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GUCA2A (guanylate cyclase activator 2A)

Identity

Alias_namesGUCA2
guanylate cyclase activator 2A (guanylin)
Alias_symbol (synonym)STARA
Other aliasGCAP-I
HGNC (Hugo) GUCA2A
LocusID (NCBI) 2980
Atlas_Id 46444
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 42628362 and ends at 42630395 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PTPRF (1p34.2) / GUCA2A (1p34.2)PTPRF 1p34.2 / GUCA2A 1p34.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GUCA2A   4682
Cards
Entrez_Gene (NCBI)GUCA2A  2980  guanylate cyclase activator 2A
AliasesGCAP-I; GUCA2; STARA
GeneCards (Weizmann)GUCA2A
Ensembl hg19 (Hinxton)ENSG00000197273 [Gene_View]  chr1:42628362-42630395 [Contig_View]  GUCA2A [Vega]
Ensembl hg38 (Hinxton)ENSG00000197273 [Gene_View]  chr1:42628362-42630395 [Contig_View]  GUCA2A [Vega]
ICGC DataPortalENSG00000197273
TCGA cBioPortalGUCA2A
AceView (NCBI)GUCA2A
Genatlas (Paris)GUCA2A
WikiGenes2980
SOURCE (Princeton)GUCA2A
Genetics Home Reference (NIH)GUCA2A
Genomic and cartography
GoldenPath hg19 (UCSC)GUCA2A  -     chr1:42628362-42630395 -  1p34.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GUCA2A  -     1p34.2   [Description]    (hg38-Dec_2013)
EnsemblGUCA2A - 1p34.2 [CytoView hg19]  GUCA2A - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIGUCA2A [Mapview hg19]  GUCA2A [Mapview hg38]
OMIM139392   
Gene and transcription
Genbank (Entrez)BC140428 BC156566 M95174 M97496 T28160
RefSeq transcript (Entrez)NM_033553
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)GUCA2A
Cluster EST : UnigeneHs.778 [ NCBI ]
CGAP (NCI)Hs.778
Alternative Splicing GalleryENSG00000197273
Gene ExpressionGUCA2A [ NCBI-GEO ]   GUCA2A [ EBI - ARRAY_EXPRESS ]   GUCA2A [ SEEK ]   GUCA2A [ MEM ]
Gene Expression Viewer (FireBrowse)GUCA2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2980
GTEX Portal (Tissue expression)GUCA2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02747   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02747  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02747
Splice isoforms : SwissVarQ02747
PhosPhoSitePlusQ02747
Domains : Interpro (EBI)Guanylin   
Domain families : Pfam (Sanger)Guanylin (PF02058)   
Domain families : Pfam (NCBI)pfam02058   
Domain structure : Prodom (Prabi Lyon)Guanylin (PD005588)   
Conserved Domain (NCBI)GUCA2A
DMDM Disease mutations2980
Blocks (Seattle)GUCA2A
PDB (SRS)1GNA    1GNB    1O8R   
PDB (PDBSum)1GNA    1GNB    1O8R   
PDB (IMB)1GNA    1GNB    1O8R   
PDB (RSDB)1GNA    1GNB    1O8R   
Structural Biology KnowledgeBase1GNA    1GNB    1O8R   
SCOP (Structural Classification of Proteins)1GNA    1GNB    1O8R   
CATH (Classification of proteins structures)1GNA    1GNB    1O8R   
SuperfamilyQ02747
Human Protein AtlasENSG00000197273
Peptide AtlasQ02747
HPRD00767
IPIIPI00026926   
Protein Interaction databases
DIP (DOE-UCLA)Q02747
IntAct (EBI)Q02747
FunCoupENSG00000197273
BioGRIDGUCA2A
STRING (EMBL)GUCA2A
ZODIACGUCA2A
Ontologies - Pathways
QuickGOQ02747
Ontology : AmiGOhormone activity  extracellular region  guanylate cyclase activator activity  positive regulation of guanylate cyclase activity  extracellular exosome  
Ontology : EGO-EBIhormone activity  extracellular region  guanylate cyclase activator activity  positive regulation of guanylate cyclase activity  extracellular exosome  
NDEx NetworkGUCA2A
Atlas of Cancer Signalling NetworkGUCA2A
Wikipedia pathwaysGUCA2A
Orthology - Evolution
OrthoDB2980
GeneTree (enSembl)ENSG00000197273
Phylogenetic Trees/Animal Genes : TreeFamGUCA2A
HOVERGENQ02747
HOGENOMQ02747
Homologs : HomoloGeneGUCA2A
Homology/Alignments : Family Browser (UCSC)GUCA2A
Gene fusions - Rearrangements
Fusion : MitelmanPTPRF/GUCA2A [1p34.2/1p34.2]  [t(1;1)(p34;p34)]  
Fusion: TCGAPTPRF 1p34.2 GUCA2A 1p34.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGUCA2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GUCA2A
dbVarGUCA2A
ClinVarGUCA2A
1000_GenomesGUCA2A 
Exome Variant ServerGUCA2A
ExAC (Exome Aggregation Consortium)GUCA2A (select the gene name)
Genetic variants : HAPMAP2980
Genomic Variants (DGV)GUCA2A [DGVbeta]
DECIPHER (Syndromes)1:42628362-42630395  ENSG00000197273
CONAN: Copy Number AnalysisGUCA2A 
Mutations
ICGC Data PortalGUCA2A 
TCGA Data PortalGUCA2A 
Broad Tumor PortalGUCA2A
OASIS PortalGUCA2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGUCA2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGUCA2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GUCA2A
DgiDB (Drug Gene Interaction Database)GUCA2A
DoCM (Curated mutations)GUCA2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GUCA2A (select a term)
intoGenGUCA2A
Cancer3DGUCA2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139392   
Orphanet
MedgenGUCA2A
Genetic Testing Registry GUCA2A
NextProtQ02747 [Medical]
TSGene2980
GENETestsGUCA2A
Huge Navigator GUCA2A [HugePedia]
snp3D : Map Gene to Disease2980
BioCentury BCIQGUCA2A
ClinGenGUCA2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2980
Chemical/Pharm GKB GenePA29065
Clinical trialGUCA2A
Miscellaneous
canSAR (ICR)GUCA2A (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGUCA2A
EVEXGUCA2A
GoPubMedGUCA2A
iHOPGUCA2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:08:27 CET 2017

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