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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
Note: we send fiscal receipts for donations equal or above 50 Euros or Dollars

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GUSB (glucuronidase, beta)

Identity

Other namesBG
MPS7
HGNC (Hugo) GUSB
LocusID (NCBI) 2990
Location 7q11.21
Location_base_pair Starts at 65425673 and ends at 65447301 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GUSB   4696
Cards
Entrez_Gene (NCBI)GUSB  2990  glucuronidase, beta
GeneCards (Weizmann)GUSB
Ensembl hg19 (Hinxton)ENSG00000169919 [Gene_View]  chr7:65425673-65447301 [Contig_View]  GUSB [Vega]
Ensembl hg38 (Hinxton)ENSG00000169919 [Gene_View]  chr7:65425673-65447301 [Contig_View]  GUSB [Vega]
ICGC DataPortalENSG00000169919
cBioPortalGUSB
AceView (NCBI)GUSB
Genatlas (Paris)GUSB
WikiGenes2990
SOURCE (Princeton)GUSB
Genomic and cartography
GoldenPath hg19 (UCSC)GUSB  -     chr7:65425673-65447301 -  7q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GUSB  -     7q11.21   [Description]    (hg38-Dec_2013)
EnsemblGUSB - 7q11.21 [CytoView hg19]  GUSB - 7q11.21 [CytoView hg38]
Mapping of homologs : NCBIGUSB [Mapview hg19]  GUSB [Mapview hg38]
OMIM253220   611499   
Gene and transcription
Genbank (Entrez)AA947121 AK096764 AK223406 AK300223 AK303819
RefSeq transcript (Entrez)NM_000181 NM_001284290 NM_001293104 NM_001293105
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_016197 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)GUSB
Cluster EST : UnigeneHs.255230 [ NCBI ]
CGAP (NCI)Hs.255230
Alternative Splicing : Fast-db (Paris)GSHG0028235
Alternative Splicing GalleryENSG00000169919
Gene ExpressionGUSB [ NCBI-GEO ]     GUSB [ SEEK ]   GUSB [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08236 (Uniprot)
NextProtP08236  [Medical]
With graphics : InterProP08236
Splice isoforms : SwissVarP08236 (Swissvar)
Catalytic activity : Enzyme3.2.1.31 [ Enzyme-Expasy ]   3.2.1.313.2.1.31 [ IntEnz-EBI ]   3.2.1.31 [ BRENDA ]   3.2.1.31 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)GLYCOSYL_HYDROL_F2_1 (PS00719)    GLYCOSYL_HYDROL_F2_2 (PS00608)   
Domains : Interpro (EBI)Galactose-bd-like    Glyco_hydro_2    Glyco_hydro_2/20_Ig-like    Glyco_hydro_2_AS    Glyco_hydro_2_CS    Glyco_hydro_2_Ig-like    Glyco_hydro_2_N    Glyco_hydro_2_TIM    Glyco_hydro_catalytic_dom    Glycoside_hydrolase_SF   
Related proteins : CluSTrP08236
Domain families : Pfam (Sanger)Glyco_hydro_2 (PF00703)    Glyco_hydro_2_C (PF02836)    Glyco_hydro_2_N (PF02837)   
Domain families : Pfam (NCBI)pfam00703    pfam02836    pfam02837   
DMDM Disease mutations2990
Blocks (Seattle)P08236
PDB (SRS)1BHG    3HN3   
PDB (PDBSum)1BHG    3HN3   
PDB (IMB)1BHG    3HN3   
PDB (RSDB)1BHG    3HN3   
Human Protein AtlasENSG00000169919
Peptide AtlasP08236
HPRD02018
IPIIPI00027745   IPI00219516   IPI00969546   IPI00927883   IPI00924575   IPI00924795   IPI01012614   
Protein Interaction databases
DIP (DOE-UCLA)P08236
IntAct (EBI)P08236
FunCoupENSG00000169919
BioGRIDGUSB
IntegromeDBGUSB
STRING (EMBL)GUSB
Ontologies - Pathways
QuickGOP08236
Ontology : AmiGObeta-glucuronidase activity  receptor binding  carbohydrate metabolic process  glycosaminoglycan catabolic process  pathogenesis  membrane  protein domain specific binding  glycosaminoglycan metabolic process  hyaluronan metabolic process  hyaluronan catabolic process  lysosomal lumen  intracellular membrane-bounded organelle  small molecule metabolic process  extracellular exosome  
Ontology : EGO-EBIbeta-glucuronidase activity  receptor binding  carbohydrate metabolic process  glycosaminoglycan catabolic process  pathogenesis  membrane  protein domain specific binding  glycosaminoglycan metabolic process  hyaluronan metabolic process  hyaluronan catabolic process  lysosomal lumen  intracellular membrane-bounded organelle  small molecule metabolic process  extracellular exosome  
Pathways : KEGGPentose and glucuronate interconversions    Starch and sucrose metabolism    Glycosaminoglycan degradation    Porphyrin and chlorophyll metabolism    Drug metabolism - other enzymes    Lysosome   
Protein Interaction DatabaseGUSB
DoCM (Curated mutations)GUSB
Wikipedia pathwaysGUSB
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerGUSB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GUSB
dbVarGUSB
ClinVarGUSB
1000_GenomesGUSB 
Exome Variant ServerGUSB
SNP (GeneSNP Utah)GUSB
SNP : HGBaseGUSB
Genetic variants : HAPMAPGUSB
Genomic Variants (DGV)GUSB [DGVbeta]
Mutations
ICGC Data PortalENSG00000169919 
Somatic Mutations in Cancer : COSMICGUSB 
CONAN: Copy Number AnalysisGUSB 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:65425673-65447301
Mutations and Diseases : HGMDGUSB
OMIM253220    611499   
MedgenGUSB
NextProtP08236 [Medical]
GENETestsGUSB
Disease Genetic AssociationGUSB
Huge Navigator GUSB [HugePedia]  GUSB [HugeCancerGEM]
snp3D : Map Gene to Disease2990
DGIdb (Drug Gene Interaction db)GUSB
General knowledge
Homologs : HomoloGeneGUSB
Homology/Alignments : Family Browser (UCSC)GUSB
Phylogenetic Trees/Animal Genes : TreeFamGUSB
Chemical/Protein Interactions : CTD2990
Chemical/Pharm GKB GenePA29075
Clinical trialGUSB
Cancer Resource (Charite)ENSG00000169919
Other databases
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
CoreMineGUSB
GoPubMedGUSB
iHOPGUSB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 15:33:52 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.