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GTF2F1 (general transcription factor IIF subunit 1)

Identity

Alias_namesgeneral transcription factor IIF, polypeptide 1 (74kD subunit)
general transcription factor IIF, polypeptide 1, 74kDa
Alias_symbol (synonym)TFIIF
BTF4
RAP74
TF2F1
Other alias
HGNC (Hugo) GTF2F1
LocusID (NCBI) 2962
Atlas_Id 40777
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 6379569 and ends at 6393280 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ACP5 (19p13.2) / GTF2F1 (19p13.3)GATS (7q22.1) / GTF2F1 (19p13.3)GTF2F1 (19p13.3) / ACP5 (19p13.2)
GTF2F1 (19p13.3) / PSPN (19p13.3)GTF2F1 (19p13.3) / S100A16 (1q21.3)GTF2F1 (19p13.3) / TCOF1 (5q32)
GTF2F1 (19p13.3) / TRBV20-1 ()KDM4B (19p13.3) / GTF2F1 (19p13.3)ACP5 19p13.2 / GTF2F1 19p13.3
GTF2F1 19p13.3 / ACP5 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GTF2F1   4652
Cards
Entrez_Gene (NCBI)GTF2F1  2962  general transcription factor IIF subunit 1
AliasesBTF4; RAP74; TF2F1; TFIIF
GeneCards (Weizmann)GTF2F1
Ensembl hg19 (Hinxton)ENSG00000125651 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125651 [Gene_View]  chr19:6379569-6393280 [Contig_View]  GTF2F1 [Vega]
ICGC DataPortalENSG00000125651
TCGA cBioPortalGTF2F1
AceView (NCBI)GTF2F1
Genatlas (Paris)GTF2F1
WikiGenes2962
SOURCE (Princeton)GTF2F1
Genetics Home Reference (NIH)GTF2F1
Genomic and cartography
GoldenPath hg38 (UCSC)GTF2F1  -     chr19:6379569-6393280 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GTF2F1  -     19p13.3   [Description]    (hg19-Feb_2009)
EnsemblGTF2F1 - 19p13.3 [CytoView hg19]  GTF2F1 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIGTF2F1 [Mapview hg19]  GTF2F1 [Mapview hg38]
OMIM189968   
Gene and transcription
Genbank (Entrez)AA323384 AK293124 AK302178 AK315240 BC000120
RefSeq transcript (Entrez)NM_002096
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GTF2F1
Cluster EST : UnigeneHs.68257 [ NCBI ]
CGAP (NCI)Hs.68257
Alternative Splicing GalleryENSG00000125651
Gene ExpressionGTF2F1 [ NCBI-GEO ]   GTF2F1 [ EBI - ARRAY_EXPRESS ]   GTF2F1 [ SEEK ]   GTF2F1 [ MEM ]
Gene Expression Viewer (FireBrowse)GTF2F1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2962
GTEX Portal (Tissue expression)GTF2F1
Human Protein AtlasENSG00000125651-GTF2F1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35269   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35269  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35269
Splice isoforms : SwissVarP35269
PhosPhoSitePlusP35269
Domains : Interpro (EBI)TFIIF-alpha    TFIIF_interaction    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)TFIIF_alpha (PF05793)   
Domain families : Pfam (NCBI)pfam05793   
Conserved Domain (NCBI)GTF2F1
DMDM Disease mutations2962
Blocks (Seattle)GTF2F1
PDB (SRS)1F3U    1I27    1J2X    1NHA    1ONV    2K7L    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (PDBSum)1F3U    1I27    1J2X    1NHA    1ONV    2K7L    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (IMB)1F3U    1I27    1J2X    1NHA    1ONV    2K7L    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (RSDB)1F3U    1I27    1J2X    1NHA    1ONV    2K7L    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
Structural Biology KnowledgeBase1F3U    1I27    1J2X    1NHA    1ONV    2K7L    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SCOP (Structural Classification of Proteins)1F3U    1I27    1J2X    1NHA    1ONV    2K7L    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
CATH (Classification of proteins structures)1F3U    1I27    1J2X    1NHA    1ONV    2K7L    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SuperfamilyP35269
Human Protein Atlas [tissue]ENSG00000125651-GTF2F1 [tissue]
Peptide AtlasP35269
HPRD01803
IPIIPI00017450   IPI00911069   IPI01010023   IPI01014438   
Protein Interaction databases
DIP (DOE-UCLA)P35269
IntAct (EBI)P35269
FunCoupENSG00000125651
BioGRIDGTF2F1
STRING (EMBL)GTF2F1
