GSTM2 (glutathione S-transferase mu 2)

2003-06-01  

Identity

HGNC
LOCATION
1p13.3
LOCUSID
ALIAS
GST4,GSTM,GSTM2-2,GTHMUS
FUSION GENES

Other Information

Locus ID:

NCBI: 2946
MIM: 138380
HGNC: 4634
Ensembl: ENSG00000213366

Variants:

dbSNP: 2946
ClinVar: 2946
TCGA: ENSG00000213366
COSMIC: GSTM2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213366ENST00000241337P28161
ENSG00000213366ENST00000241337A0A384P5E9
ENSG00000213366ENST00000369827E9PHN7
ENSG00000213366ENST00000369829E9PHN6
ENSG00000213366ENST00000369831F6XZQ7
ENSG00000213366ENST00000414179E9PGV1
ENSG00000213366ENST00000442650P28161
ENSG00000213366ENST00000460717P28161
ENSG00000213366ENST00000467579E9PLF1

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
180079942007Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort.73
180657252008Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis.32
124861192003Identification of residues in glutathione transferase capable of driving functional diversification in evolution. A novel approach to protein redesign.22
240481942013Functional compensation of glutathione S-transferase M1 (GSTM1) null by another GST superfamily member, GSTM2.22
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.20
171977022007Glutathione transferases sequester toxic dinitrosyl-iron complexes in cells. A protection mechanism against excess nitric oxide.17
248525192014Genetic susceptibility, residential radon, and lung cancer in a radon prone area.16
128719452003The specific interaction of dinitrosyl-diglutathionyl-iron complex, a natural NO carrier, with the glutathione transferase superfamily: suggestion for an evolutionary pressure in the direction of the storage of nitric oxide.14
191511922009Variation in the GST mu locus and tobacco smoke exposure as determinants of childhood lung function.14

Citation

Dessen P

GSTM2 (glutathione S-transferase mu 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/40769/gstm2