Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GSK3A (glycogen synthase kinase 3 alpha)

Identity

Other alias-
HGNC (Hugo) GSK3A
LocusID (NCBI) 2931
Atlas_Id 40760
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 42230186 and ends at 42242584 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ERF (19q13.2) / GSK3A (19q13.2)GSK3A (19q13.2) / CDH12 (5p14.3)GSK3A (19q13.2) / IGFBP3 (7p12.3)
GSK3A (19q13.2) / PWP1 (12q23.3)GSK3A (19q13.2) / ZNF564 (19p13.2)SLC3A2 (11q12.3) / GSK3A (19q13.2)
GSK3A 19q13.2 / ZNF564 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GSK3A   4616
Cards
Entrez_Gene (NCBI)GSK3A  2931  glycogen synthase kinase 3 alpha
Aliases
GeneCards (Weizmann)GSK3A
Ensembl hg19 (Hinxton)ENSG00000105723 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105723 [Gene_View]  chr19:42230186-42242584 [Contig_View]  GSK3A [Vega]
ICGC DataPortalENSG00000105723
TCGA cBioPortalGSK3A
AceView (NCBI)GSK3A
Genatlas (Paris)GSK3A
WikiGenes2931
SOURCE (Princeton)GSK3A
Genetics Home Reference (NIH)GSK3A
Genomic and cartography
GoldenPath hg38 (UCSC)GSK3A  -     chr19:42230186-42242584 -  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GSK3A  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblGSK3A - 19q13.2 [CytoView hg19]  GSK3A - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIGSK3A [Mapview hg19]  GSK3A [Mapview hg38]
OMIM606784   
Gene and transcription
Genbank (Entrez)BC027984 BC051865 CR749620 D63424 DQ891014
RefSeq transcript (Entrez)NM_019884
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GSK3A
Cluster EST : UnigeneHs.466828 [ NCBI ]
CGAP (NCI)Hs.466828
Alternative Splicing GalleryENSG00000105723
Gene ExpressionGSK3A [ NCBI-GEO ]   GSK3A [ EBI - ARRAY_EXPRESS ]   GSK3A [ SEEK ]   GSK3A [ MEM ]
Gene Expression Viewer (FireBrowse)GSK3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2931
GTEX Portal (Tissue expression)GSK3A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49840   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49840  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49840
Splice isoforms : SwissVarP49840
Catalytic activity : Enzyme2.7.11.26 [ Enzyme-Expasy ]   2.7.11.262.7.11.26 [ IntEnz-EBI ]   2.7.11.26 [ BRENDA ]   2.7.11.26 [ KEGG ]   
PhosPhoSitePlusP49840
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)GSK3A
DMDM Disease mutations2931
Blocks (Seattle)GSK3A
PDB (SRS)2DFM   
PDB (PDBSum)2DFM   
PDB (IMB)2DFM   
PDB (RSDB)2DFM   
Structural Biology KnowledgeBase2DFM   
SCOP (Structural Classification of Proteins)2DFM   
CATH (Classification of proteins structures)2DFM   
SuperfamilyP49840
Human Protein AtlasENSG00000105723
Peptide AtlasP49840
HPRD06002
IPIIPI00292228   IPI00880060   
Protein Interaction databases
DIP (DOE-UCLA)P49840
IntAct (EBI)P49840
FunCoupENSG00000105723
BioGRIDGSK3A
STRING (EMBL)GSK3A
ZODIACGSK3A
Ontologies - Pathways
QuickGOP49840
Ontology : AmiGOregulation of systemic arterial blood pressure  cardiac left ventricle morphogenesis  protein serine/threonine kinase activity  protein binding  ATP binding  mitochondrion  cytosol  glycogen metabolic process  protein phosphorylation  dopamine receptor signaling pathway  nervous system development  insulin receptor signaling pathway  negative regulation of UDP-glucose catabolic process  Wnt signaling pathway  positive regulation of cAMP biosynthetic process  beta-catenin destruction complex  beta-catenin destruction complex  negative regulation of TOR signaling  cellular response to insulin stimulus  protein kinase A catalytic subunit binding  cellular response to interleukin-3  IRE1-mediated unfolded protein response  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of glycogen biosynthetic process  positive regulation of protein catabolic process  positive regulation of heart contraction  negative regulation of glucose import  negative regulation of insulin receptor signaling pathway  tau-protein kinase activity  negative regulation of cell growth involved in cardiac muscle cell development  positive regulation of adrenergic receptor signaling pathway  negative regulation of canonical Wnt signaling pathway  extrinsic apoptotic signaling pathway in absence of ligand  postsynapse  chemical synaptic transmission, postsynaptic  positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  regulation of mitophagy  positive regulation of protein targeting to mitochondrion  negative regulation of glycogen synthase activity, transferring glucose-1-phosphate  negative regulation of type B pancreatic cell development  negative regulation of glycogen (starch) synthase activity  positive regulation of glycogen (starch) synthase activity  
