Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GZMK (granzyme K)

Identity

Alias_namesgranzyme K (serine protease, granzyme 3; tryptase II)
granzyme K (granzyme 3; tryptase II)
Alias_symbol (synonym)TRYP2
PRSS
Other alias
HGNC (Hugo) GZMK
LocusID (NCBI) 3003
Atlas_Id 64142
Location 5q11.2  [Link to chromosome band 5q11]
Location_base_pair Starts at 55024279 and ends at 55034132 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GZMK   4711
Cards
Entrez_Gene (NCBI)GZMK  3003  granzyme K
AliasesTRYP2
GeneCards (Weizmann)GZMK
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr5:55024279-55034132 [Contig_View]  GZMK [Vega]
TCGA cBioPortalGZMK
AceView (NCBI)GZMK
Genatlas (Paris)GZMK
WikiGenes3003
SOURCE (Princeton)GZMK
Genetics Home Reference (NIH)GZMK
Genomic and cartography
GoldenPath hg38 (UCSC)GZMK  -     chr5:55024279-55034132 +  5q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GZMK  -     5q11.2   [Description]    (hg19-Feb_2009)
EnsemblGZMK - 5q11.2 [CytoView hg19]  GZMK - 5q11.2 [CytoView hg38]
Mapping of homologs : NCBIGZMK [Mapview hg19]  GZMK [Mapview hg38]
OMIM600784   
Gene and transcription
Genbank (Entrez)AK312074 BC035802 DQ894093 EU176203 U26174
RefSeq transcript (Entrez)NM_002104
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GZMK
Cluster EST : UnigeneHs.277937 [ NCBI ]
CGAP (NCI)Hs.277937
Gene ExpressionGZMK [ NCBI-GEO ]   GZMK [ EBI - ARRAY_EXPRESS ]   GZMK [ SEEK ]   GZMK [ MEM ]
Gene Expression Viewer (FireBrowse)GZMK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3003
GTEX Portal (Tissue expression)GZMK
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49863   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49863  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49863
Splice isoforms : SwissVarP49863
Catalytic activity : Enzyme3.4.21.- [ Enzyme-Expasy ]   3.4.21.-3.4.21.- [ IntEnz-EBI ]   3.4.21.- [ BRENDA ]   3.4.21.- [ KEGG ]   
PhosPhoSitePlusP49863
Domaine pattern : Prosite (Expaxy)TRYPSIN_DOM (PS50240)    TRYPSIN_HIS (PS00134)    TRYPSIN_SER (PS00135)   
Domains : Interpro (EBI)Peptidase_S1_PA    Peptidase_S1A    Trypsin_dom    TRYPSIN_HIS    TRYPSIN_SER   
Domain families : Pfam (Sanger)Trypsin (PF00089)   
Domain families : Pfam (NCBI)pfam00089   
Domain families : Smart (EMBL)Tryp_SPc (SM00020)  
Conserved Domain (NCBI)GZMK
DMDM Disease mutations3003
Blocks (Seattle)GZMK
PDB (SRS)1MZA    1MZD   
PDB (PDBSum)1MZA    1MZD   
PDB (IMB)1MZA    1MZD   
PDB (RSDB)1MZA    1MZD   
Structural Biology KnowledgeBase1MZA    1MZD   
SCOP (Structural Classification of Proteins)1MZA    1MZD   
CATH (Classification of proteins structures)1MZA    1MZD   
SuperfamilyP49863
Peptide AtlasP49863
HPRD02872
IPIIPI00028602   
Protein Interaction databases
DIP (DOE-UCLA)P49863
IntAct (EBI)P49863
BioGRIDGZMK
STRING (EMBL)GZMK
ZODIACGZMK
Ontologies - Pathways
QuickGOP49863
Ontology : AmiGOserine-type endopeptidase activity  extracellular region  proteolysis  serine-type peptidase activity  
Ontology : EGO-EBIserine-type endopeptidase activity  extracellular region  proteolysis  serine-type peptidase activity  
NDEx NetworkGZMK
Atlas of Cancer Signalling NetworkGZMK
Wikipedia pathwaysGZMK
Orthology - Evolution
OrthoDB3003
Phylogenetic Trees/Animal Genes : TreeFamGZMK
HOVERGENP49863
HOGENOMP49863
Homologs : HomoloGeneGZMK
Homology/Alignments : Family Browser (UCSC)GZMK
Gene fusions - Rearrangements
Fusion: Tumor Portal GZMK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGZMK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GZMK
dbVarGZMK
ClinVarGZMK
1000_GenomesGZMK 
Exome Variant ServerGZMK
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP3003
Genomic Variants (DGV)GZMK [DGVbeta]
DECIPHERGZMK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGZMK 
Mutations
ICGC Data PortalGZMK 
TCGA Data PortalGZMK 
Broad Tumor PortalGZMK
OASIS PortalGZMK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGZMK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGZMK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GZMK
DgiDB (Drug Gene Interaction Database)GZMK
DoCM (Curated mutations)GZMK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GZMK (select a term)
intoGenGZMK
Cancer3DGZMK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600784   
Orphanet
MedgenGZMK
Genetic Testing Registry GZMK
NextProtP49863 [Medical]
TSGene3003
GENETestsGZMK
Target ValidationGZMK
Huge Navigator GZMK [HugePedia]
snp3D : Map Gene to Disease3003
BioCentury BCIQGZMK
ClinGenGZMK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD3003
Chemical/Pharm GKB GenePA29089
Clinical trialGZMK
Miscellaneous
canSAR (ICR)GZMK (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGZMK
EVEXGZMK
GoPubMedGZMK
iHOPGZMK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Nov 9 11:50:07 CET 2017

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