Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GTF2B (general transcription factor IIB)

Identity

Alias_symbol (synonym)TFIIB
Other aliasTF2B
HGNC (Hugo) GTF2B
LocusID (NCBI) 2959
Atlas_Id 56142
Location 1p22.2  [Link to chromosome band 1p22]
Location_base_pair Starts at 88852638 and ends at 88891618 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CAMK2A (5q32) / GTF2B (1p22.2)GTF2B (1p22.2) / BPI (20q11.23)GTF2B (1p22.2) / CCBL2 (1p22.2)
GTF2B (1p22.2) / MUTYH (1p34.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GTF2B   4648
Cards
Entrez_Gene (NCBI)GTF2B  2959  general transcription factor IIB
AliasesTF2B; TFIIB
GeneCards (Weizmann)GTF2B
Ensembl hg19 (Hinxton)ENSG00000137947 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000137947 [Gene_View]  chr1:88852638-88891618 [Contig_View]  GTF2B [Vega]
ICGC DataPortalENSG00000137947
TCGA cBioPortalGTF2B
AceView (NCBI)GTF2B
Genatlas (Paris)GTF2B
WikiGenes2959
SOURCE (Princeton)GTF2B
Genetics Home Reference (NIH)GTF2B
Genomic and cartography
GoldenPath hg38 (UCSC)GTF2B  -     chr1:88852638-88891618 -  1p22.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GTF2B  -     1p22.2   [Description]    (hg19-Feb_2009)
EnsemblGTF2B - 1p22.2 [CytoView hg19]  GTF2B - 1p22.2 [CytoView hg38]
Mapping of homologs : NCBIGTF2B [Mapview hg19]  GTF2B [Mapview hg38]
OMIM189963   
Gene and transcription
Genbank (Entrez)AA031701 AB451296 AI457606 AK289822 BC020597
RefSeq transcript (Entrez)NM_001514
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GTF2B
Cluster EST : UnigeneHs.481852 [ NCBI ]
CGAP (NCI)Hs.481852
Alternative Splicing GalleryENSG00000137947
Gene ExpressionGTF2B [ NCBI-GEO ]   GTF2B [ EBI - ARRAY_EXPRESS ]   GTF2B [ SEEK ]   GTF2B [ MEM ]
Gene Expression Viewer (FireBrowse)GTF2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2959
GTEX Portal (Tissue expression)GTF2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ00403   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ00403  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ00403
Splice isoforms : SwissVarQ00403
PhosPhoSitePlusQ00403
Domaine pattern : Prosite (Expaxy)TFIIB (PS00782)    ZF_TFIIB (PS51134)   
Domains : Interpro (EBI)Cyclin-like    TFIIB    TFIIB_CS    TFIIB_cyclin    Znf_TFIIB   
Domain families : Pfam (Sanger)TF_Zn_Ribbon (PF08271)    TFIIB (PF00382)   
Domain families : Pfam (NCBI)pfam08271    pfam00382   
Domain families : Smart (EMBL)CYCLIN (SM00385)  
Conserved Domain (NCBI)GTF2B
DMDM Disease mutations2959
Blocks (Seattle)GTF2B
PDB (SRS)1C9B    1DL6    1RLY    1RO4    1TFB    1VOL    2PHG    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (PDBSum)1C9B    1DL6    1RLY    1RO4    1TFB    1VOL    2PHG    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (IMB)1C9B    1DL6    1RLY    1RO4    1TFB    1VOL    2PHG    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (RSDB)1C9B    1DL6    1RLY    1RO4    1TFB    1VOL    2PHG    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
Structural Biology KnowledgeBase1C9B    1DL6    1RLY    1RO4    1TFB    1VOL    2PHG    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SCOP (Structural Classification of Proteins)1C9B    1DL6    1RLY    1RO4    1TFB    1VOL    2PHG    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
CATH (Classification of proteins structures)1C9B    1DL6    1RLY    1RO4    1TFB    1VOL    2PHG    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SuperfamilyQ00403
Human Protein AtlasENSG00000137947
Peptide AtlasQ00403
HPRD08928
IPIIPI00022820   IPI00643006   IPI00643469   
Protein Interaction databases
DIP (DOE-UCLA)Q00403
IntAct (EBI)Q00403
FunCoupENSG00000137947
BioGRIDGTF2B
STRING (EMBL)GTF2B
ZODIACGTF2B
Ontologies - Pathways
QuickGOQ00403
Ontology : AmiGOcore promoter binding  protein binding  nucleus  nucleoplasm  transcription factor TFIID complex  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  transcription factor binding  viral process  nuclear body  TBP-class protein binding  snRNA transcription from RNA polymerase II promoter  metal ion binding  thyroid hormone receptor binding  positive regulation of viral transcription  RNA polymerase II transcriptional preinitiation complex assembly  transcriptional preinitiation complex  positive regulation of core promoter binding  
Ontology : EGO-EBIcore promoter binding  protein binding  nucleus  nucleoplasm  transcription factor TFIID complex  regulation of transcription, DNA-templated  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  transcription factor binding  viral process  nuclear body  TBP-class protein binding  snRNA transcription from RNA polymerase II promoter  metal ion binding  thyroid hormone receptor binding  positive regulation of viral transcription  RNA polymerase II transcriptional preinitiation complex assembly  transcriptional preinitiation complex  positive regulation of core promoter binding  
Pathways : KEGGBasal transcription factors    Epstein-Barr virus infection    Viral carcinogenesis   
NDEx NetworkGTF2B
Atlas of Cancer Signalling NetworkGTF2B
Wikipedia pathwaysGTF2B
Orthology - Evolution
OrthoDB2959
GeneTree (enSembl)ENSG00000137947
Phylogenetic Trees/Animal Genes : TreeFamGTF2B
HOVERGENQ00403
HOGENOMQ00403
Homologs : HomoloGeneGTF2B
Homology/Alignments : Family Browser (UCSC)GTF2B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGTF2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GTF2B
dbVarGTF2B
ClinVarGTF2B
1000_GenomesGTF2B 
Exome Variant ServerGTF2B
ExAC (Exome Aggregation Consortium)GTF2B (select the gene name)
Genetic variants : HAPMAP2959
Genomic Variants (DGV)GTF2B [DGVbeta]
DECIPHERGTF2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGTF2B 
Mutations
ICGC Data PortalGTF2B 
TCGA Data PortalGTF2B 
Broad Tumor PortalGTF2B
OASIS PortalGTF2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGTF2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGTF2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GTF2B
DgiDB (Drug Gene Interaction Database)GTF2B
DoCM (Curated mutations)GTF2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GTF2B (select a term)
intoGenGTF2B
Cancer3DGTF2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM189963   
Orphanet
MedgenGTF2B
Genetic Testing Registry GTF2B
NextProtQ00403 [Medical]
TSGene2959
GENETestsGTF2B
Huge Navigator GTF2B [HugePedia]
snp3D : Map Gene to Disease2959
BioCentury BCIQGTF2B
ClinGenGTF2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2959
Chemical/Pharm GKB GenePA29035
Clinical trialGTF2B
Miscellaneous
canSAR (ICR)GTF2B (select the gene name)
Probes
Litterature
PubMed150 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGTF2B
EVEXGTF2B
GoPubMedGTF2B
iHOPGTF2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:18:09 CEST 2017

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