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GSPT1 (G1 to S phase transition 1)

Identity

Alias_symbol (synonym)GST1
ETF3A
eRF3a
Other alias551G9.2
HGNC (Hugo) GSPT1
LocusID (NCBI) 2935
Atlas_Id 40762
Location 16p13.13  [Link to chromosome band 16p13]
Location_base_pair Starts at 11868128 and ends at 11915968 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BACH1 (21q21.3) / GSPT1 (16p13.13)GSPT1 (16p13.13) / GSPT1 (16p13.13)GSPT1 (16p13.13) / HPGD (4q34.1)
NSUN3 (3q11.1) / GSPT1 (16p13.13)RBBP5 (1q32.1) / GSPT1 (16p13.13)TXNDC11 (16p13.13) / GSPT1 (16p13.13)
TXNDC11 16p13.13 / GSPT1 16p13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GSPT1   4621
Cards
Entrez_Gene (NCBI)GSPT1  2935  G1 to S phase transition 1
Aliases551G9.2; ETF3A; GST1; eRF3a
GeneCards (Weizmann)GSPT1
Ensembl hg19 (Hinxton)ENSG00000103342 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000103342 [Gene_View]  chr16:11868128-11915968 [Contig_View]  GSPT1 [Vega]
ICGC DataPortalENSG00000103342
TCGA cBioPortalGSPT1
AceView (NCBI)GSPT1
Genatlas (Paris)GSPT1
WikiGenes2935
SOURCE (Princeton)GSPT1
Genetics Home Reference (NIH)GSPT1
Genomic and cartography
GoldenPath hg38 (UCSC)GSPT1  -     chr16:11868128-11915968 -  16p13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GSPT1  -     16p13.13   [Description]    (hg19-Feb_2009)
EnsemblGSPT1 - 16p13.13 [CytoView hg19]  GSPT1 - 16p13.13 [CytoView hg38]
Mapping of homologs : NCBIGSPT1 [Mapview hg19]  GSPT1 [Mapview hg38]
OMIM139259   
Gene and transcription
Genbank (Entrez)AK095367 AK095483 AK096386 AK290382 AK315267
RefSeq transcript (Entrez)NM_001130006 NM_001130007 NM_002094
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GSPT1
Cluster EST : UnigeneHs.528780 [ NCBI ]
CGAP (NCI)Hs.528780
Alternative Splicing GalleryENSG00000103342
Gene ExpressionGSPT1 [ NCBI-GEO ]   GSPT1 [ EBI - ARRAY_EXPRESS ]   GSPT1 [ SEEK ]   GSPT1 [ MEM ]
Gene Expression Viewer (FireBrowse)GSPT1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2935
GTEX Portal (Tissue expression)GSPT1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15170   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP15170  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP15170
Splice isoforms : SwissVarP15170
PhosPhoSitePlusP15170
Domaine pattern : Prosite (Expaxy)G_TR_1 (PS00301)    G_TR_2 (PS51722)   
Domains : Interpro (EBI)EFTu-like_2    G_TR_CS    P-loop_NTPase    TF_GTP-bd_dom    Transl_B-barrel    Transl_elong_EF1A/Init_IF2_C    Transl_elong_EFTu/EF1A_C   
Domain families : Pfam (Sanger)GTP_EFTU_D2 (PF03144)    GTP_EFTU_D3 (PF03143)   
Domain families : Pfam (NCBI)pfam03144    pfam03143   
Conserved Domain (NCBI)GSPT1
DMDM Disease mutations2935
Blocks (Seattle)GSPT1
PDB (SRS)3E1Y    3J5Y    3KUI    4D61    5HXB    5LZT   
PDB (PDBSum)3E1Y    3J5Y    3KUI    4D61    5HXB    5LZT   
PDB (IMB)3E1Y    3J5Y    3KUI    4D61    5HXB    5LZT   
PDB (RSDB)3E1Y    3J5Y    3KUI    4D61    5HXB    5LZT   
Structural Biology KnowledgeBase3E1Y    3J5Y    3KUI    4D61    5HXB    5LZT   
SCOP (Structural Classification of Proteins)3E1Y    3J5Y    3KUI    4D61    5HXB    5LZT   
CATH (Classification of proteins structures)3E1Y    3J5Y    3KUI    4D61    5HXB    5LZT   
SuperfamilyP15170
Human Protein AtlasENSG00000103342
Peptide AtlasP15170
HPRD00753
IPIIPI00218829   IPI00909083   IPI00910513   
Protein Interaction databases
DIP (DOE-UCLA)P15170
IntAct (EBI)P15170
FunCoupENSG00000103342
BioGRIDGSPT1
STRING (EMBL)GSPT1
ZODIACGSPT1
Ontologies - Pathways
QuickGOP15170
Ontology : AmiGOG1/S transition of mitotic cell cycle  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  cytoplasmic translational termination  RNA binding  translation release factor activity  GTPase activity  protein binding  GTP binding  intracellular  cytosol  translational termination  protein methylation  translation release factor complex  
Ontology : EGO-EBIG1/S transition of mitotic cell cycle  nuclear-transcribed mRNA catabolic process, nonsense-mediated decay  cytoplasmic translational termination  RNA binding  translation release factor activity  GTPase activity  protein binding  GTP binding  intracellular  cytosol  translational termination  protein methylation  translation release factor complex  
Pathways : KEGGmRNA surveillance pathway   
NDEx NetworkGSPT1
Atlas of Cancer Signalling NetworkGSPT1
Wikipedia pathwaysGSPT1
Orthology - Evolution
OrthoDB2935
GeneTree (enSembl)ENSG00000103342
Phylogenetic Trees/Animal Genes : TreeFamGSPT1
HOVERGENP15170
HOGENOMP15170
Homologs : HomoloGeneGSPT1
Homology/Alignments : Family Browser (UCSC)GSPT1
Gene fusions - Rearrangements
Fusion : MitelmanTXNDC11/GSPT1 [16p13.13/16p13.13]  [t(16;16)(p13;p13)]  
Fusion: TCGATXNDC11 16p13.13 GSPT1 16p13.13 OV
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGSPT1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GSPT1
dbVarGSPT1
ClinVarGSPT1
1000_GenomesGSPT1 
Exome Variant ServerGSPT1
ExAC (Exome Aggregation Consortium)GSPT1 (select the gene name)
Genetic variants : HAPMAP2935
Genomic Variants (DGV)GSPT1 [DGVbeta]
DECIPHERGSPT1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGSPT1 
Mutations
ICGC Data PortalGSPT1 
TCGA Data PortalGSPT1 
Broad Tumor PortalGSPT1
OASIS PortalGSPT1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGSPT1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGSPT1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GSPT1
DgiDB (Drug Gene Interaction Database)GSPT1
DoCM (Curated mutations)GSPT1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GSPT1 (select a term)
intoGenGSPT1
Cancer3DGSPT1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139259   
Orphanet
MedgenGSPT1
Genetic Testing Registry GSPT1
NextProtP15170 [Medical]
TSGene2935
GENETestsGSPT1
Target ValidationGSPT1
Huge Navigator GSPT1 [HugePedia]
snp3D : Map Gene to Disease2935
BioCentury BCIQGSPT1
ClinGenGSPT1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2935
Chemical/Pharm GKB GenePA29012
Clinical trialGSPT1
Miscellaneous
canSAR (ICR)GSPT1 (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGSPT1
EVEXGSPT1
GoPubMedGSPT1
iHOPGSPT1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:36:06 CEST 2017

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