Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GSN (gelsolin)

Identity

Other namesADF
AGEL
HGNC (Hugo) GSN
LocusID (NCBI) 2934
Atlas_Id 206
Location 9q33.2
Location_base_pair Starts at 124062079 and ends at 124095120 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2015)
GSN 9q33.2 / AKAP13 15q25.3GSN 9q33.2 / CTNNB1 3p22.1GSN 9q33.2 / DDX27 20q13.13
GSN 9q33.2 / FAR1 11p15.2GSN 9q33.2 / HLA-DPB1 6p21.32GSN 9q33.2 / HLA-F 6p22.1
GSN 9q33.2 / HSPA8 11q24.1GSN 9q33.2 / TRA2A 7p15.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GSN   4620
Cards
Entrez_Gene (NCBI)GSN  2934  gelsolin
GeneCards (Weizmann)GSN
Ensembl hg19 (Hinxton)ENSG00000148180 [Gene_View]  chr9:124062079-124095120 [Contig_View]  GSN [Vega]
Ensembl hg38 (Hinxton)ENSG00000148180 [Gene_View]  chr9:124062079-124095120 [Contig_View]  GSN [Vega]
ICGC DataPortalENSG00000148180
TCGA cBioPortalGSN
AceView (NCBI)GSN
Genatlas (Paris)GSN
WikiGenes2934
SOURCE (Princeton)GSN
Genomic and cartography
GoldenPath hg19 (UCSC)GSN  -     chr9:124062079-124095120 +  9q33.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GSN  -     9q33.2   [Description]    (hg38-Dec_2013)
EnsemblGSN - 9q33.2 [CytoView hg19]  GSN - 9q33.2 [CytoView hg38]
Mapping of homologs : NCBIGSN [Mapview hg19]  GSN [Mapview hg38]
OMIM105120   137350   
Gene and transcription
Genbank (Entrez)AI742454 AK092797 AK096280 AK125819 AK295201
RefSeq transcript (Entrez)NM_000177 NM_001127662 NM_001127663 NM_001127664 NM_001127665 NM_001127666 NM_001127667 NM_001258029 NM_001258030 NM_198252
RefSeq genomic (Entrez)NC_000009 NC_018920 NG_012872 NT_008470 NW_004929366
Consensus coding sequences : CCDS (NCBI)GSN
Cluster EST : UnigeneHs.522373 [ NCBI ]
CGAP (NCI)Hs.522373
Alternative Splicing : Fast-db (Paris)GSHG0030419
Alternative Splicing GalleryENSG00000148180
Gene ExpressionGSN [ NCBI-GEO ]     GSN [ SEEK ]   GSN [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)2934
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06396 (Uniprot)
NextProtP06396  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06396
Splice isoforms : SwissVarP06396 (Swissvar)
PhosPhoSitePlusP06396
Domains : Interpro (EBI)ADF-H/Gelsolin-like_dom    Gelsolin    Gelsolin-like_dom    Villin/Gelsolin   
Domain families : Pfam (Sanger)Gelsolin (PF00626)   
Domain families : Pfam (NCBI)pfam00626   
Domain families : Smart (EMBL)GEL (SM00262)  
DMDM Disease mutations2934
Blocks (Seattle)GSN
PDB (SRS)1C0F    1C0G    1D4X    1DEJ    1EQY    1ESV    1H1V    1KCQ    1MDU    1NLV    1NM1    1NMD    1P8X    1P8Z    1SOL    1T44    1YAG    1YVN    2FF3    2FF6    2FH1    2FH2    2FH3    2FH4    3A5L    3A5M    3A5N    3A5O    3CI5    3CIP    3CJB    3CJC    3FFK    3FFN    3TU5    4PKG    4PKH    4PKI    4S10   
PDB (PDBSum)1C0F    1C0G    1D4X    1DEJ    1EQY    1ESV    1H1V    1KCQ    1MDU    1NLV    1NM1    1NMD    1P8X    1P8Z    1SOL    1T44    1YAG    1YVN    2FF3    2FF6    2FH1    2FH2    2FH3    2FH4    3A5L    3A5M    3A5N    3A5O    3CI5    3CIP    3CJB    3CJC    3FFK    3FFN    3TU5    4PKG    4PKH    4PKI    4S10   
PDB (IMB)1C0F    1C0G    1D4X    1DEJ    1EQY    1ESV    1H1V    1KCQ    1MDU    1NLV    1NM1    1NMD    1P8X    1P8Z    1SOL    1T44    1YAG    1YVN    2FF3    2FF6    2FH1    2FH2    2FH3    2FH4    3A5L    3A5M    3A5N    3A5O    3CI5    3CIP    3CJB    3CJC    3FFK    3FFN    3TU5    4PKG    4PKH    4PKI    4S10   
PDB (RSDB)1C0F    1C0G    1D4X    1DEJ    1EQY    1ESV    1H1V    1KCQ    1MDU    1NLV    1NM1    1NMD    1P8X    1P8Z    1SOL    1T44    1YAG    1YVN    2FF3    2FF6    2FH1    2FH2    2FH3    2FH4    3A5L    3A5M    3A5N    3A5O    3CI5    3CIP    3CJB    3CJC    3FFK    3FFN    3TU5    4PKG    4PKH    4PKI    4S10   