ZODIACGTF2F1
Ontologies - Pathways
QuickGOP35269
Ontology : AmiGOmRNA splicing, via spliceosome  DNA binding  transcription coactivator activity  RNA binding  catalytic activity  protein binding  nucleus  nucleus  nucleoplasm  transcription factor TFIID complex  transcription factor TFIIF complex  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  transcription factor binding  fibroblast growth factor receptor signaling pathway  response to virus  gene expression  phosphatase activator activity  protein phosphatase binding  protein domain specific binding  cell junction  positive regulation of transcription elongation from RNA polymerase II promoter  snRNA transcription from RNA polymerase II promoter  positive regulation of catalytic activity  intracellular membrane-bounded organelle  protein complex  positive regulation of viral transcription  
Ontology : EGO-EBImRNA splicing, via spliceosome  DNA binding  transcription coactivator activity  RNA binding  catalytic activity  protein binding  nucleus  nucleus  nucleoplasm  transcription factor TFIID complex  transcription factor TFIIF complex  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  transcription factor binding  fibroblast growth factor receptor signaling pathway  response to virus  gene expression  phosphatase activator activity  protein phosphatase binding  protein domain specific binding  cell junction  positive regulation of transcription elongation from RNA polymerase II promoter  snRNA transcription from RNA polymerase II promoter  positive regulation of catalytic activity  intracellular membrane-bounded organelle  protein complex  positive regulation of viral transcription  
Pathways : KEGGBasal transcription factors   
NDEx NetworkGTF2F1
Atlas of Cancer Signalling NetworkGTF2F1
Wikipedia pathwaysGTF2F1
Orthology - Evolution
OrthoDB2962
GeneTree (enSembl)ENSG00000125651
Phylogenetic Trees/Animal Genes : TreeFamGTF2F1
HOVERGENP35269
HOGENOMP35269
Homologs : HomoloGeneGTF2F1
Homology/Alignments : Family Browser (UCSC)GTF2F1
Gene fusions - Rearrangements
Fusion : MitelmanACP5/GTF2F1 [19p13.2/19p13.3]  [t(19;19)(p13;p13)]  
Fusion : MitelmanGTF2F1/ACP5 [19p13.3/19p13.2]  [t(19;19)(p13;p13)]  
Fusion: TCGAACP5 19p13.2 GTF2F1 19p13.3 SKCM
Fusion: TCGAGTF2F1 19p13.3 ACP5 19p13.2 SKCM
Fusion: Tumor Portal GTF2F1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGTF2F1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GTF2F1
dbVarGTF2F1
ClinVarGTF2F1
1000_GenomesGTF2F1 
Exome Variant ServerGTF2F1
ExAC (Exome Aggregation Consortium)ENSG00000125651
GNOMAD BrowserENSG00000125651
Genetic variants : HAPMAP2962
Genomic Variants (DGV)GTF2F1 [DGVbeta]
DECIPHERGTF2F1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGTF2F1 
Mutations
ICGC Data PortalGTF2F1 
TCGA Data PortalGTF2F1 
Broad Tumor PortalGTF2F1
OASIS PortalGTF2F1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGTF2F1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGTF2F1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GTF2F1
DgiDB (Drug Gene Interaction Database)GTF2F1
DoCM (Curated mutations)GTF2F1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GTF2F1 (select a term)
intoGenGTF2F1
Cancer3DGTF2F1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM189968   
Orphanet
MedgenGTF2F1
Genetic Testing Registry GTF2F1
NextProtP35269 [Medical]
TSGene2962
GENETestsGTF2F1
Target ValidationGTF2F1
Huge Navigator GTF2F1 [HugePedia]
snp3D : Map Gene to Disease2962
BioCentury BCIQGTF2F1
ClinGenGTF2F1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2962
Chemical/Pharm GKB GenePA29038
Clinical trialGTF2F1
Miscellaneous
canSAR (ICR)GTF2F1 (select the gene name)
Probes
Litterature
PubMed113 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGTF2F1
EVEXGTF2F1
GoPubMedGTF2F1
iHOPGTF2F1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 12:52:11 CET 2017

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