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GSTM2 (glutathione S-transferase mu 2)

Identity

Alias_namesglutathione S-transferase M2 (muscle)
glutathione S-transferase mu 2 (muscle)
Alias_symbol (synonym)GST4
Other aliasGSTM
GSTM2-2
GTHMUS
HGNC (Hugo) GSTM2
LocusID (NCBI) 2946
Atlas_Id 40769
Location 1p13.3  [Link to chromosome band 1p13]
Location_base_pair Starts at 109668022 and ends at 109675286 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALG13 (Xq23) / GSTM2 (1p13.3)EPB41L1 (20q11.23) / GSTM2 (1p13.3)GSTM2 (1p13.3) / EVC2 (4p16.2)
GSTM2 (1p13.3) / RAN (12q24.33)PTRF (17q21.2) / GSTM2 (1p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GSTM2   4634
Cards
Entrez_Gene (NCBI)GSTM2  2946  glutathione S-transferase mu 2
AliasesGST4; GSTM; GSTM2-2; GTHMUS
GeneCards (Weizmann)GSTM2
Ensembl hg19 (Hinxton)ENSG00000213366 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213366 [Gene_View]  chr1:109668022-109675286 [Contig_View]  GSTM2 [Vega]
ICGC DataPortalENSG00000213366
TCGA cBioPortalGSTM2
AceView (NCBI)GSTM2
Genatlas (Paris)GSTM2
WikiGenes2946
SOURCE (Princeton)GSTM2
Genetics Home Reference (NIH)GSTM2
Genomic and cartography
GoldenPath hg38 (UCSC)GSTM2  -     chr1:109668022-109675286 +  1p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GSTM2  -     1p13.3   [Description]    (hg19-Feb_2009)
EnsemblGSTM2 - 1p13.3 [CytoView hg19]  GSTM2 - 1p13.3 [CytoView hg38]
Mapping of homologs : NCBIGSTM2 [Mapview hg19]  GSTM2 [Mapview hg38]
OMIM138380   
Gene and transcription
Genbank (Entrez)AK299482 AK309796 BC017836 BC105038 BC105066
RefSeq transcript (Entrez)NM_000848 NM_001142368
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GSTM2
Cluster EST : UnigeneHs.279837 [ NCBI ]
CGAP (NCI)Hs.279837
Alternative Splicing GalleryENSG00000213366
Gene ExpressionGSTM2 [ NCBI-GEO ]   GSTM2 [ EBI - ARRAY_EXPRESS ]   GSTM2 [ SEEK ]   GSTM2 [ MEM ]
Gene Expression Viewer (FireBrowse)GSTM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2946
GTEX Portal (Tissue expression)GSTM2
Human Protein AtlasENSG00000213366-GSTM2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP28161   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP28161  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP28161
Splice isoforms : SwissVarP28161
Catalytic activity : Enzyme2.5.1.18 [ Enzyme-Expasy ]   2.5.1.182.5.1.18 [ IntEnz-EBI ]   2.5.1.18 [ BRENDA ]   2.5.1.18 [ KEGG ]   
PhosPhoSitePlusP28161
Domaine pattern : Prosite (Expaxy)GST_CTER (PS50405)    GST_NTER (PS50404)   
Domains : Interpro (EBI)Glutathione-S-Trfase_C-like    Glutathione_S-Trfase_N    GST_C    GST_mu    Thioredoxin-like_fold   
Domain families : Pfam (Sanger)GST_C (PF00043)    GST_N (PF02798)   
Domain families : Pfam (NCBI)pfam00043    pfam02798   
Conserved Domain (NCBI)GSTM2
DMDM Disease mutations2946
Blocks (Seattle)GSTM2
PDB (SRS)1HNA    1HNB    1HNC    1XW5    1YKC    2AB6    2C4J    2GTU    3GTU    3GUR   
PDB (PDBSum)1HNA    1HNB    1HNC    1XW5    1YKC    2AB6    2C4J    2GTU    3GTU    3GUR   
PDB (IMB)1HNA    1HNB    1HNC    1XW5    1YKC    2AB6    2C4J    2GTU    3GTU    3GUR   
PDB (RSDB)1HNA    1HNB    1HNC    1XW5    1YKC    2AB6    2C4J    2GTU    3GTU    3GUR   
Structural Biology KnowledgeBase1HNA    1HNB    1HNC    1XW5    1YKC    2AB6    2C4J    2GTU    3GTU    3GUR   
SCOP (Structural Classification of Proteins)1HNA    1HNB    1HNC    1XW5    1YKC    2AB6    2C4J    2GTU    3GTU    3GUR   
CATH (Classification of proteins structures)1HNA    1HNB    1HNC    1XW5    1YKC    2AB6    2C4J    2GTU    3GTU    3GUR   
SuperfamilyP28161
Human Protein Atlas [tissue]ENSG00000213366-GSTM2 [tissue]
Peptide AtlasP28161
HPRD00710
IPIIPI00219067   IPI00940377   IPI00639805   IPI00645711   IPI00645360   IPI00984060   
Protein Interaction databases
DIP (DOE-UCLA)P28161
IntAct (EBI)P28161
