Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GUCY1A1 (guanylate cyclase 1 soluble subunit alpha 1)

Identity

Other aliasGC-SA3
GUC1A3
GUCA3
GUCSA3
GUCY1A3
MYMY6
HGNC (Hugo) GUCY1A1
LocusID (NCBI) 2982
Atlas_Id 57292
Location 4q32.1  [Link to chromosome band 4q32]
Location_base_pair Starts at 155666963 and ends at 155737062 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)GUCY1A1   4685
Cards
Entrez_Gene (NCBI)GUCY1A1  2982  guanylate cyclase 1 soluble subunit alpha 1
AliasesGC-SA3; GUC1A3; GUCA3; GUCSA3; 
GUCY1A3; MYMY6
GeneCards (Weizmann)GUCY1A1
Ensembl hg19 (Hinxton)ENSG00000164116 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164116 [Gene_View]  ENSG00000164116 [Sequence]  chr4:155666963-155737062 [Contig_View]  GUCY1A1 [Vega]
ICGC DataPortalENSG00000164116
TCGA cBioPortalGUCY1A1
AceView (NCBI)GUCY1A1
Genatlas (Paris)GUCY1A1
WikiGenes2982
SOURCE (Princeton)GUCY1A1
Genetics Home Reference (NIH)GUCY1A1
Genomic and cartography
GoldenPath hg38 (UCSC)GUCY1A1  -     chr4:155666963-155737062 +  4q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GUCY1A1  -     4q32.1   [Description]    (hg19-Feb_2009)
EnsemblGUCY1A1 - 4q32.1 [CytoView hg19]  GUCY1A1 - 4q32.1 [CytoView hg38]
Mapping of homologs : NCBIGUCY1A1 [Mapview hg19]  GUCY1A1 [Mapview hg38]
OMIM139396   615750   
Gene and transcription
Genbank (Entrez)AK096588 AK124244 AK226125 AK309950 AK312952
RefSeq transcript (Entrez)NM_000856 NM_001130682 NM_001130683 NM_001130684 NM_001130685 NM_001130686 NM_001130687 NM_001256449
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GUCY1A1
Cluster EST : UnigeneHs.740815 [ NCBI ]
CGAP (NCI)Hs.740815
Alternative Splicing GalleryENSG00000164116
Gene ExpressionGUCY1A1 [ NCBI-GEO ]   GUCY1A1 [ EBI - ARRAY_EXPRESS ]   GUCY1A1 [ SEEK ]   GUCY1A1 [ MEM ]
Gene Expression Viewer (FireBrowse)GUCY1A1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2982
GTEX Portal (Tissue expression)GUCY1A1
Human Protein AtlasENSG00000164116-GUCY1A1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02108   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02108  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02108
Splice isoforms : SwissVarQ02108
PhosPhoSitePlusQ02108
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    H-NOX_domain_sf    Heme_NO-bd    HNOB_dom_associated    NO_sig/Golgi_transp_ligand-bd    Nucleotide_cyclase   
Domain families : Pfam (Sanger)Guanylate_cyc (PF00211)    HNOB (PF07700)    HNOBA (PF07701)   
Domain families : Pfam (NCBI)pfam00211    pfam07700    pfam07701   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)GUCY1A1
DMDM Disease mutations2982
Blocks (Seattle)GUCY1A1
PDB (SRS)3UVJ    4NI2   
PDB (PDBSum)3UVJ    4NI2   
PDB (IMB)3UVJ    4NI2   
PDB (RSDB)3UVJ    4NI2   
Structural Biology KnowledgeBase3UVJ    4NI2   
SCOP (Structural Classification of Proteins)3UVJ    4NI2   
CATH (Classification of proteins structures)3UVJ    4NI2   
SuperfamilyQ02108
Human Protein Atlas [tissue]ENSG00000164116-GUCY1A1 [tissue]
Peptide AtlasQ02108
IPIIPI00024422   IPI00910565   IPI00965001   IPI00908493   IPI00964909   IPI01015573   IPI00449099   
Protein Interaction databases
DIP (DOE-UCLA)Q02108
IntAct (EBI)Q02108
FunCoupENSG00000164116
BioGRIDGUCY1A1
STRING (EMBL)GUCY1A1
ZODIACGUCY1A1
Ontologies - Pathways
QuickGOQ02108
Ontology : AmiGOguanylate cyclase activity  protein binding  GTP binding  cGMP biosynthetic process  nitric oxide mediated signal transduction  blood circulation  guanylate cyclase complex, soluble  regulation of blood pressure  positive regulation of nitric oxide mediated signal transduction  heme binding  signaling receptor activity  response to defense-related host nitric oxide production  relaxation of vascular smooth muscle  retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission  glutamatergic synapse  GABA-ergic synapse  
Ontology : EGO-EBIguanylate cyclase activity  protein binding  GTP binding  cGMP biosynthetic process  nitric oxide mediated signal transduction  blood circulation  guanylate cyclase complex, soluble  regulation of blood pressure  positive regulation of nitric oxide mediated signal transduction  heme binding  signaling receptor activity  response to defense-related host nitric oxide production  relaxation of vascular smooth muscle  retrograde trans-synaptic signaling by nitric oxide, modulating synaptic transmission  glutamatergic synapse  GABA-ergic synapse  
NDEx NetworkGUCY1A1
Atlas of Cancer Signalling NetworkGUCY1A1
Wikipedia pathwaysGUCY1A1
Orthology - Evolution
OrthoDB2982
GeneTree (enSembl)ENSG00000164116
Phylogenetic Trees/Animal Genes : TreeFamGUCY1A1
HOVERGENQ02108
HOGENOMQ02108
Homologs : HomoloGeneGUCY1A1
Homology/Alignments : Family Browser (UCSC)GUCY1A1
Gene fusions - Rearrangements
Fusion : QuiverGUCY1A1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGUCY1A1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GUCY1A1
dbVarGUCY1A1
ClinVarGUCY1A1
1000_GenomesGUCY1A1 
Exome Variant ServerGUCY1A1
ExAC (Exome Aggregation Consortium)ENSG00000164116
GNOMAD BrowserENSG00000164116
Varsome BrowserGUCY1A1
Genetic variants : HAPMAP2982
Genomic Variants (DGV)GUCY1A1 [DGVbeta]
DECIPHERGUCY1A1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGUCY1A1 
Mutations
ICGC Data PortalGUCY1A1 
TCGA Data PortalGUCY1A1 
Broad Tumor PortalGUCY1A1
OASIS PortalGUCY1A1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDGUCY1A1
BioMutasearch GUCY1A1
DgiDB (Drug Gene Interaction Database)GUCY1A1
DoCM (Curated mutations)GUCY1A1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GUCY1A1 (select a term)
intoGenGUCY1A1
Cancer3DGUCY1A1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139396    615750   
Orphanet
DisGeNETGUCY1A1
MedgenGUCY1A1
Genetic Testing Registry GUCY1A1
NextProtQ02108 [Medical]
TSGene2982
GENETestsGUCY1A1
Target ValidationGUCY1A1
Huge Navigator GUCY1A1 [HugePedia]
snp3D : Map Gene to Disease2982
BioCentury BCIQGUCY1A1
ClinGenGUCY1A1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2982
Chemical/Pharm GKB GenePA29067
Clinical trialGUCY1A1
Miscellaneous
canSAR (ICR)GUCY1A1 (select the gene name)
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGUCY1A1
EVEXGUCY1A1
GoPubMedGUCY1A1
iHOPGUCY1A1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:09:57 CET 2018

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