GSTP1 (glutathione S-transferase pi 1)

2003-02-01 Affiliation

Identity

HGNC

GSTP1

LOCATION

11q13.2

LOCUSID

2950

ALIAS

DFN7,FAEES3,GST3,GSTP,HEL-S-22,PI

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2950
MIM: 134660
HGNC: 4638
Ensembl: ENSG00000084207

Variants:

dbSNP: 2950
ClinVar: 2950
TCGA: ENSG00000084207
COSMIC: GSTP1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000084207	ENST00000398603	A8MX94
ENSG00000084207	ENST00000398606	P09211
ENSG00000084207	ENST00000398606	V9HWE9
ENSG00000084207	ENST00000495996	A0A087X243
ENSG00000084207	ENST00000498765	A0A087X2E9
ENSG00000084207	ENST00000646888	A0A2R8Y5E5

Expression (GTEx)

500

1000

1500

2000

2500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glutathione metabolism	KEGG	ko00480
Metabolism of xenobiotics by cytochrome P450	KEGG	ko00980
Drug metabolism - cytochrome P450	KEGG	ko00982
Prostate cancer	KEGG	ko05215
Glutathione metabolism	KEGG	hsa00480
Metabolism of xenobiotics by cytochrome P450	KEGG	hsa00980
Drug metabolism - cytochrome P450	KEGG	hsa00982
Pathways in cancer	KEGG	hsa05200
Prostate cancer	KEGG	hsa05215
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Metabolism	REACTOME	R-HSA-1430728
Biological oxidations	REACTOME	R-HSA-211859
Phase II conjugation	REACTOME	R-HSA-156580
Glutathione conjugation	REACTOME	R-HSA-156590
Cellular responses to stress	REACTOME	R-HSA-2262752
Detoxification of Reactive Oxygen Species	REACTOME	R-HSA-3299685
Platinum drug resistance	KEGG	ko01524
Platinum drug resistance	KEGG	hsa01524
Neutrophil degranulation	REACTOME	R-HSA-6798695
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA128406956	fluorouracil	Chemical	ClinicalAnnotation, VariantAnnotation	associated		PD	18540691, 21449681, 27995989
PA131285527	oxaliplatin	Chemical	ClinicalAnnotation, VariantAnnotation, VipGene	associated	PK	PD	11307147, 11751440, 12435115, 15093273, 16707601, 17401013, 17409936, 9498276, 10728587, 15213713, 16707601, 17401013, 17409936, 19203783, 20530282, 21449681, 22188361, 27995989
PA150595617	platinum	Chemical	MultilinkAnnotation	associated			27462924
PA162263534	Ototoxicity	Disease	ClinicalAnnotation	associated		PD	31666714
PA164713176	Platinum compounds	Chemical	ClinicalAnnotation	associated	PK	PD	15213713, 16707601, 17401013, 17409936, 19203783, 20530282, 22188361, 27995989
PA166119041	drug-induced liver injury	Disease	ClinicalAnnotation	associated		PD	25798582, 27281183, 29036176
PA166152838	dimethyl fumarate	Chemical	ClinicalAnnotation	associated		PD	26967570
PA166154249	rs1695	Variant	VipGene	associated			11307147, 11751440, 12435115, 15093273, 16707601, 17401013, 17409936, 9498276, 10728587
PA166154320	rs1138272	Variant	VipGene	associated			9498276
PA443560	Breast Neoplasms	Disease	ClinicalAnnotation	associated		PD	20568049, 21362365, 25008867
PA443622	Carcinoma, Non-Small-Cell Lung	Disease	ClinicalAnnotation	associated	PK	PD	15213713, 16707601, 17401013, 17409936, 19203783, 20530282, 22188361, 27995989
PA444257	Gastrointestinal Neoplasms	Disease	ClinicalAnnotation	associated	PK	PD	15213713, 16707601, 17401013, 17409936, 19203783, 20530282, 22188361, 27995989
PA444614	Infection	Disease	ClinicalAnnotation	associated		PD
PA444898	Medulloblastoma	Disease	ClinicalAnnotation	associated		PD	31666714
PA445048	Nausea	Disease	ClinicalAnnotation	associated		PD
PA445062	Neoplasms	Disease	ClinicalAnnotation	associated	PK	PD	15213713, 17409936, 19203783, 22188361, 25592234, 27995989, 31666714
PA445113	Neutropenia	Disease	VipGene	associated			11307147, 11751440, 12435115, 15093273, 16707601, 17401013, 17409936, 9498276, 10728587
PA445204	Ovarian Neoplasms	Disease	ClinicalAnnotation	associated	PK	PD	15213713, 16707601, 17401013, 17409936, 19203783, 19786980, 20530282, 22188361, 27995989
PA445451	Psoriasis	Disease	ClinicalAnnotation	associated		PD	26967570
PA445503	Rectal Neoplasms	Disease	ClinicalAnnotation	associated		PD	18540691
PA445828	Testicular Neoplasms	Disease	ClinicalAnnotation	associated		PD	31666714
PA445941	Tuberculosis	Disease	ClinicalAnnotation	associated		PD	25798582, 27281183, 29036176
PA446108	Colorectal Neoplasms	Disease	ClinicalAnnotation, VariantAnnotation	associated	PK	PD	15213713, 16707601, 17401013, 17409936, 19203783, 20530282, 22188361, 27995989
PA446155	Precursor Cell Lymphoblastic Leukemia-Lymphoma	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	17180579, 17264302
PA448515	azathioprine	Chemical	MultilinkAnnotation	not associated			23787247
PA448645	bleomycin	Chemical	ClinicalAnnotation	associated		PD
PA448691	busulfan	Chemical	Pathway	associated
PA449014	cisplatin	Chemical	ClinicalAnnotation, VipGene	associated	PK	PD	15254763, 17409936, 19786980, 22188361, 25592234, 31666714
PA449165	cyclophosphamide	Chemical	ClinicalAnnotation, VipGene	associated	PK	PD	19786980, 20568049, 21362365, 22188361, 25008867
PA449212	daunorubicin	Chemical	MultilinkAnnotation	associated			25119182
PA449412	doxorubicin	Chemical	ClinicalAnnotation, VipGene	associated		PD	11351295
PA449476	epirubicin	Chemical	ClinicalAnnotation	associated		PD	20568049, 21362365, 25008867
PA449552	etoposide	Chemical	ClinicalAnnotation, VipGene	associated		PD	12969965
PA450112	isoniazid	Chemical	ClinicalAnnotation	associated		PD	25798582, 27281183, 29036176
PA450198	leucovorin	Chemical	VariantAnnotation	associated		PD
PA450428	methotrexate	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	17180579, 17264302
PA451193	pyrimethamine	Chemical	VipGene	associated			11807801
PA451250	rifampin	Chemical	ClinicalAnnotation	associated		PD	25798582, 27281183, 29036176
PA451668	thiotepa	Chemical	ClinicalAnnotation	associated

References

Pubmed ID	Year	Title	Citations
19498054	2009	Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation.	230
19498054	2009	Prenatal tobacco smoke exposure affects global and gene-specific DNA methylation.	230
16112301	2005	NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.	174
11751440	2001	Metabolic gene polymorphism frequencies in control populations.	157
18990698	2009	Novel role for glutathione S-transferase pi. Regulator of protein S-Glutathionylation following oxidative and nitrosative stress.	106
18509181	2008	Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial.	96
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15746160	2005	Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer.	83
14726165	2004	Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study.	82
17401013	2007	Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFOX-4 chemotherapy.	77

Citation

Dessen P

GSTP1 (glutathione S-transferase pi 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/40773/gstp1