GSS (glutathione synthetase)

2007-07-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
GSHS,HEL-S-64p,HEL-S-88n
FUSION GENES

Other Information

Locus ID:

NCBI: 2937
MIM: 601002
HGNC: 4624
Ensembl: ENSG00000100983

Variants:

dbSNP: 2937
ClinVar: 2937
TCGA: ENSG00000100983
COSMIC: GSS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100983ENST00000451957P48637
ENSG00000100983ENST00000642493A0A2R8Y2X9
ENSG00000100983ENST00000642498A0A2R8Y430
ENSG00000100983ENST00000642538A0A0S2Z4J7
ENSG00000100983ENST00000643188P48637
ENSG00000100983ENST00000643188V9HWJ1
ENSG00000100983ENST00000643271A0A2R8YF34
ENSG00000100983ENST00000643443A0A2R8Y6Y6
ENSG00000100983ENST00000643502A0A2R8Y5T7
ENSG00000100983ENST00000644608A0A2R8Y2F2
ENSG00000100983ENST00000644793P48637
ENSG00000100983ENST00000644793V9HWJ1
ENSG00000100983ENST00000645102A0A2R8Y790
ENSG00000100983ENST00000645328A0A2R8Y6Q7
ENSG00000100983ENST00000645408A0A2R8Y7I7
ENSG00000100983ENST00000646405A0A2R8Y446
ENSG00000100983ENST00000646735P48637
ENSG00000100983ENST00000646766A0A2R8Y4V9
ENSG00000100983ENST00000651619P48637
ENSG00000100983ENST00000651619V9HWJ1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Glutathione metabolismKEGGhsa00480
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Glutathione biosynthesis, glutamate => glutathioneKEGGhsa_M00118
Glutathione biosynthesis, glutamate => glutathioneKEGGM00118
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Glutathione synthesis and recyclingREACTOMER-HSA-174403
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27
175034802007Genetic susceptibility to environmental toxicants in ALS.24
158900652005Cloning and characterization of the human glutathione synthetase 5'-flanking region.23
189772412008Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.20
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.20
208021632011Genetic variation in the glutathione synthesis pathway, air pollution, and children's lung function growth.16
204393442010Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients.14
149905772004Function of conserved residues of human glutathione synthetase: implications for the ATP-grasp enzymes.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11

Citation

Dessen P

GSS (glutathione synthetase)

Atlas Genet Cytogenet Oncol Haematol. 2007-07-01

Online version: http://atlasgeneticsoncology.org/gene/47630/gss