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GRM5 (glutamate metabotropic receptor 5)

Identity

Alias_namesregulatory subunit 86
Alias_symbol (synonym)MGLUR5
GPRC1E
mGlu5
PPP1R86
Other alias
HGNC (Hugo) GRM5
LocusID (NCBI) 2915
Atlas_Id 43586
Location 11q14.2  [Link to chromosome band 11q14]
Location_base_pair Starts at 88504576 and ends at 89063678 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CTSC (11q14.2) / GRM5 (11q14.2)GRM5 (11q14.2) / SF3A3 (1p34.3)TTC33 (5p13.1) / GRM5 (11q14.2)
TTC33 5p13.1 / GRM5 11q14.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRM5   4597
Cards
Entrez_Gene (NCBI)GRM5  2915  glutamate metabotropic receptor 5
AliasesGPRC1E; MGLUR5; PPP1R86; mGlu5
GeneCards (Weizmann)GRM5
Ensembl hg19 (Hinxton)ENSG00000168959 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168959 [Gene_View]  chr11:88504576-89063678 [Contig_View]  GRM5 [Vega]
ICGC DataPortalENSG00000168959
TCGA cBioPortalGRM5
AceView (NCBI)GRM5
Genatlas (Paris)GRM5
WikiGenes2915
SOURCE (Princeton)GRM5
Genetics Home Reference (NIH)GRM5
Genomic and cartography
GoldenPath hg38 (UCSC)GRM5  -     chr11:88504576-89063678 -  11q14.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRM5  -     11q14.2   [Description]    (hg19-Feb_2009)
EnsemblGRM5 - 11q14.2 [CytoView hg19]  GRM5 - 11q14.2 [CytoView hg38]
Mapping of homologs : NCBIGRM5 [Mapview hg19]  GRM5 [Mapview hg38]
OMIM604102   
Gene and transcription
Genbank (Entrez)AF052171 AK291362 AW297388 AY608336 BC031602
RefSeq transcript (Entrez)NM_000842 NM_001143831
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRM5
Cluster EST : UnigeneHs.616625 [ NCBI ]
CGAP (NCI)Hs.616625
Alternative Splicing GalleryENSG00000168959
Gene ExpressionGRM5 [ NCBI-GEO ]   GRM5 [ EBI - ARRAY_EXPRESS ]   GRM5 [ SEEK ]   GRM5 [ MEM ]
Gene Expression Viewer (FireBrowse)GRM5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2915
GTEX Portal (Tissue expression)GRM5
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41594   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41594  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41594
Splice isoforms : SwissVarP41594
PhosPhoSitePlusP41594
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F3_1 (PS00979)    G_PROTEIN_RECEP_F3_2 (PS00980)    G_PROTEIN_RECEP_F3_3 (PS00981)    G_PROTEIN_RECEP_F3_4 (PS50259)   
Domains : Interpro (EBI)ANF_lig-bd_rcpt    GPCR_3    GPCR_3_9-Cys_dom    GPCR_3_C    GPCR_3_CS    GPCR_3_mtglu_rcpt    GPCR_3_mtglu_rcpt_5    Metabotropic_Glu_rcpt_Homer-bd    Peripla_BP_I   
Domain families : Pfam (Sanger)7tm_3 (PF00003)    ANF_receptor (PF01094)    GluR_Homer-bdg (PF10606)    NCD3G (PF07562)   
Domain families : Pfam (NCBI)pfam00003    pfam01094    pfam10606    pfam07562   
Domain families : Smart (EMBL)GluR_Homer-bdg (SM01229)  
Conserved Domain (NCBI)GRM5
DMDM Disease mutations2915
Blocks (Seattle)GRM5
PDB (SRS)3LMK    4OO9    5CGC    5CGD   
PDB (PDBSum)3LMK    4OO9    5CGC    5CGD   
PDB (IMB)3LMK    4OO9    5CGC    5CGD   
PDB (RSDB)3LMK    4OO9    5CGC    5CGD   
Structural Biology KnowledgeBase3LMK    4OO9    5CGC    5CGD   
SCOP (Structural Classification of Proteins)3LMK    4OO9    5CGC    5CGD   
CATH (Classification of proteins structures)3LMK    4OO9    5CGC    5CGD   
SuperfamilyP41594
Human Protein AtlasENSG00000168959
Peptide AtlasP41594
IPIIPI00220277   IPI00296244   IPI00796960   IPI00789949   IPI00797769   
Protein Interaction databases
DIP (DOE-UCLA)P41594
IntAct (EBI)P41594
FunCoupENSG00000168959
BioGRIDGRM5
STRING (EMBL)GRM5
ZODIACGRM5
Ontologies - Pathways
QuickGOP41594
