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GSN (gelsolin)

Identity

Alias_namesFinnish type
Alias_symbol (synonym)DKFZp313L0718
Other aliasADF
AGEL
HGNC (Hugo) GSN
LocusID (NCBI) 2934
Atlas_Id 206
Location 9q33.2  [Link to chromosome band 9q33]
Location_base_pair Starts at 121268102 and ends at 121332842 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GSN (9q33.2) / AKAP13 (15q25.3)GSN (9q33.2) / CSNK1D (17q25.3)GSN (9q33.2) / CTNNB1 (3p22.1)
GSN (9q33.2) / DDX27 (20q13.13)GSN (9q33.2) / FAR1 (11p15.2)GSN (9q33.2) / FOXO3 (6q21)
GSN (9q33.2) / GALC (14q31.3)GSN (9q33.2) / GSN (9q33.2)GSN (9q33.2) / HLA-DPB1 (6p21.32)
GSN (9q33.2) / HLA-F (6p22.1)GSN (9q33.2) / HSPA8 (11q24.1)GSN (9q33.2) / LUC7L (16p13.3)
GSN (9q33.2) / RUNX1 (21q22.12)GSN (9q33.2) / TRA2A (7p15.3)KCNIP4 (4p15.31) / GSN (9q33.2)
KLK3 (19q13.33) / GSN (9q33.2)PHLDA1 (12q21.2) / GSN (9q33.2)RAD23B (9q31.2) / GSN (9q33.2)
GSN 9q33.2 / AKAP13 15q25.3GSN 9q33.2 / CTNNB1 3p22.1GSN 9q33.2 / DDX27 20q13.13
GSN 9q33.2 / FAR1 11p15.2GSN 9q33.2 / HLA-DPB1 6p21.32GSN 9q33.2 / HLA-F 6p22.1
GSN 9q33.2 / HSPA8 11q24.1GSN 9q33.2 / TRA2A 7p15.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  t(3;9)(p22;q33) GSN/CTNNB1
t(6;9)(p21;q33) GSN/HLA-DPB1
t(6;9)(p22;q33) GSN/HLA-F
t(7;9)(p15;q33) GSN/TRA2A
t(9;11)(q33;p15) GSN/FAR1
t(9;11)(q33;q24) GSN/HSPA8
t(9;15)(q33;q25) GSN/AKAP13
t(9;20)(q33;q13) GSN/DDX27


External links

Nomenclature
HGNC (Hugo)GSN   4620
Cards
Entrez_Gene (NCBI)GSN  2934  gelsolin
AliasesADF; AGEL
GeneCards (Weizmann)GSN
Ensembl hg19 (Hinxton)ENSG00000148180 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000148180 [Gene_View]  ENSG00000148180 [Sequence]  chr9:121268102-121332842 [Contig_View]  GSN [Vega]
ICGC DataPortalENSG00000148180
TCGA cBioPortalGSN
AceView (NCBI)GSN
Genatlas (Paris)GSN
WikiGenes2934
SOURCE (Princeton)GSN
Genetics Home Reference (NIH)GSN
Genomic and cartography
GoldenPath hg38 (UCSC)GSN  -     chr9:121268102-121332842 +  9q33.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GSN  -     9q33.2   [Description]    (hg19-Feb_2009)
EnsemblGSN - 9q33.2 [CytoView hg19]  GSN - 9q33.2 [CytoView hg38]
Mapping of homologs : NCBIGSN [Mapview hg19]  GSN [Mapview hg38]
OMIM105120   137350   
Gene and transcription
Genbank (Entrez)AI742454 AK092797 AK096280 AK125819 AK295201
RefSeq transcript (Entrez)NM_000177 NM_001127662 NM_001127663 NM_001127664 NM_001127665 NM_001127666 NM_001127667 NM_001258029 NM_001258030 NM_001353053 NM_001353054 NM_001353055 NM_001353056 NM_001353057 NM_001353058 NM_001353059 NM_001353060 NM_001353061 NM_001353062 NM_001353063 NM_001353064 NM_001353065 NM_001353066 NM_001353067 NM_001353068 NM_001353069 NM_001353070 NM_001353071 NM_001353072 NM_001353073 NM_001353074 NM_001353075 NM_001353076 NM_001353077 NM_001353078 NM_198252
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GSN
Cluster EST : UnigeneHs.522373 [ NCBI ]
CGAP (NCI)Hs.522373
Alternative Splicing GalleryENSG00000148180
Gene ExpressionGSN [ NCBI-GEO ]   GSN [ EBI - ARRAY_EXPRESS ]   GSN [ SEEK ]   GSN [ MEM ]
Gene Expression Viewer (FireBrowse)GSN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2934
GTEX Portal (Tissue expression)GSN
Human Protein AtlasENSG00000148180-GSN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06396   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP06396  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06396
