GUCA2A (guanylate cyclase activator 2A)

2007-02-01  

Identity

HGNC
GUCA2A
LOCATION
1p34.2
LOCUSID
2980
ALIAS
GCAP-I,GUCA2,STARA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2980
MIM: 139392
HGNC: 4682
Ensembl: ENSG00000197273

Variants:

dbSNP: 2980
ClinVar: 2980
TCGA: ENSG00000197273
COSMIC: GUCA2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197273ENST00000357001Q02747

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Miscellaneous digestion eventsREACTOMER-HSA-8935690

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
202139262010Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy.21
270442582016Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa.15
157800942005Guanylin and uroguanylin regulate electrolyte transport in isolated human cortical collecting ducts.10
121633902002Guanylin and functional coupling proteins in the human salivary glands and gland tumors : expression, cellular localization, and target membrane domains.9
271088122016Guanylin and uroguanylin stimulate lipolysis in human visceral adipocytes.9
271252482016Expression of guanylate cyclase-C, guanylin, and uroguanylin is downregulated proportionally to the ulcerative colitis disease activity index.8
127072552003Solution structure of human proguanylin: the role of a hormone prosequence.6
258996742015Computational analyses and prediction of guanylin deleterious SNPs.5
149888272004Guanylin regulates chloride secretion in the human gallbladder via the bile fluid.2
159018962005Guanylin and E. coli heat-stable enterotoxin induce chloride secretion through direct interaction with basolateral compartment of rat and human colonic cells.2

Citation

Dessen P

GUCA2A (guanylate cyclase activator 2A)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46444/guca2a