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GUSB (glucuronidase beta)

Identity

Other namesBG
MPS7
HGNC (Hugo) GUSB
LocusID (NCBI) 2990
Atlas_Id 46031
Location 7q11.21  [Link to chromosome band 7q11]
Location_base_pair Starts at 65425673 and ends at 65447301 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
BZW2 (7p21.1) / GUSB (7q11.21)GUSB (7q11.21) / CCDC129 (7p14.3)GUSB (7q11.21) / CERS5 (12q13.12)
BZW2 7p21.1 / GUSB 7q11.21

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GUSB   4696
Cards
Entrez_Gene (NCBI)GUSB  2990  glucuronidase beta
AliasesBG; MPS7
GeneCards (Weizmann)GUSB
Ensembl hg19 (Hinxton)ENSG00000169919 [Gene_View]  chr7:65425673-65447301 [Contig_View]  GUSB [Vega]
Ensembl hg38 (Hinxton)ENSG00000169919 [Gene_View]  chr7:65425673-65447301 [Contig_View]  GUSB [Vega]
ICGC DataPortalENSG00000169919
TCGA cBioPortalGUSB
AceView (NCBI)GUSB
Genatlas (Paris)GUSB
WikiGenes2990
SOURCE (Princeton)GUSB
Genomic and cartography
GoldenPath hg19 (UCSC)GUSB  -     chr7:65425673-65447301 -  7q11.21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GUSB  -     7q11.21   [Description]    (hg38-Dec_2013)
EnsemblGUSB - 7q11.21 [CytoView hg19]  GUSB - 7q11.21 [CytoView hg38]
Mapping of homologs : NCBIGUSB [Mapview hg19]  GUSB [Mapview hg38]
OMIM253220   611499   
Gene and transcription
Genbank (Entrez)AA947121 AK096764 AK223406 AK300223 AK303819
RefSeq transcript (Entrez)NM_000181 NM_001284290 NM_001293104 NM_001293105
RefSeq genomic (Entrez)NC_000007 NC_018918 NG_016197 NT_007933 NW_004929332
Consensus coding sequences : CCDS (NCBI)GUSB
Cluster EST : UnigeneHs.255230 [ NCBI ]
CGAP (NCI)Hs.255230
Alternative Splicing GalleryENSG00000169919
Gene ExpressionGUSB [ NCBI-GEO ]   GUSB [ EBI - ARRAY_EXPRESS ]   GUSB [ SEEK ]   GUSB [ MEM ]
Gene Expression Viewer (FireBrowse)GUSB [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2990
GTEX Portal (Tissue expression)GUSB
Protein : pattern, domain, 3D structure
UniProt/SwissProtP08236 (Uniprot)
NextProtP08236  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP08236
Splice isoforms : SwissVarP08236 (Swissvar)
Catalytic activity : Enzyme3.2.1.31 [ Enzyme-Expasy ]   3.2.1.313.2.1.31 [ IntEnz-EBI ]   3.2.1.31 [ BRENDA ]   3.2.1.31 [ KEGG ]   
PhosPhoSitePlusP08236
Domaine pattern : Prosite (Expaxy)GLYCOSYL_HYDROL_F2_1 (PS00719)    GLYCOSYL_HYDROL_F2_2 (PS00608)   
Domains : Interpro (EBI)Galactose-bd-like    Glyco_hydro_2    Glyco_hydro_2/20_Ig-like    Glyco_hydro_2_AS    Glyco_hydro_2_cat    Glyco_hydro_2_CS    Glyco_hydro_2_Ig-like    Glyco_hydro_2_N    Glyco_hydro_catalytic_dom    Glycoside_hydrolase_SF   
Domain families : Pfam (Sanger)Glyco_hydro_2 (PF00703)    Glyco_hydro_2_C (PF02836)    Glyco_hydro_2_N (PF02837)   
Domain families : Pfam (NCBI)pfam00703    pfam02836    pfam02837   
DMDM Disease mutations2990
Blocks (Seattle)GUSB
PDB (SRS)1BHG    3HN3   
PDB (PDBSum)1BHG    3HN3   
PDB (IMB)1BHG    3HN3   
PDB (RSDB)1BHG    3HN3   
Structural Biology KnowledgeBase1BHG    3HN3   
SCOP (Structural Classification of Proteins)1BHG    3HN3   