Structural Biology KnowledgeBase1C0F    1C0G    1D4X    1DEJ    1EQY    1ESV    1H1V    1KCQ    1MDU    1NLV    1NM1    1NMD    1P8X    1P8Z    1SOL    1T44    1YAG    1YVN    2FF3    2FF6    2FH1    2FH2    2FH3    2FH4    3A5L    3A5M    3A5N    3A5O    3CI5    3CIP    3CJB    3CJC    3FFK    3FFN    3TU5    4PKG    4PKH    4PKI    4S10   
SCOP (Structural Classification of Proteins)1C0F    1C0G    1D4X    1DEJ    1EQY    1ESV    1H1V    1KCQ    1MDU    1NLV    1NM1    1NMD    1P8X    1P8Z    1SOL    1T44    1YAG    1YVN    2FF3    2FF6    2FH1    2FH2    2FH3    2FH4    3A5L    3A5M    3A5N    3A5O    3CI5    3CIP    3CJB    3CJC    3FFK    3FFN    3TU5    4PKG    4PKH    4PKI    4S10   
CATH (Classification of proteins structures)1C0F    1C0G    1D4X    1DEJ    1EQY    1ESV    1H1V    1KCQ    1MDU    1NLV    1NM1    1NMD    1P8X    1P8Z    1SOL    1T44    1YAG    1YVN    2FF3    2FF6    2FH1    2FH2    2FH3    2FH4    3A5L    3A5M    3A5N    3A5O    3CI5    3CIP    3CJB    3CJC    3FFK    3FFN    3TU5    4PKG    4PKH    4PKI    4S10   
Human Protein AtlasENSG00000148180
Peptide AtlasP06396
HPRD00674
IPIIPI00026314   IPI00646773   IPI01009415   IPI00796316   IPI01015050   IPI00647556   IPI00641047   IPI00513782   IPI00377087   
Protein Interaction databases
DIP (DOE-UCLA)P06396
IntAct (EBI)P06396
FunCoupENSG00000148180
BioGRIDGSN
IntegromeDBGSN
STRING (EMBL)GSN
ZODIACGSN
Ontologies - Pathways
QuickGOP06396
Ontology : AmiGOruffle  podosome  actin binding  calcium ion binding  protein binding  extracellular region  extracellular region  extracellular region  extracellular region  extracellular space  nucleus  cytoplasm  cytosol  cytosol  cytosol  plasma membrane  focal adhesion  phagocytosis, engulfment  apoptotic process  cellular component disassembly involved in execution phase of apoptosis  aging  positive regulation of gene expression  programmed cell death  oligodendrocyte development  striated muscle atrophy  actin cytoskeleton  sarcoplasm  protein domain specific binding  extracellular matrix disassembly  lamellipodium  actin filament polymerization  actin filament polymerization  actin filament polymerization  actin cap  cortical actin cytoskeleton  cortical actin cytoskeleton  protein destabilization  tissue regeneration  sequestering of actin monomers  myelin sheath  cellular protein metabolic process  actin nucleation  myosin II binding  response to ethanol  negative regulation of viral entry into host cell  phosphatidylinositol-mediated signaling  perinuclear region of cytoplasm  actin filament severing  actin filament severing  actin filament severing  barbed-end actin filament capping  positive regulation of actin nucleation  response to folic acid  actin filament capping  actin filament capping  cilium morphogenesis  extracellular exosome  cellular response to cadmium ion  regulation of podosome assembly  blood microparticle  actin filament reorganization  renal protein absorption  hepatocyte apoptotic process  positive regulation of keratinocyte apoptotic process  regulation of wound healing, spreading of epidermal cells  regulation of wound healing, spreading of epidermal cells  regulation of establishment of T cell polarity  regulation of plasma membrane raft polarization  regulation of receptor clustering  positive regulation of protein processing in phagocytic vesicle  amyloid fibril formation  positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  