FunCoupENSG00000213366
BioGRIDGSTM2
STRING (EMBL)GSTM2
ZODIACGSTM2
Ontologies - Pathways
QuickGOP28161
Ontology : AmiGOglutathione transferase activity  glutathione transferase activity  glutathione peroxidase activity  receptor binding  protein binding  cytoplasm  cytosol  glutathione metabolic process  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion  sarcoplasmic reticulum  nitrobenzene metabolic process  enzyme binding  xenobiotic catabolic process  protein homodimerization activity  glutathione binding  linoleic acid metabolic process  relaxation of cardiac muscle  negative regulation of ryanodine-sensitive calcium-release channel activity  positive regulation of ryanodine-sensitive calcium-release channel activity  extracellular exosome  cellular detoxification of nitrogen compound  cellular response to caffeine  cellular oxidant detoxification  glutathione derivative biosynthetic process  
Ontology : EGO-EBIglutathione transferase activity  glutathione transferase activity  glutathione peroxidase activity  receptor binding  protein binding  cytoplasm  cytosol  glutathione metabolic process  regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum  regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion  regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion  sarcoplasmic reticulum  nitrobenzene metabolic process  enzyme binding  xenobiotic catabolic process  protein homodimerization activity  glutathione binding  linoleic acid metabolic process  relaxation of cardiac muscle  negative regulation of ryanodine-sensitive calcium-release channel activity  positive regulation of ryanodine-sensitive calcium-release channel activity  extracellular exosome  cellular detoxification of nitrogen compound  cellular response to caffeine  cellular oxidant detoxification  glutathione derivative biosynthetic process  
Pathways : KEGGGlutathione metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Chemical carcinogenesis   
NDEx NetworkGSTM2
Atlas of Cancer Signalling NetworkGSTM2
Wikipedia pathwaysGSTM2
Orthology - Evolution
OrthoDB2946
GeneTree (enSembl)ENSG00000213366
Phylogenetic Trees/Animal Genes : TreeFamGSTM2
HOVERGENP28161
HOGENOMP28161
Homologs : HomoloGeneGSTM2
Homology/Alignments : Family Browser (UCSC)GSTM2
Gene fusions - Rearrangements
Fusion: Tumor Portal GSTM2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGSTM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GSTM2
dbVarGSTM2
ClinVarGSTM2
1000_GenomesGSTM2 
Exome Variant ServerGSTM2
ExAC (Exome Aggregation Consortium)ENSG00000213366
GNOMAD BrowserENSG00000213366
Genetic variants : HAPMAP2946
Genomic Variants (DGV)GSTM2 [DGVbeta]
DECIPHERGSTM2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGSTM2 
Mutations
ICGC Data PortalGSTM2 
TCGA Data PortalGSTM2 
Broad Tumor PortalGSTM2
OASIS PortalGSTM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGSTM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGSTM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GSTM2
DgiDB (Drug Gene Interaction Database)GSTM2
DoCM (Curated mutations)GSTM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GSTM2 (select a term)
intoGenGSTM2
Cancer3DGSTM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138380   
Orphanet
MedgenGSTM2
Genetic Testing Registry GSTM2
NextProtP28161 [Medical]
TSGene2946
GENETestsGSTM2
Target ValidationGSTM2
Huge Navigator GSTM2 [HugePedia]
snp3D : Map Gene to Disease2946
BioCentury BCIQGSTM2
ClinGenGSTM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2946
Chemical/Pharm GKB GenePA29023
Clinical trialGSTM2
Miscellaneous
canSAR (ICR)GSTM2 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGSTM2
EVEXGSTM2
GoPubMedGSTM2
iHOPGSTM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:52:08 CET 2017

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