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GRM8 (glutamate receptor, metabotropic 8)

Identity

Alias_namesglutamate receptor, metabotropic 8
Alias_symbol (synonym)GLUR8
GPRC1H
mGlu8
MGLUR8
Other alias
HGNC (Hugo) GRM8
LocusID (NCBI) 2918
Atlas_Id 64056
Location 7q31.33  [Link to chromosome band 7q31]
Location_base_pair Starts at 126078652 and ends at 126883569 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATXN7L1 (7q22.3) / GRM8 (7q31.33)GRM8 (7q31.33) / GANAB (11q12.3)GRM8 (7q31.33) / GRM8 (7q31.33)
GRM8 (7q31.33) / KCNQ5 (6q13)HIPK2 (7q34) / GRM8 (7q31.33)SND1 (7q32.1) / GRM8 (7q31.33)
SND1 GRM8HIPK2 GRM8

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRM8   4600
Cards
Entrez_Gene (NCBI)GRM8  2918  glutamate receptor, metabotropic 8
AliasesGLUR8; GPRC1H; MGLUR8; mGlu8
GeneCards (Weizmann)GRM8
Ensembl hg19 (Hinxton)ENSG00000179603 [Gene_View]  chr7:126078652-126883569 [Contig_View]  GRM8 [Vega]
Ensembl hg38 (Hinxton)ENSG00000179603 [Gene_View]  chr7:126078652-126883569 [Contig_View]  GRM8 [Vega]
ICGC DataPortalENSG00000179603
TCGA cBioPortalGRM8
AceView (NCBI)GRM8
Genatlas (Paris)GRM8
WikiGenes2918
SOURCE (Princeton)GRM8
Genetics Home Reference (NIH)GRM8
Genomic and cartography
GoldenPath hg19 (UCSC)GRM8  -     chr7:126078652-126883569 -  7q31.33   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GRM8  -     7q31.33   [Description]    (hg38-Dec_2013)
EnsemblGRM8 - 7q31.33 [CytoView hg19]  GRM8 - 7q31.33 [CytoView hg38]
Mapping of homologs : NCBIGRM8 [Mapview hg19]  GRM8 [Mapview hg38]
OMIM601116   
Gene and transcription
Genbank (Entrez)AJ236921 AJ236922 AK123053 AK290197 AK315203
RefSeq transcript (Entrez)NM_000845 NM_001127323
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_029532 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)GRM8
Cluster EST : UnigeneHs.449625 [ NCBI ]
CGAP (NCI)Hs.449625
Alternative Splicing GalleryENSG00000179603
Gene ExpressionGRM8 [ NCBI-GEO ]   GRM8 [ EBI - ARRAY_EXPRESS ]   GRM8 [ SEEK ]   GRM8 [ MEM ]
Gene Expression Viewer (FireBrowse)GRM8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2918
GTEX Portal (Tissue expression)GRM8
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00222   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00222  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00222
Splice isoforms : SwissVarO00222
PhosPhoSitePlusO00222
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F3_1 (PS00979)    G_PROTEIN_RECEP_F3_2 (PS00980)    G_PROTEIN_RECEP_F3_3 (PS00981)    G_PROTEIN_RECEP_F3_4 (PS50259)   
Domains : Interpro (EBI)ANF_lig-bd_rcpt    GPCR_3    GPCR_3_9-Cys_dom    GPCR_3_C    GPCR_3_CS    GPCR_3_mtglu_rcpt    GPCR_3_mtglu_rcpt_8    Peripla_BP_I   
Domain families : Pfam (Sanger)7tm_3 (PF00003)    ANF_receptor (PF01094)    NCD3G (PF07562)   
Domain families : Pfam (NCBI)pfam00003    pfam01094    pfam07562   
Conserved Domain (NCBI)GRM8
DMDM Disease mutations2918
Blocks (Seattle)GRM8
SuperfamilyO00222
Human Protein AtlasENSG00000179603
Peptide AtlasO00222
HPRD03071
IPIIPI00413310   IPI00396012   IPI00219109   IPI00010855   IPI00893559   IPI00947001   
Protein Interaction databases
DIP (DOE-UCLA)O00222
IntAct (EBI)O00222
FunCoupENSG00000179603
BioGRIDGRM8
STRING (EMBL)GRM8
ZODIACGRM8
Ontologies - Pathways
QuickGOO00222
Ontology : AmiGOgroup III metabotropic glutamate receptor activity  G-protein coupled receptor activity  plasma membrane  integral component of plasma membrane  adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway  visual perception  sensory perception of smell  glutamate receptor activity  negative regulation of cAMP biosynthetic process  presynaptic membrane  regulation of synaptic transmission, glutamatergic  
Ontology : EGO-EBIgroup III metabotropic glutamate receptor activity  G-protein coupled receptor activity  plasma membrane  integral component of plasma membrane  adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway  visual perception  sensory perception of smell  glutamate receptor activity  negative regulation of cAMP biosynthetic process  presynaptic membrane  regulation of synaptic transmission, glutamatergic  
Pathways : KEGGNeuroactive ligand-receptor interaction    Glutamatergic synapse   
NDEx NetworkGRM8
Atlas of Cancer Signalling NetworkGRM8
Wikipedia pathwaysGRM8
Orthology - Evolution
OrthoDB2918
GeneTree (enSembl)ENSG00000179603
Phylogenetic Trees/Animal Genes : TreeFamGRM8
HOVERGENO00222
HOGENOMO00222
Homologs : HomoloGeneGRM8
Homology/Alignments : Family Browser (UCSC)GRM8
Gene fusions - Rearrangements
Fusion: TCGASND1 GRM8
Fusion: TCGAHIPK2 GRM8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRM8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRM8
dbVarGRM8
ClinVarGRM8
1000_GenomesGRM8 
Exome Variant ServerGRM8
ExAC (Exome Aggregation Consortium)GRM8 (select the gene name)
Genetic variants : HAPMAP2918
Genomic Variants (DGV)GRM8 [DGVbeta]
DECIPHER (Syndromes)7:126078652-126883569  ENSG00000179603
CONAN: Copy Number AnalysisGRM8 
Mutations
ICGC Data PortalGRM8 
TCGA Data PortalGRM8 
Broad Tumor PortalGRM8
OASIS PortalGRM8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRM8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRM8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRM8
DgiDB (Drug Gene Interaction Database)GRM8
DoCM (Curated mutations)GRM8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRM8 (select a term)
intoGenGRM8
Cancer3DGRM8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601116   
Orphanet
MedgenGRM8
Genetic Testing Registry GRM8
NextProtO00222 [Medical]
TSGene2918
GENETestsGRM8
Huge Navigator GRM8 [HugePedia]
snp3D : Map Gene to Disease2918
BioCentury BCIQGRM8
ClinGenGRM8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2918
Chemical/Pharm GKB GenePA28997
Clinical trialGRM8
Miscellaneous
canSAR (ICR)GRM8 (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRM8
EVEXGRM8
GoPubMedGRM8
iHOPGRM8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:06:58 CET 2017

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