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GRM7 (glutamate receptor, metabotropic 7)

Identity

Alias_namesglutamate receptor, metabotropic 7
Alias_symbol (synonym)GLUR7
GPRC1G
mGlu7
MGLUR7
PPP1R87
Other aliasMGLU7
HGNC (Hugo) GRM7
LocusID (NCBI) 2917
Atlas_Id 64053
Location 3p26.1  [Link to chromosome band 3p26]
Location_base_pair Starts at 6902802 and ends at 7783218 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARPC4-TTLL3 (3p25.3) / GRM7 (3p26.1)CRBN (3p26.2) / GRM7 (3p26.1)GAN (16q23.2) / GRM7 (3p26.1)
RUNX1 (21q22.12) / GRM7 (3p26.1)ZFHX4 (8q21.11) / GRM7 (3p26.1)CRBN GRM7
ARPC4-TTLL3 GRM7GAN GRM7

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRM7   4599
Cards
Entrez_Gene (NCBI)GRM7  2917  glutamate receptor, metabotropic 7
AliasesGLUR7; GPRC1G; MGLU7; MGLUR7; 
PPP1R87
GeneCards (Weizmann)GRM7
Ensembl hg19 (Hinxton)ENSG00000196277 [Gene_View]  chr3:6902802-7783218 [Contig_View]  GRM7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196277 [Gene_View]  chr3:6902802-7783218 [Contig_View]  GRM7 [Vega]
ICGC DataPortalENSG00000196277
TCGA cBioPortalGRM7
AceView (NCBI)GRM7
Genatlas (Paris)GRM7
WikiGenes2917
SOURCE (Princeton)GRM7
Genetics Home Reference (NIH)GRM7
Genomic and cartography
GoldenPath hg19 (UCSC)GRM7  -     chr3:6902802-7783218 +  3p26.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GRM7  -     3p26.1   [Description]    (hg38-Dec_2013)
EnsemblGRM7 - 3p26.1 [CytoView hg19]  GRM7 - 3p26.1 [CytoView hg38]
Mapping of homologs : NCBIGRM7 [Mapview hg19]  GRM7 [Mapview hg38]
OMIM604101   
Gene and transcription
Genbank (Entrez)AB209214 AI701722 AK097817 AK123326 AK312488
RefSeq transcript (Entrez)NM_000844 NM_181874 NM_181875
RefSeq genomic (Entrez)NC_000003 NC_018914 NG_029781 NT_022517 NW_004929309
Consensus coding sequences : CCDS (NCBI)GRM7
Cluster EST : UnigeneHs.660131 [ NCBI ]
CGAP (NCI)Hs.660131
Alternative Splicing GalleryENSG00000196277
Gene ExpressionGRM7 [ NCBI-GEO ]   GRM7 [ EBI - ARRAY_EXPRESS ]   GRM7 [ SEEK ]   GRM7 [ MEM ]
Gene Expression Viewer (FireBrowse)GRM7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2917
GTEX Portal (Tissue expression)GRM7
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14831   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14831  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14831
Splice isoforms : SwissVarQ14831
PhosPhoSitePlusQ14831
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F3_1 (PS00979)    G_PROTEIN_RECEP_F3_2 (PS00980)    G_PROTEIN_RECEP_F3_3 (PS00981)    G_PROTEIN_RECEP_F3_4 (PS50259)   
Domains : Interpro (EBI)ANF_lig-bd_rcpt    GPCR_3    GPCR_3_9-Cys_dom    GPCR_3_C    GPCR_3_CS    GPCR_3_mtglu_rcpt    GPCR_3_mtglu_rcpt_7    Peripla_BP_I   
Domain families : Pfam (Sanger)7tm_3 (PF00003)    ANF_receptor (PF01094)    NCD3G (PF07562)   
Domain families : Pfam (NCBI)pfam00003    pfam01094    pfam07562   
Conserved Domain (NCBI)GRM7
DMDM Disease mutations2917
Blocks (Seattle)GRM7
PDB (SRS)3MQ4   
PDB (PDBSum)3MQ4   
PDB (IMB)3MQ4   
PDB (RSDB)3MQ4   
Structural Biology KnowledgeBase3MQ4   
SCOP (Structural Classification of Proteins)3MQ4   
CATH (Classification of proteins structures)3MQ4   
SuperfamilyQ14831
Human Protein AtlasENSG00000196277
Peptide AtlasQ14831
HPRD04979
IPIIPI00651739   IPI00376864   IPI00335261   IPI00292323   IPI01013702   IPI00796726   IPI00926162   IPI00926770   IPI00926417   IPI00745954   
Protein Interaction databases
DIP (DOE-UCLA)Q14831
IntAct (EBI)Q14831
FunCoupENSG00000196277
BioGRIDGRM7
STRING (EMBL)GRM7
ZODIACGRM7
Ontologies - Pathways
QuickGOQ14831
