Atlas of Genetics and Cytogenetics in Oncology and Haematology

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GUCY1A2 (guanylate cyclase 1 soluble subunit alpha 2)

Identity

Alias_namesGUC1A2
guanylate cyclase 1
Alias_symbol (synonym)GC-SA2
Other alias
HGNC (Hugo) GUCY1A2
LocusID (NCBI) 2977
Atlas_Id 51668
Location 11q22.3  [Link to chromosome band 11q22]
Location_base_pair Starts at 106674012 and ends at 107018445 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FCHSD2 (11q13.4) / GUCY1A2 (11q22.3)GUCY1A2 (11q22.3) / MALAT1 (11q13.1)FCHSD2 11q13.4 / GUCY1A2 11q22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q13;q22) FCHSD2/GUCY1A2

External links

Nomenclature
HGNC (Hugo)GUCY1A2   4684
Cards
Entrez_Gene (NCBI)GUCY1A2  2977  guanylate cyclase 1 soluble subunit alpha 2
AliasesGC-SA2; GUC1A2
GeneCards (Weizmann)GUCY1A2
Ensembl hg19 (Hinxton)ENSG00000152402 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152402 [Gene_View]  ENSG00000152402 [Sequence]  chr11:106674012-107018445 [Contig_View]  GUCY1A2 [Vega]
ICGC DataPortalENSG00000152402
TCGA cBioPortalGUCY1A2
AceView (NCBI)GUCY1A2
Genatlas (Paris)GUCY1A2
WikiGenes2977
SOURCE (Princeton)GUCY1A2
Genetics Home Reference (NIH)GUCY1A2
Genomic and cartography
GoldenPath hg38 (UCSC)GUCY1A2  -     chr11:106674012-107018445 -  11q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GUCY1A2  -     11q22.3   [Description]    (hg19-Feb_2009)
EnsemblGUCY1A2 - 11q22.3 [CytoView hg19]  GUCY1A2 - 11q22.3 [CytoView hg38]
Mapping of homologs : NCBIGUCY1A2 [Mapview hg19]  GUCY1A2 [Mapview hg38]
OMIM601244   
Gene and transcription
Genbank (Entrez)AK001875 AK022090 AK025115 AK098142 BC036599
RefSeq transcript (Entrez)NM_000855 NM_001256424
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GUCY1A2
Cluster EST : UnigeneHs.24321 [ NCBI ]
CGAP (NCI)Hs.24321
Alternative Splicing GalleryENSG00000152402
Gene ExpressionGUCY1A2 [ NCBI-GEO ]   GUCY1A2 [ EBI - ARRAY_EXPRESS ]   GUCY1A2 [ SEEK ]   GUCY1A2 [ MEM ]
Gene Expression Viewer (FireBrowse)GUCY1A2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2977
GTEX Portal (Tissue expression)GUCY1A2
Human Protein AtlasENSG00000152402-GUCY1A2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP33402   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP33402  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP33402
Splice isoforms : SwissVarP33402
PhosPhoSitePlusP33402
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    Heme_NO-bd    HNOB_dom_associated    NO_sig/Golgi_transp_ligand-bd    Nucleotide_cyclase   
Domain families : Pfam (Sanger)Guanylate_cyc (PF00211)    HNOB (PF07700)    HNOBA (PF07701)   
Domain families : Pfam (NCBI)pfam00211    pfam07700    pfam07701   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)GUCY1A2
DMDM Disease mutations2977
Blocks (Seattle)GUCY1A2
SuperfamilyP33402
Human Protein Atlas [tissue]ENSG00000152402-GUCY1A2 [tissue]
Peptide AtlasP33402
HPRD03146
IPIIPI00981500   IPI00217233   IPI00014254   
Protein Interaction databases
DIP (DOE-UCLA)P33402
IntAct (EBI)P33402
FunCoupENSG00000152402
BioGRIDGUCY1A2
STRING (EMBL)GUCY1A2
ZODIACGUCY1A2
Ontologies - Pathways
QuickGOP33402
Ontology : AmiGOadenylate cyclase activity  guanylate cyclase activity  protein binding  GTP binding  plasma membrane  cGMP biosynthetic process  signal transduction  guanylate cyclase complex, soluble  heme binding  positive regulation of cGMP biosynthetic process  intracellular signal transduction  
Ontology : EGO-EBIadenylate cyclase activity  guanylate cyclase activity  protein binding  GTP binding  plasma membrane  cGMP biosynthetic process  signal transduction  guanylate cyclase complex, soluble  heme binding  positive regulation of cGMP biosynthetic process  intracellular signal transduction  
Pathways : BIOCARTAIon Channels and Their Functional Role in Vascular Endothelium [Genes]   
Pathways : KEGGLong-term depression    Gap junction    Purine metabolism   
NDEx NetworkGUCY1A2
Atlas of Cancer Signalling NetworkGUCY1A2
Wikipedia pathwaysGUCY1A2
Orthology - Evolution
OrthoDB2977
GeneTree (enSembl)ENSG00000152402
Phylogenetic Trees/Animal Genes : TreeFamGUCY1A2
HOVERGENP33402
HOGENOMP33402
Homologs : HomoloGeneGUCY1A2
Homology/Alignments : Family Browser (UCSC)GUCY1A2
Gene fusions - Rearrangements
Fusion : MitelmanFCHSD2/GUCY1A2 [11q13.4/11q22.3]  [t(11;11)(q13;q22)]  
Fusion PortalFCHSD2 11q13.4 GUCY1A2 11q22.3 HNSC
Fusion : QuiverGUCY1A2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGUCY1A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GUCY1A2
dbVarGUCY1A2
ClinVarGUCY1A2
1000_GenomesGUCY1A2 
Exome Variant ServerGUCY1A2
ExAC (Exome Aggregation Consortium)ENSG00000152402
GNOMAD BrowserENSG00000152402
Genetic variants : HAPMAP2977
Genomic Variants (DGV)GUCY1A2 [DGVbeta]
DECIPHERGUCY1A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGUCY1A2 
Mutations
ICGC Data PortalGUCY1A2 
TCGA Data PortalGUCY1A2 
Broad Tumor PortalGUCY1A2
OASIS PortalGUCY1A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGUCY1A2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGUCY1A2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GUCY1A2
DgiDB (Drug Gene Interaction Database)GUCY1A2
DoCM (Curated mutations)GUCY1A2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GUCY1A2 (select a term)
intoGenGUCY1A2
Cancer3DGUCY1A2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601244   
Orphanet
DisGeNETGUCY1A2
MedgenGUCY1A2
Genetic Testing Registry GUCY1A2
NextProtP33402 [Medical]
TSGene2977
GENETestsGUCY1A2
Target ValidationGUCY1A2
Huge Navigator GUCY1A2 [HugePedia]
snp3D : Map Gene to Disease2977
BioCentury BCIQGUCY1A2
ClinGenGUCY1A2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2977
Chemical/Pharm GKB GenePA186
Clinical trialGUCY1A2
Miscellaneous
canSAR (ICR)GUCY1A2 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGUCY1A2
EVEXGUCY1A2
GoPubMedGUCY1A2
iHOPGUCY1A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:28:22 CEST 2018
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