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GUCA2B (guanylate cyclase activator 2B (uroguanylin))

Identity

Alias_namesguanylate cyclase activator 2B (uroguanylin)
Other aliasGCAP-II
UGN
HGNC (Hugo) GUCA2B
LocusID (NCBI) 2981
Atlas_Id 64113
Location 1p34.2  [Link to chromosome band 1p34]
Location_base_pair Starts at 42619092 and ends at 42621495 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ROCK1 (18q11.1) / GUCA2B (1p34.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GUCA2B   4683
Cards
Entrez_Gene (NCBI)GUCA2B  2981  guanylate cyclase activator 2B (uroguanylin)
AliasesGCAP-II; UGN
GeneCards (Weizmann)GUCA2B
Ensembl hg19 (Hinxton)ENSG00000044012 [Gene_View]  chr1:42619092-42621495 [Contig_View]  GUCA2B [Vega]
Ensembl hg38 (Hinxton)ENSG00000044012 [Gene_View]  chr1:42619092-42621495 [Contig_View]  GUCA2B [Vega]
ICGC DataPortalENSG00000044012
TCGA cBioPortalGUCA2B
AceView (NCBI)GUCA2B
Genatlas (Paris)GUCA2B
WikiGenes2981
SOURCE (Princeton)GUCA2B
Genetics Home Reference (NIH)GUCA2B
Genomic and cartography
GoldenPath hg19 (UCSC)GUCA2B  -     chr1:42619092-42621495 +  1p34.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GUCA2B  -     1p34.2   [Description]    (hg38-Dec_2013)
EnsemblGUCA2B - 1p34.2 [CytoView hg19]  GUCA2B - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIGUCA2B [Mapview hg19]  GUCA2B [Mapview hg38]
OMIM601271   
Gene and transcription
Genbank (Entrez)BC069301 BC093779 BC093781 U34279 Z50753
RefSeq transcript (Entrez)NM_007102
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)GUCA2B
Cluster EST : UnigeneHs.32966 [ NCBI ]
CGAP (NCI)Hs.32966
Alternative Splicing GalleryENSG00000044012
Gene ExpressionGUCA2B [ NCBI-GEO ]   GUCA2B [ EBI - ARRAY_EXPRESS ]   GUCA2B [ SEEK ]   GUCA2B [ MEM ]
Gene Expression Viewer (FireBrowse)GUCA2B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2981
GTEX Portal (Tissue expression)GUCA2B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16661   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16661  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16661
Splice isoforms : SwissVarQ16661
PhosPhoSitePlusQ16661
Domains : Interpro (EBI)Guanylin   
Domain families : Pfam (Sanger)Guanylin (PF02058)   
Domain families : Pfam (NCBI)pfam02058   
Domain structure : Prodom (Prabi Lyon)Guanylin (PD005588)   
Conserved Domain (NCBI)GUCA2B
DMDM Disease mutations2981
Blocks (Seattle)GUCA2B
PDB (SRS)1UYA    1UYB   
PDB (PDBSum)1UYA    1UYB   
PDB (IMB)1UYA    1UYB   
PDB (RSDB)1UYA    1UYB   
Structural Biology KnowledgeBase1UYA    1UYB   
SCOP (Structural Classification of Proteins)1UYA    1UYB   
CATH (Classification of proteins structures)1UYA    1UYB   
SuperfamilyQ16661
Human Protein AtlasENSG00000044012
Peptide AtlasQ16661
HPRD03170
IPIIPI00003437   
Protein Interaction databases
DIP (DOE-UCLA)Q16661
IntAct (EBI)Q16661
FunCoupENSG00000044012
BioGRIDGUCA2B
STRING (EMBL)GUCA2B
ZODIACGUCA2B
Ontologies - Pathways
QuickGOQ16661
Ontology : AmiGOcGMP biosynthetic process  excretion  body fluid secretion  calcium sensitive guanylate cyclase activator activity  positive regulation of guanylate cyclase activity  positive regulation of guanylate cyclase activity  negative regulation of blood pressure  extracellular exosome  
Ontology : EGO-EBIcGMP biosynthetic process  excretion  body fluid secretion  calcium sensitive guanylate cyclase activator activity  positive regulation of guanylate cyclase activity  positive regulation of guanylate cyclase activity  negative regulation of blood pressure  extracellular exosome  
NDEx NetworkGUCA2B
Atlas of Cancer Signalling NetworkGUCA2B
Wikipedia pathwaysGUCA2B
Orthology - Evolution
OrthoDB2981
GeneTree (enSembl)ENSG00000044012
Phylogenetic Trees/Animal Genes : TreeFamGUCA2B
HOVERGENQ16661
HOGENOMQ16661
Homologs : HomoloGeneGUCA2B
Homology/Alignments : Family Browser (UCSC)GUCA2B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGUCA2B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GUCA2B
dbVarGUCA2B
ClinVarGUCA2B
1000_GenomesGUCA2B 
Exome Variant ServerGUCA2B
ExAC (Exome Aggregation Consortium)GUCA2B (select the gene name)
Genetic variants : HAPMAP2981
Genomic Variants (DGV)GUCA2B [DGVbeta]
DECIPHER (Syndromes)1:42619092-42621495  ENSG00000044012
CONAN: Copy Number AnalysisGUCA2B 
Mutations
ICGC Data PortalGUCA2B 
TCGA Data PortalGUCA2B 
Broad Tumor PortalGUCA2B
OASIS PortalGUCA2B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGUCA2B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGUCA2B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GUCA2B
DgiDB (Drug Gene Interaction Database)GUCA2B
DoCM (Curated mutations)GUCA2B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GUCA2B (select a term)
intoGenGUCA2B
Cancer3DGUCA2B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601271   
Orphanet
MedgenGUCA2B
Genetic Testing Registry GUCA2B
NextProtQ16661 [Medical]
TSGene2981
GENETestsGUCA2B
Huge Navigator GUCA2B [HugePedia]
snp3D : Map Gene to Disease2981
BioCentury BCIQGUCA2B
ClinGenGUCA2B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2981
Chemical/Pharm GKB GenePA29066
Clinical trialGUCA2B
Miscellaneous
canSAR (ICR)GUCA2B (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGUCA2B
EVEXGUCA2B
GoPubMedGUCA2B
iHOPGUCA2B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:07:12 CET 2017

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