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GUCA1B (guanylate cyclase activator 1B)

Identity

Alias_namesguanylate cyclase activator 1B (retina)
Alias_symbol (synonym)GCAP2
RP48
Other aliasGUCA2
HGNC (Hugo) GUCA1B
LocusID (NCBI) 2979
Atlas_Id 64112
Location 6p21.1  [Link to chromosome band 6p21]
Location_base_pair Starts at 42183284 and ends at 42194956 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C6orf132 (6p21.1) / GUCA1B (6p21.1)CCND3 (6p21.1) / GUCA1B (6p21.1)MRPS10 (6p21.1) / GUCA1B (6p21.1)
C6orf132 GUCA1BCCND3 GUCA1B

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;6)(p21;p21) C6orf132/GUCA1B
t(6;6)(p21;p21) CCND3/GUCA1B


External links

Nomenclature
HGNC (Hugo)GUCA1B   4679
Cards
Entrez_Gene (NCBI)GUCA1B  2979  guanylate cyclase activator 1B
AliasesGCAP2; GUCA2; RP48
GeneCards (Weizmann)GUCA1B
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]   [Sequence]  chr6:42183284-42194956 [Contig_View]  GUCA1B [Vega]
TCGA cBioPortalGUCA1B
AceView (NCBI)GUCA1B
Genatlas (Paris)GUCA1B
WikiGenes2979
SOURCE (Princeton)GUCA1B
Genetics Home Reference (NIH)GUCA1B
Genomic and cartography
GoldenPath hg38 (UCSC)GUCA1B  -     chr6:42183284-42194956 -  6p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GUCA1B  -     6p21.1   [Description]    (hg19-Feb_2009)
EnsemblGUCA1B - 6p21.1 [CytoView hg19]  GUCA1B - 6p21.1 [CytoView hg38]
Mapping of homologs : NCBIGUCA1B [Mapview hg19]  GUCA1B [Mapview hg38]
OMIM602275   613827   
Gene and transcription
Genbank (Entrez)BC166640 BQ636025 BX537393
RefSeq transcript (Entrez)NM_002098
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GUCA1B
Cluster EST : UnigeneHs.446529 [ NCBI ]
CGAP (NCI)Hs.446529
Gene ExpressionGUCA1B [ NCBI-GEO ]   GUCA1B [ EBI - ARRAY_EXPRESS ]   GUCA1B [ SEEK ]   GUCA1B [ MEM ]
Gene Expression Viewer (FireBrowse)GUCA1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2979
GTEX Portal (Tissue expression)GUCA1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UMX6   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UMX6  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UMX6
Splice isoforms : SwissVarQ9UMX6
PhosPhoSitePlusQ9UMX6
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    GCAP-2   
Domain families : Pfam (Sanger)EF-hand_5 (PF13202)    EF-hand_7 (PF13499)   
Domain families : Pfam (NCBI)pfam13202    pfam13499   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)GUCA1B
DMDM Disease mutations2979
Blocks (Seattle)GUCA1B
SuperfamilyQ9UMX6
Peptide AtlasQ9UMX6
HPRD03783
IPIIPI00219035   IPI00941664   IPI00743844   
Protein Interaction databases
DIP (DOE-UCLA)Q9UMX6
IntAct (EBI)Q9UMX6
BioGRIDGUCA1B
STRING (EMBL)GUCA1B
ZODIACGUCA1B
Ontologies - Pathways
QuickGOQ9UMX6
Ontology : AmiGO###############################################################################################################################################################################################################################################################                      
Ontology : EGO-EBI###############################################################################################################################################################################################################################################################                      
Pathways : KEGGOlfactory transduction   
NDEx NetworkGUCA1B
Atlas of Cancer Signalling NetworkGUCA1B
Wikipedia pathwaysGUCA1B
Orthology - Evolution
OrthoDB2979
Phylogenetic Trees/Animal Genes : TreeFamGUCA1B
HOVERGENQ9UMX6
HOGENOMQ9UMX6
Homologs : HomoloGeneGUCA1B
Homology/Alignments : Family Browser (UCSC)GUCA1B
Gene fusions - Rearrangements
Fusion PortalC6orf132 GUCA1B
Fusion PortalCCND3 GUCA1B
Fusion : QuiverGUCA1B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGUCA1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GUCA1B
dbVarGUCA1B
ClinVarGUCA1B
1000_GenomesGUCA1B 
Exome Variant ServerGUCA1B
Varsome BrowserGUCA1B
Genetic variants : HAPMAP2979
Genomic Variants (DGV)GUCA1B [DGVbeta]
DECIPHERGUCA1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGUCA1B 
Mutations
ICGC Data PortalGUCA1B 
TCGA Data PortalGUCA1B 
Broad Tumor PortalGUCA1B
OASIS PortalGUCA1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGUCA1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGUCA1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Eye diseases - LOVD
BioMutasearch GUCA1B
DgiDB (Drug Gene Interaction Database)GUCA1B
DoCM (Curated mutations)GUCA1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GUCA1B (select a term)
intoGenGUCA1B
Cancer3DGUCA1B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602275    613827   
Orphanet659   
DisGeNETGUCA1B
MedgenGUCA1B
Genetic Testing Registry GUCA1B
NextProtQ9UMX6 [Medical]
TSGene2979
GENETestsGUCA1B
Target ValidationGUCA1B
Huge Navigator GUCA1B [HugePedia]
snp3D : Map Gene to Disease2979
BioCentury BCIQGUCA1B
ClinGenGUCA1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2979
Chemical/Pharm GKB GenePA29063
Clinical trialGUCA1B
Miscellaneous
canSAR (ICR)GUCA1B (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGUCA1B
EVEXGUCA1B
GoPubMedGUCA1B
iHOPGUCA1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 13:48:20 CEST 2018

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