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GRM6 (glutamate metabotropic receptor 6)

Identity

Alias_namesglutamate receptor, metabotropic 6
Alias_symbol (synonym)GPRC1F
mGlu6
MGLUR6
CSNB1B
Other alias
HGNC (Hugo) GRM6
LocusID (NCBI) 2916
Atlas_Id 64052
Location 5q35.3  [Link to chromosome band 5q35]
Location_base_pair Starts at 178978329 and ends at 178995123 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRM6   4598
Cards
Entrez_Gene (NCBI)GRM6  2916  glutamate metabotropic receptor 6
AliasesCSNB1B; GPRC1F; MGLUR6; mGlu6
GeneCards (Weizmann)GRM6
Ensembl hg19 (Hinxton)ENSG00000113262 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113262 [Gene_View]  chr5:178978329-178995123 [Contig_View]  GRM6 [Vega]
ICGC DataPortalENSG00000113262
TCGA cBioPortalGRM6
AceView (NCBI)GRM6
Genatlas (Paris)GRM6
WikiGenes2916
SOURCE (Princeton)GRM6
Genetics Home Reference (NIH)GRM6
Genomic and cartography
GoldenPath hg38 (UCSC)GRM6  -     chr5:178978329-178995123 -  5q35.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRM6  -     5q35.3   [Description]    (hg19-Feb_2009)
EnsemblGRM6 - 5q35.3 [CytoView hg19]  GRM6 - 5q35.3 [CytoView hg38]
Mapping of homologs : NCBIGRM6 [Mapview hg19]  GRM6 [Mapview hg38]
OMIM257270   604096   
Gene and transcription
Genbank (Entrez)AJ245871 AJ245872 BC172277 BX647168
RefSeq transcript (Entrez)NM_000843
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRM6
Cluster EST : UnigeneHs.248131 [ NCBI ]
CGAP (NCI)Hs.248131
Alternative Splicing GalleryENSG00000113262
Gene ExpressionGRM6 [ NCBI-GEO ]   GRM6 [ EBI - ARRAY_EXPRESS ]   GRM6 [ SEEK ]   GRM6 [ MEM ]
Gene Expression Viewer (FireBrowse)GRM6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2916
GTEX Portal (Tissue expression)GRM6
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15303   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15303  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15303
Splice isoforms : SwissVarO15303
PhosPhoSitePlusO15303
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F3_1 (PS00979)    G_PROTEIN_RECEP_F3_2 (PS00980)    G_PROTEIN_RECEP_F3_3 (PS00981)    G_PROTEIN_RECEP_F3_4 (PS50259)   
Domains : Interpro (EBI)ANF_lig-bd_rcpt    GPCR_3    GPCR_3_9-Cys_dom    GPCR_3_C    GPCR_3_CS    GPCR_3_mtglu_rcpt    GPCR_3_mtglu_rcpt_6    Peripla_BP_I   
Domain families : Pfam (Sanger)7tm_3 (PF00003)    ANF_receptor (PF01094)    NCD3G (PF07562)   
Domain families : Pfam (NCBI)pfam00003    pfam01094    pfam07562   
Conserved Domain (NCBI)GRM6
DMDM Disease mutations2916
Blocks (Seattle)GRM6
SuperfamilyO15303
Human Protein AtlasENSG00000113262
Peptide AtlasO15303
HPRD04975
IPIIPI00006089   IPI01011298   IPI00169239   IPI00816571   IPI00815791   IPI00983038   
Protein Interaction databases
DIP (DOE-UCLA)O15303
IntAct (EBI)O15303
FunCoupENSG00000113262
BioGRIDGRM6
STRING (EMBL)GRM6
ZODIACGRM6
Ontologies - Pathways
QuickGOO15303
Ontology : AmiGOGolgi membrane  adenylate cyclase inhibiting G-protein coupled glutamate receptor activity  G-protein coupled receptor activity  protein binding  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway  G-protein coupled glutamate receptor signaling pathway  chemical synaptic transmission  locomotory behavior  glutamate receptor activity  glutamate receptor activity  detection of visible light  dendrite  new growing cell tip  presynaptic membrane  protein homodimerization activity  detection of light stimulus involved in visual perception  regulation of synaptic transmission, glutamatergic  retina development in camera-type eye  positive regulation of calcium ion import  
Ontology : EGO-EBIGolgi membrane  adenylate cyclase inhibiting G-protein coupled glutamate receptor activity  G-protein coupled receptor activity  protein binding  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway  G-protein coupled glutamate receptor signaling pathway  chemical synaptic transmission  locomotory behavior  glutamate receptor activity  glutamate receptor activity  detection of visible light  dendrite  new growing cell tip  presynaptic membrane  protein homodimerization activity  detection of light stimulus involved in visual perception  regulation of synaptic transmission, glutamatergic  retina development in camera-type eye  positive regulation of calcium ion import  
Pathways : KEGGNeuroactive ligand-receptor interaction    Glutamatergic synapse   
NDEx NetworkGRM6
Atlas of Cancer Signalling NetworkGRM6
Wikipedia pathwaysGRM6
Orthology - Evolution
OrthoDB2916
GeneTree (enSembl)ENSG00000113262
Phylogenetic Trees/Animal Genes : TreeFamGRM6
HOVERGENO15303
HOGENOMO15303
Homologs : HomoloGeneGRM6
Homology/Alignments : Family Browser (UCSC)GRM6
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRM6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRM6
dbVarGRM6
ClinVarGRM6
1000_GenomesGRM6 
Exome Variant ServerGRM6
ExAC (Exome Aggregation Consortium)GRM6 (select the gene name)
Genetic variants : HAPMAP2916
Genomic Variants (DGV)GRM6 [DGVbeta]
DECIPHERGRM6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRM6 
Mutations
ICGC Data PortalGRM6 
TCGA Data PortalGRM6 
Broad Tumor PortalGRM6
OASIS PortalGRM6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRM6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRM6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch GRM6
DgiDB (Drug Gene Interaction Database)GRM6
DoCM (Curated mutations)GRM6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRM6 (select a term)
intoGenGRM6
Cancer3DGRM6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM257270    604096   
Orphanet923   
MedgenGRM6
Genetic Testing Registry GRM6
NextProtO15303 [Medical]
TSGene2916
GENETestsGRM6
Target ValidationGRM6
Huge Navigator GRM6 [HugePedia]
snp3D : Map Gene to Disease2916
BioCentury BCIQGRM6
ClinGenGRM6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2916
Chemical/Pharm GKB GenePA28995
Clinical trialGRM6
Miscellaneous
canSAR (ICR)GRM6 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRM6
EVEXGRM6
GoPubMedGRM6
iHOPGRM6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 15:51:29 CEST 2017

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