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GRK6 (G protein-coupled receptor kinase 6)

Identity

Alias_namesGPRK6
Other alias
HGNC (Hugo) GRK6
LocusID (NCBI) 2870
Atlas_Id 40756
Location 5q35.3  [Link to chromosome band 5q35]
Location_base_pair Starts at 177426686 and ends at 177441353 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRK6   4545
Cards
Entrez_Gene (NCBI)GRK6  2870  G protein-coupled receptor kinase 6
AliasesGPRK6
GeneCards (Weizmann)GRK6
Ensembl hg19 (Hinxton)ENSG00000198055 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198055 [Gene_View]  chr5:177426686-177441353 [Contig_View]  GRK6 [Vega]
ICGC DataPortalENSG00000198055
TCGA cBioPortalGRK6
AceView (NCBI)GRK6
Genatlas (Paris)GRK6
WikiGenes2870
SOURCE (Princeton)GRK6
Genetics Home Reference (NIH)GRK6
Genomic and cartography
GoldenPath hg38 (UCSC)GRK6  -     chr5:177426686-177441353 +  5q35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRK6  -     5q35.3   [Description]    (hg19-Feb_2009)
EnsemblGRK6 - 5q35.3 [CytoView hg19]  GRK6 - 5q35.3 [CytoView hg38]
Mapping of homologs : NCBIGRK6 [Mapview hg19]  GRK6 [Mapview hg38]
OMIM600869   
Gene and transcription
Genbank (Entrez)AF040751 AF040752 AK056697 BC009277 BC017272
RefSeq transcript (Entrez)NM_001004105 NM_001004106 NM_002082
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRK6
Cluster EST : UnigeneHs.235116 [ NCBI ]
CGAP (NCI)Hs.235116
Alternative Splicing GalleryENSG00000198055
Gene ExpressionGRK6 [ NCBI-GEO ]   GRK6 [ EBI - ARRAY_EXPRESS ]   GRK6 [ SEEK ]   GRK6 [ MEM ]
Gene Expression Viewer (FireBrowse)GRK6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2870
GTEX Portal (Tissue expression)GRK6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43250   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43250  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43250
Splice isoforms : SwissVarP43250
Catalytic activity : Enzyme2.7.11.16 [ Enzyme-Expasy ]   2.7.11.162.7.11.16 [ IntEnz-EBI ]   2.7.11.16 [ BRENDA ]   2.7.11.16 [ KEGG ]   
PhosPhoSitePlusP43250
Domaine pattern : Prosite (Expaxy)AGC_KINASE_CTER (PS51285)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    RGS (PS50132)   
Domains : Interpro (EBI)AGC-kinase_C    GPCR_kinase    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    RGS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)    RGS (PF00615)   
Domain families : Pfam (NCBI)pfam00069    pfam00615   
Domain families : Smart (EMBL)RGS (SM00315)  S_TK_X (SM00133)  S_TKc (SM00220)  
Conserved Domain (NCBI)GRK6
DMDM Disease mutations2870
Blocks (Seattle)GRK6
PDB (SRS)2ACX    3NYN    3NYO   
PDB (PDBSum)2ACX    3NYN    3NYO   
PDB (IMB)2ACX    3NYN    3NYO   
PDB (RSDB)2ACX    3NYN    3NYO   
Structural Biology KnowledgeBase2ACX    3NYN    3NYO   
SCOP (Structural Classification of Proteins)2ACX    3NYN    3NYO   
CATH (Classification of proteins structures)2ACX    3NYN    3NYO   
SuperfamilyP43250
Human Protein AtlasENSG00000198055
Peptide AtlasP43250
HPRD02925
IPIIPI00017330   IPI00220242   IPI00465441   IPI00967360   IPI00967659   IPI00966287   IPI00967950   IPI00966567   IPI00968220   IPI00974165   
Protein Interaction databases
DIP (DOE-UCLA)P43250
IntAct (EBI)P43250
FunCoupENSG00000198055
BioGRIDGRK6
STRING (EMBL)GRK6
ZODIACGRK6
Ontologies - Pathways
QuickGOP43250
Ontology : AmiGOG-protein coupled receptor kinase activity  protein binding  ATP binding  plasma membrane  protein phosphorylation  regulation of G-protein coupled receptor protein signaling pathway  membrane  Wnt signaling pathway  beta-adrenergic receptor kinase activity  beta-adrenergic receptor kinase activity  beta-adrenergic receptor kinase activity  
Ontology : EGO-EBIG-protein coupled receptor kinase activity  protein binding  ATP binding  plasma membrane  protein phosphorylation  regulation of G-protein coupled receptor protein signaling pathway  membrane  Wnt signaling pathway  beta-adrenergic receptor kinase activity  beta-adrenergic receptor kinase activity  beta-adrenergic receptor kinase activity  
Pathways : KEGGChemokine signaling pathway    Endocytosis    Morphine addiction   
NDEx NetworkGRK6
Atlas of Cancer Signalling NetworkGRK6
Wikipedia pathwaysGRK6
Orthology - Evolution
OrthoDB2870
GeneTree (enSembl)ENSG00000198055
Phylogenetic Trees/Animal Genes : TreeFamGRK6
HOVERGENP43250
HOGENOMP43250
Homologs : HomoloGeneGRK6
Homology/Alignments : Family Browser (UCSC)GRK6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRK6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRK6
dbVarGRK6
ClinVarGRK6
1000_GenomesGRK6 
Exome Variant ServerGRK6
ExAC (Exome Aggregation Consortium)GRK6 (select the gene name)
Genetic variants : HAPMAP2870
Genomic Variants (DGV)GRK6 [DGVbeta]
DECIPHERGRK6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRK6 
Mutations
ICGC Data PortalGRK6 
TCGA Data PortalGRK6 
Broad Tumor PortalGRK6
OASIS PortalGRK6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRK6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRK6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRK6
DgiDB (Drug Gene Interaction Database)GRK6
DoCM (Curated mutations)GRK6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRK6 (select a term)
intoGenGRK6
Cancer3DGRK6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600869   
Orphanet
MedgenGRK6
Genetic Testing Registry GRK6
NextProtP43250 [Medical]
TSGene2870
GENETestsGRK6
Target ValidationGRK6
Huge Navigator GRK6 [HugePedia]
snp3D : Map Gene to Disease2870
BioCentury BCIQGRK6
ClinGenGRK6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2870
Chemical/Pharm GKB GenePA28942
Clinical trialGRK6
Miscellaneous
canSAR (ICR)GRK6 (select the gene name)
Probes
Litterature
PubMed62 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRK6
EVEXGRK6
GoPubMedGRK6
iHOPGRK6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:02:31 CEST 2017

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