Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GSTA4 (glutathione S-transferase alpha 4)

Identity

Alias_namesglutathione S-transferase A4
Other aliasGSTA4-4
GTA4
HGNC (Hugo) GSTA4
LocusID (NCBI) 2941
Atlas_Id 40767
Location 6p12.2  [Link to chromosome band 6p12]
Location_base_pair Starts at 52977948 and ends at 52995380 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GSTA4 (6p12.2) / NADSYN1 (11q13.4)LRRK1 (15q26.3) / GSTA4 (6p12.2)GSTA4 6p12.2 / NADSYN1 11q13.4

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;11)(p12;q13) GSTA4/NADSYN1


External links

Nomenclature
HGNC (Hugo)GSTA4   4629
Cards
Entrez_Gene (NCBI)GSTA4  2941  glutathione S-transferase alpha 4
AliasesGSTA4-4; GTA4
GeneCards (Weizmann)GSTA4
Ensembl hg19 (Hinxton)ENSG00000170899 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000170899 [Gene_View]  ENSG00000170899 [Sequence]  chr6:52977948-52995380 [Contig_View]  GSTA4 [Vega]
ICGC DataPortalENSG00000170899
TCGA cBioPortalGSTA4
AceView (NCBI)GSTA4
Genatlas (Paris)GSTA4
WikiGenes2941
SOURCE (Princeton)GSTA4
Genetics Home Reference (NIH)GSTA4
Genomic and cartography
GoldenPath hg38 (UCSC)GSTA4  -     chr6:52977948-52995380 -  6p12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GSTA4  -     6p12.2   [Description]    (hg19-Feb_2009)
EnsemblGSTA4 - 6p12.2 [CytoView hg19]  GSTA4 - 6p12.2 [CytoView hg38]
Mapping of homologs : NCBIGSTA4 [Mapview hg19]  GSTA4 [Mapview hg38]
OMIM605450   
Gene and transcription
Genbank (Entrez)AA709059 AF020918 AF025887 AF125271 AF125272
RefSeq transcript (Entrez)NM_001512
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GSTA4
Cluster EST : UnigeneHs.485557 [ NCBI ]
CGAP (NCI)Hs.485557
Alternative Splicing GalleryENSG00000170899
Gene ExpressionGSTA4 [ NCBI-GEO ]   GSTA4 [ EBI - ARRAY_EXPRESS ]   GSTA4 [ SEEK ]   GSTA4 [ MEM ]
Gene Expression Viewer (FireBrowse)GSTA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2941
GTEX Portal (Tissue expression)GSTA4
Human Protein AtlasENSG00000170899-GSTA4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO15217   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO15217  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO15217
Splice isoforms : SwissVarO15217
Catalytic activity : Enzyme2.5.1.18 [ Enzyme-Expasy ]   2.5.1.182.5.1.18 [ IntEnz-EBI ]   2.5.1.18 [ BRENDA ]   2.5.1.18 [ KEGG ]   
PhosPhoSitePlusO15217
Domaine pattern : Prosite (Expaxy)GST_CTER (PS50405)    GST_NTER (PS50404)   
Domains : Interpro (EBI)Glutathione-S-Trfase_C-like    Glutathione-S-Trfase_C_sf    Glutathione_S-Trfase_N    GST_alpha    GST_C    Thioredoxin-like_sf   
Domain families : Pfam (Sanger)GST_C_3 (PF14497)    GST_N (PF02798)   
Domain families : Pfam (NCBI)pfam14497    pfam02798   
Conserved Domain (NCBI)GSTA4
DMDM Disease mutations2941
Blocks (Seattle)GSTA4
PDB (SRS)1GUL    1GUM    3IK7   
PDB (PDBSum)1GUL    1GUM    3IK7   
PDB (IMB)1GUL    1GUM    3IK7   
PDB (RSDB)1GUL    1GUM    3IK7   
Structural Biology KnowledgeBase1GUL    1GUM    3IK7   
SCOP (Structural Classification of Proteins)1GUL    1GUM    3IK7   
CATH (Classification of proteins structures)1GUL    1GUM    3IK7   
SuperfamilyO15217
Human Protein Atlas [tissue]ENSG00000170899-GSTA4 [tissue]
Peptide AtlasO15217
HPRD06899
IPIIPI00005659   IPI00642343   IPI00642829   
Protein Interaction databases
DIP (DOE-UCLA)O15217
IntAct (EBI)O15217
FunCoupENSG00000170899
BioGRIDGSTA4
STRING (EMBL)GSTA4
ZODIACGSTA4
Ontologies - Pathways
QuickGOO15217
Ontology : AmiGOglutathione transferase activity  glutathione transferase activity  protein binding  cytosol  glutathione metabolic process  xenobiotic metabolic process  identical protein binding  protein homodimerization activity  glutathione derivative biosynthetic process  
Ontology : EGO-EBIglutathione transferase activity  glutathione transferase activity  protein binding  cytosol  glutathione metabolic process  xenobiotic metabolic process  identical protein binding  protein homodimerization activity  glutathione derivative biosynthetic process  
Pathways : KEGGGlutathione metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Chemical carcinogenesis   
NDEx NetworkGSTA4
Atlas of Cancer Signalling NetworkGSTA4
Wikipedia pathwaysGSTA4
Orthology - Evolution
OrthoDB2941
GeneTree (enSembl)ENSG00000170899
Phylogenetic Trees/Animal Genes : TreeFamGSTA4
HOVERGENO15217
HOGENOMO15217
Homologs : HomoloGeneGSTA4
Homology/Alignments : Family Browser (UCSC)GSTA4
Gene fusions - Rearrangements
Fusion : MitelmanGSTA4/NADSYN1 [6p12.2/11q13.4]  
Fusion PortalGSTA4 6p12.2 NADSYN1 11q13.4 BRCA
Fusion : QuiverGSTA4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGSTA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GSTA4
dbVarGSTA4
ClinVarGSTA4
1000_GenomesGSTA4 
Exome Variant ServerGSTA4
ExAC (Exome Aggregation Consortium)ENSG00000170899
GNOMAD BrowserENSG00000170899
Varsome BrowserGSTA4
Genetic variants : HAPMAP2941
Genomic Variants (DGV)GSTA4 [DGVbeta]
DECIPHERGSTA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGSTA4 
Mutations
ICGC Data PortalGSTA4 
TCGA Data PortalGSTA4 
Broad Tumor PortalGSTA4
OASIS PortalGSTA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGSTA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGSTA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GSTA4
DgiDB (Drug Gene Interaction Database)GSTA4
DoCM (Curated mutations)GSTA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GSTA4 (select a term)
intoGenGSTA4
Cancer3DGSTA4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605450   
Orphanet
DisGeNETGSTA4
MedgenGSTA4
Genetic Testing Registry GSTA4
NextProtO15217 [Medical]
TSGene2941
GENETestsGSTA4
Target ValidationGSTA4
Huge Navigator GSTA4 [HugePedia]
snp3D : Map Gene to Disease2941
BioCentury BCIQGSTA4
ClinGenGSTA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2941
Chemical/Pharm GKB GenePA29019
Clinical trialGSTA4
Miscellaneous
canSAR (ICR)GSTA4 (select the gene name)
Probes
Litterature
PubMed63 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGSTA4
EVEXGSTA4
GoPubMedGSTA4
iHOPGSTA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:09:46 CET 2018

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