GSTA4 (glutathione S-transferase alpha 4)

2003-06-01  

Identity

HGNC
LOCATION
6p12.2
LOCUSID
ALIAS
GSTA4-4,GTA4
FUSION GENES

Other Information

Locus ID:

NCBI: 2941
MIM: 605450
HGNC: 4629
Ensembl: ENSG00000170899

Variants:

dbSNP: 2941
ClinVar: 2941
TCGA: ENSG00000170899
COSMIC: GSTA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170899ENST00000370959O15217
ENSG00000170899ENST00000370959A0A024RD58
ENSG00000170899ENST00000370960O15217
ENSG00000170899ENST00000370963O15217
ENSG00000170899ENST00000370963A0A024RD58
ENSG00000170899ENST00000457564Q5JW88

Expression (GTEx)

0
50
100
150
200
250
300

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
201502872010Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction.81
192400612009Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.75
147616852004Physiological role of mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal: generation and analysis of mGsta4 null mouse.58
160069972005A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer.52
1893001620084-Hydroxynonenal induces p53-mediated apoptosis in retinal pigment epithelial cells.37
180657252008Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis.32
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25

Citation

Dessen P

GSTA4 (glutathione S-transferase alpha 4)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40767/gsta4