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GSDMD (gasdermin D)

Identity

Alias_namesGSDMDC1
gasdermin domain containing 1
Alias_symbol (synonym)FLJ12150
DF5L
Other aliasDFNA5L
FKSG10
HGNC (Hugo) GSDMD
LocusID (NCBI) 79792
Atlas_Id 50915
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 143553387 and ends at 143563061 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GSDMD (8q24.3) / GSDMD (8q24.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GSDMD   25697
Cards
Entrez_Gene (NCBI)GSDMD  79792  gasdermin D
AliasesDF5L; DFNA5L; FKSG10; GSDMDC1
GeneCards (Weizmann)GSDMD
Ensembl hg19 (Hinxton)ENSG00000104518 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104518 [Gene_View]  chr8:143553387-143563061 [Contig_View]  GSDMD [Vega]
ICGC DataPortalENSG00000104518
TCGA cBioPortalGSDMD
AceView (NCBI)GSDMD
Genatlas (Paris)GSDMD
WikiGenes79792
SOURCE (Princeton)GSDMD
Genetics Home Reference (NIH)GSDMD
Genomic and cartography
GoldenPath hg38 (UCSC)GSDMD  -     chr8:143553387-143563061 +  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GSDMD  -     8q24.3   [Description]    (hg19-Feb_2009)
EnsemblGSDMD - 8q24.3 [CytoView hg19]  GSDMD - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBIGSDMD [Mapview hg19]  GSDMD [Mapview hg38]
OMIM617042   
Gene and transcription
Genbank (Entrez)AF318341 AK022212 AK093858 AK096216 AK123985
RefSeq transcript (Entrez)NM_001166237 NM_024736
RefSeq genomic (Entrez)NC_000008 NC_018919 NT_187571
Consensus coding sequences : CCDS (NCBI)GSDMD
Cluster EST : UnigeneHs.118983 [ NCBI ]
CGAP (NCI)Hs.118983
Alternative Splicing GalleryENSG00000104518
Gene ExpressionGSDMD [ NCBI-GEO ]   GSDMD [ EBI - ARRAY_EXPRESS ]   GSDMD [ SEEK ]   GSDMD [ MEM ]
Gene Expression Viewer (FireBrowse)GSDMD [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)79792
GTEX Portal (Tissue expression)GSDMD
Protein : pattern, domain, 3D structure
UniProt/SwissProtP57764   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP57764  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP57764
Splice isoforms : SwissVarP57764
PhosPhoSitePlusP57764
Domains : Interpro (EBI)Gasdermin   
Domain families : Pfam (Sanger)Gasdermin (PF04598)   
Domain families : Pfam (NCBI)pfam04598   
Conserved Domain (NCBI)GSDMD
DMDM Disease mutations79792
Blocks (Seattle)GSDMD
SuperfamilyP57764
Human Protein AtlasENSG00000104518
Peptide AtlasP57764
HPRD11014
IPIIPI00028027   IPI00658006   IPI00383307   IPI00793132   IPI00980115   IPI00979090   IPI00982429   IPI00981451   IPI00984383   
Protein Interaction databases
DIP (DOE-UCLA)P57764
IntAct (EBI)P57764
FunCoupENSG00000104518
BioGRIDGSDMD
STRING (EMBL)GSDMD
ZODIACGSDMD
Ontologies - Pathways
QuickGOP57764
Ontology : AmiGOphosphatidylserine binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  extracellular region  extracellular space  nucleoplasm  cytosol  plasma membrane  inflammatory response  cytolysis  cellular response to extracellular stimulus  specific granule lumen  pore formation in membrane of other organism  neutrophil degranulation  innate immune response  pore complex assembly  positive regulation of interleukin-1 beta secretion  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  protein homooligomerization  pyroptosis  phosphatidylinositol-4-phosphate binding  phosphatidic acid binding  NLRP3 inflammasome complex  cardiolipin binding  tertiary granule lumen  ficolin-1-rich granule lumen  
Ontology : EGO-EBIphosphatidylserine binding  protein binding  phosphatidylinositol-4,5-bisphosphate binding  extracellular region  extracellular space  nucleoplasm  cytosol  plasma membrane  inflammatory response  cytolysis  cellular response to extracellular stimulus  specific granule lumen  pore formation in membrane of other organism  neutrophil degranulation  innate immune response  pore complex assembly  positive regulation of interleukin-1 beta secretion  defense response to Gram-negative bacterium  defense response to Gram-positive bacterium  protein homooligomerization  pyroptosis  phosphatidylinositol-4-phosphate binding  phosphatidic acid binding  NLRP3 inflammasome complex  cardiolipin binding  tertiary granule lumen  ficolin-1-rich granule lumen  
NDEx NetworkGSDMD
Atlas of Cancer Signalling NetworkGSDMD
Wikipedia pathwaysGSDMD
Orthology - Evolution
OrthoDB79792
GeneTree (enSembl)ENSG00000104518
Phylogenetic Trees/Animal Genes : TreeFamGSDMD
HOVERGENP57764
HOGENOMP57764
Homologs : HomoloGeneGSDMD
Homology/Alignments : Family Browser (UCSC)GSDMD
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGSDMD [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GSDMD
dbVarGSDMD
ClinVarGSDMD
1000_GenomesGSDMD 
Exome Variant ServerGSDMD
ExAC (Exome Aggregation Consortium)GSDMD (select the gene name)
Genetic variants : HAPMAP79792
Genomic Variants (DGV)GSDMD [DGVbeta]
DECIPHERGSDMD [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGSDMD 
Mutations
ICGC Data PortalGSDMD 
TCGA Data PortalGSDMD 
Broad Tumor PortalGSDMD
OASIS PortalGSDMD [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGSDMD  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGSDMD
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GSDMD
DgiDB (Drug Gene Interaction Database)GSDMD
DoCM (Curated mutations)GSDMD (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GSDMD (select a term)
intoGenGSDMD
Cancer3DGSDMD(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM617042   
Orphanet
MedgenGSDMD
Genetic Testing Registry GSDMD
NextProtP57764 [Medical]
TSGene79792
GENETestsGSDMD
Target ValidationGSDMD
Huge Navigator GSDMD [HugePedia]
snp3D : Map Gene to Disease79792
BioCentury BCIQGSDMD
ClinGenGSDMD
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD79792
Chemical/Pharm GKB GenePA162390357
Clinical trialGSDMD
Miscellaneous
canSAR (ICR)GSDMD (select the gene name)
Probes
Litterature
PubMed12 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGSDMD
EVEXGSDMD
GoPubMedGSDMD
iHOPGSDMD
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:02:32 CEST 2017

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