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GRK5 (G protein-coupled receptor kinase 5)

Identity

Alias (NCBI)FP2025
GPRK5
HGNC (Hugo) GRK5
HGNC Previous nameGPRK5
LocusID (NCBI) 2869
Atlas_Id 54940
Location 10q26.11  [Link to chromosome band 10q26]
Location_base_pair Starts at 119207571 and ends at 119459745 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CRYAB (11q23.1) / GRK5 (10q26.11)FAM45A (10q26.11) / GRK5 (10q26.11)GRK5 (10q26.11) / GRK5 (10q26.11)
GRK5 (10q26.11) / PDZD8 (10q25.3)GRK5 (10q26.11) / PTPN3 (9q31.3)GRK5 (10q26.11) / PTPRE (10q26.2)
PRRC2B (9q34.13) / GRK5 (10q26.11)GRK5 10q26.11 / PDZD8 10q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GRK5   4544
Cards
Entrez_Gene (NCBI)GRK5    G protein-coupled receptor kinase 5
AliasesFP2025; GPRK5
GeneCards (Weizmann)GRK5
Ensembl hg19 (Hinxton)ENSG00000198873 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198873 [Gene_View]  ENSG00000198873 [Sequence]  chr10:119207571-119459745 [Contig_View]  GRK5 [Vega]
ICGC DataPortalENSG00000198873
TCGA cBioPortalGRK5
AceView (NCBI)GRK5
Genatlas (Paris)GRK5
SOURCE (Princeton)GRK5
Genetics Home Reference (NIH)GRK5
Genomic and cartography
GoldenPath hg38 (UCSC)GRK5  -     chr10:119207571-119459745 +  10q26.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRK5  -     10q26.11   [Description]    (hg19-Feb_2009)
GoldenPathGRK5 - 10q26.11 [CytoView hg19]  GRK5 - 10q26.11 [CytoView hg38]
ImmunoBaseENSG00000198873
Genome Data Viewer NCBIGRK5 [Mapview hg19]  
OMIM600870   
Gene and transcription
Genbank (Entrez)AF370369 AK097099 AK298261 AK301450 AK309761
RefSeq transcript (Entrez)NM_005308
Consensus coding sequences : CCDS (NCBI)GRK5
Gene ExpressionGRK5 [ NCBI-GEO ]   GRK5 [ EBI - ARRAY_EXPRESS ]   GRK5 [ SEEK ]   GRK5 [ MEM ]
Gene Expression Viewer (FireBrowse)GRK5 [ Firebrowse - Broad ]
GenevisibleExpression of GRK5 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2869
GTEX Portal (Tissue expression)GRK5
Human Protein AtlasENSG00000198873-GRK5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP34947   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP34947  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP34947
Catalytic activity : Enzyme2.7.11.16 [ Enzyme-Expasy ]   2.7.11.162.7.11.16 [ IntEnz-EBI ]   2.7.11.16 [ BRENDA ]   2.7.11.16 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP34947
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    RGS (PS50132)   
Domains : Interpro (EBI)AGC-kinase_C    GPCR_kinase    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    RGS    RGS_sf   
Domain families : Pfam (Sanger)Pkinase (PF00069)    RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00069    pfam00615   
Domain families : Smart (EMBL)RGS (SM00315)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)GRK5
PDB (RSDB)4TNB    4TND   
PDB Europe4TNB    4TND   
PDB (PDBSum)4TNB    4TND   
PDB (IMB)4TNB    4TND   
Structural Biology KnowledgeBase4TNB    4TND   
SCOP (Structural Classification of Proteins)4TNB    4TND   
CATH (Classification of proteins structures)4TNB    4TND   
SuperfamilyP34947
AlphaFold pdb e-kbP34947   
Human Protein Atlas [tissue]ENSG00000198873-GRK5 [tissue]
HPRD02926
Protein Interaction databases
DIP (DOE-UCLA)P34947
IntAct (EBI)P34947
BioGRIDGRK5
STRING (EMBL)GRK5
ZODIACGRK5
Ontologies - Pathways
QuickGOP34947
Ontology : AmiGOprotein kinase activity  protein serine/threonine kinase activity  G protein-coupled receptor kinase activity  protein kinase C binding  protein binding  ATP binding  phospholipid binding  cytoplasm  cytosol  plasma membrane  plasma membrane  protein phosphorylation  apoptotic process  G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  tachykinin receptor signaling pathway  regulation of G protein-coupled receptor signaling pathway  positive regulation of cell population proliferation  regulation of signal transduction  Wnt signaling pathway  nuclear speck  nuclear membrane  negative regulation of apoptotic process  protein autophosphorylation  beta-adrenergic receptor kinase activity  regulation of cell cycle  
Ontology : EGO-EBIprotein kinase activity  protein serine/threonine kinase activity  G protein-coupled receptor kinase activity  protein kinase C binding  protein binding  ATP binding  phospholipid binding  cytoplasm  cytosol  plasma membrane  plasma membrane  protein phosphorylation  apoptotic process  G protein-coupled receptor signaling pathway  adenylate cyclase-modulating G protein-coupled receptor signaling pathway  tachykinin receptor signaling pathway  regulation of G protein-coupled receptor signaling pathway  positive regulation of cell population proliferation  regulation of signal transduction  Wnt signaling pathway  nuclear speck  nuclear membrane  negative regulation of apoptotic process  protein autophosphorylation  beta-adrenergic receptor kinase activity  regulation of cell cycle  
Pathways : KEGGChemokine signaling pathway    Endocytosis    Morphine addiction   
NDEx NetworkGRK5
Atlas of Cancer Signalling NetworkGRK5
Wikipedia pathwaysGRK5
Orthology - Evolution
OrthoDB2869
GeneTree (enSembl)ENSG00000198873
Phylogenetic Trees/Animal Genes : TreeFamGRK5
Homologs : HomoloGeneGRK5
Homology/Alignments : Family Browser (UCSC)GRK5
Gene fusions - Rearrangements
Fusion : MitelmanGRK5/PDZD8 [10q26.11/10q25.3]  
Fusion : QuiverGRK5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRK5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRK5
dbVarGRK5
ClinVarGRK5
MonarchGRK5
1000_GenomesGRK5 
Exome Variant ServerGRK5
GNOMAD BrowserENSG00000198873
Varsome BrowserGRK5
ACMGGRK5 variants
VarityP34947
Genomic Variants (DGV)GRK5 [DGVbeta]
DECIPHERGRK5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRK5 
Mutations
ICGC Data PortalGRK5 
TCGA Data PortalGRK5 
Broad Tumor PortalGRK5
OASIS PortalGRK5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRK5  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGRK5
Mutations and Diseases : HGMDGRK5
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGRK5
DgiDB (Drug Gene Interaction Database)GRK5
DoCM (Curated mutations)GRK5
CIViC (Clinical Interpretations of Variants in Cancer)GRK5
Cancer3DGRK5
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600870   
Orphanet
DisGeNETGRK5
MedgenGRK5
Genetic Testing Registry GRK5
NextProtP34947 [Medical]
GENETestsGRK5
Target ValidationGRK5
Huge Navigator GRK5 [HugePedia]
ClinGenGRK5
Clinical trials, drugs, therapy
MyCancerGenomeGRK5
Protein Interactions : CTDGRK5
Pharm GKB GenePA180
PharosP34947
Clinical trialGRK5
Miscellaneous
canSAR (ICR)GRK5
HarmonizomeGRK5
DataMed IndexGRK5
Probes
Litterature
PubMed111 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGRK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:11:34 CEST 2021

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