Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GUCY1B1 (guanylate cyclase 1 soluble subunit beta 1)

Identity

Other aliasGC-S-beta-1
GC-SB3
GUC1B3
GUCB3
GUCSB3
GUCY1B3
HGNC (Hugo) GUCY1B1
LocusID (NCBI) 2983
Atlas_Id 57286
Location 4q32.1  [Link to chromosome band 4q32]
Location_base_pair Starts at 155758973 and ends at 155807642 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)GUCY1B1   4687
Cards
Entrez_Gene (NCBI)GUCY1B1  2983  guanylate cyclase 1 soluble subunit beta 1
AliasesGC-S-beta-1; GC-SB3; GUC1B3; GUCB3; 
GUCSB3; GUCY1B3
GeneCards (Weizmann)GUCY1B1
Ensembl hg19 (Hinxton)ENSG00000061918 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000061918 [Gene_View]  ENSG00000061918 [Sequence]  chr4:155758973-155807642 [Contig_View]  GUCY1B1 [Vega]
ICGC DataPortalENSG00000061918
TCGA cBioPortalGUCY1B1
AceView (NCBI)GUCY1B1
Genatlas (Paris)GUCY1B1
WikiGenes2983
SOURCE (Princeton)GUCY1B1
Genetics Home Reference (NIH)GUCY1B1
Genomic and cartography
GoldenPath hg38 (UCSC)GUCY1B1  -     chr4:155758973-155807642 +  4q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GUCY1B1  -     4q32.1   [Description]    (hg19-Feb_2009)
EnsemblGUCY1B1 - 4q32.1 [CytoView hg19]  GUCY1B1 - 4q32.1 [CytoView hg38]
Mapping of homologs : NCBIGUCY1B1 [Mapview hg19]  GUCY1B1 [Mapview hg38]
OMIM139397   
Gene and transcription
Genbank (Entrez)AF020340 AI189698 AK296680 AK299916 AK300296
RefSeq transcript (Entrez)NM_000857 NM_001291951 NM_001291952 NM_001291953 NM_001291954 NM_001291955
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GUCY1B1
Cluster EST : UnigeneHs.77890 [ NCBI ]
CGAP (NCI)Hs.77890
Alternative Splicing GalleryENSG00000061918
Gene ExpressionGUCY1B1 [ NCBI-GEO ]   GUCY1B1 [ EBI - ARRAY_EXPRESS ]   GUCY1B1 [ SEEK ]   GUCY1B1 [ MEM ]
Gene Expression Viewer (FireBrowse)GUCY1B1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2983
GTEX Portal (Tissue expression)GUCY1B1
Human Protein AtlasENSG00000061918-GUCY1B1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02153   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02153  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02153
Splice isoforms : SwissVarQ02153
PhosPhoSitePlusQ02153
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    H-NOX_domain_sf    Heme_NO-bd    HNOB_dom_associated    NO_sig/Golgi_transp_ligand-bd    Nucleotide_cyclase   
Domain families : Pfam (Sanger)Guanylate_cyc (PF00211)    HNOB (PF07700)    HNOBA (PF07701)   
Domain families : Pfam (NCBI)pfam00211    pfam07700    pfam07701   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)GUCY1B1
DMDM Disease mutations2983
Blocks (Seattle)GUCY1B1
PDB (SRS)2WZ1    3UVJ    4NI2   
PDB (PDBSum)2WZ1    3UVJ    4NI2   
PDB (IMB)2WZ1    3UVJ    4NI2   
PDB (RSDB)2WZ1    3UVJ    4NI2   
Structural Biology KnowledgeBase2WZ1    3UVJ    4NI2   
SCOP (Structural Classification of Proteins)2WZ1    3UVJ    4NI2   
CATH (Classification of proteins structures)2WZ1    3UVJ    4NI2   
SuperfamilyQ02153
Human Protein Atlas [tissue]ENSG00000061918-GUCY1B1 [tissue]
Peptide AtlasQ02153
IPIIPI00289033   IPI00215651   IPI00964377   IPI00921966   IPI00964990   IPI00965318   
Protein Interaction databases
DIP (DOE-UCLA)Q02153
IntAct (EBI)Q02153
FunCoupENSG00000061918
BioGRIDGUCY1B1
STRING (EMBL)GUCY1B1
ZODIACGUCY1B1
Ontologies - Pathways
QuickGOQ02153
Ontology : AmiGOguanylate cyclase activity  protein binding  GTP binding  cGMP biosynthetic process  nitric oxide mediated signal transduction  blood circulation  guanylate cyclase complex, soluble  cGMP-mediated signaling  heme binding  signaling receptor activity  nitric oxide-cGMP-mediated signaling pathway  metal ion binding  presynaptic active zone  cellular response to nitric oxide  trans-synaptic signaling by nitric oxide, modulating synaptic transmission  
Ontology : EGO-EBIguanylate cyclase activity  protein binding  GTP binding  cGMP biosynthetic process  nitric oxide mediated signal transduction  blood circulation  guanylate cyclase complex, soluble  cGMP-mediated signaling  heme binding  signaling receptor activity  nitric oxide-cGMP-mediated signaling pathway  metal ion binding  presynaptic active zone  cellular response to nitric oxide  trans-synaptic signaling by nitric oxide, modulating synaptic transmission  
NDEx NetworkGUCY1B1
Atlas of Cancer Signalling NetworkGUCY1B1
Wikipedia pathwaysGUCY1B1
Orthology - Evolution
OrthoDB2983
GeneTree (enSembl)ENSG00000061918
Phylogenetic Trees/Animal Genes : TreeFamGUCY1B1
HOVERGENQ02153
HOGENOMQ02153
Homologs : HomoloGeneGUCY1B1
Homology/Alignments : Family Browser (UCSC)GUCY1B1
Gene fusions - Rearrangements
Fusion : QuiverGUCY1B1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGUCY1B1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GUCY1B1
dbVarGUCY1B1
ClinVarGUCY1B1
1000_GenomesGUCY1B1 
Exome Variant ServerGUCY1B1
ExAC (Exome Aggregation Consortium)ENSG00000061918
GNOMAD BrowserENSG00000061918
Varsome BrowserGUCY1B1
Genetic variants : HAPMAP2983
Genomic Variants (DGV)GUCY1B1 [DGVbeta]
DECIPHERGUCY1B1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGUCY1B1 
Mutations
ICGC Data PortalGUCY1B1 
TCGA Data PortalGUCY1B1 
Broad Tumor PortalGUCY1B1
OASIS PortalGUCY1B1 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDGUCY1B1
BioMutasearch GUCY1B1
DgiDB (Drug Gene Interaction Database)GUCY1B1
DoCM (Curated mutations)GUCY1B1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GUCY1B1 (select a term)
intoGenGUCY1B1
Cancer3DGUCY1B1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139397   
Orphanet
DisGeNETGUCY1B1
MedgenGUCY1B1
Genetic Testing Registry GUCY1B1
NextProtQ02153 [Medical]
TSGene2983
GENETestsGUCY1B1
Target ValidationGUCY1B1
Huge Navigator GUCY1B1 [HugePedia]
snp3D : Map Gene to Disease2983
BioCentury BCIQGUCY1B1
ClinGenGUCY1B1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2983
Chemical/Pharm GKB GenePA29068
Clinical trialGUCY1B1
Miscellaneous
canSAR (ICR)GUCY1B1 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGUCY1B1
EVEXGUCY1B1
GoPubMedGUCY1B1
iHOPGUCY1B1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:09:58 CET 2018

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