GSTP1 (glutathione S-transferase pi 1)

2003-02-01  

Identity

HGNC
GSTP1
LOCATION
11q13.2
LOCUSID
2950
ALIAS
DFN7,FAEES3,GST3,GSTP,HEL-S-22,PI
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2950
MIM: 134660
HGNC: 4638
Ensembl: ENSG00000084207

Variants:

dbSNP: 2950
ClinVar: 2950
TCGA: ENSG00000084207
COSMIC: GSTP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000084207ENST00000398603A8MX94
ENSG00000084207ENST00000398606P09211
ENSG00000084207ENST00000398606V9HWE9
ENSG00000084207ENST00000495996A0A087X243
ENSG00000084207ENST00000498765A0A087X2E9
ENSG00000084207ENST00000646888A0A2R8Y5E5

Expression (GTEx)

0
500
1000
1500
2000
2500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Metabolism of xenobiotics by cytochrome P450KEGGko00980
Drug metabolism - cytochrome P450KEGGko00982
Prostate cancerKEGGko05215
Glutathione metabolismKEGGhsa00480
Metabolism of xenobiotics by cytochrome P450KEGGhsa00980
Drug metabolism - cytochrome P450KEGGhsa00982
Pathways in cancerKEGGhsa05200
Prostate cancerKEGGhsa05215
Chemical carcinogenesisKEGGhsa05204
Chemical carcinogenesisKEGGko05204
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Neutrophil degranulationREACTOMER-HSA-6798695
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotation, VariantAnnotationassociatedPD18540691, 21449681, 27995989
PA131285527oxaliplatinChemicalClinicalAnnotation, VariantAnnotation, VipGeneassociatedPKPD11307147, 11751440, 12435115, 15093273, 16707601, 17401013, 17409936, 9498276, 10728587, 15213713, 16707601, 17401013, 17409936, 19203783, 20530282, 21449681, 22188361, 27995989
PA150595617platinumChemicalMultilinkAnnotationassociated27462924
PA162263534OtotoxicityDiseaseClinicalAnnotationassociatedPD31666714
PA164713176Platinum compoundsChemicalClinicalAnnotationassociatedPKPD15213713, 16707601, 17401013, 17409936, 19203783, 20530282, 22188361, 27995989
PA166119041drug-induced liver injuryDiseaseClinicalAnnotationassociatedPD25798582, 27281183, 29036176
PA166152838dimethyl fumarateChemicalClinicalAnnotationassociatedPD26967570
PA166154249rs1695VariantVipGeneassociated11307147, 11751440, 12435115, 15093273, 16707601, 17401013, 17409936, 9498276, 10728587
PA166154320rs1138272VariantVipGeneassociated9498276
PA443560Breast NeoplasmsDiseaseClinicalAnnotationassociatedPD20568049, 21362365, 25008867
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPKPD15213713, 16707601, 17401013, 17409936, 19203783, 20530282, 22188361, 27995989
PA444257Gastrointestinal NeoplasmsDiseaseClinicalAnnotationassociatedPKPD15213713, 16707601, 17401013, 17409936, 19203783, 20530282, 22188361, 27995989
PA444614InfectionDiseaseClinicalAnnotationassociatedPD
PA444898MedulloblastomaDiseaseClinicalAnnotationassociatedPD31666714
PA445048NauseaDiseaseClinicalAnnotationassociatedPD
PA445062NeoplasmsDiseaseClinicalAnnotationassociatedPKPD15213713, 17409936, 19203783, 22188361, 25592234, 27995989, 31666714
PA445113NeutropeniaDiseaseVipGeneassociated11307147, 11751440, 12435115, 15093273, 16707601, 17401013, 17409936, 9498276, 10728587
PA445204Ovarian NeoplasmsDiseaseClinicalAnnotationassociatedPKPD15213713, 16707601, 17401013, 17409936, 19203783, 19786980, 20530282, 22188361, 27995989
PA445451PsoriasisDiseaseClinicalAnnotationassociatedPD26967570
PA445503Rectal NeoplasmsDiseaseClinicalAnnotationassociatedPD18540691
PA445828Testicular NeoplasmsDiseaseClinicalAnnotationassociatedPD31666714
PA445941TuberculosisDiseaseClinicalAnnotationassociatedPD25798582, 27281183, 29036176
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotation, VariantAnnotationassociatedPKPD15213713, 16707601, 17401013, 17409936, 19203783, 20530282, 22188361, 27995989
PA446155Precursor Cell Lymphoblastic Leukemia-LymphomaDiseaseClinicalAnnotation, VariantAnnotationambiguousPD17180579, 17264302
PA448515azathioprineChemicalMultilinkAnnotationnot associated23787247
PA448645bleomycinChemicalClinicalAnnotationassociatedPD
PA448691busulfanChemicalPathwayassociated
PA449014cisplatinChemicalClinicalAnnotation, VipGeneassociatedPKPD15254763, 17409936, 19786980, 22188361, 25592234, 31666714
PA449165cyclophosphamideChemicalClinicalAnnotation, VipGeneassociatedPKPD19786980, 20568049, 21362365, 22188361, 25008867
PA449212daunorubicinChemicalMultilinkAnnotationassociated25119182
PA449412doxorubicinChemicalClinicalAnnotation, VipGeneassociatedPD11351295
PA449476epirubicinChemicalClinicalAnnotationassociatedPD20568049, 21362365, 25008867
PA449552etoposideChemicalClinicalAnnotation, VipGeneassociatedPD12969965
PA450112isoniazidChemicalClinicalAnnotationassociatedPD25798582, 27281183, 29036176
PA450198leucovorinChemicalVariantAnnotationassociatedPD
PA450428methotrexateChemicalClinicalAnnotation, VariantAnnotationambiguousPD17180579, 17264302
PA451193pyrimethamineChemicalVipGeneassociated11807801
PA451250rifampinChemicalClinicalAnnotationassociatedPD25798582, 27281183, 29036176
PA451668thiotepaChemicalClinicalAnnotationassociated

