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GSTP1 (glutathione S-transferase pi 1)

Identity

Alias_namesFAEES3
GST3
Alias_symbol (synonym)GSTP
Other aliasDFN7
HEL-S-22
PI
HGNC (Hugo) GSTP1
LocusID (NCBI) 2950
Atlas_Id 40773
Location 11q13.2  [Link to chromosome band 11q13]
Location_base_pair Starts at 67351066 and ends at 67354124 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GSTP1 (11q13.2) / ATP5G3 (2q31.1)GSTP1 (11q13.2) / CAT (11p13)GSTP1 (11q13.2) / CTSA (20q13.12)
GSTP1 (11q13.2) / FAM53B (10q26.13)GSTP1 (11q13.2) / LAMA5 (20q13.33)GSTP1 (11q13.2) / PSMB1 (6q27)
GSTP1 (11q13.2) / SF3B2 (11q13.1)GSTP1 (11q13.2) / SLC26A4 (7q22.3)GSTP1 (11q13.2) / WHSC1 (4p16.3)
GSTP1 (11q13.2) / XRCC5 (2q35)GSTP1 11q13.2 / ATP5G3 2q31.1GSTP1 11q13.2 / SF3B2 11q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Male breast cancer
Prostate tumors: an overview


External links

Nomenclature
HGNC (Hugo)GSTP1   4638
LRG (Locus Reference Genomic)LRG_723
Cards
Entrez_Gene (NCBI)GSTP1  2950  glutathione S-transferase pi 1
AliasesDFN7; FAEES3; GST3; GSTP; 
HEL-S-22; PI
GeneCards (Weizmann)GSTP1
Ensembl hg19 (Hinxton)ENSG00000084207 [Gene_View]  chr11:67351066-67354124 [Contig_View]  GSTP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000084207 [Gene_View]  chr11:67351066-67354124 [Contig_View]  GSTP1 [Vega]
ICGC DataPortalENSG00000084207
TCGA cBioPortalGSTP1
AceView (NCBI)GSTP1
Genatlas (Paris)GSTP1
WikiGenes2950
SOURCE (Princeton)GSTP1
Genetics Home Reference (NIH)GSTP1
Genomic and cartography
GoldenPath hg19 (UCSC)GSTP1  -     chr11:67351066-67354124 +  11q13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GSTP1  -     11q13.2   [Description]    (hg38-Dec_2013)
EnsemblGSTP1 - 11q13.2 [CytoView hg19]  GSTP1 - 11q13.2 [CytoView hg38]
Mapping of homologs : NCBIGSTP1 [Mapview hg19]  GSTP1 [Mapview hg38]
OMIM134660   
Gene and transcription
Genbank (Entrez)AY579414 BC010915 BC044846 BT019949 BT019950
RefSeq transcript (Entrez)NM_000852
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_012075 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)GSTP1
Cluster EST : UnigeneHs.523836 [ NCBI ]
CGAP (NCI)Hs.523836
Alternative Splicing GalleryENSG00000084207
Gene ExpressionGSTP1 [ NCBI-GEO ]   GSTP1 [ EBI - ARRAY_EXPRESS ]   GSTP1 [ SEEK ]   GSTP1 [ MEM ]
Gene Expression Viewer (FireBrowse)GSTP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2950
GTEX Portal (Tissue expression)GSTP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09211   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09211  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09211
Splice isoforms : SwissVarP09211
Catalytic activity : Enzyme2.5.1.18 [ Enzyme-Expasy ]   2.5.1.182.5.1.18 [ IntEnz-EBI ]   2.5.1.18 [ BRENDA ]   2.5.1.18 [ KEGG ]   
PhosPhoSitePlusP09211
Domaine pattern : Prosite (Expaxy)GST_CTER (PS50405)    GST_NTER (PS50404)   
Domains : Interpro (EBI)Glutathione-S-Trfase_C-like    Glutathione_S-Trfase_N    GST_C    GST_pi    Thioredoxin-like_fold   
Domain families : Pfam (Sanger)GST_C (PF00043)    GST_N (PF02798)   
Domain families : Pfam (NCBI)pfam00043    pfam02798   
Conserved Domain (NCBI)GSTP1
DMDM Disease mutations2950
Blocks (Seattle)GSTP1
