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GUCA1C (guanylate cyclase activator 1C)

Identity

Alias (NCBI)GCAP3
HGNC (Hugo) GUCA1C
HGNC Alias symbGCAP3
HGNC Alias nameguanylyl cyclase-activating protein 3
LocusID (NCBI) 9626
Atlas_Id 54349
Location 3q13.13  [Link to chromosome band 3q13]
Location_base_pair Starts at 108907793 and ends at 108953879 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SLCO2A1 (3q22.1) / GUCA1C (3q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GUCA1C   4680
Cards
Entrez_Gene (NCBI)GUCA1C    guanylate cyclase activator 1C
AliasesGCAP3
GeneCards (Weizmann)GUCA1C
Ensembl hg19 (Hinxton)ENSG00000138472 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138472 [Gene_View]  ENSG00000138472 [Sequence]  chr3:108907793-108953879 [Contig_View]  GUCA1C [Vega]
ICGC DataPortalENSG00000138472
TCGA cBioPortalGUCA1C
AceView (NCBI)GUCA1C
Genatlas (Paris)GUCA1C
SOURCE (Princeton)GUCA1C
Genetics Home Reference (NIH)GUCA1C
Genomic and cartography
GoldenPath hg38 (UCSC)GUCA1C  -     chr3:108907793-108953879 -  3q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GUCA1C  -     3q13.13   [Description]    (hg19-Feb_2009)
GoldenPathGUCA1C - 3q13.13 [CytoView hg19]  GUCA1C - 3q13.13 [CytoView hg38]
ImmunoBaseENSG00000138472
Genome Data Viewer NCBIGUCA1C [Mapview hg19]  
OMIM605128   
Gene and transcription
Genbank (Entrez)AB593147 AF110002 AF110003 AV732101 BC103993
RefSeq transcript (Entrez)NM_001363884 NM_005459
Consensus coding sequences : CCDS (NCBI)GUCA1C
Gene ExpressionGUCA1C [ NCBI-GEO ]   GUCA1C [ EBI - ARRAY_EXPRESS ]   GUCA1C [ SEEK ]   GUCA1C [ MEM ]
Gene Expression Viewer (FireBrowse)GUCA1C [ Firebrowse - Broad ]
GenevisibleExpression of GUCA1C in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9626
GTEX Portal (Tissue expression)GUCA1C
Human Protein AtlasENSG00000138472-GUCA1C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95843   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95843  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95843
PhosPhoSitePlusO95843
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    GUCA1C    Recoverin   
Domain families : Pfam (Sanger)EF-hand_5 (PF13202)    EF-hand_7 (PF13499)   
Domain families : Pfam (NCBI)pfam13202    pfam13499   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)GUCA1C
PDB (RSDB)2GGZ   
PDB Europe2GGZ   
PDB (PDBSum)2GGZ   
PDB (IMB)2GGZ   
Structural Biology KnowledgeBase2GGZ   
SCOP (Structural Classification of Proteins)2GGZ   
CATH (Classification of proteins structures)2GGZ   
SuperfamilyO95843
AlphaFold pdb e-kbO95843   
Human Protein Atlas [tissue]ENSG00000138472-GUCA1C [tissue]
HPRD05499
Protein Interaction databases
DIP (DOE-UCLA)O95843
IntAct (EBI)O95843
BioGRIDGUCA1C
STRING (EMBL)GUCA1C
ZODIACGUCA1C
Ontologies - Pathways
QuickGOO95843
Ontology : AmiGOcalcium ion binding  protein binding  signal transduction  visual perception  calcium sensitive guanylate cyclase activator activity  regulation of rhodopsin mediated signaling pathway  positive regulation of guanylate cyclase activity  photoreceptor disc membrane  
Ontology : EGO-EBIcalcium ion binding  protein binding  signal transduction  visual perception  calcium sensitive guanylate cyclase activator activity  regulation of rhodopsin mediated signaling pathway  positive regulation of guanylate cyclase activity  photoreceptor disc membrane  
Pathways : KEGGOlfactory transduction    Phototransduction   
NDEx NetworkGUCA1C
Atlas of Cancer Signalling NetworkGUCA1C
Wikipedia pathwaysGUCA1C
Orthology - Evolution
OrthoDB9626
GeneTree (enSembl)ENSG00000138472
Phylogenetic Trees/Animal Genes : TreeFamGUCA1C
Homologs : HomoloGeneGUCA1C
Homology/Alignments : Family Browser (UCSC)GUCA1C
Gene fusions - Rearrangements
Fusion : MitelmanSLCO2A1/GUCA1C [3q22.1/3q13.13]  
Fusion : QuiverGUCA1C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGUCA1C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GUCA1C
dbVarGUCA1C
ClinVarGUCA1C
MonarchGUCA1C
1000_GenomesGUCA1C 
Exome Variant ServerGUCA1C
GNOMAD BrowserENSG00000138472
Varsome BrowserGUCA1C
ACMGGUCA1C variants
VarityO95843
Genomic Variants (DGV)GUCA1C [DGVbeta]
DECIPHERGUCA1C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGUCA1C 
Mutations
ICGC Data PortalGUCA1C 
TCGA Data PortalGUCA1C 
Broad Tumor PortalGUCA1C
OASIS PortalGUCA1C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGUCA1C  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGUCA1C
Mutations and Diseases : HGMDGUCA1C
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGUCA1C
DgiDB (Drug Gene Interaction Database)GUCA1C
DoCM (Curated mutations)GUCA1C
CIViC (Clinical Interpretations of Variants in Cancer)GUCA1C
Cancer3DGUCA1C
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605128   
Orphanet
DisGeNETGUCA1C
MedgenGUCA1C
Genetic Testing Registry GUCA1C
NextProtO95843 [Medical]
GENETestsGUCA1C
Target ValidationGUCA1C
Huge Navigator GUCA1C [HugePedia]
ClinGenGUCA1C
Clinical trials, drugs, therapy
MyCancerGenomeGUCA1C
Protein Interactions : CTDGUCA1C
Pharm GKB GenePA29064
PharosO95843
Clinical trialGUCA1C
Miscellaneous
canSAR (ICR)GUCA1C
HarmonizomeGUCA1C
DataMed IndexGUCA1C
Probes
Litterature
PubMed11 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGUCA1C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:11:45 CEST 2021

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