Identity
HGNC
LOCATION
1p34.2
LOCUSID
ALIAS
GCAP-I,GUCA2,STARA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2980
MIM: 139392
HGNC: 4682
Ensembl: ENSG00000197273
Variants:
dbSNP: 2980
ClinVar: 2980
TCGA: ENSG00000197273
COSMIC: GUCA2A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000197273 | ENST00000357001 | Q02747 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism | REACTOME | R-HSA-1430728 |
| Miscellaneous digestion events | REACTOME | R-HSA-8935690 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32037952 | 2020 | APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis. | 7 |
| 32037952 | 2020 | APC-β-catenin-TCF signaling silences the intestinal guanylin-GUCY2C tumor suppressor axis. | 7 |
| 29289697 | 2018 | Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control. | 7 |
| 29289697 | 2018 | Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control. | 7 |
| 27044258 | 2016 | Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa. | 28 |
| 27108812 | 2016 | Guanylin and uroguanylin stimulate lipolysis in human visceral adipocytes. | 17 |
| 27125248 | 2016 | Expression of guanylate cyclase-C, guanylin, and uroguanylin is downregulated proportionally to the ulcerative colitis disease activity index. | 23 |
| 27044258 | 2016 | Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa. | 28 |
| 27108812 | 2016 | Guanylin and uroguanylin stimulate lipolysis in human visceral adipocytes. | 17 |
| 27125248 | 2016 | Expression of guanylate cyclase-C, guanylin, and uroguanylin is downregulated proportionally to the ulcerative colitis disease activity index. | 23 |
| 25899674 | 2015 | Computational analyses and prediction of guanylin deleterious SNPs. | 8 |
| 25899674 | 2015 | Computational analyses and prediction of guanylin deleterious SNPs. | 8 |
| 20213926 | 2010 | Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy. | 34 |
| 20213926 | 2010 | Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy. | 34 |
| 19742348 | 2009 | [Differential expression of guanylin in colorectal cancer]. | 1 |
Citation
Dessen P
GUCA2A (guanylate cyclase activator 2A)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46444/guca2a