PDB (SRS)10GS    11GS    12GS    13GS    14GS    16GS    17GS    18GS    19GS    1AQV    1AQW    1AQX    1EOG    1EOH    1GSS    1KBN    1LBK    1MD3    1MD4    1PGT    1PX6    1PX7    1ZGN    20GS    22GS    2A2R    2A2S    2GSS    2J9H    2PGT    3CSH    3CSI    3CSJ    3DD3    3DGQ    3GSS    3GUS    3HJM    3HJO    3HKR    3IE3    3KM6    3KMN    3KMO    3N9J    3PGT    4GSS    4PGT    5GSS    6GSS    7GSS    8GSS    9GSS   
PDB (PDBSum)10GS    11GS    12GS    13GS    14GS    16GS    17GS    18GS    19GS    1AQV    1AQW    1AQX    1EOG    1EOH    1GSS    1KBN    1LBK    1MD3    1MD4    1PGT    1PX6    1PX7    1ZGN    20GS    22GS    2A2R    2A2S    2GSS    2J9H    2PGT    3CSH    3CSI    3CSJ    3DD3    3DGQ    3GSS    3GUS    3HJM    3HJO    3HKR    3IE3    3KM6    3KMN    3KMO    3N9J    3PGT    4GSS    4PGT    5GSS    6GSS    7GSS    8GSS    9GSS   
PDB (IMB)10GS    11GS    12GS    13GS    14GS    16GS    17GS    18GS    19GS    1AQV    1AQW    1AQX    1EOG    1EOH    1GSS    1KBN    1LBK    1MD3    1MD4    1PGT    1PX6    1PX7    1ZGN    20GS    22GS    2A2R    2A2S    2GSS    2J9H    2PGT    3CSH    3CSI    3CSJ    3DD3    3DGQ    3GSS    3GUS    3HJM    3HJO    3HKR    3IE3    3KM6    3KMN    3KMO    3N9J    3PGT    4GSS    4PGT    5GSS    6GSS    7GSS    8GSS    9GSS   
PDB (RSDB)10GS    11GS    12GS    13GS    14GS    16GS    17GS    18GS    19GS    1AQV    1AQW    1AQX    1EOG    1EOH    1GSS    1KBN    1LBK    1MD3    1MD4    1PGT    1PX6    1PX7    1ZGN    20GS    22GS    2A2R    2A2S    2GSS    2J9H    2PGT    3CSH    3CSI    3CSJ    3DD3    3DGQ    3GSS    3GUS    3HJM    3HJO    3HKR    3IE3    3KM6    3KMN    3KMO    3N9J    3PGT    4GSS    4PGT    5GSS    6GSS    7GSS    8GSS    9GSS   
Structural Biology KnowledgeBase10GS    11GS    12GS    13GS    14GS    16GS    17GS    18GS    19GS    1AQV    1AQW    1AQX    1EOG    1EOH    1GSS    1KBN    1LBK    1MD3    1MD4    1PGT    1PX6    1PX7    1ZGN    20GS    22GS    2A2R    2A2S    2GSS    2J9H    2PGT    3CSH    3CSI    3CSJ    3DD3    3DGQ    3GSS    3GUS    3HJM    3HJO    3HKR    3IE3    3KM6    3KMN    3KMO    3N9J    3PGT    4GSS    4PGT    5GSS    6GSS    7GSS    8GSS    9GSS   
SCOP (Structural Classification of Proteins)10GS    11GS    12GS    13GS    14GS    16GS    17GS    18GS    19GS    1AQV    1AQW    1AQX    1EOG    1EOH    1GSS    1KBN    1LBK    1MD3    1MD4    1PGT    1PX6    1PX7    1ZGN    20GS    22GS    2A2R    2A2S    2GSS    2J9H    2PGT    3CSH    3CSI    3CSJ    3DD3    3DGQ    3GSS    3GUS    3HJM    3HJO    3HKR    3IE3    3KM6    3KMN    3KMO    3N9J    3PGT    4GSS    4PGT    5GSS    6GSS    7GSS    8GSS    9GSS   
CATH (Classification of proteins structures)10GS    11GS    12GS    13GS    14GS    16GS    17GS    18GS    19GS    1AQV    1AQW    1AQX    1EOG    1EOH    1GSS    1KBN    1LBK    1MD3    1MD4    1PGT    1PX6    1PX7    1ZGN    20GS    22GS    2A2R    2A2S    2GSS    2J9H    2PGT    3CSH    3CSI    3CSJ    3DD3    3DGQ    3GSS    3GUS    3HJM    3HJO    3HKR    3IE3    3KM6    3KMN    3KMO    3N9J    3PGT    4GSS    4PGT    5GSS    6GSS    7GSS    8GSS    9GSS   
SuperfamilyP09211
Human Protein AtlasENSG00000084207
Peptide AtlasP09211
HPRD00614
IPIIPI00219757   IPI00793319   
Protein Interaction databases
DIP (DOE-UCLA)P09211
IntAct (EBI)P09211
FunCoupENSG00000084207
BioGRIDGSTP1
STRING (EMBL)GSTP1
ZODIACGSTP1
Ontologies - Pathways
QuickGOP09211
