Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GTF2A2 (general transcription factor IIA, 2, 12kDa)

Identity

Alias_namesgeneral transcription factor IIA, 2 (12kD subunit)
general transcription factor IIA, 2, 12kDa
general transcription factor IIA 2
Alias_symbol (synonym)TFIIA
HsT18745
Other aliasTF2A2
HGNC (Hugo) GTF2A2
LocusID (NCBI) 2958
Atlas_Id 64084
Location 15q22.2  [Link to chromosome band 15q22]
Location_base_pair Starts at 59930261 and ends at 59949737 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CCDC97 (19q13.2) / GTF2A2 (15q22.2)GTF2A2 (15q22.2) / LDB3 (10q23.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GTF2A2   4647
Cards
Entrez_Gene (NCBI)GTF2A2  2958  general transcription factor IIA, 2, 12kDa
AliasesHsT18745; TF2A2; TFIIA
GeneCards (Weizmann)GTF2A2
Ensembl hg19 (Hinxton)ENSG00000140307 [Gene_View]  chr15:59930261-59949737 [Contig_View]  GTF2A2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000140307 [Gene_View]  chr15:59930261-59949737 [Contig_View]  GTF2A2 [Vega]
ICGC DataPortalENSG00000140307
TCGA cBioPortalGTF2A2
AceView (NCBI)GTF2A2
Genatlas (Paris)GTF2A2
WikiGenes2958
SOURCE (Princeton)GTF2A2
Genetics Home Reference (NIH)GTF2A2
Genomic and cartography
GoldenPath hg19 (UCSC)GTF2A2  -     chr15:59930261-59949737 -  15q22.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GTF2A2  -     15q22.2   [Description]    (hg38-Dec_2013)
EnsemblGTF2A2 - 15q22.2 [CytoView hg19]  GTF2A2 - 15q22.2 [CytoView hg38]
Mapping of homologs : NCBIGTF2A2 [Mapview hg19]  GTF2A2 [Mapview hg38]
OMIM600519   
Gene and transcription
Genbank (Entrez)AK312015 BC000287 BC001919 BT007362 CR542192
RefSeq transcript (Entrez)NM_004492
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)GTF2A2
Cluster EST : UnigeneHs.512934 [ NCBI ]
CGAP (NCI)Hs.512934
Alternative Splicing GalleryENSG00000140307
Gene ExpressionGTF2A2 [ NCBI-GEO ]   GTF2A2 [ EBI - ARRAY_EXPRESS ]   GTF2A2 [ SEEK ]   GTF2A2 [ MEM ]
Gene Expression Viewer (FireBrowse)GTF2A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2958
GTEX Portal (Tissue expression)GTF2A2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52657   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52657  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52657
Splice isoforms : SwissVarP52657
PhosPhoSitePlusP52657
Domains : Interpro (EBI)TFIIA_a-hlx    TFIIA_b-brl    TFIIA_gsu    TFIIA_gsu_C    TFIIA_gsu_N   
Domain families : Pfam (Sanger)TFIIA_gamma_C (PF02751)    TFIIA_gamma_N (PF02268)   
Domain families : Pfam (NCBI)pfam02751    pfam02268   
Domain structure : Prodom (Prabi Lyon)TFIIA_gsu_N (PD009224)   
Conserved Domain (NCBI)GTF2A2
DMDM Disease mutations2958
Blocks (Seattle)GTF2A2
PDB (SRS)1NVP   
PDB (PDBSum)1NVP   
PDB (IMB)1NVP   
PDB (RSDB)1NVP   
Structural Biology KnowledgeBase1NVP   
SCOP (Structural Classification of Proteins)1NVP   
CATH (Classification of proteins structures)1NVP   
SuperfamilyP52657
Human Protein AtlasENSG00000140307
Peptide AtlasP52657
HPRD02747
IPIIPI00004353   IPI00793076   IPI00795283   
Protein Interaction databases
DIP (DOE-UCLA)P52657
IntAct (EBI)P52657
FunCoupENSG00000140307
BioGRIDGTF2A2
STRING (EMBL)GTF2A2
ZODIACGTF2A2
Ontologies - Pathways
QuickGOP52657
Ontology : AmiGORNA polymerase II repressing transcription factor binding  transcription coactivator activity  protein binding  nucleoplasm  nucleoplasm  transcription factor TFIIA complex  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  transcription factor binding  gene expression  viral process  TBP-class protein binding  cell junction  protein homodimerization activity  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  positive regulation of sequence-specific DNA binding transcription factor activity  RNA polymerase II transcriptional preinitiation complex assembly  
Ontology : EGO-EBIRNA polymerase II repressing transcription factor binding  transcription coactivator activity  protein binding  nucleoplasm  nucleoplasm  transcription factor TFIIA complex  transcription from RNA polymerase II promoter  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  transcription factor binding  gene expression  viral process  TBP-class protein binding  cell junction  protein homodimerization activity  positive regulation of transcription from RNA polymerase II promoter  protein heterodimerization activity  positive regulation of sequence-specific DNA binding transcription factor activity  RNA polymerase II transcriptional preinitiation complex assembly  
Pathways : KEGGBasal transcription factors    Viral carcinogenesis   
NDEx NetworkGTF2A2
Atlas of Cancer Signalling NetworkGTF2A2
Wikipedia pathwaysGTF2A2
Orthology - Evolution
OrthoDB2958
GeneTree (enSembl)ENSG00000140307
Phylogenetic Trees/Animal Genes : TreeFamGTF2A2
HOVERGENP52657
HOGENOMP52657
Homologs : HomoloGeneGTF2A2
Homology/Alignments : Family Browser (UCSC)GTF2A2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGTF2A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GTF2A2
dbVarGTF2A2
ClinVarGTF2A2
1000_GenomesGTF2A2 
Exome Variant ServerGTF2A2
ExAC (Exome Aggregation Consortium)GTF2A2 (select the gene name)
Genetic variants : HAPMAP2958
Genomic Variants (DGV)GTF2A2 [DGVbeta]
DECIPHER (Syndromes)15:59930261-59949737  ENSG00000140307
CONAN: Copy Number AnalysisGTF2A2 
Mutations
ICGC Data PortalGTF2A2 
TCGA Data PortalGTF2A2 
Broad Tumor PortalGTF2A2
OASIS PortalGTF2A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGTF2A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGTF2A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GTF2A2
DgiDB (Drug Gene Interaction Database)GTF2A2
DoCM (Curated mutations)GTF2A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GTF2A2 (select a term)
intoGenGTF2A2
Cancer3DGTF2A2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600519   
Orphanet
MedgenGTF2A2
Genetic Testing Registry GTF2A2
NextProtP52657 [Medical]
TSGene2958
GENETestsGTF2A2
Huge Navigator GTF2A2 [HugePedia]
snp3D : Map Gene to Disease2958
BioCentury BCIQGTF2A2
ClinGenGTF2A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2958
Chemical/Pharm GKB GenePA29034
Clinical trialGTF2A2
Miscellaneous
canSAR (ICR)GTF2A2 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGTF2A2
EVEXGTF2A2
GoPubMedGTF2A2
iHOPGTF2A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:07:05 CET 2017

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