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GUCA2B (guanylate cyclase activator 2B)

Identity

Alias (NCBI)GCAP-II
UGN
HGNC (Hugo) GUCA2B
HGNC Alias nameprepro-uroguanylin
HGNC Previous nameguanylate cyclase activator 2B (uroguanylin)
LocusID (NCBI) 2981
Atlas_Id 64113
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 42153410 and ends at 42155820 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ROCK1 (18q11.1)::GUCA2B (1p34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GUCA2B   4683
Cards
Entrez_Gene (NCBI)GUCA2B    guanylate cyclase activator 2B
AliasesGCAP-II; UGN
GeneCards (Weizmann)GUCA2B
Ensembl hg19 (Hinxton)ENSG00000044012 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000044012 [Gene_View]  ENSG00000044012 [Sequence]  chr1:42153410-42155820 [Contig_View]  GUCA2B [Vega]
ICGC DataPortalENSG00000044012
TCGA cBioPortalGUCA2B
AceView (NCBI)GUCA2B
Genatlas (Paris)GUCA2B
SOURCE (Princeton)GUCA2B
Genetics Home Reference (NIH)GUCA2B
Genomic and cartography
GoldenPath hg38 (UCSC)GUCA2B  -     chr1:42153410-42155820 +  1p34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GUCA2B  -     1p34.2   [Description]    (hg19-Feb_2009)
GoldenPathGUCA2B - 1p34.2 [CytoView hg19]  GUCA2B - 1p34.2 [CytoView hg38]
ImmunoBaseENSG00000044012
Genome Data Viewer NCBIGUCA2B [Mapview hg19]  
OMIM601271   
Gene and transcription
Genbank (Entrez)BC069301 BC093779 BC093781 U34279 Z50753
RefSeq transcript (Entrez)NM_007102
Consensus coding sequences : CCDS (NCBI)GUCA2B
Gene ExpressionGUCA2B [ NCBI-GEO ]   GUCA2B [ EBI - ARRAY_EXPRESS ]   GUCA2B [ SEEK ]   GUCA2B [ MEM ]
Gene Expression Viewer (FireBrowse)GUCA2B [ Firebrowse - Broad ]
GenevisibleExpression of GUCA2B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2981
GTEX Portal (Tissue expression)GUCA2B
Human Protein AtlasENSG00000044012-GUCA2B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16661   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16661  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16661
PhosPhoSitePlusQ16661
Domains : Interpro (EBI)Guanylin    Guanylin_sf   
Domain families : Pfam (Sanger)Guanylin (PF02058)   
Domain families : Pfam (NCBI)pfam02058   
Conserved Domain (NCBI)GUCA2B
PDB (RSDB)1UYA    1UYB   
PDB Europe1UYA    1UYB   
PDB (PDBSum)1UYA    1UYB   
PDB (IMB)1UYA    1UYB   
Structural Biology KnowledgeBase1UYA    1UYB   
SCOP (Structural Classification of Proteins)1UYA    1UYB   
CATH (Classification of proteins structures)1UYA    1UYB   
SuperfamilyQ16661
AlphaFold pdb e-kbQ16661   
Human Protein Atlas [tissue]ENSG00000044012-GUCA2B [tissue]
HPRD03170
Protein Interaction databases
DIP (DOE-UCLA)Q16661
IntAct (EBI)Q16661
BioGRIDGUCA2B
STRING (EMBL)GUCA2B
ZODIACGUCA2B
Ontologies - Pathways
QuickGOQ16661
Ontology : AmiGOprotein binding  extracellular region  digestion  excretion  calcium sensitive guanylate cyclase activator activity  cGMP-mediated signaling  guanylate cyclase activator activity  positive regulation of guanylate cyclase activity  extracellular exosome  
Ontology : EGO-EBIprotein binding  extracellular region  digestion  excretion  calcium sensitive guanylate cyclase activator activity  cGMP-mediated signaling  guanylate cyclase activator activity  positive regulation of guanylate cyclase activity  extracellular exosome  
NDEx NetworkGUCA2B
Atlas of Cancer Signalling NetworkGUCA2B
Wikipedia pathwaysGUCA2B
Orthology - Evolution
OrthoDB2981
GeneTree (enSembl)ENSG00000044012
Phylogenetic Trees/Animal Genes : TreeFamGUCA2B
Homologs : HomoloGeneGUCA2B
Homology/Alignments : Family Browser (UCSC)GUCA2B
Gene fusions - Rearrangements
Fusion : QuiverGUCA2B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGUCA2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GUCA2B
dbVarGUCA2B
ClinVarGUCA2B
MonarchGUCA2B
1000_GenomesGUCA2B 
Exome Variant ServerGUCA2B
GNOMAD BrowserENSG00000044012
Varsome BrowserGUCA2B
ACMGGUCA2B variants
VarityQ16661
Genomic Variants (DGV)GUCA2B [DGVbeta]
DECIPHERGUCA2B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGUCA2B 
Mutations
ICGC Data PortalGUCA2B 
TCGA Data PortalGUCA2B 
Broad Tumor PortalGUCA2B
OASIS PortalGUCA2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGUCA2B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGUCA2B
Mutations and Diseases : HGMDGUCA2B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGUCA2B
DgiDB (Drug Gene Interaction Database)GUCA2B
DoCM (Curated mutations)GUCA2B
CIViC (Clinical Interpretations of Variants in Cancer)GUCA2B
Cancer3DGUCA2B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601271   
Orphanet
DisGeNETGUCA2B
MedgenGUCA2B
Genetic Testing Registry GUCA2B
NextProtQ16661 [Medical]
GENETestsGUCA2B
Target ValidationGUCA2B
Huge Navigator GUCA2B [HugePedia]
ClinGenGUCA2B
Clinical trials, drugs, therapy
MyCancerGenomeGUCA2B
Protein Interactions : CTDGUCA2B
Pharm GKB GenePA29066
PharosQ16661
Clinical trialGUCA2B
Miscellaneous
canSAR (ICR)GUCA2B
HarmonizomeGUCA2B
ARCHS4GUCA2B
DataMed IndexGUCA2B
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGUCA2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 13:21:20 CET 2022

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