CATH (Classification of proteins structures)1BHG    3HN3   
SuperfamilyP08236
Human Protein AtlasENSG00000169919
Peptide AtlasP08236
HPRD02018
IPIIPI00027745   IPI00219516   IPI00969546   IPI00927883   IPI00924575   IPI00924795   IPI01012614   
Protein Interaction databases
DIP (DOE-UCLA)P08236
IntAct (EBI)P08236
FunCoupENSG00000169919
BioGRIDGUSB
STRING (EMBL)GUSB
ZODIACGUSB
Ontologies - Pathways
QuickGOP08236
Ontology : AmiGObeta-glucuronidase activity  receptor binding  extracellular space  carbohydrate metabolic process  glycosaminoglycan catabolic process  membrane  protein domain specific binding  hyaluronan catabolic process  lysosomal lumen  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  extracellular exosome  
Ontology : EGO-EBIbeta-glucuronidase activity  receptor binding  extracellular space  carbohydrate metabolic process  glycosaminoglycan catabolic process  membrane  protein domain specific binding  hyaluronan catabolic process  lysosomal lumen  intracellular membrane-bounded organelle  intracellular membrane-bounded organelle  extracellular exosome  
Pathways : KEGGPentose and glucuronate interconversions    Starch and sucrose metabolism    Glycosaminoglycan degradation    Porphyrin and chlorophyll metabolism    Drug metabolism - other enzymes    Lysosome   
NDEx NetworkGUSB
Atlas of Cancer Signalling NetworkGUSB
Wikipedia pathwaysGUSB
Orthology - Evolution
OrthoDB2990
GeneTree (enSembl)ENSG00000169919
Phylogenetic Trees/Animal Genes : TreeFamGUSB
Homologs : HomoloGeneGUSB
Homology/Alignments : Family Browser (UCSC)GUSB
Gene fusions - Rearrangements
Fusion: TCGABZW2 7p21.1 GUSB 7q11.21 LAML
Polymorphisms : SNP, variants
NCBI Variation ViewerGUSB [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GUSB
dbVarGUSB
ClinVarGUSB
1000_GenomesGUSB 
Exome Variant ServerGUSB
ExAC (Exome Aggregation Consortium)GUSB (select the gene name)
Genetic variants : HAPMAP2990
Genomic Variants (DGV)GUSB [DGVbeta]
Mutations
ICGC Data PortalGUSB 
TCGA Data PortalGUSB 
Broad Tumor PortalGUSB
OASIS PortalGUSB [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGUSB 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GUSB
DgiDB (Drug Gene Interaction Database)GUSB
DoCM (Curated mutations)GUSB (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GUSB (select a term)
intoGenGUSB
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)7:65425673-65447301  ENSG00000169919
CONAN: Copy Number AnalysisGUSB 
Mutations and Diseases : HGMDGUSB
OMIM253220    611499   
MedgenGUSB
Genetic Testing Registry GUSB
NextProtP08236 [Medical]
TSGene2990
GENETestsGUSB
Huge Navigator GUSB [HugePedia]
snp3D : Map Gene to Disease2990
BioCentury BCIQGUSB
ClinGenGUSB
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2990
Chemical/Pharm GKB GenePA29075
Clinical trialGUSB
Miscellaneous
canSAR (ICR)GUSB (select the gene name)
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGUSB
EVEXGUSB
GoPubMedGUSB
iHOPGUSB
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 18:52:06 CEST 2016

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