Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GUCY1B3 (guanylate cyclase 1 soluble subunit beta)

Identity

Alias_namesGUC1B3
guanylate cyclase 1, soluble, beta 3
Alias_symbol (synonym)GC-SB3
GC-S-beta-1
Other aliasGUCB3
GUCSB3
GUCY1B1
HGNC (Hugo) GUCY1B3
LocusID (NCBI) 2983
Atlas_Id 64116
Location 4q32.1  [Link to chromosome band 4q32]
Location_base_pair Starts at 155758973 and ends at 155807642 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GUCY1B3   4687
Cards
Entrez_Gene (NCBI)GUCY1B3  2983  guanylate cyclase 1 soluble subunit beta
AliasesGC-S-beta-1; GC-SB3; GUC1B3; GUCB3; 
GUCSB3; GUCY1B1
GeneCards (Weizmann)GUCY1B3
Ensembl hg19 (Hinxton)ENSG00000061918 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000061918 [Gene_View]  chr4:155758973-155807642 [Contig_View]  GUCY1B3 [Vega]
ICGC DataPortalENSG00000061918
TCGA cBioPortalGUCY1B3
AceView (NCBI)GUCY1B3
Genatlas (Paris)GUCY1B3
WikiGenes2983
SOURCE (Princeton)GUCY1B3
Genetics Home Reference (NIH)GUCY1B3
Genomic and cartography
GoldenPath hg38 (UCSC)GUCY1B3  -     chr4:155758973-155807642 +  4q32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GUCY1B3  -     4q32.1   [Description]    (hg19-Feb_2009)
EnsemblGUCY1B3 - 4q32.1 [CytoView hg19]  GUCY1B3 - 4q32.1 [CytoView hg38]
Mapping of homologs : NCBIGUCY1B3 [Mapview hg19]  GUCY1B3 [Mapview hg38]
OMIM139397   
Gene and transcription
Genbank (Entrez)AF020340 AI189698 AK296680 AK299916 AK300296
RefSeq transcript (Entrez)NM_000857 NM_001291951 NM_001291952 NM_001291953 NM_001291954 NM_001291955
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GUCY1B3
Cluster EST : UnigeneHs.77890 [ NCBI ]
CGAP (NCI)Hs.77890
Alternative Splicing GalleryENSG00000061918
Gene ExpressionGUCY1B3 [ NCBI-GEO ]   GUCY1B3 [ EBI - ARRAY_EXPRESS ]   GUCY1B3 [ SEEK ]   GUCY1B3 [ MEM ]
Gene Expression Viewer (FireBrowse)GUCY1B3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2983
GTEX Portal (Tissue expression)GUCY1B3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02153   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02153  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02153
Splice isoforms : SwissVarQ02153
PhosPhoSitePlusQ02153
Domaine pattern : Prosite (Expaxy)GUANYLATE_CYCLASE_1 (PS00452)    GUANYLATE_CYCLASE_2 (PS50125)   
Domains : Interpro (EBI)A/G_cyclase    A/G_cyclase_CS    Heme_NO-bd    HNOB_dom_associated    NO_sig/Golgi_transp_ligand-bd    Nucleotide_cyclase   
Domain families : Pfam (Sanger)Guanylate_cyc (PF00211)    HNOB (PF07700)    HNOBA (PF07701)   
Domain families : Pfam (NCBI)pfam00211    pfam07700    pfam07701   
Domain families : Smart (EMBL)CYCc (SM00044)  
Conserved Domain (NCBI)GUCY1B3
DMDM Disease mutations2983
Blocks (Seattle)GUCY1B3
PDB (SRS)2WZ1    3UVJ    4NI2   
PDB (PDBSum)2WZ1    3UVJ    4NI2   
PDB (IMB)2WZ1    3UVJ    4NI2   
PDB (RSDB)2WZ1    3UVJ    4NI2   
Structural Biology KnowledgeBase2WZ1    3UVJ    4NI2   
SCOP (Structural Classification of Proteins)2WZ1    3UVJ    4NI2   
CATH (Classification of proteins structures)2WZ1    3UVJ    4NI2   
SuperfamilyQ02153
Human Protein AtlasENSG00000061918
Peptide AtlasQ02153
HPRD00769
