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GTF2F2 (general transcription factor IIF subunit 2)

Identity

Alias_namesgeneral transcription factor IIF, polypeptide 1 (74kD subunit)
general transcription factor IIF, polypeptide 2, 30kDa
Alias_symbol (synonym)TFIIF
BTF4
RAP30
Other aliasTF2F2
HGNC (Hugo) GTF2F2
LocusID (NCBI) 2963
Atlas_Id 64087
Location 13q14.12  [Link to chromosome band 13q14]
Location_base_pair Starts at 45120496 and ends at 45284104 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GPALPP1 (13q14.12) / GTF2F2 (13q14.12)GTF2F2 (13q14.12) / CTIF (18q21.1)GTF2F2 (13q14.12) / NBEA (13q13.3)
GTF2F2 (13q14.12) / NPIPB15 (16q23.1)GTF2F2 (13q14.12) / S100A3 (1q21.3)GTF2F2 (13q14.12) / S100A4 (1q21.3)
GTF2F2 (13q14.12) / SMAD9 (13q13.3)LRCH1 (13q14.13) / GTF2F2 (13q14.12)GTF2F2 S100A3
GTF2F2 S100A4GTF2F2 NBEAGTF2F2 CTIF

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GTF2F2   4653
Cards
Entrez_Gene (NCBI)GTF2F2  2963  general transcription factor IIF subunit 2
AliasesBTF4; RAP30; TF2F2; TFIIF
GeneCards (Weizmann)GTF2F2
Ensembl hg19 (Hinxton)ENSG00000188342 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000188342 [Gene_View]  chr13:45120496-45284104 [Contig_View]  GTF2F2 [Vega]
ICGC DataPortalENSG00000188342
TCGA cBioPortalGTF2F2
AceView (NCBI)GTF2F2
Genatlas (Paris)GTF2F2
WikiGenes2963
SOURCE (Princeton)GTF2F2
Genetics Home Reference (NIH)GTF2F2
Genomic and cartography
GoldenPath hg38 (UCSC)GTF2F2  -     chr13:45120496-45284104 +  13q14.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GTF2F2  -     13q14.12   [Description]    (hg19-Feb_2009)
EnsemblGTF2F2 - 13q14.12 [CytoView hg19]  GTF2F2 - 13q14.12 [CytoView hg38]
Mapping of homologs : NCBIGTF2F2 [Mapview hg19]  GTF2F2 [Mapview hg38]
OMIM189969   
Gene and transcription
Genbank (Entrez)AK291545 BC001771 BT019525 CA429230 CB124466
RefSeq transcript (Entrez)NM_004128
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GTF2F2
Cluster EST : UnigeneHs.654582 [ NCBI ]
CGAP (NCI)Hs.654582
Alternative Splicing GalleryENSG00000188342
Gene ExpressionGTF2F2 [ NCBI-GEO ]   GTF2F2 [ EBI - ARRAY_EXPRESS ]   GTF2F2 [ SEEK ]   GTF2F2 [ MEM ]
Gene Expression Viewer (FireBrowse)GTF2F2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2963
GTEX Portal (Tissue expression)GTF2F2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP13984   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP13984  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP13984
Splice isoforms : SwissVarP13984
Catalytic activity : Enzyme3.6.4.12 [ Enzyme-Expasy ]   3.6.4.123.6.4.12 [ IntEnz-EBI ]   3.6.4.12 [ BRENDA ]   3.6.4.12 [ KEGG ]   
PhosPhoSitePlusP13984
Domains : Interpro (EBI)TFIIF_beta    TFIIF_interaction    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)TFIIF_beta (PF02270)   
Domain families : Pfam (NCBI)pfam02270   
Conserved Domain (NCBI)GTF2F2
DMDM Disease mutations2963
Blocks (Seattle)GTF2F2
PDB (SRS)1BBY    1F3U    2BBY    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (PDBSum)1BBY    1F3U    2BBY    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (IMB)1BBY    1F3U    2BBY    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
PDB (RSDB)1BBY    1F3U    2BBY    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
Structural Biology KnowledgeBase1BBY    1F3U    2BBY    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SCOP (Structural Classification of Proteins)1BBY    1F3U    2BBY    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
CATH (Classification of proteins structures)1BBY    1F3U    2BBY    5IY6    5IY7    5IY8    5IY9    5IYA    5IYB    5IYC    5IYD   
SuperfamilyP13984
Human Protein AtlasENSG00000188342
Peptide AtlasP13984