References

Pubmed IDYearTitleCitations
381780552024Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children.0
383871442024Involvement of GSTP1 in low dose radiation-induced apoptosis in GM12878 cells.0
384101402024GSTP1 rs4147581 C>G and NLRP3 rs3806265 T>C as Risk Factors for Chronic Obstructive Pulmonary Disease: A Case-Control Study.0
384190252024Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study.0
384289502024Ile105Val polymorphism in the GSTP1 gene is associated with susceptibility to acute myeloid leukemia: an updated systematic review and meta-analysis.0
384792222024GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway.0
384933152024Diagnostic Value of GSTP1, RASSF1, AND RASSF2 Methylation in Serum of Prostate Cancer Patients.0
387890862024Subcellular distribution and Nrf2/Keap1-interacting properties of Glutathione S-transferase P in hepatocellular carcinoma.0
381780552024Factors associated with blood mercury concentrations and their interactions with three glutathione S-transferase genes (GSTT1, GSTM1, and GSTP1): an exposure assessment study of typically developing Jamaican children.0
383871442024Involvement of GSTP1 in low dose radiation-induced apoptosis in GM12878 cells.0
384101402024GSTP1 rs4147581 C>G and NLRP3 rs3806265 T>C as Risk Factors for Chronic Obstructive Pulmonary Disease: A Case-Control Study.0
384190252024Glutathione S-transferase M1, T1, and P1 polymorphisms and periodontitis in a Caucasian population: a case-control study.0
384289502024Ile105Val polymorphism in the GSTP1 gene is associated with susceptibility to acute myeloid leukemia: an updated systematic review and meta-analysis.0
384792222024GSTP alleviates acute lung injury by S-glutathionylation of KEAP1 and subsequent activation of NRF2 pathway.0
384933152024Diagnostic Value of GSTP1, RASSF1, AND RASSF2 Methylation in Serum of Prostate Cancer Patients.0

Citation

Dessen P

GSTP1 (glutathione S-transferase pi 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40773/gstp1