Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GUCA1C (guanylate cyclase activator 1C)

Identity

Alias_symbol (synonym)GCAP3
Other alias
HGNC (Hugo) GUCA1C
LocusID (NCBI) 9626
Atlas_Id 54349
Location 3q13.13  [Link to chromosome band 3q13]
Location_base_pair Starts at 108907795 and ends at 108953830 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
SLCO2A1 (3q22.1) / GUCA1C (3q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)GUCA1C   4680
Cards
Entrez_Gene (NCBI)GUCA1C  9626  guanylate cyclase activator 1C
AliasesGCAP3
GeneCards (Weizmann)GUCA1C
Ensembl hg19 (Hinxton)ENSG00000138472 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138472 [Gene_View]  chr3:108907795-108953830 [Contig_View]  GUCA1C [Vega]
ICGC DataPortalENSG00000138472
TCGA cBioPortalGUCA1C
AceView (NCBI)GUCA1C
Genatlas (Paris)GUCA1C
WikiGenes9626
SOURCE (Princeton)GUCA1C
Genetics Home Reference (NIH)GUCA1C
Genomic and cartography
GoldenPath hg38 (UCSC)GUCA1C  -     chr3:108907795-108953830 -  3q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GUCA1C  -     3q13.13   [Description]    (hg19-Feb_2009)
EnsemblGUCA1C - 3q13.13 [CytoView hg19]  GUCA1C - 3q13.13 [CytoView hg38]
Mapping of homologs : NCBIGUCA1C [Mapview hg19]  GUCA1C [Mapview hg38]
OMIM605128   
Gene and transcription
Genbank (Entrez)AB593147 AF110002 AF110003 AV732101 BC103993
RefSeq transcript (Entrez)NM_005459
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GUCA1C
Cluster EST : UnigeneHs.233363 [ NCBI ]
CGAP (NCI)Hs.233363
Alternative Splicing GalleryENSG00000138472
Gene ExpressionGUCA1C [ NCBI-GEO ]   GUCA1C [ EBI - ARRAY_EXPRESS ]   GUCA1C [ SEEK ]   GUCA1C [ MEM ]
Gene Expression Viewer (FireBrowse)GUCA1C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9626
GTEX Portal (Tissue expression)GUCA1C
Human Protein AtlasENSG00000138472-GUCA1C [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95843   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95843  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95843
Splice isoforms : SwissVarO95843
PhosPhoSitePlusO95843
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)   
Domains : Interpro (EBI)EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    GUCA1C   
Domain families : Pfam (Sanger)EF-hand_5 (PF13202)    EF-hand_7 (PF13499)   
Domain families : Pfam (NCBI)pfam13202    pfam13499   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)GUCA1C
DMDM Disease mutations9626
Blocks (Seattle)GUCA1C
PDB (SRS)2GGZ   
PDB (PDBSum)2GGZ   
PDB (IMB)2GGZ   
PDB (RSDB)2GGZ   
Structural Biology KnowledgeBase2GGZ   
SCOP (Structural Classification of Proteins)2GGZ   
CATH (Classification of proteins structures)2GGZ   
SuperfamilyO95843
Human Protein Atlas [tissue]ENSG00000138472-GUCA1C [tissue]
Peptide AtlasO95843
HPRD05499
IPIIPI00217754   IPI00217478   IPI00953483   IPI00791298   
Protein Interaction databases
DIP (DOE-UCLA)O95843
IntAct (EBI)O95843
FunCoupENSG00000138472
BioGRIDGUCA1C
STRING (EMBL)GUCA1C
ZODIACGUCA1C
Ontologies - Pathways
QuickGOO95843
Ontology : AmiGOcalcium ion binding  signal transduction  visual perception  calcium sensitive guanylate cyclase activator activity  regulation of rhodopsin mediated signaling pathway  positive regulation of guanylate cyclase activity  photoreceptor disc membrane  
Ontology : EGO-EBIcalcium ion binding  signal transduction  visual perception  calcium sensitive guanylate cyclase activator activity  regulation of rhodopsin mediated signaling pathway  positive regulation of guanylate cyclase activity  photoreceptor disc membrane  
Pathways : KEGGOlfactory transduction    Phototransduction   
NDEx NetworkGUCA1C
Atlas of Cancer Signalling NetworkGUCA1C
Wikipedia pathwaysGUCA1C
Orthology - Evolution
OrthoDB9626
GeneTree (enSembl)ENSG00000138472
Phylogenetic Trees/Animal Genes : TreeFamGUCA1C
HOVERGENO95843
HOGENOMO95843
Homologs : HomoloGeneGUCA1C
Homology/Alignments : Family Browser (UCSC)GUCA1C
Gene fusions - Rearrangements
Fusion : MitelmanSLCO2A1/GUCA1C [3q22.1/3q13.13]  [t(3;3)(q13;q22)]  
Tumor Fusion PortalGUCA1C
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGUCA1C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GUCA1C
dbVarGUCA1C
ClinVarGUCA1C
1000_GenomesGUCA1C 
Exome Variant ServerGUCA1C
ExAC (Exome Aggregation Consortium)ENSG00000138472
GNOMAD BrowserENSG00000138472
Genetic variants : HAPMAP9626
Genomic Variants (DGV)GUCA1C [DGVbeta]
DECIPHERGUCA1C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGUCA1C 
Mutations
ICGC Data PortalGUCA1C 
TCGA Data PortalGUCA1C 
Broad Tumor PortalGUCA1C
OASIS PortalGUCA1C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGUCA1C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGUCA1C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GUCA1C
DgiDB (Drug Gene Interaction Database)GUCA1C
DoCM (Curated mutations)GUCA1C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GUCA1C (select a term)
intoGenGUCA1C
Cancer3DGUCA1C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605128   
Orphanet
DisGeNETGUCA1C
MedgenGUCA1C
Genetic Testing Registry GUCA1C
NextProtO95843 [Medical]
TSGene9626
GENETestsGUCA1C
Target ValidationGUCA1C
Huge Navigator GUCA1C [HugePedia]
snp3D : Map Gene to Disease9626
BioCentury BCIQGUCA1C
ClinGenGUCA1C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9626
Chemical/Pharm GKB GenePA29064
Clinical trialGUCA1C
Miscellaneous
canSAR (ICR)GUCA1C (select the gene name)
Probes
Litterature
PubMed5 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGUCA1C
EVEXGUCA1C
GoPubMedGUCA1C
iHOPGUCA1C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:15:35 CET 2017

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