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GUCY1A3 (guanylate cyclase 1 soluble subunit alpha)

Identity

Alias_namesGUC1A3
guanylate cyclase 1
Alias_symbol (synonym)GC-SA3
Other aliasGUCA3
GUCSA3
GUCY1A1
MYMY6
HGNC (Hugo) GUCY1A3
LocusID (NCBI) 2982
Atlas_Id 52735
Location 4q32.1  [Link to chromosome band 4q32]
Location_base_pair Starts at 155666710 and ends at 155737062 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GUCY1A3 (4q32.1) / GPM6A (4q34.2)GUCY1A3 (4q32.1) / SEC61A1 (3q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GUCY1A3   4685
Cards
Entrez_Gene (NCBI)GUCY1A3  2982  guanylate cyclase 1 soluble subunit alpha
AliasesGC-SA3; GUC1A3; GUCA3; GUCSA3; 
GUCY1A1; MYMY6
GeneCards (Weizmann)GUCY1A3
Ensembl hg19 (Hinxton)ENSG00000164116 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164116 [Gene_View]  chr4:155666710-155737062 [Contig_View]  GUCY1A3 [Vega]
ICGC DataPortalENSG00000164116
TCGA cBioPortalGUCY1A3
AceView (NCBI)GUCY1A3
Genatlas (Paris)GUCY1A3
WikiGenes2982
SOURCE (Princeton)GUCY1A3
Genetics Home Reference (NIH)GUCY1A3
Genomic and cartography
GoldenPath hg38 (UCSC)GUCY1A3  -     chr4:155666710-155737062 +  4q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GUCY1A3  -     4q32.1   [Description]    (hg19-Feb_2009)
EnsemblGUCY1A3 - 4q32.1 [CytoView hg19]  GUCY1A3 - 4q32.1 [CytoView hg38]
Mapping of homologs : NCBIGUCY1A3 [Mapview hg19]  GUCY1A3 [Mapview hg38]
OMIM139396   615750   
Gene and transcription
Genbank (Entrez)AK096588 AK124244 AK226125 AK309950 AK312952
RefSeq transcript (Entrez)NM_000856 NM_001130682 NM_001130683 NM_001130684 NM_001130685 NM_001130686 NM_001130687 NM_001256449
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GUCY1A3
Cluster EST : UnigeneHs.740815 [ NCBI ]
CGAP (NCI)Hs.740815
Alternative Splicing GalleryENSG00000164116
Gene ExpressionGUCY1A3 [ NCBI-GEO ]   GUCY1A3 [ EBI - ARRAY_EXPRESS ]   GUCY1A3 [ SEEK ]   GUCY1A3 [ MEM ]
Gene Expression Viewer (FireBrowse)GUCY1A3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2982
GTEX Portal (Tissue expression)GUCY1A3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02108   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02108  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02108
Splice isoforms : SwissVarQ02108
PhosPhoSitePlusQ02108
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    Heme_NO-bd    HNOB_dom_associated    NO_sig/Golgi_transp_ligand-bd    Nucleotide_cyclase   
Domain families : Pfam (Sanger)Guanylate_cyc (PF00211)    HNOB (PF07700)    HNOBA (PF07701)   
Domain families : Pfam (NCBI)pfam00211    pfam07700    pfam07701   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)GUCY1A3
DMDM Disease mutations2982
Blocks (Seattle)GUCY1A3
PDB (SRS)3UVJ    4NI2   
PDB (PDBSum)3UVJ    4NI2   
PDB (IMB)3UVJ    4NI2   
PDB (RSDB)3UVJ    4NI2   
Structural Biology KnowledgeBase3UVJ    4NI2   
SCOP (Structural Classification of Proteins)3UVJ    4NI2   
CATH (Classification of proteins structures)3UVJ    4NI2   
SuperfamilyQ02108
Human Protein AtlasENSG00000164116
Peptide AtlasQ02108
HPRD00768
IPIIPI00024422   IPI00910565   IPI00965001   IPI00908493   IPI00964909   IPI01015573   IPI00449099   
Protein Interaction databases
DIP (DOE-UCLA)Q02108
IntAct (EBI)Q02108
FunCoupENSG00000164116
BioGRIDGUCY1A3
STRING (EMBL)GUCY1A3
ZODIACGUCY1A3
Ontologies - Pathways
QuickGOQ02108
Ontology : AmiGOadenylate cyclase activity  guanylate cyclase activity  receptor activity  protein binding  GTP binding  plasma membrane  cGMP biosynthetic process  nitric oxide mediated signal transduction  blood circulation  guanylate cyclase complex, soluble  regulation of blood pressure  heme binding  positive regulation of cGMP biosynthetic process  response to defense-related host nitric oxide production  relaxation of vascular smooth muscle  
Ontology : EGO-EBIadenylate cyclase activity  guanylate cyclase activity  receptor activity  protein binding  GTP binding  plasma membrane  cGMP biosynthetic process  nitric oxide mediated signal transduction  blood circulation  guanylate cyclase complex, soluble  regulation of blood pressure  heme binding  positive regulation of cGMP biosynthetic process  response to defense-related host nitric oxide production  relaxation of vascular smooth muscle  
Pathways : BIOCARTAIon Channels and Their Functional Role in Vascular Endothelium [Genes]   
Pathways : KEGGPurine metabolism    Vascular smooth muscle contraction    Gap junction    Circadian entrainment    Long-term depression    Salivary secretion   
NDEx NetworkGUCY1A3
Atlas of Cancer Signalling NetworkGUCY1A3
Wikipedia pathwaysGUCY1A3
Orthology - Evolution
OrthoDB2982
GeneTree (enSembl)ENSG00000164116
Phylogenetic Trees/Animal Genes : TreeFamGUCY1A3
HOVERGENQ02108
HOGENOMQ02108
Homologs : HomoloGeneGUCY1A3
Homology/Alignments : Family Browser (UCSC)GUCY1A3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGUCY1A3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GUCY1A3
dbVarGUCY1A3
ClinVarGUCY1A3
1000_GenomesGUCY1A3 
Exome Variant ServerGUCY1A3
ExAC (Exome Aggregation Consortium)GUCY1A3 (select the gene name)
Genetic variants : HAPMAP2982
Genomic Variants (DGV)GUCY1A3 [DGVbeta]
DECIPHERGUCY1A3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGUCY1A3 
Mutations
ICGC Data PortalGUCY1A3 
TCGA Data PortalGUCY1A3 
Broad Tumor PortalGUCY1A3
OASIS PortalGUCY1A3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGUCY1A3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGUCY1A3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GUCY1A3
DgiDB (Drug Gene Interaction Database)GUCY1A3
DoCM (Curated mutations)GUCY1A3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GUCY1A3 (select a term)
intoGenGUCY1A3
Cancer3DGUCY1A3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139396    615750   
Orphanet22856   
MedgenGUCY1A3
Genetic Testing Registry GUCY1A3
NextProtQ02108 [Medical]
TSGene2982
GENETestsGUCY1A3
Target ValidationGUCY1A3
Huge Navigator GUCY1A3 [HugePedia]
snp3D : Map Gene to Disease2982
BioCentury BCIQGUCY1A3
ClinGenGUCY1A3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2982
Chemical/Pharm GKB GenePA29067
Clinical trialGUCY1A3
Miscellaneous
canSAR (ICR)GUCY1A3 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGUCY1A3
EVEXGUCY1A3
GoPubMedGUCY1A3
iHOPGUCY1A3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:36:15 CEST 2017

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