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GSS (glutathione synthetase)

Identity

Other namesGSHS
HEL-S-64p
HEL-S-88n
HGNC (Hugo) GSS
LocusID (NCBI) 2937
Atlas_Id 47630
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 33516236 and ends at 33543601 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ACSS2 (20q11.22) / GSS (20q11.22)BRWD1 (21q22.2) / GSS (20q11.22)GSS (20q11.22) / ACSS2 (20q11.22)
GSS (20q11.22) / DHFR (5q14.1)GSS (20q11.22) / GSS (20q11.22)GSS (20q11.22) / OASL (12q24.31)
MAT2A (2p11.2) / GSS (20q11.22)NCOA6 (20q11.22) / GSS (20q11.22)ZC2HC1A (8q21.12) / GSS (20q11.22)
ACSS2 20q11.22 / GSS 20q11.22GSS 20q11.22 / ACSS2 20q11.22NCOA6 20q11.22 / GSS 20q11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GSS   4624
Cards
Entrez_Gene (NCBI)GSS  2937  glutathione synthetase
AliasesGSHS; HEL-S-64p; HEL-S-88n
GeneCards (Weizmann)GSS
Ensembl hg19 (Hinxton)ENSG00000100983 [Gene_View]  chr20:33516236-33543601 [Contig_View]  GSS [Vega]
Ensembl hg38 (Hinxton)ENSG00000100983 [Gene_View]  chr20:33516236-33543601 [Contig_View]  GSS [Vega]
ICGC DataPortalENSG00000100983
TCGA cBioPortalGSS
AceView (NCBI)GSS
Genatlas (Paris)GSS
WikiGenes2937
SOURCE (Princeton)GSS
Genomic and cartography
GoldenPath hg19 (UCSC)GSS  -     chr20:33516236-33543601 -  20q11.22   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GSS  -     20q11.22   [Description]    (hg38-Dec_2013)
EnsemblGSS - 20q11.22 [CytoView hg19]  GSS - 20q11.22 [CytoView hg38]
Mapping of homologs : NCBIGSS [Mapview hg19]  GSS [Mapview hg38]
OMIM231900   266130   601002   
Gene and transcription
Genbank (Entrez)AB459500 AK293144 AK298292 AK311421 AK311567
RefSeq transcript (Entrez)NM_000178 NM_001322494 NM_001322495
RefSeq genomic (Entrez)NC_000020 NC_018931 NG_008848 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)GSS
Cluster EST : UnigeneHs.82327 [ NCBI ]
CGAP (NCI)Hs.82327
Alternative Splicing GalleryENSG00000100983
Gene ExpressionGSS [ NCBI-GEO ]   GSS [ EBI - ARRAY_EXPRESS ]   GSS [ SEEK ]   GSS [ MEM ]
Gene Expression Viewer (FireBrowse)GSS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2937
GTEX Portal (Tissue expression)GSS
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48637 (Uniprot)
NextProtP48637  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48637
Splice isoforms : SwissVarP48637 (Swissvar)
Catalytic activity : Enzyme6.3.2.3 [ Enzyme-Expasy ]   6.3.2.36.3.2.3 [ IntEnz-EBI ]   6.3.2.3 [ BRENDA ]   6.3.2.3 [ KEGG ]   
PhosPhoSitePlusP48637
Domains : Interpro (EBI)Glutathione_synth_subst-bd_euk    Glutathione_synthase_a-hlx_euk    Glutathione_synthase_dom    Glutathione_synthase_euk    Glutathione_synthase_N_euk    PreATP-grasp_dom   
Domain families : Pfam (Sanger)GSH_synth_ATP (PF03917)    GSH_synthase (PF03199)   
Domain families : Pfam (NCBI)pfam03917    pfam03199   
DMDM Disease mutations2937
Blocks (Seattle)GSS
PDB (SRS)2HGS   
PDB (PDBSum)2HGS   
PDB (IMB)2HGS   
PDB (RSDB)2HGS   
Structural Biology KnowledgeBase2HGS   
SCOP (Structural Classification of Proteins)2HGS   
CATH (Classification of proteins structures)2HGS   
SuperfamilyP48637
Human Protein AtlasENSG00000100983
Peptide AtlasP48637
HPRD03000
IPIIPI00010706   IPI00915302   IPI01013481   
Protein Interaction databases
DIP (DOE-UCLA)P48637
IntAct (EBI)P48637
FunCoupENSG00000100983
BioGRIDGSS
STRING (EMBL)GSS
ZODIACGSS
Ontologies - Pathways
QuickGOP48637
Ontology : AmiGOmagnesium ion binding  glutathione synthase activity  protein binding  ATP binding  cytosol  cellular amino acid metabolic process  glutathione biosynthetic process  glutathione biosynthetic process  response to oxidative stress  nervous system development  aging  response to xenobiotic stimulus  glycine binding  response to nutrient levels  response to tumor necrosis factor  protein homodimerization activity  response to amino acid  glutathione binding  response to cadmium ion  extracellular exosome  
Ontology : EGO-EBImagnesium ion binding  glutathione synthase activity  protein binding  ATP binding  cytosol  cellular amino acid metabolic process  glutathione biosynthetic process  glutathione biosynthetic process  response to oxidative stress  nervous system development  aging  response to xenobiotic stimulus  glycine binding  response to nutrient levels  response to tumor necrosis factor  protein homodimerization activity  response to amino acid  glutathione binding  response to cadmium ion  extracellular exosome  
Pathways : BIOCARTAFree Radical Induced Apoptosis [Genes]   
Pathways : KEGGGlutathione metabolism   
NDEx Network
Atlas of Cancer Signalling NetworkGSS
Wikipedia pathwaysGSS
Orthology - Evolution
OrthoDB2937
GeneTree (enSembl)ENSG00000100983
Phylogenetic Trees/Animal Genes : TreeFamGSS
Homologs : HomoloGeneGSS
Homology/Alignments : Family Browser (UCSC)GSS
Gene fusions - Rearrangements
Fusion: TCGAACSS2 20q11.22 GSS 20q11.22 BRCA
Fusion: TCGAGSS 20q11.22 ACSS2 20q11.22 LUAD
Fusion: TCGANCOA6 20q11.22 GSS 20q11.22 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerGSS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GSS
dbVarGSS
ClinVarGSS
1000_GenomesGSS 
Exome Variant ServerGSS
ExAC (Exome Aggregation Consortium)GSS (select the gene name)
Genetic variants : HAPMAP2937
Genomic Variants (DGV)GSS [DGVbeta]
Mutations
ICGC Data PortalGSS 
TCGA Data PortalGSS 
Broad Tumor PortalGSS
OASIS PortalGSS [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGSS 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)**PUBLIC** CCHMC Molecular Genetics Laboratory Mutation Database
BioMutasearch GSS
DgiDB (Drug Gene Interaction Database)GSS
DoCM (Curated mutations)GSS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GSS (select a term)
intoGenGSS
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)20:33516236-33543601  ENSG00000100983
CONAN: Copy Number AnalysisGSS 
Mutations and Diseases : HGMDGSS
OMIM231900    266130    601002   
MedgenGSS
Genetic Testing Registry GSS
NextProtP48637 [Medical]
TSGene2937
GENETestsGSS
Huge Navigator GSS [HugePedia]
snp3D : Map Gene to Disease2937
BioCentury BCIQGSS
ClinGenGSS
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2937
Chemical/Pharm GKB GenePA29015
Clinical trialGSS
Miscellaneous
canSAR (ICR)GSS (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGSS
EVEXGSS
GoPubMedGSS
iHOPGSS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 9 19:03:29 CEST 2016

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