GSTO1 (glutathione S-transferase omega 1)

2008-08-01  

Identity

HGNC
LOCATION
10q25.1
LOCUSID
ALIAS
GSTO
FUSION GENES

Other Information

Locus ID:

NCBI: 9446
MIM: 605482
HGNC: 13312
Ensembl: ENSG00000148834

Variants:

dbSNP: 9446
ClinVar: 9446
TCGA: ENSG00000148834
COSMIC: GSTO1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148834ENST00000369710P78417
ENSG00000148834ENST00000369713P78417
ENSG00000148834ENST00000369713V9HWG9
ENSG00000148834ENST00000432659Q5TA01
ENSG00000148834ENST00000445155Q5TA02
ENSG00000148834ENST00000539281P78417

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Vitamin C (ascorbate) metabolismREACTOMER-HSA-196836
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
MethylationREACTOMER-HSA-156581
Glutathione conjugationREACTOMER-HSA-156590
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
175486962007Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh.88
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
176379262007Metabolism of low-dose inorganic arsenic in a central European population: influence of sex and genetic polymorphisms.68
145707062003Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease.59
174502302007Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina.57
180657252008Genetic variants of glutathione S-transferase as possible risk factors for hepatocellular carcinoma: a HuGE systematic review and meta-analysis.32
238880472013A role for glutathione transferase Omega 1 (GSTO1-1) in the glutathionylation cycle.30
176013502007A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27

Citation

Dessen P

GSTO1 (glutathione S-transferase omega 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-08-01

Online version: http://atlasgeneticsoncology.org/gene/50314/gsto1