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GSDME (gasdermin E)

Identity

Other aliasDFNA5
ICERE-1
HGNC (Hugo) GSDME
LocusID (NCBI) 1687
Atlas_Id 57150
Location 7p15.3  [Link to chromosome band 7p15]
Location_base_pair Starts at 24698355 and ends at 24758020 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)GSDME   2810
Cards
Entrez_Gene (NCBI)GSDME  1687  gasdermin E
AliasesDFNA5; ICERE-1
GeneCards (Weizmann)GSDME
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]   [Sequence]  chr7:24698355-24758020 [Contig_View]  GSDME [Vega]
TCGA cBioPortalGSDME
AceView (NCBI)GSDME
Genatlas (Paris)GSDME
WikiGenes1687
SOURCE (Princeton)GSDME
Genetics Home Reference (NIH)GSDME
Genomic and cartography
GoldenPath hg38 (UCSC)GSDME  -     chr7:24698355-24758020 -  7p15.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GSDME  -     7p15.3   [Description]    (hg19-Feb_2009)
EnsemblGSDME - 7p15.3 [CytoView hg19]  GSDME - 7p15.3 [CytoView hg38]
Mapping of homologs : NCBIGSDME [Mapview hg19]  GSDME [Mapview hg38]
OMIM600994   608798   
Gene and transcription
Genbank (Entrez)AF007790 AF073308 AF075171 AF131765 AJ270686
RefSeq transcript (Entrez)NM_001127453 NM_001127454 NM_004403
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GSDME
Cluster EST : UnigeneHs.520708 [ NCBI ]
CGAP (NCI)Hs.520708
Gene ExpressionGSDME [ NCBI-GEO ]   GSDME [ EBI - ARRAY_EXPRESS ]   GSDME [ SEEK ]   GSDME [ MEM ]
Gene Expression Viewer (FireBrowse)GSDME [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1687
GTEX Portal (Tissue expression)GSDME
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60443   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60443  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60443
Splice isoforms : SwissVarO60443
PhosPhoSitePlusO60443
Domains : Interpro (EBI)Gasdermin   
Domain families : Pfam (Sanger)Gasdermin (PF04598)   
Domain families : Pfam (NCBI)pfam04598   
Conserved Domain (NCBI)GSDME
DMDM Disease mutations1687
Blocks (Seattle)GSDME
SuperfamilyO60443
Peptide AtlasO60443
IPIIPI00029656   IPI00218265   IPI00916467   IPI00916340   IPI00917302   IPI00917746   IPI00916945   
Protein Interaction databases
DIP (DOE-UCLA)O60443
IntAct (EBI)O60443
BioGRIDGSDME
STRING (EMBL)GSDME
ZODIACGSDME
Ontologies - Pathways
QuickGOO60443
Ontology : AmiGOphosphatidylinositol-4,5-bisphosphate binding  cytosol  plasma membrane  sensory perception of sound  cell death  negative regulation of cell proliferation  membrane  positive regulation of MAPK cascade  inner ear receptor cell differentiation  necrotic cell death  pyroptosis  cellular response to tumor necrosis factor  cellular response to virus  cardiolipin binding  positive regulation of intrinsic apoptotic signaling pathway  
Ontology : EGO-EBIphosphatidylinositol-4,5-bisphosphate binding  cytosol  plasma membrane  sensory perception of sound  cell death  negative regulation of cell proliferation  membrane  positive regulation of MAPK cascade  inner ear receptor cell differentiation  necrotic cell death  pyroptosis  cellular response to tumor necrosis factor  cellular response to virus  cardiolipin binding  positive regulation of intrinsic apoptotic signaling pathway  
NDEx NetworkGSDME
Atlas of Cancer Signalling NetworkGSDME
Wikipedia pathwaysGSDME
Orthology - Evolution
OrthoDB1687
Phylogenetic Trees/Animal Genes : TreeFamGSDME
HOVERGENO60443
HOGENOMO60443
Homologs : HomoloGeneGSDME
Homology/Alignments : Family Browser (UCSC)GSDME
Gene fusions - Rearrangements
Fusion : QuiverGSDME
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGSDME [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GSDME
dbVarGSDME
ClinVarGSDME
1000_GenomesGSDME 
Exome Variant ServerGSDME
Genetic variants : HAPMAP1687
Genomic Variants (DGV)GSDME [DGVbeta]
DECIPHERGSDME [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGSDME 
Mutations
ICGC Data PortalGSDME 
TCGA Data PortalGSDME 
Broad Tumor PortalGSDME
OASIS PortalGSDME [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDGSDME
BioMutasearch GSDME
DgiDB (Drug Gene Interaction Database)GSDME
DoCM (Curated mutations)GSDME (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GSDME (select a term)
intoGenGSDME
Cancer3DGSDME(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600994    608798   
Orphanet
DisGeNETGSDME
MedgenGSDME
Genetic Testing Registry GSDME
NextProtO60443 [Medical]
TSGene1687
GENETestsGSDME
Target ValidationGSDME
Huge Navigator GSDME [HugePedia]
snp3D : Map Gene to Disease1687
BioCentury BCIQGSDME
ClinGenGSDME
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1687
Chemical/Pharm GKB GenePA27281
Clinical trialGSDME
Miscellaneous
canSAR (ICR)GSDME (select the gene name)
Probes
Litterature
PubMed46 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGSDME
EVEXGSDME
GoPubMedGSDME
iHOPGSDME
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:28:11 CEST 2018

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