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GYS2 (glycogen synthase 2 (liver))

Identity

Alias_namesglycogen synthase 2 (liver)
Other alias-
HGNC (Hugo) GYS2
LocusID (NCBI) 2998
Atlas_Id 64139
Location 12p12.1  [Link to chromosome band 12p12]
Location_base_pair Starts at 21689123 and ends at 21757781 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
EPS8 (12p12.3) / GYS2 (12p12.1)FAM222B (17q11.2) / GYS2 (12p12.1)SAA1 (11p15.1) / GYS2 (12p12.1)
SAA3P (11p15.1) / GYS2 (12p12.1)C17orf63 GYS2EPS8 GYS2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GYS2   4707
Cards
Entrez_Gene (NCBI)GYS2  2998  glycogen synthase 2 (liver)
Aliases
GeneCards (Weizmann)GYS2
Ensembl hg19 (Hinxton)ENSG00000111713 [Gene_View]  chr12:21689123-21757781 [Contig_View]  GYS2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000111713 [Gene_View]  chr12:21689123-21757781 [Contig_View]  GYS2 [Vega]
ICGC DataPortalENSG00000111713
TCGA cBioPortalGYS2
AceView (NCBI)GYS2
Genatlas (Paris)GYS2
WikiGenes2998
SOURCE (Princeton)GYS2
Genetics Home Reference (NIH)GYS2
Genomic and cartography
GoldenPath hg19 (UCSC)GYS2  -     chr12:21689123-21757781 -  12p12.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GYS2  -     12p12.1   [Description]    (hg38-Dec_2013)
EnsemblGYS2 - 12p12.1 [CytoView hg19]  GYS2 - 12p12.1 [CytoView hg38]
Mapping of homologs : NCBIGYS2 [Mapview hg19]  GYS2 [Mapview hg38]
OMIM138571   240600   
Gene and transcription
Genbank (Entrez)AK308373 AV653197 BC126310 BC126312 D29685
RefSeq transcript (Entrez)NM_021957
RefSeq genomic (Entrez)NC_000012 NC_018923 NG_016167 NT_009714 NW_004929383
Consensus coding sequences : CCDS (NCBI)GYS2
Cluster EST : UnigeneHs.82614 [ NCBI ]
CGAP (NCI)Hs.82614
Alternative Splicing GalleryENSG00000111713
Gene ExpressionGYS2 [ NCBI-GEO ]   GYS2 [ EBI - ARRAY_EXPRESS ]   GYS2 [ SEEK ]   GYS2 [ MEM ]
Gene Expression Viewer (FireBrowse)GYS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2998
GTEX Portal (Tissue expression)GYS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP54840   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP54840  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP54840
Splice isoforms : SwissVarP54840
PhosPhoSitePlusP54840
Domains : Interpro (EBI)Glycogen_synth   
Domain families : Pfam (Sanger)Glycogen_syn (PF05693)   
Domain families : Pfam (NCBI)pfam05693   
Conserved Domain (NCBI)GYS2
DMDM Disease mutations2998
Blocks (Seattle)GYS2
SuperfamilyP54840
Human Protein AtlasENSG00000111713
Peptide AtlasP54840
HPRD00722
IPIIPI00008867   
Protein Interaction databases
DIP (DOE-UCLA)P54840
IntAct (EBI)P54840
FunCoupENSG00000111713
BioGRIDGYS2
STRING (EMBL)GYS2
ZODIACGYS2
Ontologies - Pathways
QuickGOP54840
Ontology : AmiGOglycogen (starch) synthase activity  glycogen (starch) synthase activity  glycogen (starch) synthase activity  cytoplasm  cytoplasm  cytosol  cytosol  cytoskeleton  cell cortex  carbohydrate metabolic process  glycogen biosynthetic process  glycogen biosynthetic process  glycogen biosynthetic process  glycogen biosynthetic process  glucose metabolic process  generation of precursor metabolites and energy  response to glucose  cortical actin cytoskeleton  protein homodimerization activity  ectoplasm  small molecule metabolic process  glycogen synthase activity, transferring glucose-1-phosphate  
Ontology : EGO-EBIglycogen (starch) synthase activity  glycogen (starch) synthase activity  glycogen (starch) synthase activity  cytoplasm  cytoplasm  cytosol  cytosol  cytoskeleton  cell cortex  carbohydrate metabolic process  glycogen biosynthetic process  glycogen biosynthetic process  glycogen biosynthetic process  glycogen biosynthetic process  glucose metabolic process  generation of precursor metabolites and energy  response to glucose  cortical actin cytoskeleton  protein homodimerization activity  ectoplasm  small molecule metabolic process  glycogen synthase activity, transferring glucose-1-phosphate  
Pathways : KEGGStarch and sucrose metabolism    PI3K-Akt signaling pathway    Insulin signaling pathway   
NDEx NetworkGYS2
Atlas of Cancer Signalling NetworkGYS2
Wikipedia pathwaysGYS2
Orthology - Evolution
OrthoDB2998
GeneTree (enSembl)ENSG00000111713
Phylogenetic Trees/Animal Genes : TreeFamGYS2
HOVERGENP54840
HOGENOMP54840
Homologs : HomoloGeneGYS2
Homology/Alignments : Family Browser (UCSC)GYS2
Gene fusions - Rearrangements
Fusion: TCGAC17orf63 GYS2
Fusion: TCGAEPS8 GYS2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGYS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GYS2
dbVarGYS2
ClinVarGYS2
1000_GenomesGYS2 
Exome Variant ServerGYS2
ExAC (Exome Aggregation Consortium)GYS2 (select the gene name)
Genetic variants : HAPMAP2998
Genomic Variants (DGV)GYS2 [DGVbeta]
DECIPHER (Syndromes)12:21689123-21757781  ENSG00000111713
CONAN: Copy Number AnalysisGYS2 
Mutations
ICGC Data PortalGYS2 
TCGA Data PortalGYS2 
Broad Tumor PortalGYS2
OASIS PortalGYS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGYS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGYS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GYS2
DgiDB (Drug Gene Interaction Database)GYS2
DoCM (Curated mutations)GYS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GYS2 (select a term)
intoGenGYS2
Cancer3DGYS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138571    240600   
Orphanet3271   
MedgenGYS2
Genetic Testing Registry GYS2
NextProtP54840 [Medical]
TSGene2998
GENETestsGYS2
Huge Navigator GYS2 [HugePedia]
snp3D : Map Gene to Disease2998
BioCentury BCIQGYS2
ClinGenGYS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2998
Chemical/Pharm GKB GenePA29085
Clinical trialGYS2
Miscellaneous
canSAR (ICR)GYS2 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGYS2
EVEXGYS2
GoPubMedGYS2
iHOPGYS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:07:18 CET 2017

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