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GSS (glutathione synthetase)

Identity

Other namesGSHS
HEL-S-64p
HEL-S-88n
HGNC (Hugo) GSS
LocusID (NCBI) 2937
Location 20q11.22
Location_base_pair Starts at 33516236 and ends at 33543601 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GSS   4624
Cards
Entrez_Gene (NCBI)GSS  2937  glutathione synthetase
GeneCards (Weizmann)GSS
Ensembl (Hinxton)ENSG00000100983 [Gene_View]  chr20:33516236-33543601 [Contig_View]  GSS [Vega]
ICGC DataPortalENSG00000100983
cBioPortalGSS
AceView (NCBI)GSS
Genatlas (Paris)GSS
WikiGenes2937
SOURCE (Princeton)NM_000178
Genomic and cartography
GoldenPath (UCSC)GSS  -  20q11.22   chr20:33516236-33543601 -  20q11.22   [Description]    (hg19-Feb_2009)
EnsemblGSS - 20q11.22 [CytoView]
Mapping of homologs : NCBIGSS [Mapview]
OMIM231900   266130   601002   
Gene and transcription
Genbank (Entrez)AB459500 AK293144 AK298292 AK311421 AK311567
RefSeq transcript (Entrez)NM_000178
RefSeq genomic (Entrez)AC_000152 NC_000020 NC_018931 NG_008848 NT_011362 NW_001838664 NW_004929418
Consensus coding sequences : CCDS (NCBI)GSS
Cluster EST : UnigeneHs.82327 [ NCBI ]
CGAP (NCI)Hs.82327
Alternative Splicing : Fast-db (Paris)GSHG0019137
Alternative Splicing GalleryENSG00000100983
Gene ExpressionGSS [ NCBI-GEO ]     GSS [ SEEK ]   GSS [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48637 (Uniprot)
NextProtP48637  [Medical]
With graphics : InterProP48637
Splice isoforms : SwissVarP48637 (Swissvar)
Catalytic activity : Enzyme6.3.2.3 [ Enzyme-Expasy ]   6.3.2.36.3.2.3 [ IntEnz-EBI ]   6.3.2.3 [ BRENDA ]   6.3.2.3 [ KEGG ]   
Domains : Interpro (EBI)Glutathione_synth_subst-bd_euk [organisation]   Glutathione_synthase_a-hlx_euk [organisation]   Glutathione_synthase_dom [organisation]   Glutathione_synthase_euk [organisation]   Glutathione_synthase_N_euk [organisation]   PreATP-grasp_dom [organisation]  
Related proteins : CluSTrP48637
Domain families : Pfam (Sanger)GSH_synth_ATP (PF03917)    GSH_synthase (PF03199)   
Domain families : Pfam (NCBI)pfam03917    pfam03199   
DMDM Disease mutations2937
Blocks (Seattle)P48637
PDB (SRS)2HGS   
PDB (PDBSum)2HGS   
PDB (IMB)2HGS   
PDB (RSDB)2HGS   
Human Protein AtlasENSG00000100983 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP48637
HPRD03000
IPIIPI00010706   IPI00915302   IPI01013481   
Protein Interaction databases
DIP (DOE-UCLA)P48637
IntAct (EBI)P48637
FunCoupENSG00000100983
BioGRIDGSS
InParanoidP48637
Interologous Interaction database P48637
IntegromeDBGSS
STRING (EMBL)GSS
Ontologies - Pathways
Ontology : AmiGOmagnesium ion binding  glutathione synthase activity  ATP binding  cytosol  cellular amino acid metabolic process  glutathione biosynthetic process  glutathione biosynthetic process  xenobiotic metabolic process  response to oxidative stress  nervous system development  aging  glycine binding  response to nutrient levels  response to tumor necrosis factor  protein homodimerization activity  response to amino acid  glutathione binding  small molecule metabolic process  response to cadmium ion  extracellular vesicular exosome  glutathione derivative biosynthetic process  
Ontology : EGO-EBImagnesium ion binding  glutathione synthase activity  ATP binding  cytosol  cellular amino acid metabolic process  glutathione biosynthetic process  glutathione biosynthetic process  xenobiotic metabolic process  response to oxidative stress  nervous system development  aging  glycine binding  response to nutrient levels  response to tumor necrosis factor  protein homodimerization activity  response to amino acid  glutathione binding  small molecule metabolic process  response to cadmium ion  extracellular vesicular exosome  glutathione derivative biosynthetic process  
Pathways : BIOCARTAFree Radical Induced Apoptosis [Genes]   
Pathways : KEGGGlutathione metabolism   
Protein Interaction DatabaseGSS
Wikipedia pathwaysGSS
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)GSS
snp3D : Map Gene to Disease2937
SNP (GeneSNP Utah)GSS
SNP : HGBaseGSS
Genetic variants : HAPMAPGSS
Exome VariantGSS
1000_GenomesGSS 
ICGC programENSG00000100983 
Somatic Mutations in Cancer : COSMICGSS 
CONAN: Copy Number AnalysisGSS 
Mutations and Diseases : HGMDGSS
Genomic VariantsGSS  GSS [DGVbeta]
dbVarGSS
ClinVarGSS
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM231900    266130    601002   
MedgenGSS
GENETestsGSS
Disease Genetic AssociationGSS
Huge Navigator GSS [HugePedia]  GSS [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneGSS
Homology/Alignments : Family Browser (UCSC)GSS
Phylogenetic Trees/Animal Genes : TreeFamGSS
Chemical/Protein Interactions : CTD2937
Chemical/Pharm GKB GenePA29015
Clinical trialGSS
Cancer Resource (Charite)ENSG00000100983
Other databases
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
CoreMineGSS
iHOPGSS
OncoSearchGSS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 13:57:10 CEST 2014

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