Splice isoforms : SwissVarP06396
PhosPhoSitePlusP06396
Domains : Interpro (EBI)ADF-H/Gelsolin-like_dom_sf    Gelsolin    Gelsolin-like_dom    Villin/Gelsolin   
Domain families : Pfam (Sanger)Gelsolin (PF00626)   
Domain families : Pfam (NCBI)pfam00626   
Domain families : Smart (EMBL)GEL (SM00262)  
Conserved Domain (NCBI)GSN
DMDM Disease mutations2934
Blocks (Seattle)GSN
PDB (SRS)1C0F    1C0G    1D4X    1DEJ    1EQY    1ESV    1H1V    1KCQ    1MDU    1NLV    1NM1    1NMD    1P8X    1P8Z    1SOL    1T44    1YAG    1YVN    2FF3    2FF6    2FH1    2FH2    2FH3    2FH4    3A5L    3A5M    3A5N    3A5O    3CI5    3CIP    3CJB    3CJC    3FFK    3FFN    3TU5    4PKG    4PKH    4PKI    4S10    4Z94    5DD2    5FAE    5FAF    5H3M    5H3N    5O2Z    5UBO   
PDB (PDBSum)1C0F    1C0G    1D4X    1DEJ    1EQY    1ESV    1H1V    1KCQ    1MDU    1NLV    1NM1    1NMD    1P8X    1P8Z    1SOL    1T44    1YAG    1YVN    2FF3    2FF6    2FH1    2FH2    2FH3    2FH4    3A5L    3A5M    3A5N    3A5O    3CI5    3CIP    3CJB    3CJC    3FFK    3FFN    3TU5    4PKG    4PKH    4PKI    4S10    4Z94    5DD2    5FAE    5FAF    5H3M    5H3N    5O2Z    5UBO   
PDB (IMB)1C0F    1C0G    1D4X    1DEJ    1EQY    1ESV    1H1V    1KCQ    1MDU    1NLV    1NM1    1NMD    1P8X    1P8Z    1SOL    1T44    1YAG    1YVN    2FF3    2FF6    2FH1    2FH2    2FH3    2FH4    3A5L    3A5M    3A5N    3A5O    3CI5    3CIP    3CJB    3CJC    3FFK    3FFN    3TU5    4PKG    4PKH    4PKI    4S10    4Z94    5DD2    5FAE    5FAF    5H3M    5H3N    5O2Z    5UBO   
PDB (RSDB)1C0F    1C0G    1D4X    1DEJ    1EQY    1ESV    1H1V    1KCQ    1MDU    1NLV    1NM1    1NMD    1P8X    1P8Z    1SOL    1T44    1YAG    1YVN    2FF3    2FF6    2FH1    2FH2    2FH3    2FH4    3A5L    3A5M    3A5N    3A5O    3CI5    3CIP    3CJB    3CJC    3FFK    3FFN    3TU5    4PKG    4PKH    4PKI    4S10    4Z94    5DD2    5FAE    5FAF    5H3M    5H3N    5O2Z    5UBO   
Structural Biology KnowledgeBase1C0F    1C0G    1D4X    1DEJ    1EQY    1ESV    1H1V    1KCQ    1MDU    1NLV    1NM1    1NMD    1P8X    1P8Z    1SOL    1T44    1YAG    1YVN    2FF3    2FF6    2FH1    2FH2    2FH3    2FH4    3A5L    3A5M    3A5N    3A5O    3CI5    3CIP    3CJB    3CJC    3FFK    3FFN    3TU5    4PKG    4PKH    4PKI    4S10    4Z94    5DD2    5FAE    5FAF    5H3M    5H3N    5O2Z    5UBO   
SCOP (Structural Classification of Proteins)1C0F    1C0G    1D4X    1DEJ    1EQY    1ESV    1H1V    1KCQ    1MDU    1NLV    1NM1    1NMD    1P8X    1P8Z    1SOL    1T44    1YAG    1YVN    2FF3    2FF6    2FH1    2FH2    2FH3    2FH4    3A5L    3A5M    3A5N    3A5O    3CI5    3CIP    3CJB    3CJC    3FFK    3FFN    3TU5    4PKG    4PKH    4PKI    4S10    4Z94    5DD2    5FAE    5FAF    5H3M    5H3N    5O2Z    5UBO   
CATH (Classification of proteins structures)1C0F    1C0G    1D4X    1DEJ    1EQY    1ESV    1H1V    1KCQ    1MDU    1NLV    1NM1    1NMD    1P8X    1P8Z    1SOL    1T44    1YAG    1YVN    2FF3    2FF6    2FH1    2FH2    2FH3    2FH4    3A5L    3A5M    3A5N    3A5O    3CI5    3CIP    3CJB    3CJC    3FFK    3FFN    3TU5    4PKG    4PKH    4PKI    4S10    4Z94    5DD2    5FAE    5FAF    5H3M    5H3N    5O2Z    5UBO   
SuperfamilyP06396
Human Protein Atlas [tissue]ENSG00000148180-GSN [tissue]
Peptide AtlasP06396
HPRD00674
IPIIPI00026314   IPI00646773   IPI01009415   IPI00796316   IPI01015050   IPI00647556   IPI00641047   IPI00513782   IPI00377087   
Protein Interaction databases
