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GRM2 (glutamate metabotropic receptor 2)

Identity

Alias_namesglutamate receptor
Alias_symbol (synonym)GPRC1B
mGlu2
MGLUR2
Other aliasGLUR2
HGNC (Hugo) GRM2
LocusID (NCBI) 2912
Atlas_Id 55952
Location 3p21.2  [Link to chromosome band 3p21]
Location_base_pair Starts at 51707033 and ends at 51718609 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRM2   4594
Cards
Entrez_Gene (NCBI)GRM2  2912  glutamate metabotropic receptor 2
AliasesGLUR2; GPRC1B; MGLUR2; mGlu2
GeneCards (Weizmann)GRM2
Ensembl hg19 (Hinxton)ENSG00000164082 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164082 [Gene_View]  chr3:51707033-51718609 [Contig_View]  GRM2 [Vega]
ICGC DataPortalENSG00000164082
TCGA cBioPortalGRM2
AceView (NCBI)GRM2
Genatlas (Paris)GRM2
WikiGenes2912
SOURCE (Princeton)GRM2
Genetics Home Reference (NIH)GRM2
Genomic and cartography
GoldenPath hg38 (UCSC)GRM2  -     chr3:51707033-51718609 +  3p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRM2  -     3p21.2   [Description]    (hg19-Feb_2009)
EnsemblGRM2 - 3p21.2 [CytoView hg19]  GRM2 - 3p21.2 [CytoView hg38]
Mapping of homologs : NCBIGRM2 [Mapview hg19]  GRM2 [Mapview hg38]
OMIM604099   
Gene and transcription
Genbank (Entrez)AB209164 AK289984 AK302671 AK313056 AK315816
RefSeq transcript (Entrez)NM_000839 NM_001130063 NM_001349116 NM_001349117
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRM2
Cluster EST : UnigeneHs.121510 [ NCBI ]
CGAP (NCI)Hs.121510
Alternative Splicing GalleryENSG00000164082
Gene ExpressionGRM2 [ NCBI-GEO ]   GRM2 [ EBI - ARRAY_EXPRESS ]   GRM2 [ SEEK ]   GRM2 [ MEM ]
Gene Expression Viewer (FireBrowse)GRM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2912
GTEX Portal (Tissue expression)GRM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14416   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14416  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14416
Splice isoforms : SwissVarQ14416
PhosPhoSitePlusQ14416
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F3_1 (PS00979)    G_PROTEIN_RECEP_F3_2 (PS00980)    G_PROTEIN_RECEP_F3_3 (PS00981)    G_PROTEIN_RECEP_F3_4 (PS50259)   
Domains : Interpro (EBI)ANF_lig-bd_rcpt    GPCR_3    GPCR_3_9-Cys_dom    GPCR_3_C    GPCR_3_CS    GPCR_3_mtglu_rcpt    GPCR_3_mtglu_rcpt_2    Peripla_BP_I   
Domain families : Pfam (Sanger)7tm_3 (PF00003)    ANF_receptor (PF01094)    NCD3G (PF07562)   
Domain families : Pfam (NCBI)pfam00003    pfam01094    pfam07562   
Conserved Domain (NCBI)GRM2
DMDM Disease mutations2912
Blocks (Seattle)GRM2
PDB (SRS)4XAQ    4XAS    5CNI    5CNJ    5KZN    5KZQ   
PDB (PDBSum)4XAQ    4XAS    5CNI    5CNJ    5KZN    5KZQ   
PDB (IMB)4XAQ    4XAS    5CNI    5CNJ    5KZN    5KZQ   
PDB (RSDB)4XAQ    4XAS    5CNI    5CNJ    5KZN    5KZQ   
Structural Biology KnowledgeBase4XAQ    4XAS    5CNI    5CNJ    5KZN    5KZQ   
SCOP (Structural Classification of Proteins)4XAQ    4XAS    5CNI    5CNJ    5KZN    5KZQ   
CATH (Classification of proteins structures)4XAQ    4XAS    5CNI    5CNJ    5KZN    5KZQ   
SuperfamilyQ14416
Human Protein AtlasENSG00000164082
Peptide AtlasQ14416
HPRD04977
IPIIPI00030834   IPI00795104   IPI00747055   IPI00927605   IPI00927846   
Protein Interaction databases
DIP (DOE-UCLA)Q14416
IntAct (EBI)Q14416
FunCoupENSG00000164082
BioGRIDGRM2
STRING (EMBL)GRM2
ZODIACGRM2
Ontologies - Pathways
QuickGOQ14416
Ontology : AmiGOgroup II metabotropic glutamate receptor activity  G-protein coupled receptor activity  calcium channel regulator activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  negative regulation of adenylate cyclase activity  adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway  G-protein coupled glutamate receptor signaling pathway  chemical synaptic transmission  glutamate receptor activity  glutamate secretion  cell junction  axon  dendrite  presynaptic membrane  regulation of synaptic transmission, glutamatergic  
Ontology : EGO-EBIgroup II metabotropic glutamate receptor activity  G-protein coupled receptor activity  calcium channel regulator activity  protein binding  intracellular  plasma membrane  integral component of plasma membrane  negative regulation of adenylate cyclase activity  adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway  G-protein coupled glutamate receptor signaling pathway  chemical synaptic transmission  glutamate receptor activity  glutamate secretion  cell junction  axon  dendrite  presynaptic membrane  regulation of synaptic transmission, glutamatergic  
Pathways : KEGGNeuroactive ligand-receptor interaction    Glutamatergic synapse    Cocaine addiction   
NDEx NetworkGRM2
Atlas of Cancer Signalling NetworkGRM2
Wikipedia pathwaysGRM2
Orthology - Evolution
OrthoDB2912
GeneTree (enSembl)ENSG00000164082
Phylogenetic Trees/Animal Genes : TreeFamGRM2
HOVERGENQ14416
HOGENOMQ14416
Homologs : HomoloGeneGRM2
Homology/Alignments : Family Browser (UCSC)GRM2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRM2
dbVarGRM2
ClinVarGRM2
1000_GenomesGRM2 
Exome Variant ServerGRM2
ExAC (Exome Aggregation Consortium)GRM2 (select the gene name)
Genetic variants : HAPMAP2912
Genomic Variants (DGV)GRM2 [DGVbeta]
DECIPHERGRM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRM2 
Mutations
ICGC Data PortalGRM2 
TCGA Data PortalGRM2 
Broad Tumor PortalGRM2
OASIS PortalGRM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRM2
DgiDB (Drug Gene Interaction Database)GRM2
DoCM (Curated mutations)GRM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRM2 (select a term)
intoGenGRM2
Cancer3DGRM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604099   
Orphanet
MedgenGRM2
Genetic Testing Registry GRM2
NextProtQ14416 [Medical]
TSGene2912
GENETestsGRM2
Huge Navigator GRM2 [HugePedia]
snp3D : Map Gene to Disease2912
BioCentury BCIQGRM2
ClinGenGRM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2912
Chemical/Pharm GKB GenePA28991
Clinical trialGRM2
Miscellaneous
canSAR (ICR)GRM2 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRM2
EVEXGRM2
GoPubMedGRM2
iHOPGRM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:18:02 CEST 2017

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