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GRM4 (glutamate metabotropic receptor 4)

Identity

Alias_namesglutamate receptor
Alias_symbol (synonym)GPRC1D
mGlu4
MGLUR4
Other alias
HGNC (Hugo) GRM4
LocusID (NCBI) 2914
Atlas_Id 46524
Location 6p21.31  [Link to chromosome band 6p21]
Location_base_pair Starts at 34018643 and ends at 34146137 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CTIF (18q21.1) / GRM4 (6p21.31)GRM4 (6p21.31) / STXBP5L (3q13.33)MGAT4C (12q21.31) / GRM4 (6p21.31)
SPINK1 (5q32) / GRM4 (6p21.31)TUBA1B (12q13.12) / GRM4 (6p21.31)CTIF 18q21.1 / GRM4 6p21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;18)(p21;q21) CTIF/GRM4


External links

Nomenclature
HGNC (Hugo)GRM4   4596
Cards
Entrez_Gene (NCBI)GRM4  2914  glutamate metabotropic receptor 4
AliasesGPRC1D; MGLUR4; mGlu4
GeneCards (Weizmann)GRM4
Ensembl hg19 (Hinxton)ENSG00000124493 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124493 [Gene_View]  ENSG00000124493 [Sequence]  chr6:34018643-34146137 [Contig_View]  GRM4 [Vega]
ICGC DataPortalENSG00000124493
TCGA cBioPortalGRM4
AceView (NCBI)GRM4
Genatlas (Paris)GRM4
WikiGenes2914
SOURCE (Princeton)GRM4
Genetics Home Reference (NIH)GRM4
Genomic and cartography
GoldenPath hg38 (UCSC)GRM4  -     chr6:34018643-34146137 -  6p21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRM4  -     6p21.31   [Description]    (hg19-Feb_2009)
EnsemblGRM4 - 6p21.31 [CytoView hg19]  GRM4 - 6p21.31 [CytoView hg38]
Mapping of homologs : NCBIGRM4 [Mapview hg19]  GRM4 [Mapview hg38]
OMIM604100   
Gene and transcription
Genbank (Entrez)AA993227 AB209104 AK122836 AK122982 AK126746
RefSeq transcript (Entrez)NM_000841 NM_001256809 NM_001256810 NM_001256811 NM_001256812 NM_001256813 NM_001256814 NM_001282847
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRM4
Cluster EST : UnigeneHs.736330 [ NCBI ]
CGAP (NCI)Hs.736330
Alternative Splicing GalleryENSG00000124493
Gene ExpressionGRM4 [ NCBI-GEO ]   GRM4 [ EBI - ARRAY_EXPRESS ]   GRM4 [ SEEK ]   GRM4 [ MEM ]
Gene Expression Viewer (FireBrowse)GRM4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2914
GTEX Portal (Tissue expression)GRM4
Human Protein AtlasENSG00000124493-GRM4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14833   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14833  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14833
Splice isoforms : SwissVarQ14833
PhosPhoSitePlusQ14833
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F3_1 (PS00979)    G_PROTEIN_RECEP_F3_2 (PS00980)    G_PROTEIN_RECEP_F3_3 (PS00981)    G_PROTEIN_RECEP_F3_4 (PS50259)   
Domains : Interpro (EBI)ANF_lig-bd_rcpt    GPCR_3    GPCR_3_9-Cys_dom    GPCR_3_9-Cys_sf    GPCR_3_C    GPCR_3_CS    GPCR_3_mtglu_rcpt    GPCR_3_mtglu_rcpt_4    Peripla_BP_I   
Domain families : Pfam (Sanger)7tm_3 (PF00003)    ANF_receptor (PF01094)    NCD3G (PF07562)   
Domain families : Pfam (NCBI)pfam00003    pfam01094    pfam07562   
Conserved Domain (NCBI)GRM4
DMDM Disease mutations2914
Blocks (Seattle)GRM4
SuperfamilyQ14833
Human Protein Atlas [tissue]ENSG00000124493-GRM4 [tissue]
Peptide AtlasQ14833
HPRD04978
IPIIPI00000839   IPI01012534   IPI01012121   IPI01013349   IPI01010134   IPI00555817   IPI00844489   
Protein Interaction databases
DIP (DOE-UCLA)Q14833
IntAct (EBI)Q14833
FunCoupENSG00000124493
BioGRIDGRM4
STRING (EMBL)GRM4
ZODIACGRM4
Ontologies - Pathways