Ontology : EGO-EBIruffle  podosome  actin binding  calcium ion binding  protein binding  extracellular region  extracellular region  extracellular region  extracellular region  extracellular space  nucleus  cytoplasm  cytosol  cytosol  cytosol  plasma membrane  focal adhesion  phagocytosis, engulfment  apoptotic process  cellular component disassembly involved in execution phase of apoptosis  aging  positive regulation of gene expression  programmed cell death  oligodendrocyte development  striated muscle atrophy  actin cytoskeleton  sarcoplasm  protein domain specific binding  extracellular matrix disassembly  lamellipodium  actin filament polymerization  actin filament polymerization  actin filament polymerization  actin cap  cortical actin cytoskeleton  cortical actin cytoskeleton  protein destabilization  tissue regeneration  sequestering of actin monomers  myelin sheath  cellular protein metabolic process  actin nucleation  myosin II binding  response to ethanol  negative regulation of viral entry into host cell  phosphatidylinositol-mediated signaling  perinuclear region of cytoplasm  actin filament severing  actin filament severing  actin filament severing  barbed-end actin filament capping  positive regulation of actin nucleation  response to folic acid  actin filament capping  actin filament capping  cilium morphogenesis  extracellular exosome  cellular response to cadmium ion  regulation of podosome assembly  blood microparticle  actin filament reorganization  renal protein absorption  hepatocyte apoptotic process  positive regulation of keratinocyte apoptotic process  regulation of wound healing, spreading of epidermal cells  regulation of wound healing, spreading of epidermal cells  regulation of establishment of T cell polarity  regulation of plasma membrane raft polarization  regulation of receptor clustering  positive regulation of protein processing in phagocytic vesicle  amyloid fibril formation  positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  
Pathways : BIOCARTAErk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia [Genes]    Rho cell motility signaling pathway [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]   
Pathways : KEGGFc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton    Viral carcinogenesis   
Protein Interaction DatabaseGSN
Atlas of Cancer Signalling NetworkGSN
Wikipedia pathwaysGSN
Orthology - Evolution
OrthoDB2934
GeneTree (enSembl)ENSG00000148180
Phylogenetic Trees/Animal Genes : TreeFamGSN
Homologs : HomoloGeneGSN
Homology/Alignments : Family Browser (UCSC)GSN
Gene fusions - Rearrangements
Fusion: TCGAGSN 9q33.2 AKAP13 15q25.3 THCA
Fusion: TCGAGSN 9q33.2 CTNNB1 3p22.1 THCA
Fusion: TCGAGSN 9q33.2 DDX27 20q13.13 HNSC
Fusion: TCGAGSN 9q33.2 FAR1 11p15.2 LUAD
Fusion: TCGAGSN 9q33.2 HLA-DPB1 6p21.32 THCA
Fusion: TCGAGSN 9q33.2 HLA-F 6p22.1 LUAD
Fusion: TCGAGSN 9q33.2 HSPA8 11q24.1 BLCA
Fusion: TCGAGSN 9q33.2 TRA2A 7p15.3 PRAD
Polymorphisms : SNP, variants
NCBI Variation ViewerGSN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GSN
dbVarGSN
ClinVarGSN
1000_GenomesGSN 
Exome Variant ServerGSN
Exome Aggregation Consortium (ExAC)ENSG00000148180
SNP (GeneSNP Utah)GSN
SNP : HGBaseGSN
Genetic variants : HAPMAPGSN
Genomic Variants (DGV)GSN [DGVbeta]
Mutations
ICGC Data PortalGSN 
TCGA Data PortalGSN 
Tumor PortalGSN
TCGA Copy Number PortalGSN
Somatic Mutations in Cancer : COSMICGSN 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GSN
DgiDB (Drug Gene Interaction Database)GSN
DoCM (Curated mutations)GSN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GSN (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)9:124062079-124095120
CONAN: Copy Number AnalysisGSN 
Mutations and Diseases : HGMDGSN
OMIM105120    137350   
MedgenGSN
NextProtP06396 [Medical]
TSGene2934
GENETestsGSN
Huge Navigator GSN [HugePedia]  GSN [HugeCancerGEM]
snp3D : Map Gene to Disease2934
BioCentury BCIQGSN
General knowledge
Chemical/Protein Interactions : CTD2934
Chemical/Pharm GKB GenePA29011
Clinical trialGSN
Other databases
Probes
Litterature
PubMed196 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGSN
GoPubMedGSN
iHOPGSN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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