HPRD01804
IPIIPI00477686   
Protein Interaction databases
DIP (DOE-UCLA)P13984
IntAct (EBI)P13984
FunCoupENSG00000188342
BioGRIDGTF2F2
STRING (EMBL)GTF2F2
ZODIACGTF2F2
Ontologies - Pathways
QuickGOP13984
Ontology : AmiGOmRNA splicing, via spliceosome  transcription factor activity, core RNA polymerase II binding  DNA binding  helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  transcription factor TFIIF complex  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  fibroblast growth factor receptor signaling pathway  gene expression  microtubule cytoskeleton  positive regulation of transcription elongation from RNA polymerase II promoter  snRNA transcription from RNA polymerase II promoter  positive regulation of viral transcription  positive regulation of transcription initiation from RNA polymerase II promoter  transcriptional preinitiation complex  
Ontology : EGO-EBImRNA splicing, via spliceosome  transcription factor activity, core RNA polymerase II binding  DNA binding  helicase activity  protein binding  ATP binding  nucleus  nucleoplasm  transcription factor TFIIF complex  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  transcription elongation from RNA polymerase II promoter  7-methylguanosine mRNA capping  fibroblast growth factor receptor signaling pathway  gene expression  microtubule cytoskeleton  positive regulation of transcription elongation from RNA polymerase II promoter  snRNA transcription from RNA polymerase II promoter  positive regulation of viral transcription  positive regulation of transcription initiation from RNA polymerase II promoter  transcriptional preinitiation complex  
Pathways : KEGGBasal transcription factors   
NDEx NetworkGTF2F2
Atlas of Cancer Signalling NetworkGTF2F2
Wikipedia pathwaysGTF2F2
Orthology - Evolution
OrthoDB2963
GeneTree (enSembl)ENSG00000188342
Phylogenetic Trees/Animal Genes : TreeFamGTF2F2
HOVERGENP13984
HOGENOMP13984
Homologs : HomoloGeneGTF2F2
Homology/Alignments : Family Browser (UCSC)GTF2F2
Gene fusions - Rearrangements
Fusion: TCGAGTF2F2 S100A3
Fusion: TCGAGTF2F2 S100A4
Fusion: TCGAGTF2F2 NBEA
Fusion: TCGAGTF2F2 CTIF
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGTF2F2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GTF2F2
dbVarGTF2F2
ClinVarGTF2F2
1000_GenomesGTF2F2 
Exome Variant ServerGTF2F2
ExAC (Exome Aggregation Consortium)GTF2F2 (select the gene name)
Genetic variants : HAPMAP2963
Genomic Variants (DGV)GTF2F2 [DGVbeta]
DECIPHERGTF2F2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGTF2F2 
Mutations
ICGC Data PortalGTF2F2 
TCGA Data PortalGTF2F2 
Broad Tumor PortalGTF2F2
OASIS PortalGTF2F2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGTF2F2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGTF2F2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GTF2F2
DgiDB (Drug Gene Interaction Database)GTF2F2
DoCM (Curated mutations)GTF2F2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GTF2F2 (select a term)
intoGenGTF2F2
Cancer3DGTF2F2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM189969   
Orphanet
MedgenGTF2F2
Genetic Testing Registry GTF2F2
NextProtP13984 [Medical]
TSGene2963
GENETestsGTF2F2
Target ValidationGTF2F2
Huge Navigator GTF2F2 [HugePedia]
snp3D : Map Gene to Disease2963
BioCentury BCIQGTF2F2
ClinGenGTF2F2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2963
Chemical/Pharm GKB GenePA29039
Clinical trialGTF2F2
Miscellaneous
canSAR (ICR)GTF2F2 (select the gene name)
Probes
Litterature
PubMed73 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGTF2F2
EVEXGTF2F2
GoPubMedGTF2F2
iHOPGTF2F2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:10:02 CEST 2017

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