Ontology : AmiGOresponse to reactive oxygen species  response to reactive oxygen species  negative regulation of acute inflammatory response  glutathione transferase activity  glutathione transferase activity  protein binding  extracellular space  intracellular  nucleus  cytoplasm  cytoplasm  mitochondrion  cytosol  plasma membrane  negative regulation of protein kinase activity  glutathione metabolic process  xenobiotic metabolic process  central nervous system development  drug binding  JUN kinase binding  response to toxic substance  negative regulation of biosynthetic process  negative regulation of tumor necrosis factor-mediated signaling pathway  oligodendrocyte development  kinase regulator activity  organ regeneration  vesicle  response to estradiol  negative regulation of interleukin-1 beta production  negative regulation of tumor necrosis factor production  cellular response to insulin stimulus  regulation of stress-activated MAPK cascade  negative regulation of stress-activated MAPK cascade  positive regulation of superoxide anion generation  response to L-ascorbic acid  common myeloid progenitor cell proliferation  S-nitrosoglutathione binding  dinitrosyl-iron complex binding  nitric oxide storage  negative regulation of apoptotic process  negative regulation of I-kappaB kinase/NF-kappaB signaling  response to amino acid  glutathione binding  negative regulation of MAP kinase activity  negative regulation of MAPK cascade  negative regulation of JUN kinase activity  response to ethanol  response to mercury ion  negative regulation of fibroblast proliferation  negative regulation of nitric-oxide synthase biosynthetic process  nitric oxide binding  extracellular exosome  regulation of ERK1 and ERK2 cascade  negative regulation of ERK1 and ERK2 cascade  negative regulation of leukocyte proliferation  cellular response to lipopolysaccharide  cellular response to epidermal growth factor stimulus  cellular response to glucocorticoid stimulus  cellular response to cell-matrix adhesion  negative regulation of monocyte chemotactic protein-1 production  TRAF2-GSTP1 complex  glutathione derivative biosynthetic process  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBIresponse to reactive oxygen species  response to reactive oxygen species  negative regulation of acute inflammatory response  glutathione transferase activity  glutathione transferase activity  protein binding  extracellular space  intracellular  nucleus  cytoplasm  cytoplasm  mitochondrion  cytosol  plasma membrane  negative regulation of protein kinase activity  glutathione metabolic process  xenobiotic metabolic process  central nervous system development  drug binding  JUN kinase binding  response to toxic substance  negative regulation of biosynthetic process  negative regulation of tumor necrosis factor-mediated signaling pathway  oligodendrocyte development  kinase regulator activity  organ regeneration  vesicle  response to estradiol  negative regulation of interleukin-1 beta production  negative regulation of tumor necrosis factor production  cellular response to insulin stimulus  regulation of stress-activated MAPK cascade  negative regulation of stress-activated MAPK cascade  positive regulation of superoxide anion generation  response to L-ascorbic acid  common myeloid progenitor cell proliferation  