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GRM3 (glutamate metabotropic receptor 3)

Identity

Alias_namesglutamate receptor
Alias_symbol (synonym)GPRC1C
mGlu3
MGLUR3
Other aliasGLUR3
HGNC (Hugo) GRM3
LocusID (NCBI) 2913
Atlas_Id 52514
Location 7q21.11  [Link to chromosome band 7q21]
Location_base_pair Starts at 86643914 and ends at 86864876 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DMTF1 (7q21.12) / GRM3 (7q21.11)GRM3 (7q21.11) / ABCB1 (7q21.12)DMTF1 7q21.12 / GRM3 7q21.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRM3   4595
Cards
Entrez_Gene (NCBI)GRM3  2913  glutamate metabotropic receptor 3
AliasesGLUR3; GPRC1C; MGLUR3; mGlu3
GeneCards (Weizmann)GRM3
Ensembl hg19 (Hinxton)ENSG00000198822 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198822 [Gene_View]  chr7:86643914-86864876 [Contig_View]  GRM3 [Vega]
ICGC DataPortalENSG00000198822
TCGA cBioPortalGRM3
AceView (NCBI)GRM3
Genatlas (Paris)GRM3
WikiGenes2913
SOURCE (Princeton)GRM3
Genetics Home Reference (NIH)GRM3
Genomic and cartography
GoldenPath hg38 (UCSC)GRM3  -     chr7:86643914-86864876 +  7q21.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRM3  -     7q21.11   [Description]    (hg19-Feb_2009)
EnsemblGRM3 - 7q21.11 [CytoView hg19]  GRM3 - 7q21.11 [CytoView hg38]
Mapping of homologs : NCBIGRM3 [Mapview hg19]  GRM3 [Mapview hg38]
OMIM601115   
Gene and transcription
Genbank (Entrez)AK291406 AK294178 AK294701 BC022496 BC041407
RefSeq transcript (Entrez)NM_000840
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRM3
Cluster EST : UnigeneHs.590575 [ NCBI ]
CGAP (NCI)Hs.590575
Alternative Splicing GalleryENSG00000198822
Gene ExpressionGRM3 [ NCBI-GEO ]   GRM3 [ EBI - ARRAY_EXPRESS ]   GRM3 [ SEEK ]   GRM3 [ MEM ]
Gene Expression Viewer (FireBrowse)GRM3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2913
GTEX Portal (Tissue expression)GRM3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14832   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14832  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14832
Splice isoforms : SwissVarQ14832
PhosPhoSitePlusQ14832
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F3_1 (PS00979)    G_PROTEIN_RECEP_F3_2 (PS00980)    G_PROTEIN_RECEP_F3_3 (PS00981)    G_PROTEIN_RECEP_F3_4 (PS50259)   
Domains : Interpro (EBI)ANF_lig-bd_rcpt    GPCR_3    GPCR_3_9-Cys_dom    GPCR_3_C    GPCR_3_CS    GPCR_3_mtglu_rcpt    GPCR_3_mtglu_rcpt_3    Peripla_BP_I   
Domain families : Pfam (Sanger)7tm_3 (PF00003)    ANF_receptor (PF01094)    NCD3G (PF07562)   
Domain families : Pfam (NCBI)pfam00003    pfam01094    pfam07562   
Conserved Domain (NCBI)GRM3
DMDM Disease mutations2913
Blocks (Seattle)GRM3
PDB (SRS)1S8M    3SM9    4XAR    5CNK    5CNM   
PDB (PDBSum)1S8M    3SM9    4XAR    5CNK    5CNM   
PDB (IMB)1S8M    3SM9    4XAR    5CNK    5CNM   
PDB (RSDB)1S8M    3SM9    4XAR    5CNK    5CNM   
Structural Biology KnowledgeBase1S8M    3SM9    4XAR    5CNK    5CNM   
SCOP (Structural Classification of Proteins)1S8M    3SM9    4XAR    5CNK    5CNM   
CATH (Classification of proteins structures)1S8M    3SM9    4XAR    5CNK    5CNM   
SuperfamilyQ14832
Human Protein AtlasENSG00000198822
Peptide AtlasQ14832
HPRD03070
IPIIPI00000837   IPI00922642   IPI00925524   IPI00383868   IPI00927181   IPI00925333   IPI00719146   
Protein Interaction databases
DIP (DOE-UCLA)Q14832
IntAct (EBI)Q14832
FunCoupENSG00000198822
BioGRIDGRM3
STRING (EMBL)GRM3
ZODIACGRM3
Ontologies - Pathways
QuickGOQ14832
Ontology : AmiGOgroup II metabotropic glutamate receptor activity  G-protein coupled receptor activity  calcium channel regulator activity  plasma membrane  integral component of plasma membrane  negative regulation of adenylate cyclase activity  adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway  G-protein coupled glutamate receptor signaling pathway  chemical synaptic transmission  glutamate receptor activity  postsynaptic density  axon  presynaptic membrane  dendritic spine  postsynaptic membrane  regulation of synaptic transmission, glutamatergic  
Ontology : EGO-EBIgroup II metabotropic glutamate receptor activity  G-protein coupled receptor activity  calcium channel regulator activity  plasma membrane  integral component of plasma membrane  negative regulation of adenylate cyclase activity  adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway  G-protein coupled glutamate receptor signaling pathway  chemical synaptic transmission  glutamate receptor activity  postsynaptic density  axon  presynaptic membrane  dendritic spine  postsynaptic membrane  regulation of synaptic transmission, glutamatergic  
Pathways : KEGGNeuroactive ligand-receptor interaction    Glutamatergic synapse    Cocaine addiction   
NDEx NetworkGRM3
Atlas of Cancer Signalling NetworkGRM3
Wikipedia pathwaysGRM3
Orthology - Evolution
OrthoDB2913
GeneTree (enSembl)ENSG00000198822
Phylogenetic Trees/Animal Genes : TreeFamGRM3
HOVERGENQ14832
HOGENOMQ14832
Homologs : HomoloGeneGRM3
Homology/Alignments : Family Browser (UCSC)GRM3
Gene fusions - Rearrangements
Fusion : MitelmanDMTF1/GRM3 [7q21.12/7q21.11]  [t(7;7)(q21;q21)]  
Fusion: TCGADMTF1 7q21.12 GRM3 7q21.11 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRM3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRM3
dbVarGRM3
ClinVarGRM3
1000_GenomesGRM3 
Exome Variant ServerGRM3
ExAC (Exome Aggregation Consortium)GRM3 (select the gene name)
Genetic variants : HAPMAP2913
Genomic Variants (DGV)GRM3 [DGVbeta]
DECIPHERGRM3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRM3 
Mutations
ICGC Data PortalGRM3 
TCGA Data PortalGRM3 
Broad Tumor PortalGRM3
OASIS PortalGRM3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRM3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRM3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRM3
DgiDB (Drug Gene Interaction Database)GRM3
DoCM (Curated mutations)GRM3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRM3 (select a term)
intoGenGRM3
Cancer3DGRM3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601115   
Orphanet
MedgenGRM3
Genetic Testing Registry GRM3
NextProtQ14832 [Medical]
TSGene2913
GENETestsGRM3
Target ValidationGRM3
Huge Navigator GRM3 [HugePedia]
snp3D : Map Gene to Disease2913
BioCentury BCIQGRM3
ClinGenGRM3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2913
Chemical/Pharm GKB GenePA28992
Clinical trialGRM3
Miscellaneous
canSAR (ICR)GRM3 (select the gene name)
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRM3
EVEXGRM3
GoPubMedGRM3
iHOPGRM3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:36:04 CEST 2017

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