QuickGOQ14833
Ontology : AmiGOactivation of MAPK activity  G protein-coupled receptor activity  intracellular  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway  adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway  G protein-coupled glutamate receptor signaling pathway  chemical synaptic transmission  neurotransmitter secretion  glutamate receptor activity  glutamate receptor activity  cytoplasmic vesicle  presynaptic membrane  positive regulation of MAPK cascade  regulation of neuron apoptotic process  regulation of synaptic transmission, glutamatergic  
Ontology : EGO-EBIactivation of MAPK activity  G protein-coupled receptor activity  intracellular  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  G protein-coupled receptor signaling pathway  adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway  adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway  G protein-coupled glutamate receptor signaling pathway  chemical synaptic transmission  neurotransmitter secretion  glutamate receptor activity  glutamate receptor activity  cytoplasmic vesicle  presynaptic membrane  positive regulation of MAPK cascade  regulation of neuron apoptotic process  regulation of synaptic transmission, glutamatergic  
Pathways : KEGGNeuroactive ligand-receptor interaction    Glutamatergic synapse    Taste transduction   
NDEx NetworkGRM4
Atlas of Cancer Signalling NetworkGRM4
Wikipedia pathwaysGRM4
Orthology - Evolution
OrthoDB2914
GeneTree (enSembl)ENSG00000124493
Phylogenetic Trees/Animal Genes : TreeFamGRM4
HOVERGENQ14833
HOGENOMQ14833
Homologs : HomoloGeneGRM4
Homology/Alignments : Family Browser (UCSC)GRM4
Gene fusions - Rearrangements
Fusion : MitelmanCTIF/GRM4 [18q21.1/6p21.31]  [t(6;18)(p21;q21)]  
Fusion PortalCTIF 18q21.1 GRM4 6p21.31 KIRC
Fusion Cancer (Beijing)SPINK1 [5q32]  -  GRM4 [6p21.31]  [FUSC003179]
Fusion : QuiverGRM4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRM4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRM4
dbVarGRM4
ClinVarGRM4
1000_GenomesGRM4 
Exome Variant ServerGRM4
ExAC (Exome Aggregation Consortium)ENSG00000124493
GNOMAD BrowserENSG00000124493
Varsome BrowserGRM4
Genetic variants : HAPMAP2914
Genomic Variants (DGV)GRM4 [DGVbeta]
DECIPHERGRM4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRM4 
Mutations
ICGC Data PortalGRM4 
TCGA Data PortalGRM4 
Broad Tumor PortalGRM4
OASIS PortalGRM4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRM4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRM4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRM4
DgiDB (Drug Gene Interaction Database)GRM4
DoCM (Curated mutations)GRM4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRM4 (select a term)
intoGenGRM4
Cancer3DGRM4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604100   
Orphanet
DisGeNETGRM4
MedgenGRM4
Genetic Testing Registry GRM4
NextProtQ14833 [Medical]
TSGene2914
GENETestsGRM4
Target ValidationGRM4
Huge Navigator GRM4 [HugePedia]
snp3D : Map Gene to Disease2914
BioCentury BCIQGRM4
ClinGenGRM4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2914
Chemical/Pharm GKB GenePA28993
Clinical trialGRM4
Miscellaneous
canSAR (ICR)GRM4 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRM4
EVEXGRM4
GoPubMedGRM4
iHOPGRM4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:09:40 CET 2018

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