DIP (DOE-UCLA)P06396
IntAct (EBI)P06396
FunCoupENSG00000148180
BioGRIDGSN
STRING (EMBL)GSN
ZODIACGSN
Ontologies - Pathways
QuickGOP06396
Ontology : AmiGOruffle  podosome  actin binding  calcium ion binding  protein binding  extracellular region  extracellular region  extracellular region  extracellular region  extracellular region  extracellular space  nucleus  cytoplasm  cytosol  cytosol  cytosol  plasma membrane  focal adhesion  phagocytosis, engulfment  aging  positive regulation of gene expression  oligodendrocyte development  striated muscle atrophy  actin cytoskeleton  sarcoplasm  extracellular matrix disassembly  lamellipodium  actin filament polymerization  actin filament polymerization  actin filament polymerization  regulation of cell adhesion  actin cap  cortical actin cytoskeleton  cortical actin cytoskeleton  protein destabilization  secretory granule lumen  tissue regeneration  sequestering of actin monomers  myelin sheath  neutrophil degranulation  cellular protein metabolic process  actin nucleation  myosin II binding  phagocytic vesicle  response to ethanol  negative regulation of viral entry into host cell  phosphatidylinositol-mediated signaling  perinuclear region of cytoplasm  actin filament severing  actin filament severing  actin filament severing  actin filament binding  barbed-end actin filament capping  positive regulation of actin nucleation  response to folic acid  actin filament capping  actin filament capping  cilium assembly  extracellular exosome  cellular response to cadmium ion  cellular response to interferon-gamma  regulation of podosome assembly  blood microparticle  actin filament reorganization  renal protein absorption  hepatocyte apoptotic process  positive regulation of keratinocyte apoptotic process  regulation of establishment of T cell polarity  regulation of plasma membrane raft polarization  regulation of receptor clustering  positive regulation of protein processing in phagocytic vesicle  ficolin-1-rich granule lumen  amyloid fibril formation  positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  
Ontology : EGO-EBIruffle  podosome  actin binding  calcium ion binding  protein binding  extracellular region  extracellular region  extracellular region  extracellular region  extracellular region  extracellular space  nucleus  cytoplasm  cytosol  cytosol  cytosol  plasma membrane  focal adhesion  phagocytosis, engulfment  aging  positive regulation of gene expression  oligodendrocyte development  striated muscle atrophy  actin cytoskeleton  sarcoplasm  extracellular matrix disassembly  lamellipodium  actin filament polymerization  actin filament polymerization  actin filament polymerization  regulation of cell adhesion  actin cap  cortical actin cytoskeleton  cortical actin cytoskeleton  protein destabilization  secretory granule lumen  tissue regeneration  sequestering of actin monomers  myelin sheath  neutrophil degranulation  cellular protein metabolic process  actin nucleation  myosin II binding  phagocytic vesicle  response to ethanol  negative regulation of viral entry into host cell  phosphatidylinositol-mediated signaling  perinuclear region of cytoplasm  actin filament severing  actin filament severing  actin filament severing  actin filament binding  barbed-end actin filament capping  positive regulation of actin nucleation  response to folic acid  actin filament capping  actin filament capping  cilium assembly  