Atlas of Genetics and Cytogenetics in Oncology and Haematology

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GTPBP4 (GTP binding protein 4)

Identity

Alias (NCBI)CRFG
NGB
NOG1
HGNC (Hugo) GTPBP4
HGNC Alias symbCRFG
NGB
FLJ10690
FLJ10686
NOG1
HGNC Alias nameG protein-binding protein CRFG
  GTP-binding protein
LocusID (NCBI) 23560
Atlas_Id 47627
Location 10p15.3  [Link to chromosome band 10p15]
Location_base_pair Starts at 988434 and ends at 1019930 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ANP32B (9q22.33) / GTPBP4 (10p15.3)ARHGAP8 (22q13.31) / GTPBP4 (10p15.3)GTPBP4 (10p15.3) / NIN (14q22.1)
MED13L (12q24.21) / GTPBP4 (10p15.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)GTPBP4   21535
Cards
Entrez_Gene (NCBI)GTPBP4    GTP binding protein 4
AliasesCRFG; NGB; NOG1
GeneCards (Weizmann)GTPBP4
Ensembl hg19 (Hinxton)ENSG00000107937 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107937 [Gene_View]  ENSG00000107937 [Sequence]  chr10:988434-1019930 [Contig_View]  GTPBP4 [Vega]
ICGC DataPortalENSG00000107937
TCGA cBioPortalGTPBP4
AceView (NCBI)GTPBP4
Genatlas (Paris)GTPBP4
SOURCE (Princeton)GTPBP4
Genetics Home Reference (NIH)GTPBP4
Genomic and cartography
GoldenPath hg38 (UCSC)GTPBP4  -     chr10:988434-1019930 +  10p15.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GTPBP4  -     10p15.3   [Description]    (hg19-Feb_2009)
GoldenPathGTPBP4 - 10p15.3 [CytoView hg19]  GTPBP4 - 10p15.3 [CytoView hg38]
ImmunoBaseENSG00000107937
Genome Data Viewer NCBIGTPBP4 [Mapview hg19]  
OMIM619169   
Gene and transcription
Genbank (Entrez)AF120334 AF325353 AI740474 AK001548 AK001552
RefSeq transcript (Entrez)NM_012341
Consensus coding sequences : CCDS (NCBI)GTPBP4
Gene ExpressionGTPBP4 [ NCBI-GEO ]   GTPBP4 [ EBI - ARRAY_EXPRESS ]   GTPBP4 [ SEEK ]   GTPBP4 [ MEM ]
Gene Expression Viewer (FireBrowse)GTPBP4 [ Firebrowse - Broad ]
GenevisibleExpression of GTPBP4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23560
GTEX Portal (Tissue expression)GTPBP4
Human Protein AtlasENSG00000107937-GTPBP4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BZE4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BZE4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BZE4
PhosPhoSitePlusQ9BZE4
Domaine pattern : Prosite (Expaxy)G_OBG (PS51710)   
Domains : Interpro (EBI)G_OBG    GTP-bd    NOG1    NOG1_N    NOG1_Rossman_fold_dom    NOG_C    P-loop_NTPase    Small_GTP-bd_dom   
Domain families : Pfam (Sanger)NOG1 (PF06858)    NOG1_N (PF17835)    NOGCT (PF08155)   
Domain families : Pfam (NCBI)pfam06858    pfam17835    pfam08155   
Conserved Domain (NCBI)GTPBP4
PDB (RSDB)6LSS    6LU8   
PDB Europe6LSS    6LU8   
PDB (PDBSum)6LSS    6LU8   
PDB (IMB)6LSS    6LU8   
Structural Biology KnowledgeBase6LSS    6LU8   
SCOP (Structural Classification of Proteins)6LSS    6LU8   
CATH (Classification of proteins structures)6LSS    6LU8   
SuperfamilyQ9BZE4
AlphaFold pdb e-kbQ9BZE4   
Human Protein Atlas [tissue]ENSG00000107937-GTPBP4 [tissue]
HPRD09976
Protein Interaction databases
DIP (DOE-UCLA)Q9BZE4
IntAct (EBI)Q9BZE4
BioGRIDGTPBP4
STRING (EMBL)GTPBP4
ZODIACGTPBP4
Ontologies - Pathways
QuickGOQ9BZE4
Ontology : AmiGOregulation of cyclin-dependent protein serine/threonine kinase activity  maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)  osteoblast differentiation  RNA binding  GTPase activity  protein binding  GTP binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  negative regulation of DNA replication  negative regulation of cell population proliferation  membrane  negative regulation of cell-cell adhesion  negative regulation of cell migration  negative regulation of protein ubiquitination  nuclear membrane  negative regulation of collagen binding  perinuclear region of cytoplasm  protein stabilization  
Ontology : EGO-EBIregulation of cyclin-dependent protein serine/threonine kinase activity  maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)  osteoblast differentiation  RNA binding  GTPase activity  protein binding  GTP binding  nucleus  nucleus  nucleoplasm  nucleolus  cytoplasm  cytosol  negative regulation of DNA replication  negative regulation of cell population proliferation  membrane  negative regulation of cell-cell adhesion  negative regulation of cell migration  negative regulation of protein ubiquitination  nuclear membrane  negative regulation of collagen binding  perinuclear region of cytoplasm  protein stabilization  
Pathways : KEGGRibosome biogenesis in eukaryotes   
NDEx NetworkGTPBP4
Atlas of Cancer Signalling NetworkGTPBP4
Wikipedia pathwaysGTPBP4
Orthology - Evolution
OrthoDB23560
GeneTree (enSembl)ENSG00000107937
Phylogenetic Trees/Animal Genes : TreeFamGTPBP4
Homologs : HomoloGeneGTPBP4
Homology/Alignments : Family Browser (UCSC)GTPBP4
Gene fusions - Rearrangements
Fusion : QuiverGTPBP4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGTPBP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GTPBP4
dbVarGTPBP4
ClinVarGTPBP4
MonarchGTPBP4
1000_GenomesGTPBP4 
Exome Variant ServerGTPBP4
GNOMAD BrowserENSG00000107937
Varsome BrowserGTPBP4
ACMGGTPBP4 variants
VarityQ9BZE4
Genomic Variants (DGV)GTPBP4 [DGVbeta]
DECIPHERGTPBP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGTPBP4 
Mutations
ICGC Data PortalGTPBP4 
TCGA Data PortalGTPBP4 
Broad Tumor PortalGTPBP4
OASIS PortalGTPBP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGTPBP4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGTPBP4
Mutations and Diseases : HGMDGTPBP4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGTPBP4
DgiDB (Drug Gene Interaction Database)GTPBP4
DoCM (Curated mutations)GTPBP4
CIViC (Clinical Interpretations of Variants in Cancer)GTPBP4
Cancer3DGTPBP4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM619169   
Orphanet
DisGeNETGTPBP4
MedgenGTPBP4
Genetic Testing Registry GTPBP4
NextProtQ9BZE4 [Medical]
GENETestsGTPBP4
Target ValidationGTPBP4
Huge Navigator GTPBP4 [HugePedia]
ClinGenGTPBP4
Clinical trials, drugs, therapy
MyCancerGenomeGTPBP4
Protein Interactions : CTDGTPBP4
Pharm GKB GenePA134922009
PharosQ9BZE4
Clinical trialGTPBP4
Miscellaneous
canSAR (ICR)GTPBP4
HarmonizomeGTPBP4
DataMed IndexGTPBP4
Probes
Litterature
PubMed98 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGTPBP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:11:45 CEST 2021
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