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GSTM4 (glutathione S-transferase mu 4)

Identity

Alias_namesglutathione S-transferase M4
Other aliasGSTM4-4
GTM4
HGNC (Hugo) GSTM4
LocusID (NCBI) 2948
Atlas_Id 40771
Location 1p13.3  [Link to chromosome band 1p13]
Location_base_pair Starts at 109656076 and ends at 109661709 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GSTM5 (1p13.3) / GSTM4 (1p13.3)KCNC4 (1p13.3) / GSTM4 (1p13.3)KCNC4 1p13.3 / GSTM4 1p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GSTM4   4636
Cards
Entrez_Gene (NCBI)GSTM4  2948  glutathione S-transferase mu 4
AliasesGSTM4-4; GTM4
GeneCards (Weizmann)GSTM4
Ensembl hg19 (Hinxton)ENSG00000168765 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168765 [Gene_View]  chr1:109656076-109661709 [Contig_View]  GSTM4 [Vega]
ICGC DataPortalENSG00000168765
TCGA cBioPortalGSTM4
AceView (NCBI)GSTM4
Genatlas (Paris)GSTM4
WikiGenes2948
SOURCE (Princeton)GSTM4
Genetics Home Reference (NIH)GSTM4
Genomic and cartography
GoldenPath hg38 (UCSC)GSTM4  -     chr1:109656076-109661709 +  1p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GSTM4  -     1p13.3   [Description]    (hg19-Feb_2009)
EnsemblGSTM4 - 1p13.3 [CytoView hg19]  GSTM4 - 1p13.3 [CytoView hg38]
Mapping of homologs : NCBIGSTM4 [Mapview hg19]  GSTM4 [Mapview hg38]
OMIM138333   
Gene and transcription
Genbank (Entrez)AI949679 AK291880 AK311000 BC015513 BC108729
RefSeq transcript (Entrez)NM_000850 NM_147148 NM_147149
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GSTM4
Cluster EST : UnigeneHs.348387 [ NCBI ]
CGAP (NCI)Hs.348387
Alternative Splicing GalleryENSG00000168765
Gene ExpressionGSTM4 [ NCBI-GEO ]   GSTM4 [ EBI - ARRAY_EXPRESS ]   GSTM4 [ SEEK ]   GSTM4 [ MEM ]
Gene Expression Viewer (FireBrowse)GSTM4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2948
GTEX Portal (Tissue expression)GSTM4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ03013   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ03013  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ03013
Splice isoforms : SwissVarQ03013
Catalytic activity : Enzyme2.5.1.18 [ Enzyme-Expasy ]   2.5.1.182.5.1.18 [ IntEnz-EBI ]   2.5.1.18 [ BRENDA ]   2.5.1.18 [ KEGG ]   
PhosPhoSitePlusQ03013
Domaine pattern : Prosite (Expaxy)GST_CTER (PS50405)    GST_NTER (PS50404)   
Domains : Interpro (EBI)Glutathione-S-Trfase_C-like    Glutathione_S-Trfase_N    GST_C    GST_mu    Thioredoxin-like_fold   
Domain families : Pfam (Sanger)GST_C_3 (PF14497)    GST_N (PF02798)   
Domain families : Pfam (NCBI)pfam14497    pfam02798   
Conserved Domain (NCBI)GSTM4
DMDM Disease mutations2948
Blocks (Seattle)GSTM4
PDB (SRS)4GTU   
PDB (PDBSum)4GTU   
PDB (IMB)4GTU   
PDB (RSDB)4GTU   
Structural Biology KnowledgeBase4GTU   
SCOP (Structural Classification of Proteins)4GTU   
CATH (Classification of proteins structures)4GTU   
SuperfamilyQ03013
Human Protein AtlasENSG00000168765
Peptide AtlasQ03013
HPRD00706
IPIIPI00008770   IPI00470739   IPI00619967   IPI00644555   
Protein Interaction databases
DIP (DOE-UCLA)Q03013
IntAct (EBI)Q03013
FunCoupENSG00000168765
BioGRIDGSTM4
STRING (EMBL)GSTM4
ZODIACGSTM4
Ontologies - Pathways
QuickGOQ03013
Ontology : AmiGOglutathione transferase activity  glutathione transferase activity  protein binding  cytoplasm  cytosol  glutathione metabolic process  enzyme binding  xenobiotic catabolic process  protein homodimerization activity  glutathione binding  glutathione derivative biosynthetic process  
Ontology : EGO-EBIglutathione transferase activity  glutathione transferase activity  protein binding  cytoplasm  cytosol  glutathione metabolic process  enzyme binding  xenobiotic catabolic process  protein homodimerization activity  glutathione binding  glutathione derivative biosynthetic process  
Pathways : KEGGGlutathione metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Chemical carcinogenesis   
NDEx NetworkGSTM4
Atlas of Cancer Signalling NetworkGSTM4
Wikipedia pathwaysGSTM4
Orthology - Evolution
OrthoDB2948
GeneTree (enSembl)ENSG00000168765
Phylogenetic Trees/Animal Genes : TreeFamGSTM4
HOVERGENQ03013
HOGENOMQ03013
Homologs : HomoloGeneGSTM4
Homology/Alignments : Family Browser (UCSC)GSTM4
Gene fusions - Rearrangements
Fusion : MitelmanKCNC4/GSTM4 [1p13.3/1p13.3]  [t(1;1)(p13;p13)]  
Fusion: TCGAKCNC4 1p13.3 GSTM4 1p13.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGSTM4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GSTM4
dbVarGSTM4
ClinVarGSTM4
1000_GenomesGSTM4 
Exome Variant ServerGSTM4
ExAC (Exome Aggregation Consortium)GSTM4 (select the gene name)
Genetic variants : HAPMAP2948
Genomic Variants (DGV)GSTM4 [DGVbeta]
DECIPHERGSTM4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGSTM4 
Mutations
ICGC Data PortalGSTM4 
TCGA Data PortalGSTM4 
Broad Tumor PortalGSTM4
OASIS PortalGSTM4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGSTM4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGSTM4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GSTM4
DgiDB (Drug Gene Interaction Database)GSTM4
DoCM (Curated mutations)GSTM4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GSTM4 (select a term)
intoGenGSTM4
Cancer3DGSTM4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138333   
Orphanet
MedgenGSTM4
Genetic Testing Registry GSTM4
NextProtQ03013 [Medical]
TSGene2948
GENETestsGSTM4
Target ValidationGSTM4
Huge Navigator GSTM4 [HugePedia]
snp3D : Map Gene to Disease2948
BioCentury BCIQGSTM4
ClinGenGSTM4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2948
Chemical/Pharm GKB GenePA29026
Clinical trialGSTM4
Miscellaneous
canSAR (ICR)GSTM4 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGSTM4
EVEXGSTM4
GoPubMedGSTM4
iHOPGSTM4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:36:09 CEST 2017

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