10q26.11)GRK5 10q26.11 / PDZD8 10q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRK5   4544
Cards
Entrez_Gene (NCBI)GRK5  2869  G protein-coupled receptor kinase 5
AliasesGPRK5
GeneCards (Weizmann)GRK5
Ensembl hg19 (Hinxton)ENSG00000198873 [Gene_View]  chr10:120967197-121215131 [Contig_View]  GRK5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000198873 [Gene_View]  chr10:120967197-121215131 [Contig_View]  GRK5 [Vega]
ICGC DataPortalENSG00000198873
TCGA cBioPortalGRK5
AceView (NCBI)GRK5
Genatlas (Paris)GRK5
WikiGenes2869
SOURCE (Princeton)GRK5
Genetics Home Reference (NIH)GRK5
Genomic and cartography
GoldenPath hg19 (UCSC)GRK5  -     chr10:120967197-121215131 +  10q26.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GRK5  -     10q26.11   [Description]    (hg38-Dec_2013)
EnsemblGRK5 - 10q26.11 [CytoView hg19]  GRK5 - 10q26.11 [CytoView hg38]
Mapping of homologs : NCBIGRK5 [Mapview hg19]  GRK5 [Mapview hg38]
OMIM600870   
Gene and transcription
Genbank (Entrez)AF370369 AK097099 AK298261 AK301450 AK309761
RefSeq transcript (Entrez)NM_005308
RefSeq genomic (Entrez)NC_000010 NC_018921 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)GRK5
Cluster EST : UnigeneHs.736460 [ NCBI ]
CGAP (NCI)Hs.736460
Alternative Splicing GalleryENSG00000198873
Gene ExpressionGRK5 [ NCBI-GEO ]   GRK5 [ EBI - ARRAY_EXPRESS ]   GRK5 [ SEEK ]   GRK5 [ MEM ]
Gene Expression Viewer (FireBrowse)GRK5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2869
GTEX Portal (Tissue expression)GRK5
Protein : pattern, domain, 3D structure
UniProt/SwissProtP34947   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP34947  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP34947
Splice isoforms : SwissVarP34947
Catalytic activity : Enzyme2.7.11.16 [ Enzyme-Expasy ]   2.7.11.162.7.11.16 [ IntEnz-EBI ]   2.7.11.16 [ BRENDA ]   2.7.11.16 [ KEGG ]   
PhosPhoSitePlusP34947
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    RGS (PS50132)   
Domains : Interpro (EBI)AGC-kinase_C    GPCR_kinase    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    RGS    Ser/Thr_dual-sp_kinase   
Domain families : Pfam (Sanger)Pkinase (PF00069)    RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00069    pfam00615   
Domain families : Smart (EMBL)RGS (SM00315)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)GRK5
DMDM Disease mutations2869
Blocks (Seattle)GRK5
PDB (SRS)4TNB    4TND   
PDB (PDBSum)4TNB    4TND   
PDB (IMB)4TNB    4TND   
PDB (RSDB)4TNB    4TND   
Structural Biology KnowledgeBase4TNB    4TND   
SCOP (Structural Classification of Proteins)4TNB    4TND   
CATH (Classification of proteins structures)4TNB    4TND   
SuperfamilyP34947
Human Protein AtlasENSG00000198873
Peptide AtlasP34947
HPRD02926
IPIIPI00414058   IPI00908958   IPI00873601   IPI00514400   
Protein Interaction databases
DIP (DOE-UCLA)P34947
IntAct (EBI)P34947
FunCoupENSG00000198873
BioGRIDGRK5
STRING (EMBL)GRK5
ZODIACGRK5
Ontologies - Pathways
QuickGOP34947
Ontology : AmiGOdesensitization of G-protein coupled receptor protein signaling pathway  protein serine/threonine kinase activity  G-protein coupled receptor kinase activity  protein kinase C binding  protein binding  ATP binding  phospholipid binding  nucleus  cytoplasm  plasma membrane  plasma membrane  focal adhesion  apoptotic process  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  tachykinin receptor signaling pathway  regulation of G-protein coupled receptor protein signaling pathway  positive regulation of cell proliferation  Wnt signaling pathway  nuclear membrane  response to drug  negative regulation of apoptotic process  fat cell differentiation  protein autophosphorylation  beta-adrenergic receptor kinase activity  beta-adrenergic receptor kinase activity  regulation of cell cycle  
Ontology : EGO-EBIdesensitization of G-protein coupled receptor protein signaling pathway  protein serine/threonine kinase activity  G-protein coupled receptor kinase activity  protein kinase C binding  protein binding  ATP binding  phospholipid binding  nucleus  cytoplasm  plasma membrane  plasma membrane  focal adhesion  apoptotic process  adenylate cyclase-modulating G-protein coupled receptor signaling pathway  tachykinin receptor signaling pathway  regulation of G-protein coupled receptor protein signaling pathway  positive regulation of cell proliferation  Wnt signaling pathway  nuclear membrane  response to drug  negative regulation of apoptotic process  fat cell differentiation  protein autophosphorylation  beta-adrenergic receptor kinase activity  beta-adrenergic receptor kinase activity  regulation of cell cycle  
Pathways : KEGGChemokine signaling pathway    Endocytosis    Morphine addiction   
NDEx NetworkGRK5
Atlas of Cancer Signalling NetworkGRK5
Wikipedia pathwaysGRK5
Orthology - Evolution
OrthoDB2869
GeneTree (enSembl)ENSG00000198873
Phylogenetic Trees/Animal Genes : TreeFamGRK5
HOVERGENP34947
HOGENOMP34947
Homologs : HomoloGeneGRK5
Homology/Alignments : Family Browser (UCSC)GRK5
Gene fusions - Rearrangements
Fusion : MitelmanGRK5/PDZD8 [10q26.11/10q25.3]  
Fusion: TCGAGRK5 10q26.11 PDZD8 10q25.3 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRK5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRK5
dbVarGRK5
ClinVarGRK5
1000_GenomesGRK5 
Exome Variant ServerGRK5
ExAC (Exome Aggregation Consortium)GRK5 (select the gene name)
Genetic variants : HAPMAP2869
Genomic Variants (DGV)GRK5 [DGVbeta]
DECIPHER (Syndromes)10:120967197-121215131  ENSG00000198873
CONAN: Copy Number AnalysisGRK5 
Mutations
ICGC Data PortalGRK5 
TCGA Data PortalGRK5 
Broad Tumor PortalGRK5
OASIS PortalGRK5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRK5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRK5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRK5
DgiDB (Drug Gene Interaction Database)GRK5
DoCM (Curated mutations)GRK5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRK5 (select a term)
intoGenGRK5
Cancer3DGRK5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600870   
Orphanet
MedgenGRK5
Genetic Testing Registry GRK5
NextProtP34947 [Medical]
TSGene2869
GENETestsGRK5
Huge Navigator GRK5 [HugePedia]
snp3D : Map Gene to Disease2869
BioCentury BCIQGRK5
ClinGenGRK5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2869
Chemical/Pharm GKB GenePA180
Clinical trialGRK5
Miscellaneous
canSAR (ICR)GRK5 (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRK5
EVEXGRK5
GoPubMedGRK5
iHOPGRK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:08:15 CET 2017

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