IPIIPI00289033   IPI00215651   IPI00964377   IPI00921966   IPI00964990   IPI00965318   
Protein Interaction databases
DIP (DOE-UCLA)Q02153
IntAct (EBI)Q02153
FunCoupENSG00000061918
BioGRIDGUCY1B3
STRING (EMBL)GUCY1B3
ZODIACGUCY1B3
Ontologies - Pathways
QuickGOQ02153
Ontology : AmiGOadenylate cyclase activity  guanylate cyclase activity  receptor activity  protein binding  GTP binding  plasma membrane  cGMP biosynthetic process  nitric oxide mediated signal transduction  blood circulation  guanylate cyclase complex, soluble  heme binding  nitric oxide-cGMP-mediated signaling pathway  metal ion binding  cellular response to nitric oxide  
Ontology : EGO-EBIadenylate cyclase activity  guanylate cyclase activity  receptor activity  protein binding  GTP binding  plasma membrane  cGMP biosynthetic process  nitric oxide mediated signal transduction  blood circulation  guanylate cyclase complex, soluble  heme binding  nitric oxide-cGMP-mediated signaling pathway  metal ion binding  cellular response to nitric oxide  
Pathways : BIOCARTAIon Channels and Their Functional Role in Vascular Endothelium [Genes]   
Pathways : KEGGPurine metabolism    Vascular smooth muscle contraction    Gap junction    Circadian entrainment    Long-term depression    Salivary secretion   
NDEx NetworkGUCY1B3
Atlas of Cancer Signalling NetworkGUCY1B3
Wikipedia pathwaysGUCY1B3
Orthology - Evolution
OrthoDB2983
GeneTree (enSembl)ENSG00000061918
Phylogenetic Trees/Animal Genes : TreeFamGUCY1B3
HOVERGENQ02153
HOGENOMQ02153
Homologs : HomoloGeneGUCY1B3
Homology/Alignments : Family Browser (UCSC)GUCY1B3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGUCY1B3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GUCY1B3
dbVarGUCY1B3
ClinVarGUCY1B3
1000_GenomesGUCY1B3 
Exome Variant ServerGUCY1B3
ExAC (Exome Aggregation Consortium)GUCY1B3 (select the gene name)
Genetic variants : HAPMAP2983
Genomic Variants (DGV)GUCY1B3 [DGVbeta]
DECIPHERGUCY1B3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGUCY1B3 
Mutations
ICGC Data PortalGUCY1B3 
TCGA Data PortalGUCY1B3 
Broad Tumor PortalGUCY1B3
OASIS PortalGUCY1B3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGUCY1B3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGUCY1B3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GUCY1B3
DgiDB (Drug Gene Interaction Database)GUCY1B3
DoCM (Curated mutations)GUCY1B3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GUCY1B3 (select a term)
intoGenGUCY1B3
Cancer3DGUCY1B3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM139397   
Orphanet
MedgenGUCY1B3
Genetic Testing Registry GUCY1B3
NextProtQ02153 [Medical]
TSGene2983
GENETestsGUCY1B3
Target ValidationGUCY1B3
Huge Navigator GUCY1B3 [HugePedia]
snp3D : Map Gene to Disease2983
BioCentury BCIQGUCY1B3
ClinGenGUCY1B3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2983
Chemical/Pharm GKB GenePA29068
Clinical trialGUCY1B3
Miscellaneous
canSAR (ICR)GUCY1B3 (select the gene name)
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGUCY1B3
EVEXGUCY1B3
GoPubMedGUCY1B3
iHOPGUCY1B3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:10:06 CEST 2017

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