Ontology : EGO-EBIregulation of systemic arterial blood pressure  cardiac left ventricle morphogenesis  protein serine/threonine kinase activity  protein binding  ATP binding  mitochondrion  cytosol  glycogen metabolic process  protein phosphorylation  dopamine receptor signaling pathway  nervous system development  insulin receptor signaling pathway  negative regulation of UDP-glucose catabolic process  Wnt signaling pathway  positive regulation of cAMP biosynthetic process  beta-catenin destruction complex  beta-catenin destruction complex  negative regulation of TOR signaling  cellular response to insulin stimulus  protein kinase A catalytic subunit binding  cellular response to interleukin-3  IRE1-mediated unfolded protein response  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of glycogen biosynthetic process  positive regulation of protein catabolic process  positive regulation of heart contraction  negative regulation of glucose import  negative regulation of insulin receptor signaling pathway  tau-protein kinase activity  negative regulation of cell growth involved in cardiac muscle cell development  positive regulation of adrenergic receptor signaling pathway  negative regulation of canonical Wnt signaling pathway  extrinsic apoptotic signaling pathway in absence of ligand  postsynapse  chemical synaptic transmission, postsynaptic  positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  regulation of mitophagy  positive regulation of protein targeting to mitochondrion  negative regulation of glycogen synthase activity, transferring glucose-1-phosphate  negative regulation of type B pancreatic cell development  negative regulation of glycogen (starch) synthase activity  positive regulation of glycogen (starch) synthase activity  
Pathways : BIOCARTAPhosphoinositides and their downstream targets. [Genes]   
Pathways : KEGGChemokine signaling pathway    Dopaminergic synapse    Non-alcoholic fatty liver disease (NAFLD)   
NDEx NetworkGSK3A
Atlas of Cancer Signalling NetworkGSK3A
Wikipedia pathwaysGSK3A
Orthology - Evolution
OrthoDB2931
GeneTree (enSembl)ENSG00000105723
Phylogenetic Trees/Animal Genes : TreeFamGSK3A
HOVERGENP49840
HOGENOMP49840
Homologs : HomoloGeneGSK3A
Homology/Alignments : Family Browser (UCSC)GSK3A
Gene fusions - Rearrangements
Fusion : MitelmanERF/GSK3A [19q13.2/19q13.2]  [t(19;19)(q13;q13)]  
Fusion : MitelmanGSK3A/ZNF564 [19q13.2/19p13.2]  [t(19;19)(p13;q13)]  
Fusion: TCGAGSK3A 19q13.2 ZNF564 19p13.2 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGSK3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GSK3A
dbVarGSK3A
ClinVarGSK3A
1000_GenomesGSK3A 
Exome Variant ServerGSK3A
ExAC (Exome Aggregation Consortium)GSK3A (select the gene name)
Genetic variants : HAPMAP2931
Genomic Variants (DGV)GSK3A [DGVbeta]
DECIPHERGSK3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGSK3A 
Mutations
ICGC Data PortalGSK3A 
TCGA Data PortalGSK3A 
Broad Tumor PortalGSK3A
OASIS PortalGSK3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGSK3A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGSK3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GSK3A
DgiDB (Drug Gene Interaction Database)GSK3A
DoCM (Curated mutations)GSK3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GSK3A (select a term)
intoGenGSK3A
Cancer3DGSK3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606784   
Orphanet
MedgenGSK3A
Genetic Testing Registry GSK3A
NextProtP49840 [Medical]
TSGene2931
GENETestsGSK3A
Target ValidationGSK3A
Huge Navigator GSK3A [HugePedia]
snp3D : Map Gene to Disease2931
BioCentury BCIQGSK3A
ClinGenGSK3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2931
Chemical/Pharm GKB GenePA29008
Clinical trialGSK3A
Miscellaneous
canSAR (ICR)GSK3A (select the gene name)
Probes
Litterature
PubMed147 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGSK3A
EVEXGSK3A
GoPubMedGSK3A
iHOPGSK3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:54:49 CEST 2017

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