Ontology : AmiGOG-protein coupled receptor activity  cytoplasm  plasma membrane  integral component of plasma membrane  adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway  phospholipase C-activating G-protein coupled glutamate receptor signaling pathway  G-protein coupled glutamate receptor signaling pathway  chemical synaptic transmission  learning  locomotory behavior  glutamate receptor activity  postsynaptic density  presynaptic membrane  neuron projection  regulation of long-term neuronal synaptic plasticity  cognition  regulation of synaptic transmission, glutamatergic  regulation of postsynaptic membrane potential  extracellular exosome  G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential  chemical synaptic transmission, postsynaptic  regulation of postsynaptic cytosolic calcium ion concentration  neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration  
Ontology : EGO-EBIG-protein coupled receptor activity  cytoplasm  plasma membrane  integral component of plasma membrane  adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway  phospholipase C-activating G-protein coupled glutamate receptor signaling pathway  G-protein coupled glutamate receptor signaling pathway  chemical synaptic transmission  learning  locomotory behavior  glutamate receptor activity  postsynaptic density  presynaptic membrane  neuron projection  regulation of long-term neuronal synaptic plasticity  cognition  regulation of synaptic transmission, glutamatergic  regulation of postsynaptic membrane potential  extracellular exosome  G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential  chemical synaptic transmission, postsynaptic  regulation of postsynaptic cytosolic calcium ion concentration  neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration  
Pathways : KEGGCalcium signaling pathway    Neuroactive ligand-receptor interaction    Gap junction    Long-term potentiation    Retrograde endocannabinoid signaling    Glutamatergic synapse    Huntington's disease   
NDEx NetworkGRM5
Atlas of Cancer Signalling NetworkGRM5
Wikipedia pathwaysGRM5
Orthology - Evolution
OrthoDB2915
GeneTree (enSembl)ENSG00000168959
Phylogenetic Trees/Animal Genes : TreeFamGRM5
HOVERGENP41594
HOGENOMP41594
Homologs : HomoloGeneGRM5
Homology/Alignments : Family Browser (UCSC)GRM5
Gene fusions - Rearrangements
Fusion : MitelmanTTC33/GRM5 [5p13.1/11q14.2]  [t(5;11)(p13;q14)]  
Fusion: TCGATTC33 5p13.1 GRM5 11q14.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRM5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRM5
dbVarGRM5
ClinVarGRM5
1000_GenomesGRM5 
Exome Variant ServerGRM5
ExAC (Exome Aggregation Consortium)GRM5 (select the gene name)
Genetic variants : HAPMAP2915
Genomic Variants (DGV)GRM5 [DGVbeta]
DECIPHERGRM5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRM5 
Mutations
ICGC Data PortalGRM5 
TCGA Data PortalGRM5 
Broad Tumor PortalGRM5
OASIS PortalGRM5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRM5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRM5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRM5
DgiDB (Drug Gene Interaction Database)GRM5
DoCM (Curated mutations)GRM5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRM5 (select a term)
intoGenGRM5
Cancer3DGRM5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604102   
Orphanet
MedgenGRM5
Genetic Testing Registry GRM5
NextProtP41594 [Medical]
TSGene2915
GENETestsGRM5
Target ValidationGRM5
Huge Navigator GRM5 [HugePedia]
snp3D : Map Gene to Disease2915
BioCentury BCIQGRM5
ClinGenGRM5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2915
Chemical/Pharm GKB GenePA28994
Clinical trialGRM5
Miscellaneous
canSAR (ICR)GRM5 (select the gene name)
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRM5
EVEXGRM5
GoPubMedGRM5
iHOPGRM5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:10:41 CEST 2017

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