GSTA3 (glutathione S-transferase alpha 3)

2003-06-01 Affiliation

Identity

HGNC

GSTA3

LOCATION

6p12.2

LOCUSID

2940

ALIAS

GSTA3-3,GTA3

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2940
MIM: 605449
HGNC: 4628
Ensembl: ENSG00000174156

Variants:

dbSNP: 2940
ClinVar: 2940
TCGA: ENSG00000174156
COSMIC: GSTA3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000174156	ENST00000211122	Q16772
ENSG00000174156	ENST00000370968	Q5JW85
ENSG00000174156	ENST00000431899	Q5JW84

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glutathione metabolism	KEGG	ko00480
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Glutathione metabolism	KEGG	hsa00480
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glutathione conjugation	REACTOME	R-HSA-156590
Platinum drug resistance	KEGG	ko01524
Platinum drug resistance	KEGG	hsa01524
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
17601350	2007	A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.	27
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	27
18977241	2008	Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.	20
20200426	2010	Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.	20
20083122	2010	Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases.	7
18426392	2008	Targeting human glutathione transferase A3-3 attenuates progesterone production in human steroidogenic cells.	6
28005267	2017	Human gingiva transcriptome during wound healing.	6
30106150	2018	Novel prognostic biomarkers of gastric cancer based on gene expression microarray: COL12A1, GSTA3, FGA and FGG.	6
15454730	2004	Functional polymorphism of human glutathione transferase A3: effects on xenobiotic metabolism and steroid biosynthesis.	5
19343046	2009	Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.	3

Citation

Dessen P

GSTA3 (glutathione S-transferase alpha 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40766/gsta3