GTF3C1 (general transcription factor IIIC subunit 1)

2014-11-01  

Identity

HGNC
GTF3C1
LOCATION
16p12.1
LOCUSID
2975
ALIAS
TFIIIC,TFIIIC220,TFIIICalpha
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2975
MIM: 603246
HGNC: 4664
Ensembl: ENSG00000077235

Variants:

dbSNP: 2975
ClinVar: 2975
TCGA: ENSG00000077235
COSMIC: GTF3C1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077235ENST00000356183Q12789
ENSG00000077235ENST00000561623Q12789
ENSG00000077235ENST00000564664H3BU55
ENSG00000077235ENST00000568569H3BRD0
ENSG00000077235ENST00000569653H3BU37
ENSG00000077235ENST00000571886I3L1Z3

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription InitiationREACTOMER-HSA-76046
RNA Polymerase III Transcription Initiation From Type 1 PromoterREACTOMER-HSA-76061
RNA Polymerase III Transcription Initiation From Type 2 PromoterREACTOMER-HSA-76066

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
205431382010mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1.81
239668772013Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories.29
174093852007Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC.20
186448732008Different functional modes of p300 in activation of RNA polymerase III transcription from chromatin templates.18
117419932002The activity of transcription factor IIIC1 is impaired during differentiation of F9 cells.3

Citation

Dessen P

GTF3C1 (general transcription factor IIIC subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64094/gtf3c1