extracellular exosome  cellular response to cadmium ion  cellular response to interferon-gamma  regulation of podosome assembly  blood microparticle  actin filament reorganization  renal protein absorption  hepatocyte apoptotic process  positive regulation of keratinocyte apoptotic process  regulation of establishment of T cell polarity  regulation of plasma membrane raft polarization  regulation of receptor clustering  positive regulation of protein processing in phagocytic vesicle  ficolin-1-rich granule lumen  amyloid fibril formation  positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  
Pathways : KEGGFc gamma R-mediated phagocytosis    Regulation of actin cytoskeleton    Viral carcinogenesis   
NDEx NetworkGSN
Atlas of Cancer Signalling NetworkGSN
Wikipedia pathwaysGSN
Orthology - Evolution
OrthoDB2934
GeneTree (enSembl)ENSG00000148180
Phylogenetic Trees/Animal Genes : TreeFamGSN
HOVERGENP06396
HOGENOMP06396
Homologs : HomoloGeneGSN
Homology/Alignments : Family Browser (UCSC)GSN
Gene fusions - Rearrangements
Fusion : MitelmanGSN/AKAP13 [9q33.2/15q25.3]  
Fusion : MitelmanGSN/CTNNB1 [9q33.2/3p22.1]  [t(3;9)(p22;q33)]  
Fusion : MitelmanGSN/DDX27 [9q33.2/20q13.13]  [t(9;20)(q33;q13)]  
Fusion : MitelmanGSN/FAR1 [9q33.2/11p15.2]  [t(9;11)(q33;p15)]  
Fusion : MitelmanGSN/HLA-DPB1 [9q33.2/6p21.32]  [t(6;9)(p21;q33)]  
Fusion : MitelmanGSN/HLA-F [9q33.2/6p22.1]  [t(6;9)(p22;q33)]  
Fusion : MitelmanGSN/HSPA8 [9q33.2/11q24.1]  [t(9;11)(q33;q24)]  
Fusion : MitelmanGSN/TRA2A [9q33.2/7p15.3]  [t(7;9)(p15;q33)]  
Fusion PortalGSN 9q33.2 AKAP13 15q25.3 THCA
Fusion PortalGSN 9q33.2 CTNNB1 3p22.1 THCA
Fusion PortalGSN 9q33.2 DDX27 20q13.13 HNSC
Fusion PortalGSN 9q33.2 FAR1 11p15.2 LUAD
Fusion PortalGSN 9q33.2 HLA-DPB1 6p21.32 THCA
Fusion PortalGSN 9q33.2 HLA-F 6p22.1 LUAD
Fusion PortalGSN 9q33.2 HSPA8 11q24.1 BLCA
Fusion PortalGSN 9q33.2 TRA2A 7p15.3 PRAD
Fusion : QuiverGSN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGSN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GSN
dbVarGSN
ClinVarGSN
1000_GenomesGSN 
Exome Variant ServerGSN
ExAC (Exome Aggregation Consortium)ENSG00000148180
GNOMAD BrowserENSG00000148180
Varsome BrowserGSN
Genetic variants : HAPMAP2934
Genomic Variants (DGV)GSN [DGVbeta]
DECIPHERGSN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGSN 
Mutations
ICGC Data PortalGSN 
TCGA Data PortalGSN 
Broad Tumor PortalGSN
OASIS PortalGSN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGSN  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGSN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GSN
DgiDB (Drug Gene Interaction Database)GSN
DoCM (Curated mutations)GSN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GSN (select a term)
intoGenGSN
Cancer3DGSN(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM105120    137350   
Orphanet11721   
DisGeNETGSN
MedgenGSN
Genetic Testing Registry GSN
NextProtP06396 [Medical]
TSGene2934
GENETestsGSN
Target ValidationGSN
Huge Navigator GSN [HugePedia]
snp3D : Map Gene to Disease2934
BioCentury BCIQGSN
ClinGenGSN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2934
Chemical/Pharm GKB GenePA29011
Clinical trialGSN
Miscellaneous
canSAR (ICR)GSN (select the gene name)
Probes
Litterature
PubMed247 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGSN
EVEXGSN
GoPubMedGSN
iHOPGSN
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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