S-nitrosoglutathione binding  dinitrosyl-iron complex binding  nitric oxide storage  negative regulation of apoptotic process  negative regulation of I-kappaB kinase/NF-kappaB signaling  response to amino acid  glutathione binding  negative regulation of MAP kinase activity  negative regulation of MAPK cascade  negative regulation of JUN kinase activity  response to ethanol  response to mercury ion  negative regulation of fibroblast proliferation  negative regulation of nitric-oxide synthase biosynthetic process  nitric oxide binding  extracellular exosome  regulation of ERK1 and ERK2 cascade  negative regulation of ERK1 and ERK2 cascade  negative regulation of leukocyte proliferation  cellular response to lipopolysaccharide  cellular response to epidermal growth factor stimulus  cellular response to glucocorticoid stimulus  cellular response to cell-matrix adhesion  negative regulation of monocyte chemotactic protein-1 production  TRAF2-GSTP1 complex  glutathione derivative biosynthetic process  negative regulation of extrinsic apoptotic signaling pathway  
Pathways : BIOCARTAMulti-Drug Resistance Factors [Genes]   
Pathways : KEGGGlutathione metabolism    Metabolism of xenobiotics by cytochrome P450    Drug metabolism - cytochrome P450    Pathways in cancer    Chemical carcinogenesis    Prostate cancer   
NDEx NetworkGSTP1
Atlas of Cancer Signalling NetworkGSTP1
Wikipedia pathwaysGSTP1
Orthology - Evolution
OrthoDB2950
GeneTree (enSembl)ENSG00000084207
Phylogenetic Trees/Animal Genes : TreeFamGSTP1
HOVERGENP09211
HOGENOMP09211
Homologs : HomoloGeneGSTP1
Homology/Alignments : Family Browser (UCSC)GSTP1
Gene fusions - Rearrangements
Fusion : MitelmanGSTP1/ATP5G3 [11q13.2/2q31.1]  
Fusion : MitelmanGSTP1/SF3B2 [11q13.2/11q13.1]  [t(11;11)(q13;q13)]  
Fusion: TCGAGSTP1 11q13.2 ATP5G3 2q31.1 HNSC
Fusion: TCGAGSTP1 11q13.2 SF3B2 11q13.1 SKCM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGSTP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GSTP1
dbVarGSTP1
ClinVarGSTP1
1000_GenomesGSTP1 
Exome Variant ServerGSTP1
ExAC (Exome Aggregation Consortium)GSTP1 (select the gene name)
Genetic variants : HAPMAP2950
Genomic Variants (DGV)GSTP1 [DGVbeta]
DECIPHER (Syndromes)11:67351066-67354124  ENSG00000084207
CONAN: Copy Number AnalysisGSTP1 
Mutations
ICGC Data PortalGSTP1 
TCGA Data PortalGSTP1 
Broad Tumor PortalGSTP1
OASIS PortalGSTP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGSTP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGSTP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GSTP1
DgiDB (Drug Gene Interaction Database)GSTP1
DoCM (Curated mutations)GSTP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GSTP1 (select a term)
intoGenGSTP1
Cancer3DGSTP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM134660   
Orphanet
MedgenGSTP1
Genetic Testing Registry GSTP1
NextProtP09211 [Medical]
TSGene2950
GENETestsGSTP1
Huge Navigator GSTP1 [HugePedia]
snp3D : Map Gene to Disease2950
BioCentury BCIQGSTP1
ClinGenGSTP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2950
Chemical/Pharm GKB GenePA29028
Clinical trialGSTP1
Miscellaneous
canSAR (ICR)GSTP1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGSTP1
EVEXGSTP1
GoPubMedGSTP1
iHOPGSTP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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