GRSF1 (G-rich RNA sequence binding factor 1)

2014-11-01  

Identity

HGNC
LOCATION
4q13.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 2926
MIM: 604851
HGNC: 4610
Ensembl: ENSG00000132463

Variants:

dbSNP: 2926
ClinVar: 2926
TCGA: ENSG00000132463
COSMIC: GRSF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132463ENST00000254799Q12849
ENSG00000132463ENST00000499044H0YAK1
ENSG00000132463ENST00000502323Q12849
ENSG00000132463ENST00000502323A0A024RD99
ENSG00000132463ENST00000506453H0YAM1
ENSG00000132463ENST00000514161H0Y8R1
ENSG00000132463ENST00000545193F5H5I6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
271982272016HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP.42
265074542015miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively.22
122393182002Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis.17
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.17
299673812018Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria.15
307154862019Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB.6
251843402014Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment.4
300865372018GRSF1 suppresses cell senescence.2
307536712019Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program.2
292881252018Functional characterization of isolated RNA-binding domains of the GRSF1 protein.1

Citation

Dessen P

GRSF1 (G-rich RNA sequence binding factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64059/grsf1