Ontology : AmiGOgroup III metabotropic glutamate receptor activity  conditioned taste aversion  behavioral fear response  voltage-gated calcium channel activity  calcium channel regulator activity  calcium ion binding  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  cell cortex  negative regulation of adenylate cyclase activity  adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway  synaptic transmission  sensory perception of sound  sensory perception of smell  short-term memory  glutamate receptor activity  adenylate cyclase inhibitor activity  negative regulation of glutamate secretion  integral component of membrane  glutamate binding  transmission of nerve impulse  PDZ domain binding  axon  dendrite  adult behavior  negative regulation of cAMP biosynthetic process  regulation of cyclase activity  asymmetric synapse  presynaptic membrane  dendritic shaft  receptor complex  postsynaptic membrane  presynaptic active zone  regulation of synaptic transmission, glutamatergic  calcium ion transmembrane transport  serine binding  
Ontology : EGO-EBIgroup III metabotropic glutamate receptor activity  conditioned taste aversion  behavioral fear response  voltage-gated calcium channel activity  calcium channel regulator activity  calcium ion binding  plasma membrane  integral component of plasma membrane  integral component of plasma membrane  cell cortex  negative regulation of adenylate cyclase activity  adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway  synaptic transmission  sensory perception of sound  sensory perception of smell  short-term memory  glutamate receptor activity  adenylate cyclase inhibitor activity  negative regulation of glutamate secretion  integral component of membrane  glutamate binding  transmission of nerve impulse  PDZ domain binding  axon  dendrite  adult behavior  negative regulation of cAMP biosynthetic process  regulation of cyclase activity  asymmetric synapse  presynaptic membrane  dendritic shaft  receptor complex  postsynaptic membrane  presynaptic active zone  regulation of synaptic transmission, glutamatergic  calcium ion transmembrane transport  serine binding  
Pathways : KEGGNeuroactive ligand-receptor interaction    Glutamatergic synapse   
NDEx NetworkGRM7
Atlas of Cancer Signalling NetworkGRM7
Wikipedia pathwaysGRM7
Orthology - Evolution
OrthoDB2917
GeneTree (enSembl)ENSG00000196277
Phylogenetic Trees/Animal Genes : TreeFamGRM7
HOVERGENQ14831
HOGENOMQ14831
Homologs : HomoloGeneGRM7
Homology/Alignments : Family Browser (UCSC)GRM7
Gene fusions - Rearrangements
Fusion: TCGACRBN GRM7
Fusion: TCGAARPC4-TTLL3 GRM7
Fusion: TCGAGAN GRM7
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRM7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRM7
dbVarGRM7
ClinVarGRM7
1000_GenomesGRM7 
Exome Variant ServerGRM7
ExAC (Exome Aggregation Consortium)GRM7 (select the gene name)
Genetic variants : HAPMAP2917
Genomic Variants (DGV)GRM7 [DGVbeta]
DECIPHER (Syndromes)3:6902802-7783218  ENSG00000196277
CONAN: Copy Number AnalysisGRM7 
Mutations
ICGC Data PortalGRM7 
TCGA Data PortalGRM7 
Broad Tumor PortalGRM7
OASIS PortalGRM7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRM7  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRM7
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRM7
DgiDB (Drug Gene Interaction Database)GRM7
DoCM (Curated mutations)GRM7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRM7 (select a term)
intoGenGRM7
Cancer3DGRM7(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604101   
Orphanet
MedgenGRM7
Genetic Testing Registry GRM7
NextProtQ14831 [Medical]
TSGene2917
GENETestsGRM7
Huge Navigator GRM7 [HugePedia]
snp3D : Map Gene to Disease2917
BioCentury BCIQGRM7
ClinGenGRM7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2917
Chemical/Pharm GKB GenePA28996
Clinical trialGRM7
Miscellaneous
canSAR (ICR)GRM7 (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRM7
EVEXGRM7
GoPubMedGRM7
iHOPGRM7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:06:57 CET 2017

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